Factores personales y familiares que inciden en la violencia que se suscita en el grado und?cimo del Instituto T?cnico Rafael Garc?a Herreros de la ciudad de Bucaramanga

113 P?ginasRecurso Electr?nicoLa violencia escolar es una problem?tica que afecta diariamente las instituciones educativas. Esta situaci?n est? supeditada a factores extr?nsecos tales como los culturales, pol?ticos, sociales, educativos; y a factores intr?nsecos tales como los personales y familiares, los cuales en conjunto, de forma silenciosa, afectan al joven en la consolidaci?n de su personalidad. Debido a esto, durante la investigaci?n se hace una observaci?n de los estudiantes en su ?mbito escolar, se realiza una revisi?n documental (observador del estudiante), se aplican encuestas y entrevistas a estudiantes y se ejecuta una revisi?n bibliogr?fica con el fin de identificar los factores personales y familiares que suscitan la violencia escolar en el aula de clase de und?cimo grado del Instituto T?cnico Rafael Garc?a Herreros. En la investigaci?n tan solo se indaga en los factores familiares y personales que intervienen en los actos violentos de los j?venes en la escuela, puesto que la familia, es el principal n?cleo de formaci?n de la sociedad, el cual repercute directamente en la consolidaci?n de la personalidad de los ni?os. De igual forma, se quiere indagar sobre la correspondencia entre las relaciones intrapersonales e interpersonales negativas con la presencia de violencia escolar en el aula de clase.ABSTRACT. School violence is a problem that affects daily educational institutions. This situation is committed to extrinsic factors such as cultural, political, social and educational; and intrinsic factors such as personal and family, which together, silently, affect the young in the consolidation of his personality. Therefore, during the investigation, an observation of students in their school environment and a documentary review (student observer) are performed, surveys and interviews with students are applied and a literature review is implemented in order to identify personal and familiar factors that raise school violence in the junior classroom of eleventh grade of the Technical Institute Rafael Garc?a Herreros. The research only explores family and personal factors involved in violent acts of young people in school since the family is the core of society formation, which directly affects the consolidation of personality of children. Furthermore, it is necessary to investigate the correspondence between negative intrapersonal and interpersonal relationships with the presence of school violence in the classroom.INTRODUCCI?N 12 1. EL PROBLEMA DE INVESTIGACI?N 14 1.1 CONTEXTO DE LA INVESTIGACI?N 14 1.1.1 Contexto Municipal 14 1.1.2 Contexto Institucional 16 1.1.3 Descripci?n Socio Econ?mica de las Familias 16 1.1.4 Componente Habitacional 19 1.2 PROBLEMA 20 1.2.1 Planteamiento del Problema 20 1.2.2 Formulaci?n del Problema 21 1.3 JUSTIFICACI?N 21 1.4 OBJETIVOS 22 1. 4.1 Objetivo General 22 1.4.2 Objetivos Espec?ficos 22 2 MARCO TE?RICO 23 2.1 REVISI?N DE ANTECEDENTES 23 2.2 MARCO LEGAL 28 2.2.1 Pol?ticas Estatales Sobre la violencia Escolar 28 2.2.2 Ley 1620 del 15 de Marzo de 2013 29 2.2.3 Est?ndares B?sicos de Competencias Ciudadanas 30 2.3 MARCO REFERENCIAL 31 2.3.1 La Violencia Escolar 31 2.3.2 Tipos de Violencia Escolar 34 2.3.3 Otras Formas de Violencia Escolar 35 2.3.4 Actores de la Violencia Escolar 36 2.3.5 Las Relaciones familiares y la Violencia Escolar 37 2.3.6 La Inteligencia Emocional en la Relaci?n con el Entorno 38 3 DISE?O METODOL?GICO 41 3.1 ENFOQUE DE LA INVESTIGACI?N 41 3.2 TIPO DE INVESTIGACI?N 43 3.3 DESCRIPCI?N DE LA POBLACI?N Y MUESTRA DE LA INVESTIGACI?N 43 3.3.1 Poblaci?n 43 3.3.2 Muestra 44 3.4 T?CNICAS E INSTRUMENTOS PARA LA RECOLECCI?N DE DATOS 44 3.5 DEFINICI?N OPERACIONAL 44 4 AN?LISIS DE RESULTADOS 53 4.1 AN?LISIS DE DATOS CUANTITATIVOS 53 4.1.1 Relaciones Familiares o Clima Familiar 53 4.1.2 Conducta Violenta en la Escuela 61 4.1.3 Relaciones Interpersonales e Intrapersonales 64 4.2 AN?LISIS DE DATOS CUALITATIVOS 66 4.3 AN?LISIS DE OBSERVACI?N DOCUMENTAL 69 5 TRIANGULACI?N DE DATOS 72 6 CONCLUSIONES 76 7 PERSPECTIVAS NUEVAS DE INVESTIGACI?N 83 RECOMENDACIONES 84 REFERENCIAS BIBLIOGR?FICAS 85 ANEXOS 9

Plasticity of the auditory system: theoretical considerations

AbstractAuditory plasticity refers to the possibility of anatomical and/or functional changes in the system where transmission of auditory information takes place. The auditory system is often required in communication; it is important to learn how the auditory system reacts to stimuli in order to improve performance in individual communication of subjects with impaired hearing.AimTo review the literature on auditory plasticity and the possibility and ability of plastic responses in the auditory system; also to review the evidence of auditory plasticity.MethodologyA review of the Brazilian and international literature (journals, books, and graduate studies) was carried out. The MEDLINE, SCIELO, BIREME, PUBMED, and LILACS data bases were consulted, as well as 24 papers from the 1990s to the present date; each paper was assessed for relevance to the topic.ConclusionThe findings showed that the auditory system is able to reorganize itself if there is variation, whether by by reducing, increasing, or conditioning of sound stimuli. This is evidence of plasticity in the auditory system

¿Qué considerar al evaluar una dextrocardia por ecocardiografía transtorácica?

Dextrocardia is a cardiac malposition in which the orientation of the cardiac apex is downwards and to the right side of the thorax, with different spatial dispositions of the chambers according to visceral situs and associated with other congenital cardiac defects. Therefore for the evaluation of these patients we need to place and perform non-conventional maneuvers with the transducer during our daily practice, in order to obtain reproducible and interpretable echocardiographic planes which allow us to reach the best diagnostic approach.La Dextrocardia es una malposición cardíaca que cursa con una orientación del ápex hacia abajo y a la derecha del tórax, acompañada con disposiciones espaciales de las cámaras diferentes según el tipo de Situs Visceral y la presencia de cardiopatías congénitas asociadas. Por lo tanto, para la evaluación de estos pacientes se requiere la localización y ejecución de maniobras con el transductor poco convencionales durante la práctica diaria, con el fin de obtener proyecciones ecocardiográficas reproducibles e interpretables que logren una mejor aproximación diagnóstica

A colorectal cancer susceptibility new variant at 4q26 in the Spanish population identified by genome-wide association analysis

This work was partially supported by the CENIT program from the Centro Tecnológico Industrial (CEN-20091016), grants from the Spanish Institute of Health Carlos III (ADE10/00026, PI09/02444, PI12/00511, Acción Transversal de Cáncer) grants from the Fondo de Investigacion Sanitaria/FEDER (08/1276, 08/0024, PS09/02368, 11/00219, 11/00681), and by COST office through COST action BM1206. SCB is supported by contracts from the Fondo de Investigación Sanitaria (CP 03-0070). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Centro Tecnológico IndustrialInstituto de Salud Carlos IIIFondo de Investigación Sanitaria / FEDE

Gravidez não planejada no Brasil: estudo nacional em oito hospitais universitários

OBJECTIVE: To estimate the prevalence of unplanned pregnancy in eight public university hospitals, distributed in the five regions that make up Brazil. METHODS: A secondary analysis of a national multicenter cross-sectional study, carried out in eight public university hospitals between June 1 and August 31, 2020, in Brazil. Convenience sample including women who gave birth within sixty consecutive days and met the following criteria: over 18 years old; gestational age over 36 weeks at delivery; with a single and live newborn, without malformations. RESULTS: Sample composed of 1,120 postpartum women, of whom 756 (67.5%) declared that the pregnancy had not been planned. The median prevalence of unplanned pregnancy was 59.7%. The prevalence of unplanned pregnancy across hospitals differed significantly: Campinas (54.8%), Porto Alegre (58.2%), Florianópolis (59%), Teresina (61.2%), Brasília (64.3%), São Paulo (64.6%), Campo Grande (73.9%) and Manaus (95.3%) (p < 0.001). Factors significantly associated with unplanned pregnancy were maternal age, black color, lower family income, greater number of children, greater number of people living in household, and not having a partner. CONCLUSION: In the studied sample, about two thirds of the pregnancies were declared as unplanned. The prevalence of unplanned pregnancies was related to social and demographic factors and varied significantly across the university hospitals evaluated.OBJETIVO: Estimar a prevalência de gestação não planejada (GNP) em oito hospitais públicos universitários, distribuídos nas cinco regiões que compõem o Brasil. MÉTODOS: Análise secundária de um estudo transversal multicêntrico nacional, realizado em oito hospitais universitários públicos, entre 1º de junho e 31 de agosto de 2020, no Brasil. Amostra por conveniência incluindo mulheres que deram à luz em período de sessenta dias consecutivos e atenderam aos seguintes critérios: maiores de 18 anos; idade gestacional acima de 36 semanas no parto; com recém-nascido único e vivo, sem malformações. RESULTADOS: Amostra composta por 1.120 puérperas, das quais 756 (67,5%) declararam que a gravidez não tinha sido programada. A mediana da prevalência de GNP foi de 59,7%. Observou-se diferença significativa na prevalência de GNP entre os hospitais: Campinas (54,8%), Porto Alegre (58,2%), Florianópolis (59%), Teresina (61,2%), Brasília (64,3%), São Paulo (64,6%), Campo Grande (73,9%) e Manaus (95,3%) (p < 0,001). Foram fatores significativamente associados a GNP a idade materna, cor negra, menor renda familiar, maior número de filhos, maior número de pessoas convivendo em casa e não ter parceiro. CONCLUSÃO: na amostra estudada, cerca de dois terços das gestações foram declaradas como não programadas. A prevalência de gestação não planejada teve relação com fatores sociais e demográficos e variou significativamente entre os hospitais universitários avaliados

A colorectal cancer genome-wide association study in a Spanish cohort identifies two variants associated with colorectal cancer risk at 1p33 and 8p12

Background: Colorectal cancer (CRC) is a disease of complex aetiology, with much of the expected inherited risk being due to several common low risk variants. Genome-Wide Association Studies (GWAS) have identified 20 CRC risk variants. Nevertheless, these have only been able to explain part of the missing heritability. Moreover, these signals have only been inspected in populations of Northern European origin. Results: Thus, we followed the same approach in a Spanish cohort of 881 cases and 667 controls. Sixty-four variants at 24 loci were found to be associated with CRC at p-values <10-5. We therefore evaluated the 24 loci in another Spanish replication cohort (1481 cases and 1850 controls). Two of these SNPs, rs12080929 at 1p33 (Preplication=0.042; Ppooled=5.523x10-03; OR (CI95%)=0.866(0.782-0.959)) and rs11987193 at 8p12 (Preplication=0.039; Ppooled=6.985x10-5; OR (CI95%)=0.786(0.705-0.878)) were replicated in the second Phase, although they did not reach genome-wide statistical significance. Conclusions: We have performed the first CRC GWAS in a Southern European population and by these means we were able to identify two new susceptibility variants at 1p33 and 8p12 loci. These two SNPs are located near the SLC5A9 and DUSP4 loci, respectively, which could be good functional candidates for the association signals. We therefore believe that these two markers constitute good candidates for CRC susceptibility loci and should be further evaluated in other larger datasets. Moreover, we highlight that were these two SNPs true susceptibility variants, they would constitute a decrease in the CRC missing heritability fraction

BMP2/BMP4 colorectal cancer susceptibility loci in northern and southern european populations

Genome-wide association studies have successfully identified 20 colorectal cancer susceptibility loci. Amongst these, four of the signals are defined by tagging single nucleotide polymorphisms (SNPs) on regions 14q22.2 (rs4444235 and rs1957636) and 20p12.3 (rs961253 and rs4813802). These markers are located close to two of the genes involved in bone morphogenetic protein (BMP) signaling (BMP4 and BMP2, respectively). By investigating these four SNPs in an initial cohort of Spanish origin, we found substantial evidence that minor allele frequencies (MAFs) may be different in northern and southern European populations. Therefore, we genotyped three additional southern European cohorts comprising a total of 2028 cases and 4273 controls. The meta-analysis results show that only one of the association signals (rs961253) is effectively replicated in the southern European populations, despite adequate power to detect all four. The other three SNPs (rs4444235, rs1957636 and rs4813802) presented discordant results in MAFs and linkage disequilibrium patterns between northern and southern European cohorts. We hypothesize that this lack of replication could be the result of differential tagging of the functional variant in both sets of populations. Were this true, it would have complex consequences in both our ability to understand the nature of the real causative variants, as well as for further study designs

Development of a Panel of Genome-Wide Ancestry Informative Markers to Study Admixture Throughout the Americas

Most individuals throughout the Americas are admixed descendants of Native American, European, and African ancestors. Complex historical factors have resulted in varying proportions of ancestral contributions between individuals within and among ethnic groups. We developed a panel of 446 ancestry informative markers (AIMs) optimized to estimate ancestral proportions in individuals and populations throughout Latin America. We used genome-wide data from 953 individuals from diverse African, European, and Native American populations to select AIMs optimized for each of the three main continental populations that form the basis of modern Latin American populations. We selected markers on the basis of locus-specific branch length to be informative, well distributed throughout the genome, capable of being genotyped on widely available commercial platforms, and applicable throughout the Americas by minimizing within-continent heterogeneity. We then validated the panel in samples from four admixed populations by comparing ancestry estimates based on the AIMs panel to estimates based on genome-wide association study (GWAS) data. The panel provided balanced discriminatory power among the three ancestral populations and accurate estimates of individual ancestry proportions (R2>0.9 for ancestral components with significant between-subject variance). Finally, we genotyped samples from 18 populations from Latin America using the AIMs panel and estimated variability in ancestry within and between these populations. This panel and its reference genotype information will be useful resources to explore population history of admixture in Latin America and to correct for the potential effects of population stratification in admixed samples in the region

A colorectal cancer susceptibility new variant at 4q26 in the Spanish population identified by genome-wide association analysis

BACKGROUND: Non-hereditary colorectal cancer (CRC) is a complex disorder resulting from the combination of genetic and non-genetic factors. Genome-wide association studies (GWAS) are useful for identifying such genetic susceptibility factors. However, the single loci so far associated with CRC only represent a fraction of the genetic risk for CRC development in the general population. Therefore, many other genetic risk variants alone and in combination must still remain to be discovered. The aim of this work was to search for genetic risk factors for CRC, by performing single-locus and two-locus GWAS in the Spanish population. RESULTS: A total of 801 controls and 500 CRC cases were included in the discovery GWAS dataset. 77 single nucleotide polymorphisms (SNP)s from single-locus and 243 SNPs from two-locus association analyses were selected for replication in 423 additional CRC cases and 1382 controls. In the meta-analysis, one SNP, rs3987 at 4q26, reached GWAS significant p-value (p = 4.02×10(-8)), and one SNP pair, rs1100508 CG and rs8111948 AA, showed a trend for two-locus association (p = 4.35×10(-11)). Additionally, our GWAS confirmed the previously reported association with CRC of five SNPs located at 3q36.2 (rs10936599), 8q24 (rs10505477), 8q24.21(rs6983267), 11q13.4 (rs3824999) and 14q22.2 (rs4444235). CONCLUSIONS: Our GWAS for CRC patients from Spain confirmed some previously reported associations for CRC and yielded a novel candidate risk SNP, located at 4q26. Epistasis analyses also yielded several novel candidate susceptibility pairs that need to be validated in independent analyses

Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins

<p>Abstract</p> <p>Background</p> <p>Colorectal cancer (CRC) is the second leading cause of cancer death in developed countries. Familial aggregation in CRC is also important outside syndromic forms and, in this case, a polygenic model with several common low-penetrance alleles contributing to CRC genetic predisposition could be hypothesized. Mucins and GALNTs (N-acetylgalactosaminyltransferase) are interesting candidates for CRC genetic susceptibility and have not been previously evaluated. We present results for ten genetic variants linked to CRC risk in previous studies (previously identified category) and 18 selected variants from the mucin gene family in a case-control association study from the Spanish EPICOLON consortium.</p> <p>Methods</p> <p>CRC cases and matched controls were from EPICOLON, a prospective, multicenter, nationwide Spanish initiative, comprised of two independent stages. Stage 1 corresponded to 515 CRC cases and 515 controls, whereas stage 2 consisted of 901 CRC cases and 909 controls. Also, an independent cohort of 549 CRC cases and 599 controls outside EPICOLON was available for additional replication. Genotyping was performed for ten previously identified SNPs in <it>ADH1C</it>, <it>APC</it>, <it>CCDN1</it>, <it>IL6</it>, <it>IL8</it>, <it>IRS1</it>, <it>MTHFR</it>, <it>PPARG</it>, <it>VDR </it>and <it>ARL11</it>, and 18 selected variants in the mucin gene family.</p> <p>Results</p> <p>None of the 28 SNPs analyzed in our study was found to be associated with CRC risk. Although four SNPs were significant with a <it>P</it>-value < 0.05 in EPICOLON stage 1 [rs698 in <it>ADH1C </it>(OR = 1.63, 95% CI = 1.06-2.50, <it>P</it>-value = 0.02, recessive), rs1800795 in <it>IL6 </it>(OR = 1.62, 95% CI = 1.10-2.37, <it>P</it>-value = 0.01, recessive), rs3803185 in <it>ARL11 </it>(OR = 1.58, 95% CI = 1.17-2.15, <it>P</it>-value = 0.007, codominant), and rs2102302 in <it>GALNTL2 </it>(OR = 1.20, 95% CI = 1.00-1.44, <it>P</it>-value = 0.04, log-additive 0, 1, 2 alleles], only rs3803185 achieved statistical significance in EPICOLON stage 2 (OR = 1.34, 95% CI = 1.06-1.69, <it>P</it>-value = 0.01, recessive). In the joint analysis for both stages, results were only significant for rs3803185 (OR = 1.12, 95% CI = 1.00-1.25, <it>P</it>-value = 0.04, log-additive 0, 1, 2 alleles) and borderline significant for rs698 and rs2102302. The rs3803185 variant was not significantly associated with CRC risk in an external cohort (MCC-Spain), but it still showed some borderline significance in the pooled analysis of both cohorts (OR = 1.08, 95% CI = 0.98-1.18, <it>P</it>-value = 0.09, log-additive 0, 1, 2 alleles).</p> <p>Conclusions</p> <p><it>ARL11</it>, <it>ADH1C</it>, <it>GALNTL2 </it>and <it>IL6 </it>genetic variants may have an effect on CRC risk. Further validation and meta-analyses should be undertaken in larger CRC studies.</p