Determinación del factor de intensidad de tensiones para fisuras con forma cóncava de mayor profundidad contenidas en ejes giratorios

En este Trabajo De Fin de Grado se ha determinado el Factor de Intensidad de Tensiones (FIT) a lo largo del frente de una fisura de gran profundidad semielíptica con forma cóncava contenida en un eje giratorio. Este parámetro se encuentra en función de la profundidad relativa de la fisura, el factor de forma de la fisura, la posición relativa del frente de fisura y el ángulo de giro del eje en el momento del estudio. Para ello, se ha realizado un modelo numérico mediante el software Abaqus, basado en el Método de Elementos Finitos (MEF).In this End-Of-Degree Project, the Stress Intensity Factor (SIF) has been determined along the front of a great depht, semi-elliptical fissure with a concave shape contained in a rotating shaft. This parameter is based on the relative depth of the crack, the crack form factor, the relative position of the crack front and the angle of rotation of the axis at the time of the survey. For this purpose, a numerical model has been mad eusing the Abaqus software, based on the Finite Element Method (FEM).Ingeniería en Tecnologías Industriale

Aplicación de metodologías activas para el estudio de la narración audiovisual. Gamificación y aula invertida

El proyecto “Aplicación de metodologías activas para el estudio de la Narración Audiovisual. Gamificación y Aula Invertida” amplía la investigación realizada el curso académico anterior con el proyecto titulado “Hacia una metodología activa para el estudio de la narración audiovisual a través del videojuego” en el seno de los Proyectos Innova Docencia. Ambos tienen como principal objetivo la necesidad de potenciar la dinámica de las clases tanto dentro como fuera del aula. En este proyecto hemos centrado nuestra actuación en el desarrollo de elementos que permitan la interacción con el estudiante a través del campus virtual UCM para de este modo activar su acceso al conocimiento, la relación entre estudiantes a través de la herramienta y la potenciación de los modelos gamificados y de aula invertida

Atlas de terapias urbanas basado en casos reales

El “Atlas de terapias urbanas1 ” se propone como una herramienta encaminada a facilitar la identificación y evaluación de mejoras urbanas adaptadas a las vocaciones de los diferentes entornos. El objeto de su creación está encaminado a servir en la toma de decisiones inteligentes a las instituciones y actores involucrados en la revitalización de los barrios andaluces. Proponemos una herramienta de mediación, que no solo se base en deficiencias barriales sino también en potencialidades; no solo en los deseos de la ciudadanía, sino también en las vocaciones de los entornos. El presente artículo trata de compendiar, de forma resumida, los avances y documentos internos desarrollados hasta la fecha por los autores que conforman esta investigación. En él se explican los conceptos y procesos fundamentales sobre los que se asienta el diseño de la herramienta buscada

Study on aerosol properties over Madrid (Spain) by multiple instrumentation during SPALI10 lidar campaign

Understanding the effect of aerosols upon radiative forcing requ ires information about vertical profiles. Lidar techniques represent a powerful tool for studies of the vertical structure of the aerosol field. During the SPAin Lidar Intercomparison 20 10 (SPALI10) campaign, several multiwavelen gth Raman lidar systems measured simultaneously in order to assess their performances. Multiwavelength lidars can pr ovide relevant vertically-resolved information on aerosol optical properties because the wavelength dependence of the backscatter and extinction coefficients allows for a more detailed discrimination of aerosol types. Several lidar stations belonging to SPALINET, the Spanish and Portuguese Lidar NETwork and also EARLINET, the European Aerosol Research Lidar NETwork, intercompared during a campaign that took place in Madrid from 18 October to 5 November 2010. The products provided by the lidar systems were compared with ancillary data. At ground level, aerosol size distribution was continuously monitored. Additionally, the column-integrated characterization of the atmospheric aerosol was performed by means of a sun photometer. The extensive dataset obtained during SPALI10 field campaign enables to compare ground-level in-situ measurements with remote sensing techniques to determine vertically-resolved optical and microphysical properties of aerosols. Several relevant features shown in the comparison of the results obtained by the different instruments are discussed in this work.Peer ReviewedPostprint (published version

EARLINET instrument intercomparison campaigns: Overview on strategy and results

This paper introduces the recent European Aerosol Research Lidar Network (EARLINET) quality-assurance efforts at instrument level. Within two dedicated campaigns and five single-site intercomparison activities, 21 EARLINET systems from 18 EARLINET stations were intercompared between 2009 and 2013. A comprehensive strategy for campaign setup and data evaluation has been established. Eleven systems from nine EARLINET stations participated in the EARLINET Lidar Intercomparison 2009 (EARLI09). In this campaign, three reference systems were qualified which served as traveling standards thereafter. EARLINET systems from nine other stations have been compared against these reference systems since 2009. We present and discuss comparisons at signal and at product level from all campaigns for more than 100 individual measurement channels at the wavelengths of 355, 387, 532, and 607 nm. It is shown that in most cases, a very good agreement of the compared systems with the respective reference is obtained. Mean signal deviations in predefined height ranges are typically below ±2 %. Particle backscatter and extinction coefficients agree within ±2  ×  10−4 km−1 sr−1 and ± 0.01 km−1, respectively, in most cases. For systems or channels that showed larger discrepancies, an in-depth analysis of deficiencies was performed and technical solutions and upgrades were proposed and realized. The intercomparisons have reinforced confidence in the EARLINET data quality and allowed us to draw conclusions on necessary system improvements for some instruments and to identify major challenges that need to be tackled in the future

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

EARLINET instrument intercomparison campaigns: overview on strategy and results

This paper introduces the recent European Aerosol Research Lidar Network (EARLINET) quality-assurance efforts at instrument level. Within two dedicated campaigns and five single-site intercomparison activities, 21 EARLINET systems from 18 EARLINET stations were intercompared between 2009 and 2013. A comprehensive strategy for campaign setup and data evaluation has been established. Eleven systems from nine EARLINET stations participated in the EARLINET Lidar Intercomparison 2009 (EARLI09). In this campaign, three reference systems were qualified which served as traveling standards thereafter. EARLINET systems from nine other stations have been compared against these reference systems since 2009. We present and discuss comparisons at signal and at product level from all campaigns for more than 100 individual measurement channels at the wavelengths of 355, 387, 532, and 607¿nm. It is shown that in most cases, a very good agreement of the compared systems with the respective reference is obtained. Mean signal deviations in predefined height ranges are typically below ±2¿%. Particle backscatter and extinction coefficients agree within ±2¿¿×¿¿10-4¿km-1¿sr-1 and ±¿0.01¿km-1, respectively, in most cases. For systems or channels that showed larger discrepancies, an in-depth analysis of deficiencies was performed and technical solutions and upgrades were proposed and realized. The intercomparisons have reinforced confidence in the EARLINET data quality and allowed us to draw conclusions on necessary system improvements for some instruments and to identify major challenges that need to be tackled in the future.Peer ReviewedPostprint (published version

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

I Congreso - Convergencias y divergencias. Hacia educaciones y desarrollo otros.

La presente colección, en su primera publicación, recoge la experiencia del I Congreso Internacional de Educación para el Desarrollo en Perspectiva Latinoamericana- EpDl “Convergencias y divergencias. Hacia educaciones y desarrollos otros.” organizado por el Centro de Educación para el Desarrollo-CED de UNIMINUTO, específicamente en relación con las ponencias, libros e iniciativas fotográficas presentadas en las seis líneas temáticas de este evento académico, a saber: (a) experiencias y prácticas pedagógicas; (b) acciones colectivas, movimientos y redes sociales; (c) perspectivas críticas al desarrollo; (d) producción de conocimiento; (e) diferencias, identidades y ciudadanía; (f) cuerpos, emociones y espiritualidades; a partir de éstas propuestas y en el marco de estas líneas, se reflexionó sobre las dinámicas y problemáticas derivadas del desarrollo hegemónico, así como sobre la posibilidad de diálogo entre saberes y conocimientos construidos de forma contextualizada, que permitan agenciar apuestas y proyectos alternativos disidentes en la búsqueda de “desarrollos y educaciones otras” desde América Latina