Letter from Anne Annie L. Muir to John Muir, ca. 1861

page 8 [they have drawn a lot of lumber?] down near McHays to build a Roman Catholic church so you see they are getting on [but I illegible illegible illegible illegible illegible deleted] well John I cannot think of much more to say but let me see I [illegible] you said in your letter to Mary that you believed if [Clide?] ws to come into the room you would kiss him but I guess you will never see [him?] again you may see his grave but I think that will be all I guess next Sunday the prayer meetings will have 09912 page 4 to be closed is there any of them closed where you are. I should think you would be lonesome living all alone unless you are are pretty busy all the time I suppose I will have to close my letter now for I cant think of any more to say but you must write a longer letter then this excuse all mistakes and bad writing from your afectionate sister Anne Muir write soo

Letter from Anne Annie L. Muir to John Muir, 1861 Feb 19

Dear John: I am very glad I have the chance to write to you. I have always been ashamed when I think of the letter I wrote to you the first time. I was in a great hurry and had nothing to say hardly, so I just said anything that I first thought of. But I will try and do better this time. Anna and myself have been busy washing all day, and I don\u27t think that I will have time to finish it. Father is getting ready to go to a meeting at Mr. Arnot\u27s house. Father goes to a meeting every other Sunday at a schoolhouse beyond Belfountain, and he goes through the week sometimes to a prayer meeting there too. And there is a prayer meeting in Mr. Smith\u27s house every week. There is a prayer meeting every Sunday night at Gray\u27s schoolhouse. There is no Sunday School there now and we have to go with Father now. I have got a little book called Dew Drops. I bought it this morning from a colporteur. I guess this will be enough, so goodbye. Write soon as you can. From Mary Muir. (Hand).00261 Feb. 19, 1861.Dear John: I suppose you think I should have written long before, but I guess the moss has not grown over the one you wrote to me yet. But I did write part of one to you, and then I thought you would come and so I put it in the fire. But perhaps you did not know that Mary and myself were going to school. We have gone most all winter, but Joanna has not gone more than half of the time. But it closes just one week from to-day, and the teacher\u27s name is Mr. Daniel E. Gilfillan, and he is a Scotchman, like yourself. There is a lot of lumber drawn to make a new schoolhouse,-it is just a little piece this side of Mr. Kinny\u27s gate. It will be a good lot nearer for us. But we were very much disappointed when you did not come. Joanna was sure you would come. But you must try and come soon - just as soon as you can. I have been up at Mrs. Margaret R[eid]\u27s house just once. This was about the same time that we were all sick, and a lot of us have been sick again.- Mother and Daniel and David and Mary and Joanna any myself but we are all better but Daniel. But there is someone knocking at the door . In comes a colporteur (?) from the American tract society. His name is Mr. Sawyer. But I will have to stop now. Be sure and write soon. It is miserable writing, but when I try to write well

Letter from Anne Annie L. Muir to John Muir, ca. 1861

page 8 [they have drawn a lot of lumber?] down near McHays to build a Roman Catholic church so you see they are getting on [but I illegible illegible illegible illegible illegible deleted] well John I cannot think of much more to say but let me see I [illegible] you said in your letter to Mary that you believed if [Clide?] ws to come into the room you would kiss him but I guess you will never see [him?] again you may see his grave but I think that will be all I guess next Sunday the prayer meetings will have 09912 page 4 to be closed is there any of them closed where you are. I should think you would be lonesome living all alone unless you are are pretty busy all the time I suppose I will have to close my letter now for I cant think of any more to say but you must write a longer letter then this excuse all mistakes and bad writing from your afectionate sister Anne Muir write soo

Letter from Anne Annie L. Muir to John Muir, 1862 Mar 2

March 2nd Dear Brother John: are you quite well we are all pretty well here. I am attending the high school I like it very well Mary and myself stay up stairs most of the time where Miss Brigs teaches I like her firstrate we recite all of our lessons to Miss Brigs with the exception of our grammer lesson we go down to Mr Magoffin to recite that. the Saturday before last was George Washingtons birthday and there was a celebration among the schools we all gathered at the school house as usual in the morning at about 9 oclock and Mr Carswell lent us eighteen little flags well after all was reads we all went out and marched down to [Vandercooks?] hall and then we sang the red white and blue then Mr Magoffin read part of George Washingtons farewell adress and there was two fiddlers there so we sang the Star Spangled banner and dixy and one or two more and they fiddled to them well well enough of that now John Muir what will I do to you if you don\u27t come home when your school is out John you promised to write soon you must remember from your affectionate Sister Anne Muir0028

Letter from Anne Annie L. Muir to John Muir, 1862 Spring

[4] Dear Brother I have been on the farm and spent two weeks there. I go to the forth ward now and my Teachers name is Mrs [Cornwall?] We have to go to school seven weeks more and then we will have a vacation and [I is glad to see you soon?] [illegible]00293 [Spr. 1862] [1] Dear Brother John [time since I deleted] it is a long time since I wrote to you last but I rather think it is a great deal longer since you have written to me. We are all as well as usual and I hope you are the same . We have had an exhibition it was pretty good [xx deleted] we did not a single failure . I hardly know how to [2]answer your question but I suppose our heads were made so that they would not ache when we are on the under side of the globe if that is not the reason please tell me when you write next. The trees are busy geting on their new clothes I suppose Madison will be very beautiful now I would like very much to come[3]and see it now. I suppose you know that we have moved up the other end of the town so if you come at the end of the term (which I hope you will not fail to do) you will know not to go up their. Now John be sure to write to me soon from your sister Anneexcuse my mistakes and do not send this bac

Transforming LIS Education through Disability Inclusion

Combining perspectives from Australia, Canada, New Zealand, and the US, this international panel will develop an honest dialog on disability inclusion in LIS education, drawing on empirical research, discursive analysis, and practical experience. All introductory talks will be followed by nuanced and carefully developed experiential activities prepared by each group of presenters and delivered at the two thematically arranged round tables. Jointly, seven interconnected presentations will address LIS pedagogy, educational policy, and educational content from the standpoint of disability inclusion and its potential to transform LIS education

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The influence of human harvest on evolution of secondary sexual characteristics has implications for sustainable management of wildlife populations. The phenotypic consequences of selectively removing males with large horns or antlers from ungulate populations have been a topic of heightened concern in recent years. Harvest can affect size of horn-like structures in two ways: (a) shifting age structure toward younger age classes, which can reduce the mean size of horn-like structures, or (b) selecting against genes that produce large, fast-growing males. We evaluated effects of age, climatic and forage conditions, and metrics of harvest on horn size and growth of mountain sheep (Ovis canadensis ssp.) in 72 hunt areas across North America from 1981 to 2016. In 50% of hunt areas, changes in mean horn size during the study period were related to changes in age structure of harvested sheep. Environmental conditions explained directional changes in horn growth in 28% of hunt areas, 7% of which did not exhibit change before accounting for effects of the environment. After accounting for age and environment, horn size of mountain sheep was stable or increasing in the majority (similar to 78%) of hunt areas. Age-specific horn size declined in 44% of hunt areas where harvest was regulated solely by morphological criteria, which supports the notion that harvest practices that are simultaneously selective and intensive might lead to changes in horn growth. Nevertheless, phenotypic consequences are not a foregone conclusion in the face of selective harvest; over half of the hunt areas with highly selective and intensive harvest did not exhibit age-specific declines in horn size. Our results demonstrate that while harvest regimes are an important consideration, horn growth of harvested male mountain sheep has remained largely stable, indicating that changes in horn growth patterns are an unlikely consequence of harvest across most of North America.Utah Division of Wildlife Resources; National Wild Sheep Foundation (WSF); Wyoming Wild Sheep Foundation; Alberta Wild Sheep Foundation; California Wild Sheep Foundation; Arizona Desert Bighorn Sheep Society; Wyoming Governor's Big Game License Coalition; Iowa Foundation for North American Wild Sheep; Utah Foundation for North American Wild Sheep; Pope and Young ClubOpen access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

Height, selected genetic markers and prostate cancer risk:Results from the PRACTICAL consortium

Background: Evidence on height and prostate cancer risk is mixed, however, recent studies with large data sets support a possible role for its association with the risk of aggressive prostate cancer. Methods: We analysed data from the PRACTICAL consortium consisting of 6207 prostate cancer cases and 6016 controls and a subset of high grade cases (2480 cases). We explored height, polymorphisms in genes related to growth processes as main effects and their possible interactions. Results: The results suggest that height is associated with high-grade prostate cancer risk. Men with height 4180cm are at a 22% increased risk as compared to men with height o173cm (OR 1.22, 95% CI 1.01–1.48). Genetic variants in the growth pathway gene showed an association with prostate cancer risk. The aggregate scores of the selected variants identified a significantly increased risk of overall prostate cancer and high-grade prostate cancer by 13% and 15%, respectively, in the highest score group as compared to lowest score group. Conclusions: There was no evidence of gene-environment interaction between height and the selected candidate SNPs. Our findings suggest a role of height in high-grade prostate cancer. The effect of genetic variants in the genes related to growth is seen in all cases and high-grade prostate cancer. There is no interaction between these two exposures.</p

Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression.

Genome-wide association studies have identified SNPs near ZNF365 at 10q21.2 that are associated with both breast cancer risk and mammographic density. To identify the most likely causal SNPs, we fine mapped the association signal by genotyping 428 SNPs across the region in 89,050 European and 12,893 Asian case and control subjects from the Breast Cancer Association Consortium. We identified four independent sets of correlated, highly trait-associated variants (iCHAVs), three of which were located within ZNF365. The most strongly risk-associated SNP, rs10995201 in iCHAV1, showed clear evidence of association with both estrogen receptor (ER)-positive (OR = 0.85 [0.82-0.88]) and ER-negative (OR = 0.87 [0.82-0.91]) disease, and was also the SNP most strongly associated with percent mammographic density. iCHAV2 (lead SNP, chr10: 64,258,684:D) and iCHAV3 (lead SNP, rs7922449) were also associated with ER-positive (OR = 0.93 [0.91-0.95] and OR = 1.06 [1.03-1.09]) and ER-negative (OR = 0.95 [0.91-0.98] and OR = 1.08 [1.04-1.13]) disease. There was weaker evidence for iCHAV4, located 5' of ADO, associated only with ER-positive breast cancer (OR = 0.93 [0.90-0.96]). We found 12, 17, 18, and 2 candidate causal SNPs for breast cancer in iCHAVs 1-4, respectively. Chromosome conformation capture analysis showed that iCHAV2 interacts with the ZNF365 and NRBF2 (more than 600 kb away) promoters in normal and cancerous breast epithelial cells. Luciferase assays did not identify SNPs that affect transactivation of ZNF365, but identified a protective haplotype in iCHAV2, associated with silencing of the NRBF2 promoter, implicating this gene in the etiology of breast cancer.This is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/10.1016/j.ajhg.2015.05.002