Situación actual de la COX-2 en oncología veterinaria

La enzima prostaglandina G/H sintetasa, también conocida como ciclooxigenasa (COX), controla la síntesis de prostaglandinas a partir del acido araquidónico. Se reconocen fundamentalmente dos isoformas de esta enzima que son denominadas COX-I y COX2. En la actualidad sabemos que un importante número de tumores sobrexpresan (sobreexpresan) la COX-2, mientras que esto no sucede en los tejidos normales de los cuales proceden. Este artículo pretende actualizar la información referente a la COX-2 y su implicación en oncología veterinaria

Transformations due to mylonitization processes in granitic rocks

[Resumen] El objetivo de este estudio es determinar las transformaciones, tanto a nivel mineralógico como textural, experimentadas por rocas graníticas tardihercínicas afectadas por procesos de milonitización en el sector oriental de la Sierra de Gredos (Sistema Central Español). De igual modQ se intenta determinar la influencia de dichas transformaciones en la composición química de las rocas milonitizadas . El incremento progresivo de la deformación provoca una serie de transformaciones texturales en las que a partir de granitoides de grano grueso porfídicos se generan unas milonitas porfidoclásticas planolineares en el núcleo de la banda de fractura. Desde el punto de vista mineralógico se aprecia una total trituración y degradación de la biotita, que se transforma a clorita de grano muy fino dispersa en la matriz milonítica. También se observan ciertas removilizaciones de feldespato potásico y albita y reajustes metamórficos de bajo grado (en facies de esquistos verdes). Los cambios composicionales acompañantes consisten en un enriquecimiento en Si02, CaO y Na20 en la zona de máxima milonitización y un empobrecimiento en K20 y P20 S en el mismo sentido. En cuanto a los elementos traza, tan sólo Rb y Sr muestran un ligero empobrecimiento en la zona milonítica.[Abstract] The aim of this paper is the determination of the textural and mineralogical transformations introduced in late-Hercynian granitic rocks which have undergone mylonitization processes in the Eastern Sierra de Gredos (Spanish Central System). It also is intended to determine the influence of such changes on the chemical composition of the mylonitic rocks. The progressive increasing of strain causes a series of textural transformations in the originally porphyritic, coarse-grained granitoids leading to formation of porphyroclastic mylonitic rocks with development of planelinear fabrics at the core of the fracture zone. From a mineralogical point of view, transformation~ consist in entire crushing and degradation of biotite, which converts into very fine-grained chlorite disseminated within the mylonitic matrix. Likewise, K-feldspar and albite remobilizations and low grade (greenschists facies) metamorphic readjustments can be observed. The accompanying compositional changes are Si02, CaO and Na20 enrichment and K20 and P20S impoverishment towards the zone of maximum mylonitization. Concerning the trace elements, only Rb and Sr show a weak impoverishment within the mylonitic zone

Dynamics and control of the expansion of finite-size plasmas produced in ultraintense laser-matter interactions

The strong influence of the electron dynamics provides the possibility of controlling the expansion of laser-produced plasmas by appropriately shaping the laser pulse. A simple irradiation scheme is proposed to tailor the explosion of large deuterium clusters, inducing the formation of shock structures, capable of driving nuclear fusion reactions. Such a scenario has been thoroughly investigated, resorting to two- and three-dimensional particle-in-cell simulations. Furthermore, the intricate dynamics of ions and electrons during the collisionless expansion of spherical nanoplasmas has been analyzed in detail using a self-consistent ergodic-kinetic model. This study clarifies the transition from hydrodynamic-like to Coulomb-explosion regimes

Quantitative monitoring of surface movements on active landslides by multi-temporal, high-resolution X-Band SAR amplitude information: Preliminary results

Multi-temporal image cross-correlation is a method for tracking moving features and can there-fore be used for quantitative assessments of surface displacements. Accuracies of up to 1/8th of the original image geometric resolution can be achieved. We present the results of an analysis car- ried out on Corvara landslide located in the Italian Dolomites. Image offset-tracking was applied to CosmoSky-Med amplitude images acquired between October 2013 and August 2015. The presence of a validation dataset consisting of periodical GPS surveys carried out on 16 benchmarks represents an ideal opportunity to test the applicability of SAR-based image cross-correlation for landslide moni- toring. Despite the relative low accuracy of the results amplitude-based offset-tracking proved to be beneficial due to the ability of this method to capture large displacements. In particular the results evidence its complementarity with respect to multi-temporal interferometry that is confined to slow displacements along E-W directions

Efficient calculation of van der Waals dispersion coefficients with time-dependent density functional theory in real time: application to polycyclic aromatic hydrocarbons

The van der Waals dispersion coefficients of a set of polycyclic aromatic hydrocarbons, ranging in size from the single-cycle benzene to circumovalene (C66H20), are calculated with a real-time propagation approach to time-dependent density functional theory (TDDFT). In the non-retarded regime, the Casimir-Polder integral is employed to obtain C6, once the dynamic polarizabilities have been computed at imaginary frequencies with TDDFT. On the other hand, the numerical coefficient that characterizes the fully retarded regime is obtained from the static polarizabilities. This ab initio strategy has favorable scaling with the size of the system - as demonstrated by the size of the reported molecules - and can be easily extended to obtain higher order van der Waals coefficients.Comment: submitted to J. Chem. Phy

Mapping and monitoring geomorphological processes in mountainous areas using PSI data: Central Pyrenees case study

In this paper the Stable Point Network technique, an established Persistent Scatterer InSAR (PSI) technique, (SPN), has been applied for the first time to the analysis of several geomorphological processes present in the Gállego river basin (Central Pyrenees, Spain). The SPN coherence based approach has been used to process three different SAR images datasets covering two temporal periods: 1995 to 2001 and 2001 to 2007. This approach has permitted the detection of more than 40 000 natural ground targets or Persistent Scatterers (PSs) in the study area, characterised by the presence of vegetation and a low urban density. Derived displacement maps have permitted the detection and monitoring of deformations in landslides, alluvial fans and erosive areas. In the first section, the study area is introduced. Then the specifics of the SPN processing are presented. The deformation results estimated with the SPN technique for the different processed datasets are compared and analysed with previous available geo-information. Then several detailed studies are presented to illustrate the processes detected by the satellite based analysis. In addition, a comparison between the performance of ERS and ENVISAT satellites with terrestrial SAR has demonstrates that these are complementary techniques, which can be integrated in order to monitor deformation processes, like landslides, that over the same monitoring area may show very different ranges of movement. The most relevant conclusions of this work are finally discussed

All-optical trapping and acceleration of heavy particles

A scheme for fast, compact, and controllable acceleration of heavy particles in vacuum is proposed, in which two counterpropagating lasers with variable frequencies drive a beat-wave structure with variable phase velocity, thus allowing for trapping and acceleration of heavy particles, such as ions or muons. Fine control over the energy distribution and the total charge of the beam is obtained via tuning of the frequency variation. The acceleration scheme is described with a one-dimensional theory, providing the general conditions for trapping and scaling laws for the relevant features of the particle beam. Two-dimensional, electromagnetic particle-in-cell simulations confirm the validity and the robustness of the physical mechanism.Comment: 10 pages, 3 figures, to appear in New Journal of Physic

Detecting Recent Dynamics in Large-Scale Landslides via the Digital Image Correlation of Airborne Optic and LiDAR Datasets: Test Sites in South Tyrol (Italy)

Large-scale slow-moving deep-seated landslides are complex and potentially highly damaging phenomena. The detection of their dynamics in terms of displacement rate distribution is therefore a key point to achieve a better understanding of their behavior and support risk management. Due to their large dimensions, ranging from 1.5 to almost 4 km(2), in situ monitoring is generally integrated using satellite and airborne remote sensing techniques. In the framework of the EFRE-FESR SoLoMon project, three test-sites located in the Autonomous Province of Bolzano (Italy) were selected for testing the possibility of retrieving significant slope displacement data from the analysis of multi-temporal airborne optic and light detection and ranging (LiDAR) surveys with digital image correlation (DIC) algorithms such as normalized cross-correlation (NCC) and phase correlation (PC). The test-sites were selected for a number of reasons: they are relevant in terms of hazard and risk; they are representative of different type of slope movements (earth-slides, deep seated gravitational slope Deformation and rockslides), and different rates of displacement (from few cm/years to some m/years); and they have been mapped and monitored with ground-based systems for many years (DIC results can be validated both qualitatively and quantitatively). Specifically, NCC and PC algorithms were applied to high-resolution (5 to 25 cm/px) airborne optic and LiDAR-derived datasets (such as hillshade and slope maps computed from digital terrain models) acquired during the 2019-2021 period. Qualitative and quantitative validation was performed based on periodic GNSS surveys as well as on manual homologous point tracking. The displacement maps highlight that both DIC algorithms succeed in identifying and quantifying slope movements of multi-pixel magnitude in non-densely vegetated areas, while they struggle to quantify displacement patterns in areas characterized by movements of sub-pixel magnitude, especially if densely vegetated. Nonetheless, in all three landslides, they proved to be able to differentiate stable and active parts at the slope scale, thus representing a useful integration of punctual ground-based monitoring systems

Towards a more accurate characterization of granular media 2.0: Involving AI in the process

publishedVersio

Navigating surgical anatomy of the Denonvilliers' fascia and dissection planes of the anterior mesorectum with a cadaveric simulation model

Anterior dissection of the rectum in the male pelvis represents one of the most complex phases of total meso-rectal excision. However, the possible existence of different anatomical planes is controversial and the exact anatomical topography of Denonvilliers' fascia is still debated. The aim of the study is to accurately define in a cadaveric simulation model the existence and boundaries of Denonvilliers' fascia, identifying the anatomical planes suitable for surgical dissection. The pelvises of 31 formalin-preserved male cadavers were dissected. Careful and detailed dissection was carried out to visualize the anatomical structures and the potential dissection planes, simulating an anterior meso-rectum dissection. Denonvilliers' fascia was identified in 100% of the pelvises, as a single-layer fascia that originates from the peritoneal reflection and descends until its firm adhesion to the prostate capsule. The fascia divides the space providing an anterior and a posterior plane. Anteriorly to the fascia, during the caudal dissection, its firm adhesion to the prostate capsule forces to section it sharply. The cadaveric simulation model allowed an accurate description of Denonvilliers' fascia, defining several planes for anterior dissection of the meso-rectum