Antifreeze in the hot core of Orion - First detection of ethylene glycol in Orion-KL

Comparison of their chemical compositions shows, to first order, a good agreement between the cometary and interstellar abundances. However, a complex O-bearing organic molecule, ethylene glycol (CH$_{2}$OH)$_{2}$, seems to depart from this correlation because it was not easily detected in the interstellar medium although it proved to be rather abundant with respect to other O-bearing species in comet Hale-Bopp. Ethylene glycol thus appears, together with the related molecules glycolaldehyde CH$_{2}$OHCHO and ethanol CH$_{3}$CH$_{2}$OH, as a key species in the comparison of interstellar and cometary ices as well as in any discussion on the formation of cometary matter. We focus here on the analysis of ethylene glycol in the nearest and best studied hot core-like region, Orion-KL. We use ALMA interferometric data because high spatial resolution observations allow us to reduce the line confusion problem with respect to single-dish observations since different molecules are expected to exhibit different spatial distributions. Furthermore, a large spectral bandwidth is needed because many individual transitions are required to securely detect large organic molecules. Confusion and continuum subtraction are major issues and have been handled with care. We have detected the aGg' conformer of ethylene glycol in Orion-KL. The emission is compact and peaks towards the Hot Core close to the main continuum peak, about 2" to the south-west; this distribution is notably different from other O-bearing species. Assuming optically thin lines and local thermodynamic equilibrium, we derive a rotational temperature of 145 K and a column density of 4.6 10$^{15}$ cm$^{-2}$. The limit on the column density of the gGg' conformer is five times lower.Comment: 19 pages, 10 figures, A&A accepte

HCOOCH3 as a probe of temperature and structure of Orion-KL

We studied the O-bearing molecule HCOOCH3 to characterize the physical conditions of the different molecular source components in Orion-KL. We identify 28 methyl formate emission peaks throughout the 50" field of observations. The two strongest peaks are in the Compact Ridge (MF1) and in the SouthWest of the Hot Core (MF2). Spectral confusion is still prevailing as half of the expected transitions are blended over the region. Assuming that the transitions are thermalized, we derive the temperature at the five main emission peaks. At the MF1 position we find a temperature of 80K in a 1.8"x0.8" beam size and 120K on a larger scale (3.6" x2.2"), suggesting an external source of heating, whereas the temperature is about 130K at the MF2 position on both scales. Transitions of HCOOCH3 in vt=1 are detected as well and the good agreement of the positions on the rotational diagrams between the vt=0 and the vt=1 transitions suggests a similar temperature. The velocity of the gas is between 7.5 and 8.0km/s depending on the positions and column density peaks vary from 1.6x10^16 to 1.6x10^17cm^-2. A second velocity component is observed around 9-10 km/s in a North-South structure stretching from the Compact Ridge up to the BN object; this component is warmer at the MF1 peak. The two other C2H4O2 isomers are not detected and the derived upper limit for the column density is <3x10^14cm^-2 for glycolaldehyde and <2x10^15cm^-2 for acetic acid. From the 223GHz continuum map, we identify several dust clumps with associated gas masses in the range 0.8 to 5.8Msun. Assuming that the HCOOCH3 is spatially distributed as the dust, we find relative abundances of HCOOCH3 in the range <0.1x10^-8 to 5.2x10^-8. We suggest a relation between the methyl formate distribution and shocks as traced by 2.12 mum H2 emission.Comment: Accepted for publication in A&

Gamma and beta frequency oscillations in response to novel auditory stimuli: A comparison of human electroencephalogram (EEG) data with in vitro models

Investigations using hippocampal slices maintained in vitro have demonstrated that bursts of oscillatory field potentials in the gamma frequency range (30-80 Hz) are followed by a slower oscillation in the beta 1 range (12-20 Hz). In this study, we demonstrate that a comparable gamma-to-beta transition is seen in the human electroencephalogram (EEG) in response to novel auditory stimuli. Correlations between gamma and beta 1 activity revealed a high degree of interdependence of synchronized oscillations in these bands in the human EEG. Evoked (stimulus-locked) gamma oscillations preceded beta 1 oscillations in response to novel stimuli, suggesting that this may be analogous to the gamma-to-beta shift observed in vitro. Beta 1 oscillations were the earliest discriminatory responses to show enhancement to novel stimuli, preceding changes in the broad-band event-related potential (mismatch negativity). Later peaks of induced beta activity over the parietal cortex were always accompanied by an underlying gamma frequency oscillation as seen in vitro. A further analogy between in vitro and human recordings was that both gamma and beta oscillations habituated markedly after the initial novel stimulus presentation

Modelling and simulation of operation and maintenance strategy for offshore wind farms based on multiagent system

This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.Maintenance of offshore wind turbines is a complex and costly undertaking which acts as a barrier to the development of this source of energy. Factors such as the size of the turbines, the size of the wind farms, their distance from the coast and meteorological conditions make it difficult for the stakeholders to select the optimal maintenance strategy. With the objective of reducing costs and duration of such operations it is important that new maintenance techniques are investigated. In this paper we propose a hybrid model of maintenance that is based on multi-agent systems; this allows for the modelling of systems with dynamic interactions between multiple parts. A multi-criteria decision algorithm has been developed to allow analysis and selection of different maintenance strategies. A cost model that includes maintenance action cost, energy loss and installation of monitoring system cost has been presented. For the purposes of this research we have developed a simulator using NetLogo software and have provided experimental results. The results show that employing the proposed hybrid maintenance strategy could increase wind farm productivity and reduce maintenance cost.Acknowledgement is made to European Union for the support of this research through the European Program INTERREG IVA France-Channel-UK by funding project entitled MER Innovate

Editorial: Neuromechanics in Movement and Disease With Physiological and Pathophysiological Implications: From Fundamental Experiments to Bio-Inspired Technologies.

SCOPUS: ed.jinfo:eu-repo/semantics/publishe

Formation of disclination lines near a free nematic interface

We have studied the nucleation and the physical properties of a -1/2 wedge disclination line near the free surface of a confined nematic liquid crystal. The position of the disclination line has been related to the material parameters (elastic constants, anchoring energy and favored anchoring angle of the molecules at the free surface). The use of a planar model for the structure of the director field (whose predictions have been contrasted to those of a fully three-dimensional model) has allowed us to relate the experimentally observed position of the disclination line to the relevant properties of the liquid crystals. In particular, we have been able to observe the collapse of the disclination line due to a temperature-induced anchoring angle transition, which has allowed us to rule out the presence of a real disclination line near the nematic/isotropic front in directional growth experiments. 61.30.Jf,61.30.G

The wonderful complexity of the Mira AB system

We have mapped the CO(3-2) line emission around the Mira AB system at 0.5 resolution using the Atacama Large Millimeter/submillimeter Array (ALMA). The CO map shows amazing complexity. The circumstellar gas has been shaped by different dynamical actors during the evolution of the system and several morphological components can be identified. The companion is marginally resolved in continuum emission and is currently at 0.487$\pm$0.006 separation. In the main line component, centered on the stellar velocity, spiral arcs around Mira A are found. The spiral appears to be relatively flat and oriented in the orbital plane. An accretion wake behind the companion is clearly visible and the projected arc separation is of order 5''. In the blue wing of the line emission, offset from the main line, several large ($\sim$5-10''), opposing arcs are found. We tentatively suggest that this structure is created by the wind of Mira B blowing a bubble in the expanding envelope of Mira A.Comment: Letter accepted in A&

Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans

A CAPN1 missense mutation in Parson Russell Terrier dogs is associated with spinocerebellar ataxia. We now report that homozygous or heterozygous CAPN1-null mutations in humans result in cerebellar ataxia and limb spasticity in four independent pedigrees. Calpain-1 knockout (KO) mice also exhibit a mild form of ataxia due to abnormal cerebellar development, including enhanced neuronal apoptosis, decreased number of cerebellar granule cells, and altered synaptic transmission. Enhanced apoptosis is due to absence of calpain-1-mediated cleavage of PH domain and leucine-rich repeat protein phosphatase 1 (PHLPP1), which results in inhibition of the Akt pro-survival pathway in developing granule cells. Injection of neonatal mice with the indirect Akt activator, bisperoxovanadium, or crossing calpain-1 KO mice with PHLPP1 KO mice prevented increased postnatal cerebellar granule cell apoptosis and restored granule cell density and motor coordination in adult mice. Thus, mutations in CAPN1 are an additional cause of ataxia in mammals, including humans