Particle-in-cell simulation of a mildly relativistic collision of an electron-ion plasma carrying a quasi-parallel magnetic field: Electron acceleration and magnetic field amplification at supernova shocks

Plasma processes close to SNR shocks result in the amplification of magnetic fields and in the acceleration of electrons, injecting them into the diffusive acceleration mechanism. The acceleration of electrons and the B field amplification by the collision of two plasma clouds, each consisting of electrons and ions, at a speed of 0.5c is investigated. A quasi-parallel guiding magnetic field, a cloud density ratio of 10 and a plasma temperature of 25 keV are considered. A quasi-planar shock forms at the front of the dense plasma cloud. It is mediated by a circularly left-hand polarized electromagnetic wave with an electric field component along the guiding magnetic field. Its propagation direction is close to that of the guiding field and orthogonal to the collision boundary. It has a low frequency and a wavelength that equals several times the ion inertial length, which would be indicative of a dispersive Alfven wave close to the ion cyclotron resonance frequency of the left-handed mode (ion whistler), provided that the frequency is appropriate. However, it moves with the super-alfvenic plasma collision speed, suggesting that it is an Alfven precursor or a nonlinear MHD wave such as a Short Large-Amplitude Magnetic Structure (SLAMS). The growth of the magnetic amplitude of this wave to values well in excess of those of the quasi-parallel guiding field and of the filamentation modes results in a quasi-perpendicular shock. We present evidence for the instability of this mode to a four wave interaction. The waves developing upstream of the dense cloud give rise to electron acceleration ahead of the collision boundary. Energy equipartition between the ions and the electrons is established at the shock and the electrons are accelerated to relativistic speeds.Comment: 16 pages, 18 figures, Accepted for publication by Astron & Astrophy

Contribution of WFS1 to Pancreatic Beta Cell Survival and Adaptive Alterations in WFS1 Deficiency: A Dissertation

Diabetes mellitus comprises a cohort of genetic and metabolic diseases which are characterized by the hallmark symptom of hyperglycemia. Diabetic subtypes are based on their pathogenetic origins: the most prevalent subtypes are the autoimmune-mediated type 1 diabetes mellitus (T1DM) and the metabolic disease of type 2 diabetes mellitus (T2DM). Genetic factors are major contributory aspects to diabetes development, particularly in T2DM where there is close to 80% concordance rates between monozygotic twins. However, the functional state of the pancreatic β cell is of paramount importance to the development of diabetes. Perturbations that lead to β cell dysfunction impair insulin production and secretion and precede diabetes onset. The endoplasmic reticulum (ER) is a subcellular organelle network of tubes and cisternae with multifaceted roles in cellular metabolism. Alterations to ER function such as those begotten by the accumulation of misfolded and unfolded ER client proteins upset the ER homeostatic balance, leading to a condition termed ER stress. Subsequent sensing of ER stress by three ER transmembrane proteins, initiates an adaptive reaction to alleviate ER stress: this is known as the unfolded protein response (UPR). Divergent cascades of the UPR attempt to mitigate ER stress and restore ER homeostasis: Failing that, the UPR initiates pro-apoptotic pathways. The demand of insulin production on the β cell necessitates the presence of a highly functional ER. However, the consequence of dependence on the ER for insulin synthesis and secretion portends disaster for the functional state of the β cell. Disturbances to the ER that elicit ER stress and UPR activation causes β cell dysfunction and may lead to apoptosis. There are numerous well-characterized models of ER stress-mediated diabetes, including genetic mutations in UPR transducers and insulin. Recently, polymorphisms in Wolfram syndrome 1 (WFS1), an ER transmembrane protein involved in the UPR, were suggested to contribute to T2DM risk. In this thesis, one of the highlighted WFS1 polymorphism, H611R, was examined to identify its contribution to β cell function and viability, and hence, diabetes risk. It was revealed that augmentation of WFS1 expression increased insulin secretion and cellular content. In addition, WFS1 protected β cells against ER stress-mediated dysfunction, with a more pronounced effect in the WFS1-R611 protective allele. Subsequent gene expression analysis identified netrin-1 as a WFS1-induced survival factor. As a contributory factor to diabetes progression, ER stress and UPR are potential drug and biomarker targets. In this dissertation, a novel UPR-regulating microRNA (miRNA) family was uncovered in ER stressed, WFS1-deficient islets. These miRNAs, the miR-29 family, are induced in WFS1 -/- islets as a possible adaptive alteration to chronic ER stress conditions, and indirectly decreases the expression of UPR transducers, while directly targeting downstream ER stress-related pro-apoptotic factors. Collectively, this work extends the function of WFS1 as a protective factor in the pancreatic β cell through the induction of netrin-1 signaling. Additionally, it further strengthens the role of miRNA as regulatory members of the UPR which contribute to cell survival

Micro-device for coupling, multiplexing and demultiplexing using elliptical-core two-mode fiber

We propose and demonstrate experimentally a fiber optic micro-device that is capable of tunably splitting, multiplexing, and demultiplexing optical signals using elliptical-core two-mode optical fiber. A crosstalk of 15 dB with an insertion loss of 1.2 dB was obtained

ER stress as a trigger for beta-cell dysfunction and autoimmunity in type 1 diabetes

Comment on: Tersey SA, Nishiki Y, Templin AT, Cabrera SM, Stull ND, Colvin SC, Evans-Molina C, Rickus JL, Maier B, Mirmira RG. Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model. Diabetes. 2012 Apr;61(4):818-27

Practical Bayesian Modeling and Inference for Massive Spatial Datasets On Modest Computing Environments

With continued advances in Geographic Information Systems and related computational technologies, statisticians are often required to analyze very large spatial datasets. This has generated substantial interest over the last decade, already too vast to be summarized here, in scalable methodologies for analyzing large spatial datasets. Scalable spatial process models have been found especially attractive due to their richness and flexibility and, particularly so in the Bayesian paradigm, due to their presence in hierarchical model settings. However, the vast majority of research articles present in this domain have been geared toward innovative theory or more complex model development. Very limited attention has been accorded to approaches for easily implementable scalable hierarchical models for the practicing scientist or spatial analyst. This article is submitted to the Practice section of the journal with the aim of developing massively scalable Bayesian approaches that can rapidly deliver Bayesian inference on spatial process that are practically indistinguishable from inference obtained using more expensive alternatives. A key emphasis is on implementation within very standard (modest) computing environments (e.g., a standard desktop or laptop) using easily available statistical software packages without requiring message-parsing interfaces or parallel programming paradigms. Key insights are offered regarding assumptions and approximations concerning practical efficiency.Comment: 20 pages, 4 figures, 2 table

An Empirical Study of Off-by-one Loop Mutation

Context: Developing test cases that are measurably effective in finding faults in programs is a very challenging research problem. Mutation testing, a prominent technique developed to address this challenge, often becomes com- putationally too expensive for practical use due to the very large number of mutants that need to be analyzed. Objective: This paper evaluates the impact of One-by-one (OBO) loop mutation in reducing the cost of mutation analysis and investigates this technique\u27s effectiveness in measuring the strength or weakness of test suites. Method: A set of Java and C programs have been used to generate both OBO and traditional mutants. Mutation scores are computed and analyzed for both sets of mutants. An analysis of first order vs. higher order loop mutations have also been performed. Results: On average, 89.15% fewer mutants are generated by OBO op- erator in comparison to traditional operators while the two sets of muta- tion scores still remain highly positively correlated (correlation coefficient of .9228) indicating the usefulness of OBO operator in measuring test suite\u27s ef- fectiveness of finding faults in programs. We also investigate the relationship between first order OBO mutation (FOM) and their corresponding higher order mutations (HOM). We have found that OBO HOMs do not subsume their corresponding FOMs. Conclusion: We conclude that One-by-one (OBO) loop mutant operator, which targets specific program elements for mutation, can greatly reduce the number of mutants generated, and thus make the mutation analysis relatively inexpensive and practical while still being capable of providing useful measurement of the strength or weakness of a test suite. Our investigation into the relationship between higher order OBO mutants (HOM) and first order OBO mutants (FOM) has revealed that OBO HOMs usually do not add any value to the mutation analysis over the corresponding FOMs

Reliability, Usefulness, and Validity of Field-Based Vertical Jump Measuring Devices

Comyns, TM,Murphy, J, and O’Leary, D. Reliability, usefulness, and validity of field-based vertical jump measuring devices. J Strength Cond Res 37(8): 1594–1599, 2023—The purpose of this study was to examine the test-retest reliability, usefulness, and validity of field based devices, in determining jump height (JH) during a countermovement jump (CMJ). Twenty-one male (22.8 6 2.4 years; 1.82 6 0.07m; 86.0610.4 kg) and 7 female field sport athletes (20.561.5 years; 1.6560.06 m; 65.467.2 kg) performed 3CMJs with data simultaneously recorded using a force plate (criterion measure), Opto jump, Output Capture, and Push-Band 2.0. Reliability was determined by intraclass correlation (ICC) and coefficient of variation (CV) analyses. Usefulness was assessed by comparing typical error (TE) with the smallest worthwhile change (SWC), and the validity analyses involved repeated measures analysis of variance with post hoc analysis, Pearson correlation coefficient (r), coefficient of determination, and Bland-Altman 95%limits of agreement analyses. All 3 field-based devices were deemed reliable in assessing CMJ height as the respective ICCs $ 0.80 and the CV # 10%. Only the Opto jump and Output Capture devices were rated as “good” at detecting the SWC in performance (Opto jump SWC: 1.44.TE: 1.04; Output Capture SWC: 1.47 . TE: 1.05). The Output Capture device demonstrated acceptable validity for CMJ height assessment, whereas the Push-Band 2.0 showed systematic bias when compared with the criterion force plate data. Systematic difference was also evident for the Opto jump potentially due to the optical switching-cell position on the Opto jump. Although all 3 devices showed excellent reliability, the Opto jump and Output Capture devices offer practitioners a cost effective, reliable, and valid method of assessing the smallest worthwhile change in CMJ performance in an applied setting

Effect of restricted access time to pasture on dairy cow milk production, grazing behavior, and dry matter intake

The objective of this experiment was to investigate the effect of restricting pasture access time on milk production and composition, body weight and body condition score change, dry matter intake, and grazing behavior of autumn calving dairy cows in midlactation. Fifty-two (19 primiparous and 33 multiparous) Holstein-Friesian dairy cows (mean calving date, August 17 ± 91.2 d) were randomly assigned to a 4-treatment (n = 13) randomized block design grazing study. The 4 grazing treatments were: (i) full-time access to pasture (22H; control), (ii) 9-h access to pasture (9H), (iii) two 4.5-h periods of access to pasture after both milkings (2 × 4.5H), and (iv) two 3-h periods of access to pasture after both milkings (2 × 3H). Experimental treatments were imposed from March 7 to April 6, 2007 (31 d). The pregrazing herbage mass of swards offered to all treatments was 1,268 kg of dry matter/ha, and sward organic matter digestibility was 86.4%, indicating high-quality swards conducive to high dry matter intake. Swards where animals had 22H and 2 × 4.5H access to pasture had the lowest postgrazing sward heights (3.5 cm), reflecting the greatest levels of sward utilization. After the experimental period, there were no differences in milk production; however, the 2 × 3H animals tended to have lower milk protein concentration (−0.17%) compared with 22H animals. Furthermore, dry matter intake of the 9H animals was lower than 22H animals. Although restricting access time to pasture decreased grazing time, animals compensated by increasing their intake/minute and intake/bite. Restricting pasture access time resulted in much greater grazing efficiency, because the 9H, 2 × 4.5H, and 2 × 3H treatments spent a greater proportion of their time at pasture grazing (81, 81, and 96%, respectively) than 22H animals (42%). Results of this study indicate that allocating animals restricted access to pasture does not significantly affect milk production. This study also found that the total access time should be greater than 6 h and that perhaps needs to be divided into 2 periods

Impact of the Wiggler Coherent Synchrotron Radiation Impedance on the Beam Instability

Coherent Synchrotron Radiation (CSR) can play an important role by not only increasing the energy spread and emittance of a beam, but also leading to a potential instability. Previous studies of the CSR induced longitudinal instability were carried out for the CSR impedance due to dipole magnets. However, many storage rings include long wigglers where a large fraction of the synchrotron radiation is emitted. This includes high-luminosity factories such as DAPHNE, PEP-II, KEK-B, and CESR-C as well as the damping rings of future linear colliders. In this paper, the instability due to the CSR impedance from a wiggler is studied assuming a large wiggler parameter $K$. The primary consideration is a low frequency microwave-like instability, which arises near the pipe cut-off frequency. Detailed results are presented on the growth rate and threshold for the damping rings of several linear collider designs. Finally, the optimization of the relative fraction of damping due to the wiggler systems is discussed for the damping rings.Comment: 10 pages, 7 figure

(Sub)millimetre interferometric imaging of a sample of COSMOS/AzTEC submillimetre galaxies. II. The spatial extent of the radio-emitting regions

Radio emission at centimetre wavelengths from highly star-forming galaxies, like submillimetre galaxies (SMGs), is dominated by synchrotron radiation arising from supernova activity. Hence, radio continuum imaging has the potential to determine the spatial extent of star formation in these types of galaxies. Using deep, high-resolution (1σ = 2.3 μJy beam-1; 0.75 arcsec) centimetre radio-continuum observations taken by the Karl G. Jansky Very Large Array (VLA)-COSMOS 3 GHz Large Project, we studied the radio-emitting sizes of a flux-limited sample of SMGs in the COSMOS field. The target SMGs were originally discovered in a 1.1 mm continuum survey carried out with the AzTEC bolometer, and followed up with higher resolution interferometric (sub)millimetre continuum observations. Of the 39 SMGs studied here, 3 GHz emission was detected towards 18 of them (~46 ± 11%) with signal-to-noise ratios in the range of S/N = 4.2-37.4. Towards four SMGs (AzTEC2, 5, 8, and 11), we detected two separate 3 GHz sources with projected separations of ~1''&dotbelow;5-6''&dotbelow;6, but they might be physically related in only one or two cases (AzTEC2 and 11). Using two-dimensional elliptical Gaussian fits, we derived a median deconvolved major axis FWHM size of 0''&dotbelow;54±0''&dotbelow;11 for our 18 SMGs detected at 3 GHz. For the 15 SMGs with known redshift we derived a median linear major axis FWHM of 4.2 ± 0.9 kpc. No clear correlation was found between the radio-emitting size and the 3 GHz or submm flux density, or the redshift of the SMG. However, there is a hint of larger radio sizes at z ~ 2.5-5 compared to lower redshifts. The sizes we derived are consistent with previous SMG sizes measured at 1.4 GHz and in mid-J CO emission, but significantly larger than those seen in the (sub)mm continuum emission (typically probing the rest-frame far-infrared with median FWHM sizes of only ~1.5-2.5 kpc). One possible scenario is that SMGs have i) an extended gas component with a low dust temperature, which can be traced by low- to mid-J CO line emission and radio continuum emission; and ii) a warmer, compact starburst region giving rise to the high-excitation line emission of CO, which could dominate the dust continuum size measurements. Because of the rapid cooling of cosmic-ray electrons in dense starburst galaxies (~104-105 yr), the more extended synchrotron radio-emitting size being a result of cosmic-ray diffusion seems unlikely. Instead, if SMGs are driven by galaxy mergers - a process where the galactic magnetic fields can be pulled out to larger spatial scales - the radio synchrotron emission might arise from more extended magnetised interstellar medium around the starburst region