Immediate and long-term consequences of COVID-19 infections for the development of neurological disease

Increasing evidence suggests that infection with Sars-CoV-2 causes neurological deficits in a substantial proportion of affected patients. While these symptoms arise acutely during the course of infection, less is known about the possible long-term consequences for the brain. Severely affected COVID-19 cases experience high levels of proinflammatory cytokines and acute respiratory dysfunction and often require assisted ventilation. All these factors have been suggested to cause cognitive decline. Pathogenetically, this may result from direct negative effects of the immune reaction, acceleration or aggravation of pre-existing cognitive deficits, or de novo induction of a neurodegenerative disease. This article summarizes the current understanding of neurological symptoms of COVID-19 and hypothesizes that affected patients may be at higher risk of developing cognitive decline after overcoming the primary COVID-19 infection. A structured prospective evaluation should analyze the likelihood, time course, and severity of cognitive impairment following the COVID-19 pandemic

The Hanbury Brown and Twiss Experiment with Fermions

We realized an equivalent Hanbury Brown and Twiss experiment for a beam of electrons in a two dimensional electron gas in the quantum Hall regime. A metallic split gate serves as a tunable beam splitter which is used to partition the incident beam into transmitted and reflected partial beams. The current fluctuations in the reflected and transmitted beam are fully anticorrelated demonstrating that fermions tend to exclude each other (anti-bunching). If the occupation probability of the incident beam is lowered by an additional gate, the anticorrelation is reduced and disappears in the classical limit of a highly diluted beam

open-UST: An Open-Source Ultrasound Tomography Transducer Array System

Fast imaging methods are needed to promote widespread clinical adoption of Ultrasound Tomography (UST), and more widely available UST hardware could support the experimental validation of new measurement configurations. In this work, an open-source 256-element transducer ring array was developed (morganjroberts.github.io/open-UST) and manufactured using rapid prototyping, for only £2k. Novel manufacturing techniques were used, resulting in a 1.17° mean beam axis skew angle, a 104 μm mean element position error, and a ±13.6 μm deviation in matching layer thickness. The nominal acoustic performance was measured using hydrophone scans and watershot data, and the 61.2 dB SNR, 55.4° opening angle, 10.2 mm beamwidth and 54% transmit-receive bandwidth (-12 dB), were found to be similar to existing systems, and compatible with state of the art full-waveform-inversion image reconstruction methods. The inter-element variation in acoustic performance was typically <10% without using normalisation, meaning that the elements can be modelled identically during image reconstruction, removing the need for individual source definitions based on hydrophone measurements. Finally, data from a phantom experiment was successfully reconstructed. These results demonstrate that the open-UST system is accessible for users, and suitable for UST imaging research

Agriculture is the main driver of deforestation in Tanzania

Reducing deforestation can generate multiple economic, social and ecological benefits by safeguarding the climate and other ecosystem services provided by forests. Understanding the relative contribution of different drivers of deforestation is needed to guide policies seeking to maintain natural forest cover. We assessed 119 randomly selected plots from areas deforested between 2010 and 2017, in Tanzania. Through ground surveys and stakeholder interviews we assessed the proximate deforestation drivers at each point. Crop cultivation was the most commonly observed driver occurring in 89% of plots, compared to livestock grazing (69%) and charcoal (35%). There was evidence of fire in 77% of plots. Most deforestation events involved multiple drivers, with 83% of plots showing signs of two or more drivers. Stakeholder interviews identified agriculture as the primary deforestation driver in 81% of plots, substantially more than charcoal production (12%), timber harvesting (1%) and livestock (1%). Policy-makers in Tanzania have sought to reduce deforestation by reducing demand for charcoal. However, our work demonstrates that agriculture, not charcoal, is the main driver of deforestation in Tanzania. Beyond protected areas, there is no clear policy limiting the conversion of forests to agricultural land. Reducing deforestation in Tanzania requires greater inter-sectoral coordination between the agriculture, livestock, land, energy and forest sectors

Intravenous Prenatal Nicotine Exposure Alters METH-Induced Hyperactivity, Conditioned Hyperactivity, and BDNF in Adult Rat Offspring

In the USA, approximately 15% of women smoke tobacco cigarettes during pregnancy. In utero tobacco smoke exposure produces somatic growth deficits like intrauterine growth restriction and low birth w

Short photoperiod-induced decrease of histamine H3 receptors facilitates activation of hypothalamic neurons in the Siberian Hamster

Nonhibernating seasonal mammals have adapted to temporal changes in food availability through behavioral and physiological mechanisms to store food and energy during times of predictable plenty and conserve energy during predicted shortage. Little is known, however, of the hypothalamic neuronal events that lead to a change in behavior or physiology. Here we show for the first time that a shift from long summer-like to short inter-like photoperiod, which induces physiological adaptation to winter in the Siberian hamster, including a body weight decrease of up to 30%, increases neuronal activity in the dorsomedial region of the arcuate nucleus (dmpARC) assessed by electro physiological patch-clamping recording. Increased neuronal activity in short days is dependent on a photoperiod-driven down-regulation of H3 receptor expression and can be mimicked in long-day dmpARC neurons by the application of the H3 receptor antagonist, clobenproprit. Short-day activation of dmpARC neurons results in increased c-Fos expression. Tract tracing with the trans-synaptic retrograde tracer, pseudorabies virus, delivered into adipose tissue reveals a multisynaptic neuronal sympathetic outflow from dmpARC to white adipose tissue. These data strongly suggest that increased activity of dmpARC neurons, as a consequence of down-regulation of the histamine H3 receptor, contributes to the physiological adaptation of body weight regulation in seasonal photoperiod

Feeding and metabolic consequences of scheduled consumption of large, binge-type meals of high fat diet in the Sprague–Dawley rat

Peer reviewedPublisher PD

An XMM-Newton view of Planetary Nebulae in the Small Magellanic Cloud. The X-ray luminous central star of SMP SMC 22

During an X-ray survey of the Small Magellanic Cloud, carried out with the XMM-Newton satellite, we detected significant soft X-ray emission from the central star of the high-excitation planetary nebula SMP SMC 22. Its very soft spectrum is well fit with a non local thermodynamical equilibrium model atmosphere composed of H, He, C, N, and O, with abundances equal to those inferred from studies of its nebular lines. The derived effective temperature of 1.5x10^5 K is in good agreement with that found from the optical/UV data. The unabsorbed flux in the 0.1-0.5 keV range is about 3x10^{-11} erg cm^-2 s^-1, corresponding to a luminosity of 1.2x10^37 erg/s at the distance of 60 kpc. We also searched for X-ray emission from a large number of SMC planetary nebulae, confirming the previous detection of SMP SMC 25 with a luminosity of (0.2-6)x10^35 erg/s (0.1-1 keV). For the remaining objects that were not detected, we derived flux upper limits corresponding to luminosity values from several tens to hundreds times smaller than that of SMP SMC 22. The exceptionally high X-ray luminosity of SMP SMC 22 is probably due to the high mass of its central star, quickly evolving toward the white dwarf's cooling branch, and to a small intrinsic absorption in the nebula itself.Comment: Accepted for publication on Astronomy and Astrophysic