¿Cómo se aprende el léxico de una L2? Una propuesta de actualización para Aléxandros

In this paper, we intend to offer, firstly, a brief conceptual framework derived from second language acquisition theories applied to the learning of modern languages or L2, with a focus on vocabulary acquisition. Secondly, within the context of Ancient Greek, a practical proposal for updating one of the most popular manuals in Spain, taking into account the principles outlined and considering the learning and acquisition of Ancient Greek at the same level as a modern language.En este trabajo pretendemos ofrecer, en primer lugar, un breve aparataje conceptual procedente de las teorías de adquisición de segundas lenguas aplicadas al aprendizaje de lenguas modernas o L2, poniendo el foco en la adquisición del vocabulario; en segundo lugar, en el marco del griego antiguo, una propuesta práctica de actualización para uno de los manuales más populares en España, teniendo en cuenta los preceptos expuestos y considerando el aprendizaje y la adquisición del griego antiguo en el mismo nivel que una lengua moderna

Shortest path computing in directed graphs with weighted edges mapped on random networks of memristors

Electronic version of an article published as [Fernandez, Carlos, Ioannis Vourkas, and Antonio Rubio. "Shortest Path Computing in Directed Graphs with Weighted Edges Mapped on Random Networks of Memristors." Parallel Processing Letters 30.01 (2020): 2050002] [https://doi.org/10.1142/S0129626420500024] © [copyright World Scientific Publishing Company] [https://www.worldscientific.com/worldscinet/ppl]To accelerate the execution of advanced computing tasks, in-memory computing with resistive memory provides a promising solution. In this context, networks of memristors could be used as parallel computing medium for the solution of complex optimization problems. Lately, the solution of the shortest-path problem (SPP) in a two-dimensional memristive grid has been given wide consideration. Some still open problems in such computing approach concern the time required for the grid to reach to a steady state, and the time required to read the result, stored in the state of a subset of memristors that represent the solution. This paper presents a circuit simulation-based performance assessment of memristor networks as SPP solvers. A previous methodology was extended to support weighted directed graphs. We tried memristor device models with fundamentally different switching behavior to check their suitability for such applications and the impact on the timely detection of the solution. Furthermore, the requirement of binary vs. analog operation of memristors was evaluated. Finally, the memristor network-based computing approach was compared to known algorithmic solutions to the SPP over a large set of random graphs of different sizes and topologies. Our results contribute to the proper development of bio-inspired memristor network-based SPP solvers.This work was supported by the Chilean research grants CONICYT REDES ETAPA INICIAL Convocatoria 2017 No. REDI170604, CONICYT BASAL FB0008, and by the Spanish MINECO and ERDF (TEC2016-75151-C3-2-R).Peer ReviewedPostprint (author's final draft

Investigaciones en curso sobre interfaces gráficos en dos y tres dimensiones para el acceso a la información electrónica

En este trabajo se presentan una serie de proyectos de investigación sobre interfaces gráficos. Se consideran tanto los intefaces bidimensionales como los tridimensionales, especialmente los basados en VRML. Se pone énfasis en las redes neuronales (SOM) como métodos de organización de la información. Por último, se presenta el proyecto de investigación IRVAIE, que tiene por objetivo el desarrollo de un nuevo intefaz para el acceso a información electrónica, con particular énfasis en el diseño de una metáfora tridimensional que permita la comunicación entre los usuarios y facilite la exploración de grandes volúmenes de información

The femur of \u3ci\u3eOrrorin tugenensis\u3c/i\u3e exhibits morphometric affinities with both Miocene apes and later hominins

Orrorin tugenensis (Kenya, ca. 6 Ma) is one of the earliest putative hominins. Its proximal femur, BAR 1002′00, was originally described as being very human-like, although later multivariate analyses showed an australopith pattern. However, some of its traits (for example, laterally protruding greater trochanter, medially oriented lesser trochanter and presence of third trochanter) are also present in earlier Miocene apes. Here, we use geometric morphometrics to reassess the morphological affinities of BAR 1002′00 within a large sample of anthropoids (including fossil apes and hominins) and reconstruct hominoid proximal femur evolution using squared-change parsimony. Our results indicate that both hominin and modern great ape femora evolved in different directions from a primitive morphology represented by some fossil apes. Orrorin appears intermediate between Miocene apes and australopiths in shape space. This evidence is consistent with femoral shape similarities in extant great apes being derived and homoplastic and has profound implications for understanding the origins of human bipedalism

Rescue of Advanced Pompe Disease in Mice with Hepatic Expression of Secretable Acid α-Glucosidase.

Pompe disease is a neuromuscular disorder caused by disease-associated variants in the gene encoding for the lysosomal enzyme acid α-glucosidase (GAA), which converts lysosomal glycogen to glucose. We previously reported full rescue of Pompe disease in symptomatic 4-month-old Gaa knockout (Gaa-/-) mice by adeno-associated virus (AAV) vector-mediated liver gene transfer of an engineered secretable form of GAA (secGAA). Here, we showed that hepatic expression of secGAA rescues the phenotype of 4-month-old Gaa-/- mice at vector doses at which the native form of GAA has little to no therapeutic effect. Based on these results, we then treated severely affected 9-month-old Gaa-/- mice with an AAV vector expressing secGAA and followed the animals for 9 months thereafter. AAV-treated Gaa-/- mice showed complete reversal of the Pompe phenotype, with rescue of glycogen accumulation in most tissues, including the central nervous system, and normalization of muscle strength. Transcriptomic profiling of skeletal muscle showed rescue of most altered pathways, including those involved in mitochondrial defects, a finding supported by structural and biochemical analyses, which also showed restoration of lysosomal function. Together, these results provide insight into the reversibility of advanced Pompe disease in the Gaa-/- mouse model via liver gene transfer of secGAA.This work was supported by Genethon, the French Muscular Dystro-phy Association (AFM), and Spark Therapeutics. It was also sup-ported by the European Union’s Research and Innovation Programunder grant agreement number 667751 (to F.M.), the EuropeanResearch Council Consolidator Grant under grant agreement number617432 (to F.M.), and Marie Skłodowska-Curie Actions-IndividualFellowship (MSCA-IF) grant agreement number 797144 (to U.C.)S

Reassessment of the phylogenetic relationships of the late Miocene apes Hispanopithecus and Rudapithecus based on vestibular morphology

Late Miocene great apes are key to reconstructing the ancestral morphotype from which earliest hominins evolved. Despite consensus that the late Miocene dryopith great apes Hispanopithecus laietanus (Spain) and Rudapithecus hungaricus (Hungary) are closely related (Hominidae), ongoing debate on their phylogenetic relationships with extant apes (stem hominids, hominines, or pongines) complicates our understanding of great ape and human evolution. To clarify this question, we rely on the morphology of the inner ear semicircular canals, which has been shown to be phylogenetically informative. Based on microcomputed tomography scans, we describe the vestibular morphology of Hispanopithecus and Rudapithecus, and compare them with extant hominoids using landmark-free deformation-based three-dimensional geometric morphometric analyses. We also provide critical evidence about the evolutionary patterns of the vestibular apparatus in living and fossil hominoids under different phylogenetic assumptions for dryopiths. Our results are consistent with the distinction of Rudapithecus and Hispanopithecus at the genus rank, and further support their allocation to the Hominidae based on their derived semicircular canal volumetric proportions. Compared with extant hominids, the vestibular morphology of Hispanopithecus and Rudapithecus most closely resembles that of African apes, and differs from the derived condition of orangutans. However, the vestibular morphologies reconstructed for the last common ancestors of dryopiths, crown hominines, and crown hominids are very similar, indicating that hominines are plesiomorphic in this regard. Therefore, our results do not conclusively favor a hominine or stem hominid status for the investigated dryopiths.DATA AVAILABITY : The 3D mesh data have been deposited in MorphoSource, https://morphosource.org/ (Rudapithecus hungaricus: RUD:77 R: https://doi.org/10.17602/M2/M126214; RUD:77 L: https://doi.org/10.17602/M2/M126215; RUD:200: https://doi.org/10.17602/M2/M126216; Hispanopithecus laietanus: IPS:18000: https://doi.org/10.17602/M2/M126217; Nacholapithecus kerioi: KNM:BG:42744: https://doi.org/10.17602/M2/M166427; Oreopithecus bambolii: NMB:BAC:208: https://doi.org/10.17602/M2/M166428).The Agencia Estatal de Investigación; the Generalitat de Catalunya (CERCA Programme); the consolidated research groups 2017 SGR 86 and 2017 SGR 116 GRC; and the French Centre National de la Recherche Scientifique.https://www.pnas.orghj2022Anatom

Microbead-based spoligotyping of Mycobacterium tuberculosis from Ziehl-Neelsen-stained microscopy preparations in Ethiopia

The worldwide dissemination of Mycobacterium tuberculosis strains has led to the study of their genetic diversity. One of the most used genotyping methods is spoligotyping, based on the detection of spacers in the clustered regularly interspaced short palindromic repeats (CRISPR) locus. This study assessed the performance of a microbead-based spoligotyping assay using samples extracted from Ziehl-Neelsen-stained smear-microscopy preparations and described the genetic diversity of Mycobacterium tuberculosis among new TB patients in Southern Nations, Nationalities and Peoples’ Region (SNNPR) in Ethiopia. Among the 91 samples analysed, 59 (64.8%) generated spoligotyping patterns. Fifty (84.7%) samples were classified into 12 clusters (mostly Lineage 4 or 3) comprising 2–11 samples and nine had unique spoligotyping patterns. Among the 59 spoligotyping patterns, 25 belonged to the T1 sublineage, 11 to the T3-ETH, 5 to the URAL, 4 to the H3 and 14 to other L4 sublineages. There was a remarkable variation in genetic distribution in SNNPR compared to other regions of the country. Microbead-based spoligotyping is an easy-to-perform, high-throughput assay that can generate genotyping information using material obtained from smear microscopy preparations. The method provides an opportunity to obtain data of the M. tuberculosis genetic epidemiology in settings with limited laboratory resources

Insulin Signaling Disruption and INF-γ Upregulation Induce Aβ1–42 and Hyperphosphorylated-Tau Proteins Synthesis and Cell Death after Paraquat Treatment of Primary Hippocampal Cells

Acute and long-term paraquat (PQ) exposure produces hippocampal neurodegeneration and cognition decline. Although some mechanisms involved in these effects were found, the rest are unknown. PQ treatment, for 1 and 14 days, upregulated interferon-gamma signaling, which reduced insulin levels and downregulated the insulin pathway through phosphorylated-c-Jun N-terminal-kinase upregulation, increasing glucose levels and the production of Aβ1–42 and phosphorylated-tau, by beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) overexpression and phosphorylated-GSK3β (p-GSK3β; ser9) level reduction, respectively, which induced primary hippocampal neuronal loss. This novel information on the PQ mechanisms leading to hippocampal neurodegeneration could help reveal the PQ actions that lead to cognition dysfunction

Decision making impairment: A shared vulnerability in obesity, gambling disorder and substance use disorders?

Introduction: Addictions are associated with decision making impairments. The present study explores decision making in Substance use disorder (SUD), Gambling disorder (GD) and Obesity (OB) when assessed by Iowa Gambling Task (IGT) and compares them with healthy controls (HC). Methods: For the aims of this study, 591 participants (194 HC, 178 GD, 113 OB, 106 SUD) were assessed according to DSM criteria, completed a sociodemographic interview and conducted the IGT. Results: SUD, GD and OB present impaired decision making when compared to the HC in the overall task and task learning, however no differences are found for the overall performance in the IGT among the clinical groups. Results also reveal some specific learning across the task patterns within the clinical groups: OB maintains negative scores until the third set where learning starts but with a less extend to HC, SUD presents an early learning followed by a progressive although slow improvement and GD presents more random choices with no learning. Conclusions: Decision making impairments are present in the studied clinical samples and they display individual differences in the task learning. Results can help understanding the underlying mechanisms of OB and addiction behaviors as well as improve current clinical treatments