Interesting dynamics at high mutual inclination in the framework of the Kozai problem with an eccentric perturber

We study the dynamics of the 3-D three-body problem of a small body moving under the attractions of a star and a giant planet which orbits the star on a much wider and elliptic orbit. In particular, we focus on the influence of an eccentric orbit of the outer perturber on the dynamics of a small highly inclined inner body. Our analytical study of the secular perturbations relies on the classical octupole hamiltonian expansion (third-order theory in the ratio of the semi-major axes), as third-order terms are needed to consider the secular variations of the outer perturber and potential secular resonances between the arguments of the pericenter and/or longitudes of the node of both bodies. Short-period averaging and node reduction (Laplace plane) reduce the problem to two degrees of freedom. The four-dimensional dynamics is analyzed through representative planes which identify the main equilibria of the problem. As in the circular problem (i.e. perturber on a circular orbit), the "Kozai-bifurcated" equilibria play a major role in the dynamics of an inner body on quasi-circular orbit: its eccentricity variations are very limited for mutual inclination between the orbital planes smaller than ~40^{\deg}, while they become large and chaotic for higher mutual inclination. Particular attention is also given to a region around 35^{\deg} of mutual inclination, detected numerically by Funk et al. (2011) and consisting of long-time stable and particularly low eccentric orbits of the small body. Using a 12th-order Hamiltonian expansion in eccentricities and inclinations, in particular its action-angle formulation obtained by Lie transforms in Libert & Henrard (2008), we show that this region presents an equality of two fundamental frequencies and can be regarded as a secular resonance. Our results also apply to binary star systems where a planet is revolving around one of the two stars.Comment: 12 pages, 9 figures, accepted for publication in MNRA

Structure of even-even nuclei using a mapped collective Hamiltonian and the D1S Gogny interaction

A systematic study of low energy nuclear structure at normal deformation is carried out using the Hartree-Fock-Bogoliubov theory extended by the Generator Coordinate Method and mapped onto a 5-dimensional collective quadrupole Hamiltonian. Results obtained with the Gogny D1S interaction are presented from dripline to dripline for even-even nuclei with proton numbers Z=10 to Z=110 and neutron numbers N less than 200. The properties calculated for the ground states are their charge radii, 2-particle separation energies, correlation energies, and the intrinsic quadrupole shape parameters. For the excited spectroscopy, the observables calculated are the excitation energies and quadrupole as well as monopole transition matrix elements. We examine in this work the yrast levels up to J=6, the lowest excited 0^+ states, and the two next yrare 2^+ states. The theory is applicable to more than 90% of the nuclei which have tabulated measurements. The data set of the calculated properties of 1712 even-even nuclei, including spectroscopic properties for 1693 of them, are provided in CEA website and EPAPS repository with this article \cite{epaps}.Comment: 51 pages with 26 Figures and 4 internal tables; this version is accepted by Physical Review

A RADICAL APPROACH TO DIAGNOSING INFECTION

SCOPUS: no.jinfo:eu-repo/semantics/publishe

Naked mole rat TRF1 safeguards glycolytic capacity and telomere replication under low oxygen.

The naked mole rat (NMR), a long-lived and cancer-resistant rodent, is highly resistant to hypoxia. Here, using robust cellular models wherein the mouse telomeric protein TRF1 is substituted by NMR TRF1 or its mutant forms, we show that TRF1 supports maximal glycolytic capacity under low oxygen, shows increased nuclear localization and association with telomeres, and protects telomeres from replicative stress. We pinpoint this evolutionary gain of metabolic function to specific amino acid changes in the homodimerization domain of this protein. We further find that NMR TRF1 accelerates telomere shortening. These findings reveal an evolutionary strategy to adapt telomere biology for metabolic control under an extreme environment

Secular dynamics of a planar model of the Sun-Jupiter-Saturn-Uranus system; effective stability into the light of Kolmogorov and Nekhoroshev theories

We investigate the long-time stability of the Sun-Jupiter-Saturn-Uranus system by considering a planar secular model, that can be regarded as a major refinement of the approach first introduced by Lagrange. Indeed, concerning the planetary orbital revolutions, we improve the classical circular approximation by replacing it with a solution that is invariant up to order two in the masses; therefore, we investigate the stability of the secular system for rather small values of the eccentricities. First, we explicitly construct a Kolmogorov normal form, so as to find an invariant KAM torus which approximates very well the secular orbits. Finally, we adapt the approach that is at basis of the analytic part of the Nekhoroshev's theorem, so as to show that there is a neighborhood of that torus for which the estimated stability time is larger than the lifetime of the Solar System. The size of such a neighborhood, compared with the uncertainties of the astronomical observations, is about ten times smaller.Comment: 31 pages, 2 figures. arXiv admin note: text overlap with arXiv:1010.260

Transfer of Communication Skills to the Workplace during Clinical Rounds : Impact of a Program for Residents

peer reviewe

The enrichment of an alkaliphilic biofilm consortia capable of the anaerobic degradation of isosaccharinic acid from cellulosic materials incubated within an anthropogenic, hyperalkaline environment.

Anthropogenic hyper-alkaline sites provide an environment that is analogous to proposed cementitious geological disposal facilities (GDF) for radioactive waste. Under anoxic, alkaline conditions cellulosic wastes will hydrolyse to a range of cellulose degradation products (CDP) dominated by isosaccharinic acids (ISA). In order to investigate the potential for microbial activity in a cementitious GDF, cellulose samples were incubated in the alkaline (∼pH 12), anaerobic zone of a lime kiln waste site. Following retrieval, these samples had undergone partial alkaline hydrolysis and were colonised by a Clostridia dominated biofilm community, where hydrogenotrophic, alkaliphilic methanogens were also present. When these samples were used to establish an alkaline CDP fed microcosm, the community shifted away from Clostridia, methanogens became undetectable and a flocculate community dominated by Alishewanella sp. established. These flocs were composed of bacteria embedded in polysaccharides and protein stabilised by extracellular DNA. This community was able to degrade all forms of ISA with >60% of the carbon flow being channelled into extracellular polymeric substance (EPS) production. This study demonstrated that alkaliphilic microbial communities can degrade the CDP associated with some radioactive waste disposal concepts at pH 11. These communities divert significant amounts of degradable carbon to EPS formation, suggesting that EPS has a central role in the protection of these communities from hyper-alkaline conditions

Necrostatin-1 Analogues: Critical Issues on the Specificity, Activity and In Vivo Use in Experimental Disease Models

Necrostatin-1 (Nec-1) is widely used in disease models to examine the contribution of receptor-interacting protein kinase (RIPK) 1 in cell death and inflammation. We studied three Nec-1 analogs: Nec-1, the active inhibitor of RIPK1, Nec-1 inactive (Nec-1i), its inactive variant, and Nec-1 stable (Nec-1s), its more stable variant. We report that Nec-1 is identical to methyl-thiohydantoin-tryptophan, an inhibitor of the potent immunomodulatory enzyme indoleamine 2,3-dioxygenase (IDO). Both Nec-1 and Nec-1i inhibited human IDO, but Nec-1s did not, as predicted by molecular modeling. Therefore, Nec-1s is a more specific RIPK1 inhibitor lacking the IDO-targeting effect. Next, although Nec-1i was ∼100 × less effective than Nec-1 in inhibiting human RIPK1 kinase activity in vitro, it was only 10 times less potent than Nec-1 and Nec-1s in a mouse necroptosis assay and became even equipotent at high concentrations. Along the same line, in vivo, high doses of Nec-1, Nec-1i and Nec-1s prevented tumor necrosis factor (TNF)-induced mortality equally well, excluding the use of Nec-1i as an inactive control. Paradoxically, low doses of Nec-1 or Nec-1i, but not Nec -1s, even sensitized mice to TNF-induced mortality. Importantly, Nec-1s did not exhibit this low dose toxicity, stressing again the preferred use of Nec-1s in vivo. Our findings have important implications for the interpretation of Nec-1-based data in experimental disease models

Quantifying Web Adblocker Privacy

Web advertisements, an integral part of today\u27s web browsing experience, financially support countless websites. Meaningful advertisements, however, require behavioral targeting, user tracking and profile fingerprinting that raise serious privacy concerns. To counter privacy issues and enhance usability, adblockers emerged as a popular way to filter web requests that do not serve the website\u27s main content. Despite their popularity, little work has focused on quantifying the privacy provisions of adblockers. In this paper, we develop a quantitative approach to objectively compare the privacy of adblockers. We propose a model based on a set of privacy metrics that captures not only the technical web architecture, but also the underlying corporate institutions of the problem across time and geography. We investigate experimentally the effect of various combinations of ad-blocking software and browser settings on 1000 Web sites. Our results highlight a significant difference among adblockers in terms of filtering performance, in particular affected by the applied configurations. Besides the ability to judge the filtering capabilities of existing adblockers and their particular configurations, our work provides a general framework to evaluate new adblocker proposals