Medidas experimentales de desplazamientos micrométricos basadas en vórtices ópticos

In this work, a system for measuring micrometer-displacements based on the characteristics of optical vortices is presented. In the proposal, a binary vortex-producing lens (BVPL) programmed to generate optimized optical vortices is transversally displaced from the optical axis, inducing perturbations on the optical characteristics of the vortices that are used as transduction parameters. Specifically, the method proposed theoretically by Anzolin et al. [18], which is based on the asymmetry of the intensity patterns of the off-axis optical vortices, is studied experimentally by using BVPLs. Experimental implementation is completely described and compared with theoretical results, likewise, metrological characteristics of the experimental metrological system are analyzed. Based on the results, we experimentally confirm the possibility of creating high sensitivity metrological systems by using optical vortices, opening the door for new vortex metrology techniques.En este trabajo, un sistema para medir desplazamientos micrométricos basados en las características de vórtices ópticos es presentado. En la propuesta, una lente productora de vórtices binaria (BVPL) programada para generar vórtices ópticos optimizados es desplazada transversalmente del eje óptico, induciendo perturbaciones en las características ópticas de los vórtices que son usadas como parámetros de transducción. Específicamente, el método propuesto por Anzolín et al [18], el cuál es basado en la asimetría de los patrones de intensidad de los vórtices ópticos fuera del eje, es estudiado experimentalmente usando BVPLs. Se describe completamente la implementación experimental y se compara con los resultados teóricos, así mismo, se analizan características metrológicas del sistema metrológico experimental. En base a los resultados, confirmamos experimentalmente la posibilidad de crear sistemas metrológicos de alta sensibilidad utilizando vórtices ópticos, abriendo la puerta para nuevas técnicas de metrología de vórtices.Centro de Investigaciones Óptica

Realistic Exact Solution for the Exterior Field of a Rotating Neutron Star

A new six-parametric, axisymmetric and asymptotically flat exact solution of Einstein-Maxwell field equations having reflection symmetry is presented. It has arbitrary physical parameters of mass, angular momentum, mass--quadrupole moment, current octupole moment, electric charge and magnetic dipole, so it can represent the exterior field of a rotating, deformed, magnetized and charged object; some properties of the closed-form analytic solution such as its multipolar structure, electromagnetic fields and singularities are also presented. In the vacuum case, this analytic solution is matched to some numerical interior solutions representing neutron stars, calculated by Berti & Stergioulas (Mon. Not. Roy. Astron. Soc. 350, 1416 (2004)), imposing that the multipole moments be the same. As an independent test of accuracy of the solution to describe exterior fields of neutron stars, we present an extensive comparison of the radii of innermost stable circular orbits (ISCOs) obtained from Berti & Stergioulas numerical solutions, Kerr solution (Phys. Rev. Lett. 11, 237 (1963)), Hartle & Thorne solution (Ap. J. 153, 807, (1968)), an analytic series expansion derived by Shibata & Sasaki (Phys. Rev. D. 58 104011 (1998)) and, our exact solution. We found that radii of ISCOs from our solution fits better than others with realistic numerical interior solutions.Comment: 13 pages, 13 figures, LaTeX documen

The double-Kerr equilibrium configurations involving one extreme object

We demonstrate the existence of equilibrium states in the limiting cases of the double-Kerr solution when one of the constituents is an extreme object. In the `extreme-subextreme' case the negative mass of one of the constituents is required for the balance, whereas in the `extreme-superextreme' equilibrium configurations both Kerr particles may have positive masses. We also show that the well-known relation |J|=M^2 between the mass and angular momentum in the extreme single Kerr solution ceases to be a characteristic property of the extreme Kerr particle in a binary system.Comment: 12 pages, 3 figures, submitted to Class. Quantum Gra

Medidas experimentales de desplazamientos micrométricos basadas en vórtices ópticos

In this work, a system for measuring micrometer-displacements based on the characteristics of optical vortices is presented. In the proposal, a binary vortex-producing lens (BVPL) programmed to generate optimized optical vortices is transversally displaced from the optical axis, inducing perturbations on the optical characteristics of the vortices that are used as transduction parameters. Specifically, the method proposed theoretically by Anzolin et al. [18], which is based on the asymmetry of the intensity patterns of the off-axis optical vortices, is studied experimentally by using BVPLs. Experimental implementation is completely described and compared with theoretical results, likewise, metrological characteristics of the experimental metrological system are analyzed. Based on the results, we experimentally confirm the possibility of creating high sensitivity metrological systems by using optical vortices, opening the door for new vortex metrology techniques.En este trabajo, un sistema para medir desplazamientos micrométricos basados en las características de vórtices ópticos es presentado. En la propuesta, una lente productora de vórtices binaria (BVPL) programada para generar vórtices ópticos optimizados es desplazada transversalmente del eje óptico, induciendo perturbaciones en las características ópticas de los vórtices que son usadas como parámetros de transducción. Específicamente, el método propuesto por Anzolín et al [18], el cuál es basado en la asimetría de los patrones de intensidad de los vórtices ópticos fuera del eje, es estudiado experimentalmente usando BVPLs. Se describe completamente la implementación experimental y se compara con los resultados teóricos, así mismo, se analizan características metrológicas del sistema metrológico experimental. En base a los resultados, confirmamos experimentalmente la posibilidad de crear sistemas metrológicos de alta sensibilidad utilizando vórtices ópticos, abriendo la puerta para nuevas técnicas de metrología de vórtices.Centro de Investigaciones Óptica

La ruta del mosaico romano: el sur de hispania (Anadalucía y Algarve)

A Hispânia meridional corresponde ao sul de duas províncias romanas – a Bética (actual Andaluzia) e a Lusitania (Portugal) – que tiveram grande prosperidade económica, desde a época de Augusto até ao final da Antiguidade (finais do século IV). Os mosaicos que decoravam o chão das casas mais ricas aparecidas nos últimos vinte anos nas escavações em cidades – como em Faro/Ossonoba, na Lusitania e em Écija/ Astigi, na Bética – e nas villae rurais que se encontram maioritariamente nos arredores das cidades – como em Cerro da Vila (Vilamoura)e em Milreu (Estoi), no Algarve – demonstram o elevado nível de desenvolvimento económico,social e cultural das duas províncias durante o período compreendido entre os séculos I e IV d.C

A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort

<p><b>Objectives</b> The aim of this study was to confirm the influence of TNFSF4 polymorphisms on systemic sclerosis (SSc) susceptibility and phenotypic features.</p> <p><b>Methods</b> A total of 8 European populations of Caucasian ancestry were included, comprising 3014 patients with SSc and 3125 healthy controls. Four genetic variants of TNFSF4 gene promoter (rs1234314, rs844644, rs844648 and rs12039904) were selected as genetic markers.</p> <p><b>Results</b> A pooled analysis revealed the association of rs1234314 and rs12039904 polymorphisms with SSc (OR 1.15, 95% CI 1.02 to 1.31; OR 1.18, 95% CI 1.08 to 1.29, respectively). Significant association of the four tested variants with patients with limited cutaneous SSc (lcSSc) was revealed (rs1234314 OR 1.22, 95% CI 1.07 to 1.38; rs844644 OR 0.91, 95% CI 0.83 to 0.99; rs844648 OR 1.10, 95% CI 1.01 to 1.20 and rs12039904 OR 1.20, 95% CI 1.09 to 1.33). Association of rs1234314, rs844648 and rs12039904 minor alleles with patients positive for anti-centromere antibodies (ACA) remained significant (OR 1.23, 95% CI 1.10 to 1.37; OR 1.12, 95% CI 1.01 to 1.25; OR 1.22, 95% CI 1.07 to 1.38, respectively). Haplotype analysis confirmed a protective haplotype associated with SSc, lcSSc and ACA positive subgroups (OR 0.88, 95% CI 0.82 to 0.96; OR 0.88, 95% CI 0.80 to 0.96; OR 0.86, 95% CI 0.77 to 0.97, respectively) and revealed a new risk haplotype associated with the same groups of patients (OR 1.14, 95% CI 1.03 to 1.26; OR 1.20, 95% CI 1.08 to 1.35; OR 1.23, 95% CI 1.07 to 1.42, respectively).</p> <p><b>Conclusions</b> The data confirm the influence of TNFSF4 polymorphisms in SSc genetic susceptibility, especially in subsets of patients positive for lcSSc and ACA.</p&gt

Deep Sea Sedimentation

This article offers an overview of the main sedimentary systems defining the geomorphology of deep sea environments from low to high latitudes. Mass-transport deposits, turbidite systems, contourites, volcaniclastic aprons, glacial trough mouth systems, carbonate mounds and other bathyal systems, such as pelagites, hemipelagites, mid-ocean channels and polymetallic mineral deposits, are presented with special attention to their morphology, sediments, processes and controlling factors. The integration of the main systems on the continental margins and adjacent abyssal plains in the North Atlantic and westernmost Mediterranean allows to characterize different sedimentation models.En prens

Early invasive vulvar squamous cell carcinoma arising in a woman with vulvar pemphigus vulgaris and systemic lupus erythematosus

Pemphigus vulgaris (PV) is an autoimmune blistering disease of the skin and mucous membranes. Genital involvement occurs when most other common sites are concurrently affected or are in remission. Systemic lupus erythematosus (SLE) is an autoimmune disease that may affect many parts of the body and the skin with occasional bullous lesions. Pemphigus vulgaris and SLE may be associated, albeit rarely. Here, we report the first case of a woman affected with SLE presenting with early invasive squamous cell carcinoma (SCC) arising from Pemphigus Vulgaris of the vulva

Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study

Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the APOE locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (LZTFL1, SLC6A20) implicated in the susceptibility to SARS-CoV-2 infection and TYK2 gene might be involved in COVID-19 severity. Nevertheless, no statistically significant association was observed in the COVID-19 fatal outcome or in the stratified analyses (dementia-only and non-dementia strata) for the APOE locus not supporting its involvement in SARS-CoV-2 pathobiology or COVID-19 prognosis

Psychometric characteristics of the Spanish version of instruments to measure neck pain disability

Background: The NDI, COM and NPQ are evaluation instruments for disability due to NP. There was no Spanish version of NDI or COM for which psychometric characteristics were known. The objectives of this study were to translate and culturally adapt the Spanish version of the Neck Disability Index Questionnaire (NDI), and the Core Outcome Measure (COM), to validate its use in Spanish speaking patients with non-specific neck pain (NP), and to compare their psychometric characteristics with those of the Spanish version of the Northwick Pain Questionnaire (NPQ). Methods: Translation/re-translation of the English versions of the NDI and the COM was done blindly and independently by a multidisciplinary team. The study was done in 9 primary care Centers and 12 specialty services from 9 regions in Spain, with 221 acute, subacute and chronic patients who visited their physician for NP: 54 in the pilot phase and 167 in the validation phase. Neck pain (VAS), referred pain (VAS), disability (NDI, COM and NPQ), catastrophizing (CSQ) and quality of life (SF-12) were measured on their first visit and 14 days later. Patients' self-assessment was used as the external criterion for pain and disability. In the pilot phase, patients' understanding of each item in the NDI and COM was assessed, and on day 1 test-retest reliability was estimated by giving a second NDI and COM in which the name of the questionnaires and the order of the items had been changed. Results: Comprehensibility of NDI and COM were good. Minutes needed to fill out the questionnaires [median, (P25, P75)]: NDI. 4 (2.2, 10.0), COM: 2.1 (1.0, 4.9). Reliability: [ICC, (95%CI)]: NDI: 0.88 (0.80, 0.93). COM: 0.85 (0.75,0.91). Sensitivity to change: Effect size for patients having worsened, not changed and improved between days 1 and 15, according to the external criterion for disability: NDI: -0.24, 0.15, 0.66; NPQ: -0.14, 0.06, 0.67; COM: 0.05, 0.19, 0.92. Validity: Results of NDI, NPQ and COM were consistent with the external criterion for disability, whereas only those from NDI were consistent with the one for pain. Correlations with VAS, CSQ and SF-12 were similar for NDI and NPQ (absolute values between 0.36 and 0.50 on day 1, between 0.38 and 0.70 on day 15), and slightly lower for COM (between 0.36 and 0.48 on day 1, and between 0.33 and 0.61 on day 15). Correlation between NDI and NPQ: r = 0.84 on day 1, r = 0.91 on day 15. Correlation between COM and NPQ: r = 0.63 on day 1, r = 0.71 on day 15. Conclusion: Although most psychometric characteristics of NDI, NPQ and COM are similar, those from the latter one are worse and its use may lead to patients' evolution seeming more positive than it actually is. NDI seems to be the best instrument for measuring NP-related disability, since its results are the most consistent with patient's assessment of their own clinical status and evolution. It takes two more minutes to answer the NDI than to answer the COM, but it can be reliably filled out by the patient without assistance