3,421 research outputs found
Gas Chromatography-Mass Spectrometry Study of the Essential Oils of Schinus longifolia (Lindl.) Speg., Schinus fasciculata (Griseb.) I. M. Johnst., and Schinus areira L.
The essential oil composition from the aerial parts of three Anacardiaceae growing in Bah¨ªa Blanca, Argentina was studied by gas chromatography and gas chromatography-mass spectrometry. The essential oils of S. longifolia and S. fasciculata have been studied for the first time. The major constituents were ¦Á-pinene (46.5%), ¦Â-pinene (15.1%) and ¦Á-phellandrene (10.1%) for S. longifolia and limonene (10.9%), ¦Â-phellandrene (6.16%) and ¦Á-phellandrene (5.6%) for S. fasciculata. The major components of the essential oil of S. areira were limonene (28.6%), ¦Á-phellandrene (10.1%), sabinene (9.2%) and camphene (9.2%) differing from the literature data. The essential oils from S. areira and S. longifolia exhibited a high biotoxicity in a brine shrimp assay with Artemia persimilis.Fil: Murray, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur. Departamento de Química. Instituto de Investigaciones en Química Orgánica; ArgentinaFil: Frontera, Maria Eugenia. Universidad Nacional del Sur. Departamento de Química. Instituto de Investigaciones en Química Orgánica; ArgentinaFil: Tomas, María A.. Universidad Nacional del Sur. Departamento de Química. Instituto de Investigaciones en Química Orgánica; ArgentinaFil: Mulet, María Cristina. Universidad Nacional del Sur. Departamento de Química. Instituto de Investigaciones en Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentin
Pancreatic Cancer Signature Center: Providing the Research Tools Necessary to Advance Pancreatic Cancer Patient Care
poster abstractThere were approximately 43,000 new cases of pancreatic ductal adenocarcinoma (PDAC) in the U.S. in 2010, and approximately 37,000 deaths. PDAC thus constitutes the fourth leading cause of cancer deaths, and PDAC patients have a dismal 5-year survival rate of 6%. PDAC is notoriously resistant to chemotherapy and radiation and even with our best treatment options, a complete margin-negative surgical resection, few patients achieving long-term survival. Despite these statistics, surprisingly only a small number of NCI-designated cancer centers have a specialized pancreatic cancer program. The creation of the IUPUI Signature Center for Pancreatic Cancer Research has been the foundation for putting IUPUI, the IU School of Medicine, Purdue University and the IU Simon Cancer Center at the forefront of pancreatic cancer treatment and research across the nation. The Signature Center, comprised of basic, translational and clinical researchers, represents the continuum of the disease from biological / molecular investigation to clinical trials. Funding from the Signature Center Initiative is being utilized to develop genetically engineered mouse models, orthotopic pancreatic cancer models as well as a human pancreatic cancer xenograft model. Establishment and characterization of these in vivo models provides the groundwork to be used by all members in their translational research projects. Additionally, work has begun on a web portal to promote and educate both patients and clinicians about the IUSCC Pancreas Cancer Clinic which became operational in 2010. Taken together the development of these in vivo models as well as web support of the Pancreas Cancer Clinic provides the infrastructure to support pancreas cancer research across the continuum of bench to bedside to practice. The availability of these resources to all members promotes inter-disciplinary collaborations aimed at increasing our understanding of pancreatic cancer so that advancements can be made in diagnosis, prevention and treatment of this malignancy
Synthesis and conformational analysis of fluorinated uridine analogues provide insight into a neighbouring-group participation mechanism
Funding: This work was supported by the EPSRC council (Grant number 1398501) and GlaxoSmithKline.Fluorinated nucleoside analogues have attracted much attention as anticancer and antiviral agents and as probes for enzymatic function. However, the lack of direct synthetic methods, especially for 2′,3′-dideoxy-2′,3′-difluoro nucleosides, hamper their practical utility. In order to design more efficient synthetic methods, a better understanding of the conformation and mechanism of formation of these molecules is important. Herein, we report the synthesis and conformational analysis of a 2′,3′-dideoxy-2′,3′-difluoro and a 2′-deoxy-2′-fluoro uridine derivative and provide an insight into the reaction mechanism. We suggest that the transformation most likely diverges from the SN1 or SN2 pathway, but instead operates via a neighbouring-group participation mechanism.Publisher PDFPeer reviewe
Inhibition of prolyl oligopeptidase with a synthetic unnatural dipeptide
A new inhibitor, containing a linked proline-piperidine structure, for the enzyme prolyl oligopeptidase (POP) has been synthesised and demonstrated to bind covalently with the enzyme at the active site. This provides evidence that covalent inhibitors of POP do not have to be limited to structures containing five-membered N-containing heterocyclic rings
A long look at the BALQSO LBQS 2212-1759 with XMM-Newton
Very long (172 ks effective exposure time) observations of the BALQSO LBQS
2212-1759 with XMM-Newton yield a stringent upper-limit on its 0.2-10 keV
(rest- frame 0.64-32.2 keV) flux, F < 6 E-17 erg/cm2/s, while simultaneous UV
and optical observations reveal a rather blue spectrum extending to 650 A in
the source rest frame. These results are used to set a tight upper-limit on its
optical to X-ray spectral index alpha_{ox} < -2.56. Given the HI-BAL nature of
LBQS 212-1759, its X-ray weakness is most likely due to intrinsic absorption.
If this is the case, and assuming that the intrinsic alpha_{ox} of LBQS
2212-1759 is -1.63 - a value appropriate for a radio-quiet quasar of this
luminosity - one can set a lower limit on the X-ray absorbing column N_{H} >
3.4 E25 cm-2. Such a large column has a Thomson optical depth to electron
scattering tau > 23, sufficient to extinguish the optical and UV emission. The
problem only gets worse if the gas is neutral since the opacity in the Lyman
continuum becomes extremely large, > 2 E8, conflicting with the source
detection below 912 A. This apparent contradiction probably means that our
lines-of-sight to the X-ray and to the UV emitting regions are different, such
that the gas covers completely the compact X-ray source but only partially the
more extended source of ultraviolet photons. An extended (~ 1') X-ray source is
detected 2' to the south-east of the QSO. Given its thermal spectrum and
temperature (1.5 < T < 3.0 keV}, it is probably a foreground (0.29 < z < 0.46)
cluster of galaxies.Comment: 9 pages, 3 figures, A&A latex, accepted for publication in Astronomy
& Astrophysic
Fatigue life analysis of hybrid E-glass/carbon fibre powder epoxy materials for wind turbine blades
CANDELS/GOODS-S, CDFS, ECDFS: Photometric Redshifts For Normal and for X-Ray-Detected Galaxies
We present photometric redshifts and associated probability distributions for
all detected sources in the Extended Chandra Deep Field South (ECDFS). The work
makes use of the most up-to-date data from the Cosmic Assembly Near-IR Deep
Legacy Survey (CANDELS) and the Taiwan ECDFS Near-Infrared Survey (TENIS) in
addition to other data. We also revisit multi-wavelength counterparts for
published X-ray sources from the 4Ms-CDFS and 250ks-ECDFS surveys, finding
reliable counterparts for 1207 out of 1259 sources (). Data used for
photometric redshifts include intermediate-band photometry deblended using the
TFIT method, which is used for the first time in this work. Photometric
redshifts for X-ray source counterparts are based on a new library of
AGN/galaxy hybrid templates appropriate for the faint X-ray population in the
CDFS. Photometric redshift accuracy for normal galaxies is 0.010 and for X-ray
sources is 0.014, and outlier fractions are and respectively. The
results within the CANDELS coverage area are even better as demonstrated both
by spectroscopic comparison and by galaxy-pair statistics. Intermediate-band
photometry, even if shallow, is valuable when combined with deep broad-band
photometry. For best accuracy, templates must include emission lines.Comment: The paper has been accepted by ApJ. The materials we provide are
available under [Surveys] > [CDFS] through the portal
http://www.mpe.mpg.de/XraySurvey
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