Las remesas familiares frente a la cuenta corriente en México, 1980-2006

Este trabajo intenta aportar una nueva dimensión a los estudios realizados en torno a las remesas familiares, donde su originalidad consiste en relacionarlas desde una perspectiva histórica con los saldos de la cuenta corriente. Este análisis macroeconómico se centra en algunas coyunturas y políticas económicas para el periodo que se estudia, en donde se enfatiza de manera especial en algunos años que caracterizaron a la economía del país por las crisis relacionadas con los déficit de la cuenta corriente y la escasez de divisas para afrontarlas. Al relacionar el peso de las remesas familiares en el financiamiento de la cuenta corriente, es posible observar a la vez su evolución e importancia

Expression of DDX11 and DNM1L at the 12p11 Locus Modulates Systemic Lupus Erythematosus Susceptibility

This study employed genetic and functional analyses using OASIS meta-analysis of multiple existing GWAS and gene-expression datasets to identify novel SLE genes. Methods: Four hundred and ten genes were mapped using SNIPPER to 30 SLE GWAS loci and investigated for expression in three SLE GEO-datasets and the Cordoba GSE50395-dataset. Blood eQTL for significant SNPs in SLE loci and STRING for functional pathways of differentially expressed genes were used. Confirmatory qPCR on SLE monocytes was performed. The entire 12p11 locus was investigated for genetic association using two additional GWAS. Expression of 150 genes at this locus was assessed. Based on this significance, qPCRs for DNM1L and KRAS were performed. Results: Fifty genes were differentially expressed in at least two SLE GEO-datasets, with all probes directionally aligned. DDX11, an RNA helicase involved in genome stability, was downregulated in both GEO and Cordoba datasets. The most significant SNP, rs3741869 in OASIS locus 12p11.21, containing DDX11, was a cis-eQTL regulating DDX11 expression. DDX11 was found repressed. The entire 12p11 locus showed three association peaks. Gene expression in GEO datasets identified DNM1L and KRAS, besides DDX11. Confirmatory qPCR validated DNM1L as an SLE susceptibility gene. DDX11, DNM1L and KRAS interact with each other and multiple known SLE genes including STAT1/STAT4 and major components of IFN-dependent gene expression, and are responsible for signal transduction of cytokines, hormones, and growth-factors, deregulation of which is involved in SLE-development. Conclusion: A genomic convergence approach with OASIS analysis of multiple GWAS and expression datasets identified DDX11 and DNM1L as novel SLE-genes, the expression of which is altered in monocytes from SLE patients. This study lays the foundation for understanding the pathogenic involvement of DDX11 and DNM1L in SLE by identifying them using a systems-biology approach, while the 12p11 locus harboring these genes was previously missed by four independent GWAS

Learning of second order of differential equations through the study of the movement of simple within the framework international World Pendulum Alliance WP@elab

This research is about to analyze the effects of the implementation of a virtual learning space in the homogeneous second-order differential equations applied to the modeling of the phenomenon of simple pendulum physics in the framework of the alliance with the international project World Pendulum Alliance WPA. The collection of information was carried out with a five question, using pre-test and post-test. The effectiveness of the strategy was measured with the Hake gain and the evolution of learning with the vectors of Bao. It was found that the strategy is more effective, but close to that achieved by traditional models, so that students largely achieve the proposed learning objectives. The evolution of learning suggests that students after the implementation of the strategy are marked under the model of acceptable explanation in the literature, although some participants still lean towards the incorrect model or the distracter. Therefore, it is necessary to include in the strategy a greater number of activities related to the description of the physical phenomenon to be studied and the improvement of the algebraic procedures seen in previous courses.Comment: 24 pages, in Portuguese, 7 figure

Comparative Study of One-Step Cross-Linked Electrospun Chitosan-Based Membranes

Chitosan membranes are widely applied for tissue engineering; however, a major drawback is their low resistance in aqueous phases and therefore the structure collapses impeding their long-term use. Although there is extensive research, because of chitosan’s importance as a biomaterial, studies involving chitosan-based membranes are still needed. Herein, a detailed investigation of diverse chemical routes to cross-link fibers in situ by electrospinning process is described. In case of using genipin as cross-linker, a close relationship with the content and the mean diameter values is reported, suggesting a crucial effect over the design of nanostructures. Also, the physical resistance is enhanced for the combination of two types of methods, such as chemical and physical methods. Cross-linked fibers upon exposure to long wave ultraviolet A (UVA light) change their morphology, but not their chemical composition. When they are incubated in aqueous phase for 70 days, they show an extensive improvement of their macrostructural integrity which makes them attractive candidates for tissue engineering application. As a result, the thermal properties of these materials reveal less crystallinity and higher temperature of degradation

Avances recientes en el estudio de factores de estrés prefaenado sobre la calidad de la carne bovina, aviar y porcina

Stress in the pre-slaughter stage is a critical period in the production chain because it causes losses in animal live weight, affects carcass yield and quality, and leads to a loss of animal welfare due to an alteration in the homeostasis of the organism as a result of exposure to stressful situations. This review identifies and describes the stressors that have been reported in the last 5 years as the main causes of meat quality deterioration, including animal handling activities by farm or plant personnel (transport, loading and unloading, in the slaughter plant), environmental conditions (temperature, vibrations), waiting time prior to slaughter and mixing of lots, water and food fasting period, and fatigue states, as well as the biomarkers routinely used for the study of conditions associated with stress. Although research on the subject is abundant, the biochemical mechanisms involved in obtaining certain organoleptic characteristics of meat with respect to stress levels and the individual variations observable in different groups of animals are still not completely clear, and more research is needed on stress biomarkers that allow a more specific, effective and non-invasive identification and measurement.El estrés en la etapa de prefaenado es un periodo crítico dentro de la cadena productiva al provocar pérdidas en el peso vivo del animal, afectaciones en el rendimiento y calidad de la canal y pérdida del bienestar animal debido a una alteración de homeóstasis del organismo por la exposición a situaciones estresantes. En la presente revisión se identifican y describen los factores estresores que se han reportado en los últimos 5 años como principales causas de deterioro de la calidad de la carne entre los cuales se incluyen actividades de manejo de los animales por parte del personal de granja o planta (transporte, carga y descarga, en planta de sacrificio), condiciones ambientales (temperatura, vibraciones), tiempo de espera previo al sacrificio y mezcla de lotes, periodo de ayuno de agua y comida, y estados de fatiga, así como los biomarcadores usados rutinariamente para el estudio de condiciones asociadas al estrés. Aunque las investigaciones sobre el tema son abundantes, aún no es totalmente claro los mecanismos bioquímicos involucrados en la obtención de ciertas características organolépticas de la carne con respecto a niveles de estrés y las variaciones individuales observables en diferentes grupos de animales, así mismo, se requiere mayor investigación en los biomarcadores de estrés que permitan una identificación y medición más específica, efectiva y no invasiva

Olfactomedin‑like 2 A and B (OLFML2A and OLFML2B) expression profile in primates (human and baboon)

Background: The olfactomedin‑like domain (OLFML) is present in at least four families of proteins, including OLFML2A and OLFML2B, which are expressed in adult rat retina cells. However, no expression of their orthologous has ever been reported in human and baboon. Objective: The aim of this study was to investigate the expression of OLFML2A and OLFML2B in ocular tissues of baboons (Papio hamadryas) and humans, as a key to elucidate OLFML function in eye physiology. Methods: OLFML2A and OLFML2B cDNA detection in ocular tissues of these species was performed by RT‑PCR. The amplicons were cloned and sequenced, phylogenetically analyzed and their proteins products were confirmed by immunofluorescence assays. Results: OLFML2A and OLFML2B transcripts were found in human cornea, lens and retina and in baboon cornea, lens, iris and retina. The baboon OLFML2A and OLFML2B ORF sequences have 96% similarity with their human’s orthologous. OLFML2A and OLFML2B evolution fits the hypothesis of purifying selection. Phylogenetic analysis shows clear orthology in OLFML2A genes, while OLFML2B orthology is not clear. Conclusions: Expression of OLFML2A and OLFML2B in human and baboon ocular tissues, including their high simi‑ larity, make the baboon a powerful model to deduce the physiological and/or metabolic function of these proteins in the eye

C3G promotes a selective release of angiogenic factors from activated mouse platelets to regulate angiogenesis and tumor metastasis

[EN]Previous observations indicated that C3G (RAPGEF1) promotes α-granule release, evidenced by the increase in P-selectin exposure on the platelet surface following its activation. The goal of the present study is to further characterize the potential function of C3G as a modulator of the platelet releasate and its implication in the regulation of angiogenesis. Proteomic analysis revealed a decreased secretion of anti-angiogenic factors from activated transgenic C3G and C3GΔCat platelets. Accordingly, the secretome from both transgenic platelets had an overall pro-angiogenic effect as evidenced by an in vitro capillary-tube formation assay with HUVECs (human umbilical vein endothelial cells) and by two in vivo models of heterotopic tumor growth. In addition, transgenic C3G expression in platelets greatly increased mouse melanoma cells metastasis. Moreover, immunofluorescence microscopy showed that the pro-angiogenic factors VEGF and bFGF were partially retained into α-granules in thrombin- and ADP-activated mouse platelets from both, C3G and C3GΔCat transgenic mice. The observed interaction between C3G and Vesicle-associated membrane protein (Vamp)-7 could explain these results. Concomitantly, increased platelet spreading in both transgenic platelets upon thrombin activation supports this novel function of C3G in α-granule exocytosis. Collectively, our data point out to the co-existence of Rap1GEF-dependent and independent mechanisms mediating C3G effects on platelet secretion, which regulates pathological angiogenesis in tumors and other contexts. The results herein support an important role for platelet C3G in angiogenesis and metastasis

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