195 research outputs found
Terapêutica intravesical com bacilo de Calmette-Guérin no tratamento do carcinoma da bexiga / o que sabemos até agora
AbstractIntroductionThe use of intravesical Bacillus Calmette-Guérin is a valid option in the treatment of non-muscle invasive bladder tumors, making it the main subject of a lot of publications. The aim of the present study is to review and consolidate the data available about this subject.MethodsA review of the data available was made on PubMed with the keywords: “intravesical BCG” and “non-muscle invasive bladder cancer”. Original and review articles written in English or Portuguese were selected. We present the discussion alongside the results for structural purposes.Results and discussionScientific evidence strongly advises in favor of BCG use on intermediate and high risk tumors, due to its impact on the recurrence and possibly on the progression rates. It is important to be watchful for possible local and systemic side effects, that when detected call for a rightful therapeutically decision alongside the recommended schemes.ConclusionThe use of intravesical BCG with therapeutically purposes has strong evidence on the non-muscle invasive bladder tumors. More studies are needed in order to better understand the best administration scheme and its mechanism of action
Stabilities of nanohydrated thymine radical cations: insights from multiphoton ionization experiments and ab initio calculations
Multi-photon ionization experiments have been carried out on thymine-water clusters in the gas phase. Metastable H2O loss from T+(H2O)n was observed at n ≥ 3 only. Ab initio quantum-chemical calculations of a large range of optimized T+(H2O)n conformers have been performed up to n = 4, enabling binding energies of water to be derived. These decrease smoothly with n, consistent with the general trend of increasing metastable H2O loss in the experimental data. The lowest-energy conformers of T+(H2O)3 and T+(H2O)4 feature intermolecular bonding via charge-dipole interactions, in contrast with the purely hydrogen-bonded neutrals. We found no evidence for a closed hydration shell at n = 4, also contrasting with studies of neutral clusters
Multifragmentation of a very heavy nuclear system (II): bulk properties and spinodal decomposition
The properties of fragments and light charged particles emitted in
multifragmentation of single sources formed in central 36AMeV Gd+U collisions
are reviewed. Most of the products are isotropically distributed in the
reaction c.m. Fragment kinetic energies reveal the onset of radial collective
energy. A bulk effect is experimentally evidenced from the similarity of the
charge distribution with that from the lighter 32AMeV Xe+Sn system. Spinodal
decomposition of finite nuclear matter exhibits the same property in simulated
central collisions for the two systems, and appears therefore as a possible
mechanism at the origin of multifragmentation in this incident energy domain.Comment: 28 pages including 14 figures; submitted to Nucl. Phys.
Study of intermediate velocity products in the Ar+Ni collisions between 52 and 95 A.MeV
Intermediate velocity products in Ar+Ni collisions from 52 to 95 A.MeV are
studied in an experiment performed at the GANIL facility with the 4
multidetector INDRA. It is shown that these emissions cannot be explained by
statistical decays of the quasi-projectile and the quasi-target in complete
equilibrium. Three methods are used to isolate and characterize intermediate
velocity products. The total mass of these products increases with the violence
of the collision and reaches a large fraction of the system mass in mid-central
collisions. This mass is found independent of the incident energy, but strongly
dependent on the geometry of the collision. Finally it is shown that the
kinematical characteristics of intermediate velocity products are weakly
dependent on the experimental impact parameter, but strongly dependent on the
incident energy. The observed trends are consistent with a
participant-spectator like scenario or with neck emissions and/or break-up.Comment: 37 pages, 13 figure
Early cyclosporine a withdrawal in kidney transplant recipients under a sirolimus-based immunosuppressive regimen: pathological study of graft biopsies at 1-year posttransplant
Early elimination of cyclosporine in kidney transplant recipients receiving sirolimus prevents progression of chronic pathologic allograft lesions
Avaliação de genótipos de trigo para a região do Vale do Paranapanema ano quadriênio 1981-84
Pb and Cd on growth, leaf ultrastructure and essential oil yield mint (Mentha arvensis L.)
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