Consideraciones sobre la pizarra digital interactiva en el aula de Música: la realidad educativa actual en la ciudad de Valencia

El presente trabajo trata de dar a conocer las posibilidades y aplicaciones de la Pizarra Digital Interactiva en el aula de música en dos centros de la Comunidad Valenciana desde un punto de vista crítico. Este proceso investigador supone la necesidad de reflexión con respecto a la indispensable respuesta del sistema educativo a las demandas sociales así como a la imprescindible formación permanente en la labor docente

Magnetic Core-Shell Nanoparticles Using Molecularly Imprinted Polymers for Zearalenone Determination

This paper describes the synthesis of novel molecularly imprinted magnetic nano-beads for the selective extraction (MISPE) of zearalenone mycotoxin in river and tap waters and further analysis by high-performance liquid chromatography (HPLC) with fluorescence detection (FLD). A semi-covalent imprinting approach was achieved for the synthesis of the molecularly imprinted polymers (MIP). The nanoparticles were prepared by covering the starting Fe3O4 material with a first layer of tetraethyl orthosilicate (TEOS) and then with a second layer using cyclododecyl 2-hydroxy-4-(3-triethoxysilylpropylcarbamoyloxy) benzoate. The last was used with a dual role, template and functional monomer after the extraction of the template molecule. The material was characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopies (FT-IR). The solid phase extraction was optimized in all the steps: loading, washing and elution. The optimal conditions allowed the determination of zearalenone in trace levels of 12.5, 25 and 50 µg L−1 without significant differences between the fortified and found level concentrations.Depto. de Química AnalíticaFac. de Ciencias QuímicasTRUEMICINpu

La imatge de la dona a la premsa de la Guerra Civil : ABC i Solidaridad Obrera: dos models antagònics

La Guerra Civil Espanyola (juliol de 1936 - abril de 1939) fou un període caracteritzat pels conflictes socials, polítics i bèl·lics a gran part dels territoris espanyols. En aquest estudi s'analitza el tractament de la imatge de la dona a partir de dos periòdics d'ideologia oposada, l'ABC i Solidaridad Obrera, incloent-hi líders i moviments feministes sorgits a la Guerra Civil, com Federica Montseny i "Mujeres Libres", o el tradicionalisme femení marcat per Pilar Primo de Rivera i la "Sección Femenina", elements clau durant la guerra per situar el paper de la dona en la societat.La Guerra Civil Española (julio de 1936 - abril de 1939) fue un periodo caracterizado por los conflictos sociales, políticos y bélicos en gran parte de los territorios españoles. En este estudio se analiza el tratamiento de la imagen de la mujer a partir de dos periódicos con ideología opuesta, el ABC y Solidaridad Obrera, incluyendo líderes y movimientos feministas surgidos durante la Guerra Civil, como Federica Montseny y Mujeres Libres, o el tradicionalismo femenino marcado por Pilar Primo de Rivera y la Sección Femenina, elementos clave durante la guerra para situar el papel de la mujer en la sociedad.The Spanish Civil War (july of 1936 - April of 1939) was a period characterized by social, political and military conflicts in the major part of the spanish region. In this study, we will analise the treatment of the women portrait based on two newspapers which share opposing views, ABC and Solidaridad Obrera. It will include leaders and feminist movements arising during the Civil War, such as Federica Montseny and "Mujeres Libres" or the feminine traditionalism lead by Pilar Primo de Rivera and the "Sección Femenina", key elements during the Civil War in order to describe the role of women in society

A CONSTRUÇÃO DE GÊNERO NO PÁTIO DA ESCOLA

In the vast majority of educational centers, the playground area has a very significant socializing role among the students, but these interactions are not free of sexism. The behavior of the students depending on the occupation of the spaces and the choice of activities in this recreation time can contribute to a greater or lesser equality of opportunities. For this reason, the purpose of this research is to detect sexist behavior of students during recess time, based on the transformation of spaces and activities in the playground of a Primary Education center. The methodology used has consisted of a case study, in which a total of 250 students (117 girls and 133 boys) have participated, belonging to a school in the province of Valencia. The results show that the transformation of spaces and activities in the playground fosters social relationships among students, regardless of gender or age, with equal opportunities for both girls and boys, reducing the number of conflicts in this time interval. Therefore, the transformation of school playgrounds into active, inclusive and co-educational playgrounds is recommended; where the entire educational community must be involved in order to carry out this transformation.En la gran mayoría de los centros educativos, la zona del patio tiene un papel socializador muy significativo entre el alumnado, pero estas interacciones no están libres de sexismo. El comportamiento del alumnado en función de la ocupación de los espacios y la elección de las actividades en este tiempo de recreo puede contribuir a una mayor o menor igualdad de oportunidades. Por ello, la finalidad de esta investigación es detectar comportamientos sexistas del alumnado durante el tiempo de recreo, a partir de la transformación de los espacios y las actividades en el patio de un centro de Educación Primaria. La metodología utilizada ha consistido en un estudio de casos, en el que han participado un total de 250 estudiantes (117 niñas y 133 niños), pertenecientes a un colegio de la provincia de Valencia. Los resultados muestran que la transformación de espacios y actividades en el patio fomenta las relaciones sociales entre el alumnado, independientemente del sexo o la edad, en igualdad de oportunidades tanto de niñas como de niños, reduciendo el número de conflictos en este intervalo de tiempo. Por lo que se recomienda la transformación de los patios escolares en patios activos, inclusivos y coeducativos; en donde toda la comunidad educativa debe implicarse para poder llevar a cabo esta transformación.Na grande maioria dos centros educacionais, a área do recreio tem um papel socializador muito significativo entre os alunos, mas essas interações não são isentas de machismo. O comportamento dos alunos em função da ocupação dos espaços e da escolha das atividades neste tempo de recreio pode contribuir para uma maior ou menor igualdade de oportunidades. Por esse motivo, o objetivo desta pesquisa é detectar comportamentos sexistas de alunos durante o recreio, a partir da transformação de espaços e atividades no pátio de recreio de um centro de Educação Básica. A metodologia utilizada consistiu em um estudo de caso, no qual participaram um total de 250 alunos (117 meninas e 133 meninos), pertencentes a uma escola da província de Valência. Os resultados mostram que a transformação dos espaços e das atividades no pátio favorece as relações sociais entre os alunos, independente de sexo ou idade, com igualdade de oportunidades para meninas e meninos, reduzindo o número de conflitos nesse intervalo de tempo. Assim, recomenda-se a transformação dos recreios escolares em recreios ativos, inclusivos e co-educativos; onde toda a comunidade educativa deve estar envolvida para realizar esta transformação

Synthesis and Antimicrobial Activity of a Silver-Hydroxyapatite Nanocomposite

A silver-hydroxyapatite nanocomposite has been obtained by a colloidal chemical route and subsequent reduction process in H2/Ar atmosphere at C. This material has been characterized by TEM, XRD, and UV-Visible spectroscopy, showing the silver nanoparticles (65 nm) supported onto the HA particles (130 nm) surface without a high degree of agglomeration. The bactericidal effect against common Gram-positive and Gram-negative bacteria has been also investigated. The results indicated a high antimicrobial activity for Staphylococcus aureus, Pneumococcus and Escherichia coli, so this material can be a promising antimicrobial biomaterial for implant and reconstructive surgery applications.This work was supported by Bioker Research S.L. and by the Spanish Ministry of Education and Science under Project CENIT-INTELIMPLANT (ref.: 20071210). M. Díaz has been supported by Spanish Ministry of Education and Science and CSIC under I3P Program financed by European Social FundS

Estrategias víricas contra el silenciamiento génico en plantas

Plant viruses have developed strategies to evade genetic silencing, which is the main defense of plants against intracellular pathogens. There are two types of RNA silencing in plants: transcriptional silencing and postranscriptional silencing, which involves Dicer proteins and small RNAs. In order to fight these defenses, plant viruses encode suppressor proteinsLos virus de plantas han desarrollado estrategias de evasión del silenciamiento genético, la principal vía de defensa ante patógenos intracelulares. Existen dos fenómenos de silenciamiento de RNA en plantas, el silenciamiento génico transcripcional y el silenciamiento génico postranscripcional, que se lleva a cabo gracias a proteínas Dicer y RNAs de pequeño tamaño. Para hacer frente a estas defensas, los virus de plantas presentan diversas estrategias, entre las que destacan las proteínas supresoras del silenciamiento

Design of a case management model for people with chronic disease (Heart Failure and COPD). Phase I: modeling and identification of the main components of the intervention through their actors: patients and professionals (DELTA-ICE-PRO Study

Background Chronic diseases account for nearly 60% of deaths around the world. The extent of this silent epidemic has not met determined responses in governments, policies or professionals in order to transform old Health Care Systems, configured for acute diseases. There is a large list of research about alternative models for people with chronic conditions, many of them with an advanced practice nurse as a key provider, as case management. But some methodological concerns raise, above all, the design of the intervention (intensity, frequency, components, etc). Methods/Design Objectives: General: To develop the first and second phases (theorization and modeling) for designing a multifaceted case-management intervention in people with chronic conditions (COPD and heart failure) and their caregivers. Specific aims: 1) To identify key events in people living with chronic disease and their relation with the Health Care System, from their point of view. 2) To know the coping mechanisms developed by patients and their caregivers along the story with the disease. 3) To know the information processing and its utilization in their interactions with health care providers. 4) To detect potential unmet needs and the ways deployed by patients and their caregivers to resolve them. 5) To obtain a description from patients and caregivers, about their itineraries along the Health Care System, in terms of continuity, accessibility and comprehensiveness of care. 6) To build up a list of promising case-management interventions in patients with Heart Failure and COPD with this information in order to frame it into theoretical models for its reproducibility and conceptualization. 7) To undergo this list to expert judgment to assess its feasibility and pertinence in the Andalusian Health Care. Design: Qualitative research with two phases: For the first five objectives, a qualitative technique with biographic stories will be developed and, for the remaining objectives, an expert consensus through Delphi technique, on the possible interventions yielded from the first phase. The study will be developed in the provinces of Almería, Málaga and Granada in the Southern Spain, from patients included in the Andalusian Health Care Service database with the diagnosis of COPD or Heart Failure, with the collaboration of case manager nurses and general practitioners for the assessment of their suitability to inclusion criteria. Patients and caregivers will be interviewed in their homes or their Health Centers, with their family or their case manager nurse as mediator. Discussion First of a series of studies intended to design a case-management service for people with heart failure and COPD, in the Andalusian Health Care System, where case management has been implemented since 2002. Accordingly with the steps of a theoretical model for complex interventions, in this study, theorization and intervention modeling phases will be developed.This research was carried out with the support of one research grant, awarded by the Regional Health Ministry of Andalusia (Exp. 0222/2008

Impacto de la caries y trauma dental en la calidad de vida de preescolares en instituciones educativas urbanas y urbano marginales, Arequipa.

Objective: To determine the impact of caries and dental trauma on the quality of life of pre-school children and their families. Material and Methods: Observational, cross-sectional study in 150 pre-school children from 3 to 5 years old of both genders of urban and marginal urban educational institutions. The parents signed the consent and answered the socio-economic file and the ECOHIS questionnaire (Early Childhood Oral Health Impact Scale) according to the perception of oral health related Quality of Life (QoL) of their children. Three examiners were calibrated, intra and inter-examiner agreement was measured, the result was Kappa 0.9. The clinical examination for caries and dental trauma was according to the criteria established by the WHO. The statistical analysis was performed by SPSS statistical package and spreadsheets. Dental caries was related to HRQOL (p <0.005 Anova), and dental trauma to HRQOL (p <0.05 U of Mann Whitney). Results: The domains with negative impact on ECOHIS were oral symptoms (20%) and parental distress (44.7%). The impact on the child section of the ECOHIS rural public schools presented a high average experience (14) and progression (1.47) of caries. While the impact on the family section, urban private schools were affect by dental trauma (66.7%). Conclusions: Caries generated a negative impact on children, families and HRQoL of pre-school children from rural public schools. Dental trauma only affected families in urban private schools.Objetivos: Determinar el impacto de caries y trauma dental en la calidad de vida de preescolares y sus familias. Material y Métodos: Estudio observacional, transversal en 150 preescolares de 3 a 5 años de ambos géneros de escuelas privadas urbanas y públicas urbano marginales. Los padres firmaron el consentimiento, respondieron la ficha socioeconómica y el cuestionario ECOHIS (Early Childhood Oral Health Impact Scale) según la percepción de Calidad de Vida Relacionada a la Salud Bucal(CVRSB) de sus hijos. Tres examinadoras fueron calibradas y se midió la concordancia intra e inter-examinador resultando Kappa 0,9. El examen clínico de caries y traumatismos fue según los criterios establecidos por la OMS. Para el análisis estadístico se utilizó el paquete estadístico SPSS y hojas de cálculo. Se relacionó caries dental y CVRSB (p<0,005 Anova), traumatismo dental y CVRSB (p<0,05 U de Mann Whitney). Resultados: Los dominios con impacto negativo en ECOHIS fueron síntomas orales (20%) y angustia de los padres (44,7%). En la sección impacto en el niño del ECOHIS, las escuelas públicas rurales presentaron un promedio alto de experiencia (14) y progresión (1,47) de caries. Mientras que en la sección impacto en la familia las escuelas privadas urbanas fueron más afectadas por el dominio traumatismos dentales (66,7%). Conclusiones: La caries dental generó un impacto negativo en los niños, familias y CVRSB de preescolares de escuelas públicas rurales. Los traumatismos dentales sólo afectaron a las familias en escuelas privadas urbanas

Analysis of the role of AMPK activity as the possible cause of the longevity phenotype of the sul-2 mutants

Aging is a biological process caused by cell impairment that increase susceptibility to diseases and death. Some of these diseases, such as Alzheimer or Parkinson, are originated by loss of proteostasis and the generation of protein aggregates. Sulfated steroid hormones are of great importance in the maintenance of proteostasis, and by inhibiting the steroid sulfatase enzyme, it is possible to generate a reservoir of sulfated hormones that prevents cells from generating protein aggregates. Loss of function of the steroid sulfatase sul-2 gene has been proved to increase longevity and to ameliorate protein aggregates diseases in Caenorhabditis elegans. To explain the metabolic pathways involved in this process, two RNAseq have been performed with sul-2 mutants and the resulting data were uploaded to WormExp, where it was found that sul-2 mutants share expression patterns with AMPK activation mutants (Pérez-Jiménez et al. (2021)). AMPK activation mutants are also long-lived (Burkewizt et al. 2016), which suggests that AMPK activity could cause the sul-2 increased-longevity phenotype. To improve the understanding of this subject, we have backcrossed three times AMPK deficient hermaphrodite aak2-(ok524) with N2 males obtaining a deficient mutant with a known background. In the following experiments we will try to confirm the similar expression pattern of AMPK and sul-2 mutants and then will be evaluated the role of AMPK in sul-2 mutant longevity and proteostasis. In addition, we are evaluating other phenotypes of the sul-2 mutants, in particular stress resistance