Modeling vibrotactile detection by logistic regression

In this study we introduce logistic regression as a method for modeling, in this case the user's detection rate, to more easily show cross-effecting factors, necessary in order to design an adaptive system. Previously such effects have been investigated by a variety of linear regression type methods but these are not well suited for developing adaptive systems. We investigate the method on a qualitative and quantitative dataset with ages spanning from seven to 79 years under indoor and outdoor experimental settings. The results show that the method is indeed a suitable candidate for quantification of, in this instance vibrotactile information, and for the future design of useradaptive vibrotactile displays. More generally the model shows potential for designing a variety of adaptive systems. Copyright © 2012 ACM

Final design report on Kajakai Dam, Arghandab Dam, and Boghra Canal Projects

The purpose of this Report on the Kajakai Dam, Arghandab Dam, and the Boghra Canal .Projects is to describe the design criteria, preliminary and final designs and to present the as constructed drawings of the completed structures

Urban vibrations:Sensitivities in the field with a broad demographic

In this paper we describe a field study conducted with a wearable vibration belt where we test to determine the vibration intensity sensitivity ranges on a large diverse group of participants with evenly distributed ages and gender, ranging from seven to 79 years. We test for alterations in sensitivity in the field by introducing an escalating level of distraction in increasingly busy environments. The findings on sensitivity detection range differ from previous lab studies in that we found a decreased detection rate in busy environments. Here we test with a much larger sample and age range, and contribute with the first vibration sensitivity testing outside the lab in an urban public environment. © 2012 IEEE

VLA 1.4 GHz Catalogs of the Abell 370 and Abell 2390 Cluster Fields

We present 1.4 GHz catalogs for the cluster fields Abell 370 and Abell 2390 observed with the Very Large Array. These are two of the deepest radio images of cluster fields ever taken. The Abell 370 image covers an area of 40'x40' with a synthesized beam of ~1.7" and a noise level of ~5.7 uJy near field center. The Abell 2390 image covers an area of 34'x34' with a synthesized beam of ~1.4" and a noise level of ~5.6 uJy near field center. We catalog 200 redshifts for the Abell 370 field. We construct differential number counts for the central regions (radius < 16') of both clusters. We find that the faint (S_1.4GHz < 3 mJy) counts of Abell 370 are roughly consistent with the highest blank field number counts, while the faint number counts of Abell 2390 are roughly consistent with the lowest blank field number counts. Our analyses indicate that the number counts are primarily from field radio galaxies. We suggest that the disagreement of our counts can be largely attributed to cosmic variance.Comment: 13 pages, accepted for publication in ApJ

Precise Identifications of Submillimeter Galaxies: Measuring the History of Massive Star-Forming Galaxies to z>5

We carried out extremely sensitive Submillimeter Array (SMA) 340 GHz (860 micron) continuum imaging of a complete sample of SCUBA 850 micron sources (>4 sigma) with fluxes >3 mJy in the GOODS-N. Using these data and new SCUBA-2 data, we do not detect 4 of the 16 SCUBA sources, and we rule out the original SCUBA fluxes at the 4 sigma level. Three more resolve into multiple fainter SMA galaxies, suggesting that our understanding of the most luminous high-redshift dusty galaxies may not be as reliable as we thought. 10 of the 16 independent SMA sources have spectroscopic redshifts (optical/infrared or CO) to z=5.18. Using a new, ultradeep 20 cm image obtained with the Karl G. Jansky Very Large Array (rms of 2.5 microJy), we find that all 16 of the SMA sources are detected at >5 sigma. Using Herschel far-infrared (FIR) data, we show that the five isolated SMA sources with Herschel detections are well described by an Arp 220 spectral energy distribution template in the FIR. They also closely obey the local FIR-radio correlation, a result that does not suffer from a radio bias. We compute the contribution from the 16 SMA sources to the universal star formation rate (SFR) per comoving volume. With individual SFRs in the range 700-5000 solar masses per year, they contribute ~30% of the extinction-corrected ultraviolet-selected SFR density from z=1 to at least z=5. Star formation histories determined from extinction-corrected ultraviolet populations and from submillimeter galaxy populations only partially overlap, due to the extreme ultraviolet faintness of some submillimeter galaxies.Comment: 26 pages, minor changes to match published versio

Randomised clinical study: inulin short-chain fatty acid esters for targeted delivery of short-chain fatty acids to the human colon

Summary Background Short-chain fatty acids (SCFA) produced through fermentation of nondigestible carbohydrates by the gut microbiota are associated with positive metabolic effects. However, well-controlled trials are limited in humans. Aims To develop a methodology to deliver SCFA directly to the colon, and to optimise colonic propionate delivery in humans, to determine its role in appetite regulation and food intake. Methods Inulin SCFA esters were developed and tested as site-specific delivery vehicles for SCFA to the proximal colon. Inulin propionate esters containing 0–61 wt% (IPE-0–IPE-61) propionate were assessed in vitro using batch faecal fermentations. In a randomised, controlled, crossover study, with inulin as control, ad libitum food intake (kcal) was compared after 7 days on IPE-27 or IPE-54 (10 g/day all treatments). Propionate release was determined using 13C-labelled IPE variants. Results In vitro, IPE-27–IPE-54 wt% propionate resulted in a sevenfold increase in propionate production compared with inulin (P < 0.05). In vivo, IPE-27 led to greater 13C recovery in breath CO2 than IPE-54 (64.9 vs. 24.9%, P = 0.001). IPE-27 also led to a reduction in energy intake during the ad libitum test meal compared with both inulin (439.5 vs. 703.9 kcal, P = 0.025) and IPE-54 (439.5 vs. 659.3 kcal, P = 0.025), whereas IPE-54 was not significantly different from inulin control. Conclusions IPE-27 significantly reduced food intake suggesting colonic propionate plays a role in appetite regulation. Inulin short-chain fatty acid esters provide a novel tool for probing the diet–gut microbiome–host metabolism axis in human

The utility of B-type natriuretic peptide in the diagnosis of heart failure in the emergency department: a systematic review

<p>Abstract</p> <p>Background</p> <p>Dyspnea is a common chief complaint in the emergency department (ED); differentiating heart failure (HF) from other causes can be challenging. Brain Natriuretic Peptide (BNP) is a new diagnostic test for HF for use in dyspneic patients in the ED. The purpose of this study is to systematically review the accuracy of BNP in the emergency diagnosis of HF.</p> <p>Methods</p> <p>We searched MEDLINE (1975–2005) supplemented by reference tracking. We included studies that reported the sensitivity and specificity of BNP for diagnosing HF in ED patients with acute dyspnea. Two reviewers independently assessed study quality. We pooled sensitivities and specificities within five ranges of BNP cutoffs.</p> <p>Results</p> <p>Ten studies including 3,344 participants met inclusion criteria. Quality was variable; possible verification or selection bias was common. No studies eliminated patients with obvious medical causes of dyspnea. Most studies used the Triage BNP assay; all utilized a clinical reference standard. Pooled sensitivity and specificity at a BNP cutoff of 100–105 pg/ml were 90% and 74% with negative likelihood ratio (LR) of 0.14; pooled sensitivity was 81% with specificity of 90% at cutoffs between 300 and 400 pg/ml with positive LR of 7.6.</p> <p>Conclusion</p> <p>Our analysis suggests that BNP has moderate accuracy in detecting HF in the ED. Our results suggest utilizing a BNP of less than 100 pg/ml to rule out HF and a BNP of greater than 400 pg/ml to diagnose HF. Many studies were of marginal quality, and all included patients with varying degrees of diagnostic uncertainty. Further studies focusing on patients with diagnostic uncertainty will clarify the real-world utility of BNP in the emergency management of dyspnea.</p

Skeeter Buster: A Stochastic, Spatially Explicit Modeling Tool for Studying Aedes aegypti Population Replacement and Population Suppression Strategies

Dengue is a viral disease that affects approximately 50 million people annually, and is estimated to result in 12,500 fatalities. Dengue viruses are vectored by mosquitoes, predominantly by the species Aedes aegypti. Because there is currently no vaccine or specific treatment, the only available strategy to reduce dengue transmission is to control the populations of these mosquitoes. This can be achieved by traditional approaches such as insecticides, or by recently developed genetic methods that propose the release of mosquitoes genetically engineered to be unable to transmit dengue viruses. The expected outcome of different control strategies can be compared by simulating the population dynamics and genetics of mosquitoes at a given location. Development of optimal control strategies can then be guided by the modeling approach. To that end, we introduce a new modeling tool called Skeeter Buster. This model describes the dynamics and the genetics of Ae. aegypti populations at a very fine scale, simulating the contents of individual houses, and even the individual water-holding containers in which mosquito larvae reside. Skeeter Buster can be used to compare the predicted outcomes of multiple control strategies, traditional or genetic, making it an important tool in the fight against dengue

Role of breast regression protein-39/YKL-40 in asthma and allergic responses

BRP-39 and its human homolog YKL-40 have been regarded as a prototype of chitinase-like proteins (CLP) in mammals. Exaggerated levels of YKL-40 protein and/or mRNA have been noted in a number of diseases characterized by inflammation, tissue remodeling, and aberrant cell growth. Asthma is an inflammatory disease characterized by airway hyperresponsiveness and airway remodeling. Recently, the novel regulatory role of BRP-39/YKL-40 in the pathogenesis of asthma has been demonstrated both in human studies and allergic animal models. The levels of YKL-40 are increased in the circulation and lungs from asthmatics where they correlate with disease severity, and CHI3L1 polymorphisms correlate with serum YKL-40 levels, asthma and abnormal lung function. Animal studies using BRP-39 null mutant mice demonstrated that BRP-39 was required for optimal allergen sensitization and Th2 inflammation. These studies suggest the potential use of BRP-39 as a biomarker as well as a therapeutic target for asthma and other allergic diseases. Here, we present an overview of chitin/chitinase biology and summarize recent findings on the role of BRP-39 in the pathogenesis of asthma and allergic responses

An AzTEC 1.1 mm survey of the GOODS-N field – II. Multiwavelength identifications and redshift distribution

We present results from a multiwavelength study of 29 sources (false detection probabilities <5 per cent) from a survey of the Great Observatories Origins Deep Survey-North (GOODS-N) field at 1.1 mm using the Astronomical Thermal Emission Camera (AzTEC). Comparing with existing 850 μm Submillimetre Common-User Bolometer Array (SCUBA) studies in the field, we examine differences in the source populations selected at the two wavelengths. The AzTEC observations uniformly cover the entire survey field to a 1σ depth of ~1 mJy. Searching deep 1.4 GHz Very Large Array (VLA) and Spitzer 3–24 μm catalogues, we identify robust counterparts for 21 1.1 mm sources, and tentative associations for the remaining objects. The redshift distribution of AzTEC sources is inferred from available spectroscopic and photometric redshifts. We find a median redshift of z= 2.7 , somewhat higher than z= 2.0 for 850 μm selected sources in the same field, and our lowest redshift identification lies at a spectroscopic redshift z= 1.1460 . We measure the 850 μm to 1.1 mm colour of our sources and do not find evidence for '850 μm dropouts', which can be explained by the low signal-to-noise ratio of the observations. We also combine these observed colours with spectroscopic redshifts to derive the range of dust temperatures T, and dust emissivity indices β for the sample, concluding that existing estimates T ~ 30 K and β ~ 1.75 are consistent with these new data