Medical Lawfare: The Palestinian Nakba and Israel’s Attacks on Healthcare

In this article, the authors coin the phrase medical lawfare to describe how Israel has been justifying its systematic attacks on healthcare facilities in the Gaza Strip during its five military assaults on the besieged enclave between 2008 and 2023. They show how Israel mobilizes the laws of armed conflict dealing with human shields and “hospital shields” to securitize lifesaving and sustaining infrastructures and legitimize their destruction. They describe how medical lawfare works as a racialized form of necropolitical governance that intensifies the Nakba’s settler-colonial logic of elimination while casting Palestinians as guilty of bringing disaster upon themselves

The recovery of historical paths for tourism as tool for social and territorial development: the palestinian case of Battir

status: publishe

Implementation of the Hydrographic Data Acquisition and Processing System (HDAPS) in the NOAA Fleet

The U.S. National Oceanic and Atmospheric Administration (NOAA) has developed an automated system for acquiring and processing hydrographic field data in support of its charting mission. The Hydrographic Data Acquisition and Processing System (HDAPS) addresses NOAA’s broad requirement to conduct hydrographic surveys in the coastal waters of the U.S. Systems have been successfully deployed on ships, launches, and small boats. Two types of HDAPS data acquisition systems (DAS) are presented. The first system, based on Hewlett-Packard (HP) hardware, is deployed on ships and launches. The second type is a small boat, 24-volt system, based on 1BM-PC compatible hardware. Both types of DAS are capable of conducting echo sounding and side scan sonar surveys. Data acquired by both systems are processed on an HP-based data processing system

The Good, Bad and the Indifferent: Explorations in Recommender System Health

Our work is based on the premise that analysis of the connections exploited by a recommender algorithm can provide insight into the algorithm that could be useful to predict its performance in a fielded system. We use the jumping connections model defined by Mirza et al. [6], which describes the recommendation process in terms of graphs. Here we discuss our work that has come out of trying to understand algorithm behavior in terms of these graphs. We start by describing a natural extension of the jumping connections model of Mirza et al., and then discuss observations that have come from our studies, and the directions in which we are going

Design of a multi-purpose building "to zero energy consumption" according to european directive 2010/31/ce: Architectural and plant solutions

Considering the significant impact that the residential sector has on energy consumption, it is particularly important to implement policies aimed at improving energy efficiency in buildings for saving primary energy, and also to spread the concept of sustainable development through the use of appropriate technology and proper project criteria for new constructions. For these reasons the Municipality of Città della Pieve promoted the creation of a "Renewable Energy Park" in a deprived area of its territory, so that there were the main technologies for the production of green energy. In this context, it could not be lacking an educational/demonstrative "zero energy consumption" building for multifunctional activities realized with the most innovative techniques to save energy. The building will exemplify the optimization of the benefits derived from improved energy efficiency in synergy with systems of energy production from renewable sources, such as to make possible the transition from "passive" building to get to "active" building. In this paper we describe the technical solutions adopted both in the building envelope and the system concept for the project of that "zero energy consumption" building according to Directive 2010/31/CE. In order to validate the proposed solutions, it has also been carried out a simulation of the behaviour of the building in summer and winter so that it is possible to assess the actual benefits obtained both in terms of energy and in economic terms following the adoption of the proposed solutions

From knock-out phenotype to three-dimensional structure of a promising antibiotic target from streptococcus pneumoniae

Given the rise in drug-resistant Streptococcus pneumoniae, there is an urgent need to discover new antimicrobials targeting this pathogen and an equally urgent need to characterize new drug targets. A promising antibiotic target is dihydrodipicolinate synthase (DHDPS), which catalyzes the rate-limiting step in lysine biosynthesis. In this study, we firstly show by gene knock out studies that S. pneumoniae (sp) lacking the DHDPS gene is unable to grow unless supplemented with lysine-rich media. We subsequently set out to characterize the structure, function and stability of the enzyme drug target. Our studies show that sp-DHDPS is folded and active with a kcat = 22 s-1 , KM PYR = 2.55 ± 0.05 mM and KM ASA = 0.044 ± 0.003 mM. Thermal denaturation experiments demonstrate sp-DHDPS exhibits an apparent melting temperature (TM app) of 72 °C, which is significantly greater than Escherichia coli DHDPS (Ec-DHDPS) (TM app = 59 °C). Sedimentation studies show that sp-DHDPS exists in a dimer-tetramer equilibrium with a KD 4→2 = 1.7 nM, which is considerably tighter than its E. coli ortholog (KD 4→2 = 76 nM). To further characterize the structure of the enzyme and probe its enhanced stability, we solved the high resolution (1.9 Å) crystal structure of sp-DHDPS (PDB ID 3VFL). The enzyme is tetrameric in the crystal state, consistent with biophysical measurements in solution. Although the sp-DHDPS and Ec-DHDPS active sites are almost identical, the tetramerization interface of the s. pneumoniae enzyme is significantly different in composition and has greater buried surface area (800 Å2 ) compared to its E. coli counterpart (500 Å2 ). This larger interface area is consistent with our solution studies demonstrating that sp-DHDPS is considerably more thermally and thermodynamically stable than Ec-DHDPS

Dynamic Agent Systems in the CoAX Binni 2002 Experiment

The University of Edinburgh and research sponsors are authorised to reproduce and distribute reprints and on-line copies for their purposes notwithstanding any copyright annotation hereon. The views and conclusions contained herein are the author’s and shouldn’t be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of other parties.The goal of the international CoAX (Coalition Agents eXperiment) program was to demonstrate how agent systems could be used to provide agile and flexible command and control systems for coalition operations, and facilitate rapid integration of national C2 systems. The CoAX experiments modelled a coalition C4ISR system as a distributed, heterogeneous agent network using the DARPA CoABS (Control of Agent Based Systems) Grid infrastructure based on Java JINI technology. This paper outlines the CoAX Binni experiment which was held in October 2002 at the US Naval Warfare College, Newport RI. It describes the technology used in this experiment and the role of the ATTITUDE multi-agent architecture in the Australian component of the experiment. This involved logistics planning (and dynamic replanning) for a casualty evacuation from an Australian ship using BDI agents developed in the ATTITUDE architecture, and included interactions with Coalition medical and planning agents. Distributed agents were used to represent the various organisational entities involved in a simplified logistics model, and agent interactions with the Coalition C4ISR system were mediated by human operators using I-X Process Panels. This provided a semi-autonomous system, where human approval initiated further autonomous interactions between Coalition and Australian agents

Sunscreens - Which and what for?

It is well established that sun exposure is the main cause for the development of skin cancer. Chronic continuous UV radiation is believed to induce malignant melanoma, whereas intermittent high-dose UV exposure contributes to the occurrence of actinic keratosis as precursor lesions of squamous cell carcinoma as well as basal cell carcinoma. Not only photocarcinogenesis but also the mechanisms of photoaging have recently become apparent. In this respect the use of sunscreens seemed to prove to be more and more important and popular within the last decades. However, there is still inconsistency about the usefulness of sunscreens. Several studies show that inadequate use and incomplete UV spectrum efficacy may compromise protection more than previously expected. The sunscreen market is crowded by numerous products. Inorganic sunscreens such as zinc oxide and titanium oxide have a wide spectral range of activity compared to most of the organic sunscreen products. It is not uncommon for organic sunscreens to cause photocontact allergy, but their cosmetic acceptability is still superior to the one given by inorganic sunscreens. Recently, modern galenic approaches such as micronization and encapsulation allow the development of high-quality inorganic sunscreens. The potential systemic toxicity of organic sunscreens has lately primarily been discussed controversially in public, and several studies show contradictory results. Although a matter of debate, at present the sun protection factor (SPF) is the most reliable information for the consumer as a measure of sunscreen filter efficacy. In this context additional tests have been introduced for the evaluation of not only the protective effect against erythema but also protection against UV-induced immunological and mutational effects. Recently, combinations of UV filters with agents active in DNA repair have been introduced in order to improve photoprotection. This article reviews the efficacy of sunscreens in the prevention of epithelial and nonepithelial skin cancer, the effect on immunosuppression and the value of the SPF as well as new developments on the sunscreen market. Copyright (C) 2005 S. Karger AG, Basel

Bioremediation in marine ecosystems: a computational study combining ecological modeling and flux balance analysis

The pressure to search effective bioremediation methodologies for contaminated ecosystems has led to the large-scale identification of microbial species and metabolic degradation pathways. However, minor attention has been paid to the study of bioremediation in marine food webs and to the definition of integrated strategies for reducing bioaccumulation in species. We propose a novel computational framework for analysing the multiscale effects of bioremediation at the ecosystem level, based on coupling food web bioaccumulation models and metabolic models of degrading bacteria. The combination of techniques from synthetic biology and ecological network analysis allows the specification of arbitrary scenarios of contaminant removal and the evaluation of strategies based on natural or synthetic microbial strains. In this study, we derive a bioaccumulation model of polychlorinated biphenyls (PCBs) in the Adriatic food web, and we extend a metabolic reconstruction of Pseudomonas putida KT2440 (iJN746) with the aerobic pathway of PCBs degradation. We assess the effectiveness of different bioremediation scenarios in reducing PCBs concentration in species and we study indices of species centrality to measure their importance in the contaminant diffusion via feeding links. The analysis of the Adriatic sea case study suggests that our framework could represent a practical tool in the design of effective remediation strategies, providing at the same time insights into the ecological role of microbial communities within food webs