An evolutionary model identifies the main evolutionary biases for the evolution of genome-replication profiles

Recent results comparing the temporal program of genome replication of yeast species belonging to the Lachancea clade support the scenario that the evolution of the replication timing program could be mainly driven by correlated acquisition and loss events of active replication origins. Using these results as a benchmark, we develop an evolutionary model defined as birth-death process for replication origins and use it to identify the evolutionary biases that shape the replication timing profiles. Comparing different evolutionary models with data, we find that replication origin birth and death events are mainly driven by two evolutionary pressures, the first imposes that events leading to higher double-stall probability of replication forks are penalized, while the second makes less efficient origins more prone to evolutionary loss. This analysis provides an empirically grounded predictive framework for quantitative evolutionary studies of the replication timing program

The Politics of Exhaustion and the Externalization of British Border Control. An Articulation of a Strategy Designed to Deter, Control and Exclude

In response to contemporary forms of human mobility, there has been a continued hardening of borders seeking to deter, control and exclude certain groups of people from entering nation states in Europe, North America and Australasia. Within this context, a disconcerting evolution of new and increasingly sophisticated forms of border control measures have emerged, which often play out within bilateral arrangements of “externalised” or “offshore” border controls. Drawing on extensive first‐hand field research among displaced people in Calais, Paris and Brussels in 2016–2019, this paper argues that the externalization of the British border to France is contingent upon a harmful strategy, which can be understood as the “politics of exhaustion.” This is a raft of (micro) practices and methods strategically aimed to deter, control and exclude certain groups of people on the move who have been profiled as “undesirable,” with a detrimental (un)intended impact on human lives

European “freedoms”: a critical analysis

Faced with the present migrant crisis and the dismal record of Europe in protecting vulnerable refugees’ and migrants’ rights, what could be the view of the moral philosopher? The contrast between the principles enshrined in the European Charter of Fundamental Rights and the reality of present policies is shocking, but more scrutiny will show that it is the result of a larger trend towards an understanding of freedom mostly in economic terms, at a time when economists such as Amartya Sen have revised their approach to economic growth and prosperity, noting the central role played by a much richer conception of freedom. The paper will scrutinize these inconsistencies and the conception of the person from which they derive and will provide an alternative and more coherent moral vision that could strengthen the legitimacy of the European Charter, at a time of growing dissatisfaction and so-called democratic deficit. Such a vision could help reconnect the Charter with a conception of the human person as in need not solely of passive legal protection, but also of active promotion of her self-respect and capabilities, and of her aspiration to a valuable life

Refugee artists and memories of displacement: a visual semiotics analysis

This paper considers the ways in which refugee artists represent the experience of displacement, their cultural traditions and the longing for home through paintings and how, by doing so, they become the visual interpreters of the current refugee crisis. The starting point of this article is that little attention has been paid towards the visual narratives of artworks produced by refugee artists and shared on social media. Through the visual semiotics analysis of 150 images of paintings (exhibited on the Facebook page Syria.Art) and through a number of individual interviews with the artists themselves, the article identifies three emerging visual narratives. These are concerned primarily with reminiscences about people, places and cultural practices lost (or in danger of being lost) because of the forced journey and because of the displacement. Within this context, these visual discourses become part of an open repository, which mediates, re-organises and preserves memories, both personal and collective as a form of emotional survival and resilience. It is argued that these visual narratives and representations nurture empathy for the human condition of the refugees and universalise the migrant experience

Braided geographies: bordered forms and cross-border formations in refugee comics

This article offers a close analysis of a trilogy of ‘refugee comics’ entitled ‘A Perilous Journey’, which were produced in 2015 by the non-profit organisation PositiveNegatives, to conceive of comics as a bordered form able to establish alternative cross-border formations, or ‘counter-geographies’, as it calls them. Drawing on the work of Martina Tazzioloi, Thierry Groensteen, Jason Dittmer, Michael Rothberg and others, the article argues that it is by building braided, multi-directional relationships between different geographic spaces, both past and present, that refugee comics realise a set of counter-geographic and potentially decolonising imaginaries. Through their spatial form, refugee comics disassemble geographic space to reveal counter-geographies of multiple synchronic and diachronic relations and coformations, as these occur between different regions and locations, and as they accumulate through complex aggregations of traumatic and other affective memories. The article contends that we need an interdisciplinary combination of the critical reading skills of humanities scholars and the rigorous anthropological, sociological and theoretical work of the social sciences to make sense of the visualisation of these counter-geographic movements in comics. It concludes by showing how the counter-geographies visualised by refugee comics can subvert the geopolitical landscape of discrete nation-states and their territorially bound imagined communities

The government of migrant mobs: Temporary divisible multiplicities in border zones

This article engages with the production and government of migrant multiplicities in border zones of Europe, arguing that the specificity of migrant multiplicities consists in their temporary and divisible character. It is argued that there are three different forms of migrant multiplicities: (1) the multiplicity produced due to migrants’ spatial proximity; (2) the virtual multiplicity generated through data; and (3) the visualized and narrated multiplicity that emerges from media portraits of the ‘spectacle’ of the arrivals of migrants. It is claimed that multiplicities are made to divide and partition the migrants and thus prevent the formation of a collective political subject. In the concluding section, the article deals with the ambivalent character of the term ‘the mob’, addressing the twofold dimension of migrant multiplicities: these are in fact generated by techniques of power, at the same time exceeding them and representing potential emerging political subjects