Identificacion de las mejores practicas de una organización de desarrollo software mediante la gestión de su conocimiento

En este artículo se describe un método para la identificación de las mejores prácticas de una organización de desarrollo de software, enfocándose en la disminución de la resistencia al cambio, a través de la gestión de su conocimiento. La importancia de la identificación de las mejores prácticas de una organización radica en que esta actividad permite conocer cómo trabaja una organización mediante la formalización, conservación y promoción de su conocimiento clave, lo cual, permitirá que las iniciativas de mejora de los procesos de la organización sean llevadas a cabo con éxito

Whole sequence of the mitochondrial DNA genome of Kearns Sayre Syndrome patients: Identification of deletions and variants

Mitochondria both produce the energy of the cell as ATP via respiration and regulate cellular metabolism. Accordingly, any deletion or mutation in the mitochondrial DNA (mtDNA) may result in a disease. One of these diseases is Kearns Sayre syndrome (KSS), described for the first time in 1958, where different large-scale deletions of different sizes and at different positions have been reported in the mitochondrial genome of patients with similar clinical symptoms. In this study, sequences of the mitochondrial genome of three patients with clinic features of KSS were analyzed. Our results revealed the position, heteroplasmy percentage, size of deletions, and their haplogroups. Two patients contained deletions reported previously and one patient showed a new deletion not reported previously. These results display for the first time a systematic analysis of mtDNA variants in the whole mtDNA genome of patients with KSS to help to understand their association with the disease

Scaling up cancer care for children without medical insurance in developing countries: The case of Mexico

Background: In 2006, the Mexican government launched the Fund for Protection Against Catastrophic Expenditures (FPGC) to support financially healthcare of high cost illnesses. This study aimed at answering the question whether FPGC improved coverage for cancer care and to measure survival of FPGC affiliated children with cancer. Procedure A retrospective cohort study (2006–2009) was conducted in 47 public hospitals. Information of children and adolescents with cancer was analyzed. The coverage was estimated in accordance with expected number of incident cases and those registered at FPGC. The survival was analyzed by using Kaplan–Meier survival curves and Cox proportional hazards regression modeling. Results: The study included 3,821 patients. From 2006 to 2009, coverage of new cancer cases increased from 3.3% to 55.3%. Principal diagnoses were acute lymphoblastic leukemia (ALL, 46.4%), central nervous system (CNS) tumors (8.2%), and acute myeloid leukemia (AML, 7.4%). The survival rates at 36 months were ALL (50%), AML (30.5%), Hodgkin lymphoma (74.5%), Non-Hodgkin lymphoma (40.1%), CNS tumors (32.8%), renal tumors (58.4%), bone tumors (33.4%), retinoblastoma (59.2%), and other solid tumors (52.6%). The 3-year overall survival rates varied among the regions; children between the east and south-southeast had the higher risks (hazard ratio 3.0; 95% CI: 2.3–3.9) and 2.4; 95% CI: 2.0–2.8) of death from disease when compared with those from the central region. Conclusion: FPGC has increased coverage of cancer cases. Survival rates were different throughout the country. It is necessary to evaluate the effectiveness of this policy to increase access and identify opportunities to reduce the differences in survival

Cuerpo y educación : variaciones en torno a un mismo tema

El presente texto es una compilación de los trabajos realizados por el Instituto para la Investigación Educativa y el Desarrollo Pedagógico, IDEP, con un grupo de investigadores que orientaron los estudios y los procesos de cualificación en el ámbito de Subjetividad, diversidad e interculturalidad, propuesto desde el Componente de Educación y Políticas Públicas del proyecto misional del IDEP. El hilo conductor en cada uno de los textos es el lugar del cuerpo, unas veces como eje central de la propuesta investigativa, y otras como elemento relevante desde su relación con distintas dimensiones que surgen en los diferentes trabajos desarrollados por los colectivos de maestros y maestras.Presentación 1. Obertura 1.1 Cuerpo y recreación. Reconfiguración subjetiva a través del uso de las prácticas lúdico-creativas 2. Primer Movimiento 2.1. Reflexiones sobre el cuerpo. Conciencia, experiencia, vivencias 2.2. El cuerpo de la memoria. Políptico de mnemotecnias 3. Segundo Movimiento 3.1. Cuerpo y Erotismo en la Escuela. Discursos y Tensiones 3.2. El Poder de la Apariencia. Construcciones Escolares del Cuerpo 4. Tercer Movimiento 4.1. Diversidad epistémica e interculturalidad crítica. Una perspectiva para los estudios sobre diversidad en la escuela 4.2. Territorio y derechos. Cartografías Corporales en la Investigación sobre Territorio en los Contextos Escolares 5. Coda 5.1. Videojuegos y conocimiento: un estado de la cuestió

Factores biológicos, socioambientales y clínico radiológicos asociados a neumonía adquirida en la comunidad en menores de 5 años en un hospital público del Perú

Introducción: La neumonía adquirida en la comunidad (NAC) es una patología inflamatoria que daña la vía respiratoria baja, generalmente de etiología infecciosa. Afecta el parénquima pulmonar, lo cual produce alteración en la hematosis alveolar y ocasiona hipoxemia progresiva. Objetivo: Determinar cómo los factores biológicos, socioambientales, clínico radiológicos y analíticos se asocian al desarrollo de NAC en menores de 5 años hospitalizados en un hospital público del Perú durante 2019. Materiales y métodos: Estudio observacional, retrospectivo, analítico, tipo casos y controles. El tamaño muestral se realizó mediante muestreo aleatorio simple, no pareado, y se obtuvieron 71 casos y 71 controles en el Servicio de Pediatría del Hospital San José durante 2019. Resultados: El sexo masculino predominó en los pacientes con NAC (54.9 %); pero no hubo asociación significativa entre este sexo y NAC (OR: 1.67 IC: 0.86-3.23, p: 0.13). Los resultados estadísticamente significativos asociados a NAC fueron lactancia materna no efectiva (OR: 6.85, IC 95 %: 3.18-14.75) y antecedente de enfermedades respiratorias (OR: 5.41, IC 95 %: 2.58-11.34). Conclusiones: Los factores biológicos, lactancia materna no efectiva y antecedente de enfermedades respiratorias se encuentran asociados a NAC en menores de 5 años.Escuela de Postgrad

Sediment source apportionment following wildfire in an upland commercial forest catchment

File replaced (incorrect version) on 09/05/2022 by KT (LDS).Purpose: Wildfires can have major impacts on water scarcity and water quality linked to off-site transfer of polluting ash and nutrients. Understanding sediment sources in burnt landscapes can help to develop mitigation strategies, especially in catchments planted with introduced species that are prone to fire. We investigated sediment sources activated by post-fire rainfall in a small-forested catchment that was impacted by a severe wildfire. The aim was to use environmental radionuclides and elemental geochemistry as tracers to apportion sediment sources within burnt plantation systems. Methods: Surficial (0–2 cm) topsoil (n = 9), sub-surficial (2–4 cm) topsoil (i.e. below the burnt layer; n = 8) samples from burnt hillslopes and forest roads (n = 5) and stream banks (n = 5) soil samples were taken in the Quivolgo catchment, El Maule region, Chile. Sediment samples (n = 9) were collected from behind a v-notched weir on three dates after the fire: May 2017, July 2017 and October 2017. Soil and sediment samples were analysed by gamma spectrometry and wavelength-dispersive X-ray fluorescence (WD-XRF) used to obtain tracer properties. These were evaluated visually and statistically to identify potential non-conservative tracers. Sediment apportionment was undertaken using the MixSIAR mixing model. Results: The tracer selection procedure resulted in ten tracers being used for sediment apportionment. Tracer suitability was based on (i) weak and non-significant linear relationship between tracer concentrations and specific surface area (SSA) and soil organic matter (SOM), and (ii) conservative behaviour supported by the inclusion of sediment samples within source convex hull. Sediments from sub-surface layer (2–4 cm) were the dominant source during the first two periods contributing 55 ± 11 and 78 ± 10% respectively, whereas road contribution was only important in the last period (71 ± 14%). Apportionment showed a shift in sediment source (i.e. from forest roads to hillslopes) compared to a previous study in the same catchment before wildfire. The main driver of erosion was attributed to overland flow convergence and consequent rill erosion across burnt hillslopes. Conclusion: The study demonstrated combined use of environmental radionuclides with elemental geochemistry for sediment apportionment within burnt forest plantations and highlighted a switch in predominant source (e.g. sub-surface burnt soil) activated by post-fire rainfall events. The findings in this research will help forest companies to develop strategies to reduce off-site impacts of sediment release after wildfire in forest plantations

Different HCV Exposure Drives Specific miRNA Profile in PBMCs of HIV Patients

Micro RNAs (miRNAs) are essential players in HIV and HCV infections, as both viruses modulate cellular miRNAs and interact with the miRNA-mediated host response. We aim to analyze the miRNA profile of HIV patients with different exposure to HCV to explore specific signatures in the miRNA profile of PBMCs for each type of infection. We massively sequenced small RNAs of PBMCs from 117 HIV+ infected patients: 45 HIV+ patients chronically infected with HCV (HIV/HCV+), 36 HIV+ that spontaneously clarified HCV after acute infection (HIV/HCV-) and 36 HIV+ patients without previous HCV infection (HIV). Thirty-two healthy patients were used as healthy controls (HC). Differential expression analysis showed significantly differentially expressed (SDE) miRNAs in HIV/HCV+ (n = 153), HIV/HCV- (n = 169) and HIV (n = 153) patients. We found putative dysregulated pathways, such as infectious-related and PI3K signaling pathways, common in all contrasts. Specifically, putatively targeted genes involved in antifolate resistance (HIV/HV+), cancer-related pathways (HIV/HCV-) and HIF-signaling (HIV) were identified, among others. Our findings revealed that HCV strongly influences the expression profile of PBMCs from HIV patients through the disruption of its miRNome. Thus, different HCV exposure can be identified by specific miRNA signatures in PBMCs.This work has been supported by grants from Institute of Health Carlos III, [PI15CIII/00031 and PI18CIII/00020/ to AFR and VB] and the Foundation Universidad Alfonso X el Sabio-Santander [grant number 1.010.932 to AFR] and the Spanish AIDS Research Network (RD16CIII/0002/0002), and Centro de Investigación Biomédica en Red (CIBER) en Enfermedades Infecciosas (CB21/13/00044). AFR is supported by the Miguel Servet programme from Fondo de Investigación Sanitaria (ISCIII) [CP14/CIII/00010 and CPII20CIII/0001].info:eu-repo/semantics/publishedVersio

Production of highly-polarized positrons using polarized electrons at MeV energies

The Polarized Electrons for Polarized Positrons experiment at the injector of the Continuous Electron Beam Accelerator Facility has demonstrated for the first time the efficient transfer of polarization from electrons to positrons produced by the polarized bremsstrahlung radiation induced by a polarized electron beam in a high-$Z$ target. Positron polarization up to 82\% have been measured for an initial electron beam momentum of 8.19~MeV/$c$, limited only by the electron beam polarization. This technique extends polarized positron capabilities from GeV to MeV electron beams, and opens access to polarized positron beam physics to a wide community.Comment: 5 pages, 4 figure

Segmentation and kinematics of the North America-Caribbean plate boundary offshore Hispaniola

We explored the submarine portions of the Enriquillo–Plantain Garden Fault zone (EPGFZ) and the Septentrional–Oriente Fault zone (SOFZ) along the Northern Caribbean plate boundary using high-resolution multibeam echo-sounding and shallow seismic reflection. The bathymetric data shed light on poorly documented or previously unknown submarine fault zones running over 200 km between Haiti and Jamaica (EPGFZ) and 300 km between the Dominican Republic and Cuba (SOFZ). The primary plate-boundary structures are a series of strike-slip fault segments associated with pressure ridges, restraining bends, step overs and dogleg offsets indicating very active tectonics. Several distinct segments 50–100 km long cut across pre-existing structures inherited from former tectonic regimes or bypass recent morphologies formed under the current strike-slip regime. Along the most recent trace of the SOFZ, we measured a strike-slip offset of 16.5 km, which indicates steady activity for the past ~1.8 Ma if its current GPS-derived motion of 9.8 ± 2 mm a−1 has remained stable during the entire Quaternary.Depto. de Geodinámica, Estratigrafía y PaleontologíaFac. de Ciencias GeológicasTRUEpu