12 research outputs found
ANDREU PINTADO, J. (ed.), Oppida Labentia, transformaciones, cambios y alteración en las ciudades hispanas entre el siglo II y la tardoantigüedad, Serie Monografías “Los Bañales”, Fundación Uncastillo, Uncastillo, 2017, 569 pp., ISBN: 978-84-617-9718-9. [RESEÑA]
The use of tubi fittili for vaulting roof in roman Hispania. Bibliographical review and status of the issue
El hallazgo de numerosas piezas cerámicas, conocidas
como tubi fittili, en la villa romana de Salar nos ha permitido
realizar un análisis de los casos conocidos en Hispania
del uso de este tipo de material cerámico en la construcción de
cubiertas abovedadas, poniendo de relieve los errores cometidos
en su identificación, la escasez de casos fehacientes documentados
en Hispania, así como la peculiar concentración
de estas piezas en villas del entorno de la Vega de Granada.The discovery of numerous terracotta vaulting
tubes (tubi fittili) in the Roman villa of Salar has allowed us
to carry out an analysis of the known cases in Spain of the
use of this type of material in the vaulted ceiling, highlighting
the mistakes made in their identification, the scarcity of documented
cases in Hispania, as well as the peculiar concentration
of these pieces in villae around the Vega de Granada.Ministerio de Ciencia e Innovación HAR2016–75843–
LA IMPORTANCIA DE LA INVESTIGACIÓN, CONSERVACIÓN Y PUESTA EN VALOR DEL PATRIMONIO HISTÓRICO LOCAL: EL EJEMPLO DE LA VILLA ROMANA DE SALAR (GRANADA)
The determined bid of the Salar City Council for the research, conservation and enhancement of some of its heritage assets, the Roman villa of Salar (Granada), has had rapid consequences for this small and unknown municipality: in only two years, it has located as reference, not only at the provincial level, but also regional, of good practices with heritage, and a clear example of how to invest in this heritage reverses, in the short term and multiplied, in the locality that steers it, not only economically, but also socially and culturally.La decidida apuesta del Ayuntamiento de Salar (Granada) por la investigación, conservación y puesta en valor de unos de sus bienes patrimoniales, la villa romana de Salar, ha tenido unas rápidas consecuencias para este pequeño y, otrora, desconocido municipio: en solo dos años, lo ha situado como un referente, no solo a nivel comarcal y provincial, sino también regional, de buenas prácticas con el patrimonio, y un claro ejemplo de cómo la inversión en dicho patrimonio revierte, a corto plazo y multiplicado, en la localidad que lo protagoniza, no solo a nivel económico, sino también social y cultural
Strategies to reengage patients lost to follow up in HIV care in high income countries, a scoping review
Background: Despite remarkable achievements in antiretroviral therapy (ART), losses to follow-up (LTFU) might prevent the long-term success of HIV treatment and might delay the achievement of the 90-90-90 objectives. This scoping review is aimed at the description and analysis of the strategies used in high-income countries to reengage LTFU in HIV care, their implementation and impact. Methods: A scoping review was done following Arksey & O'Malley's methodological framework and recommendations from Joanna Briggs Institute. Peer reviewed articles were searched for in Pubmed, Scopus and Web of Science; and grey literature was searched for in Google and other sources of information. Documents were charted according to the information presented on LTFU, the reengagement procedures used in HIV units in high-income countries, published during the last 15 years. In addition, bibliographies of chosen articles were reviewed for additional articles. Results: Twenty-eight documents were finally included, over 80% of them published in the United States later than 2015. Database searches, phone calls and/or mail contacts were the most common strategies used to locate and track LTFU, while motivational interviews and strengths-based techniques were used most often during reengagement visits. Outcomes like tracing activities efficacy, rates of reengagement and viral load reduction were reported as outcome measures. Conclusions: This review shows a recent and growing trend in developing and implementing patient reengagement strategies in HIV care. However, most of these strategies have been implemented in the United States and little information is available for other high-income countries. The procedures used to trace and contact LTFU are similar across reviewed studies, but their impact and sustainability are widely different depending on the country studied
Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)
This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe
ANDREU PINTADO, J. (ed.), Oppida Labentia, transformaciones, cambios y alteración en las ciudades hispanas entre el siglo II y la tardoantigüedad, Serie Monografías “Los Bañales”, Fundación Uncastillo, Uncastillo, 2017, 569 pp., ISBN: 978-84-617-9718-9. [RESEÑA]
Design and validation of a food frequency questionnaire (FFQ) for the nutritional evaluation of food intake in the Peruvian Amazon
Immunological Biomarkers of Fatal COVID-19: A Study of 868 Patients
Information on the immunopathobiology of coronavirus disease 2019 (COVID-19) is rapidly increasing; however, there remains a need to identify immune features predictive of fatal outcome. This large-scale study characterized immune responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection using multidimensional flow cytometry, with the aim of identifying high-risk immune biomarkers. Holistic and unbiased analyses of 17 immune cell-types were conducted on 1,075 peripheral blood samples obtained from 868 COVID-19 patients and on samples from 24 patients presenting with non-SARS-CoV-2 infections and 36 healthy donors. Immune profiles of COVID-19 patients were significantly different from those of age-matched healthy donors but generally similar to those of patients with non-SARS-CoV-2 infections. Unsupervised clustering analysis revealed three immunotypes during SARS-CoV-2 infection; immunotype 1 (14% of patients) was characterized by significantly lower percentages of all immune cell-types except neutrophils and circulating plasma cells, and was significantly associated with severe disease. Reduced B-cell percentage was most strongly associated with risk of death. On multivariate analysis incorporating age and comorbidities, B-cell and non-classical monocyte percentages were independent prognostic factors for survival in training (n=513) and validation (n=355) cohorts. Therefore, reduced percentages of B-cells and non-classical monocytes are high-risk immune biomarkers for risk-stratification of COVID-19 patients
Immunological Biomarkers of Fatal COVID-19: A Study of 868 Patients
Information on the immunopathobiology of coronavirus disease 2019 (COVID-19) is rapidly increasing; however, there remains a need to identify immune features predictive of fatal outcome. This large-scale study characterized immune responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection using multidimensional flow cytometry, with the aim of identifying high-risk immune biomarkers. Holistic and unbiased analyses of 17 immune cell-types were conducted on 1,075 peripheral blood samples obtained from 868 COVID-19 patients and on samples from 24 patients presenting with non-SARS-CoV-2 infections and 36 healthy donors. Immune profiles of COVID-19 patients were significantly different from those of age-matched healthy donors but generally similar to those of patients with non-SARS-CoV-2 infections. Unsupervised clustering analysis revealed three immunotypes during SARS-CoV-2 infection; immunotype 1 (14% of patients) was characterized by significantly lower percentages of all immune cell-types except neutrophils and circulating plasma cells, and was significantly associated with severe disease. Reduced B-cell percentage was most strongly associated with risk of death. On multivariate analysis incorporating age and comorbidities, B-cell and non-classical monocyte percentages were independent prognostic factors for survival in training (n=513) and validation (n=355) cohorts. Therefore, reduced percentages of B-cells and non-classical monocytes are high-risk immune biomarkers for risk-stratification of COVID-19 patients