2021 Indiana Civic Health Index

This fifth edition of the Indiana Bar Foundation's Indiana Civic Health Index (INCHI) takes stock of Indiana's successes and shortcomings during the past decade and defines action steps to ensure Indiana becomes a national leader in civic health. In this latest INCHI we examine three election cycles – six elections during 10 years – and analyze trends during that time. The insights gained by examining Hoosiers' participation in civic life from 2010 to the present will inform and inspire citizens and leaders alike to build a culture of civic engagement enhancing our economic, social, and political well-being.Building on the recommendations outlined in the 2019 Indiana Civic Health Index, section one of the report details progress in advancing civic education in schools and promoting citizen participation in the election process, two goals that are profoundly intertwined. Studies show a consistent and robust relationship between school experiences with voting education and civic participation later in life. As cornerstones of representative democracy, civic education and participation are crucial to advancing our civic health.The second section of the report continues the review of Indiana's performance on an array of civic health indicators. Drawing on earlier analyses and incorporating the newest data, we examine ten years (2010-2020) of Indiana's civic activity, identifying areas of strength as well as opportunities for improvement. We hope this unique overview will further stimulate discussion and inspire a renewed commitment to advancing our civic health.  Strengthening Hoosiers' civic health will require a concerted effort of all stakeholders interested in supporting citizen participation in its many forms; the result will be a more vibrant, successful, and engaged Indiana and nation

Translational strategies in drug development for knee osteoarthritis.

Osteoarthritis (OA) is a common disease worldwide with large unmet medical needs. To bring innovative treatments to OA patients, we at Merck have implemented a comprehensive strategy for drug candidate evaluation. We have a clear framework for decision-making in our preclinical pipeline, to design our clinical proof-of-concept trials for OA patients. We have qualified our strategy to define and refine dose and dosing regimen, for treatments administered either systemically or intra-articularly (IA). We do this through preclinical in vitro and in vivo studies, and by back-translating results from clinical studies in OA patients

Serendipitous Geodesy from Bennu's Short-Lived Moonlets

The Origins, Spectral Interpretation, Resource Identification, and Security-Regolith Explorer (OSIRIS-REx; or OREx) spacecraft arrived at its target, near-Earth asteroid (101955) Bennu, on December 3, 2018. The OSIRIS-REx spacecraft has since collected a wealth of scientific information in order to select a suitable site for sampling. Shortly after insertion into orbit on December 31, 2018, particles were identified in starfield images taken by the navigation camera (NavCam 1). Several groups within the OSlRlS-REx team analyzed the particle data in an effort to better understand this newfound activity of Bennu and to investigate the potential sensitivity of the particles to Bennu's geophysical parameters. A number of particles were identified through automatic and manual methods in multiple images, which could be turned into short sequences of optical tracking observations. Here, we discuss the precision orbit determination (OD) effort focused on these particles at NASA GSFC, which involved members of the Independent Navigation Team (INT) in particular. The particle data are combined with other OSIRIS-REx tracking data (radiometric from OSN and optical landmark data) using the NASA GSFC GEODYN orbit determination and geodetic parameter estimation software. We present the results of our study, particularly those pertaining to the gravity field of Bennu. We describe the force modeling improvements made to GEODYN specifically for this work, e.g., with a raytracing-based modeling of solar radiation pressure. The short-lived, low-flying moonlets enable us to determine a gravity field model up to a relatively high degree and order: at least degree 6 without constraints, and up to degree 10 when applying Kaula-like regularization. We can backward- and forward-integrate the trajectory of these particles to the ejection and landing sites on Bennu. We assess the recovered field by its impact on the OSIRIS-REx trajectory reconstruction and prediction quality in the various mission phases (e.g., Orbital A, Detailed Survey, and Orbital B)

People pollinating partnerships: harnessing collaborations between botanic gardens and agricultural research organizations on crop diversity

The world's botanic gardens are repositories of plant diversity but are seldom considered to be major contributors to conservation and research of crops. Thus, botanic gardens and agricultural research organizations have had somewhat limited interactions historically. An unprecedented three-year collaboration between the American Society of Agronomy, Crop Science Society of America, Soil Science Society of America, the American Public Gardens Association, and the World Food Prize Foundation brought together experts from botanic gardens and the agricultural research community, culminating in a Symposium in April 2019 in Des Moines, Iowa. Funded by a grant from the United States Department of Agriculture – National Institute of Food and Agriculture (USDA – NIFA), one of the major outcomes of this collaboration was the development of a shared Road Map for conservation, use, and public engagement around North America’s crop wild relatives and wild utilized plants – species of interest to both communities. Key takeaways from this collaboration are discussed

Human Sensory LTP Predicts Memory Performance and Is Modulated by the BDNF Val66Met Polymorphism

Background: Long-term potentiation (LTP) is recognised as a core neuronal process underlying long-term memory. However, a direct relationship between LTP and human memory performance is yet to be demonstrated. The first aim of the current study was thus to assess the relationship between LTP and human long-term memory performance. With this also comes an opportunity to explore factors thought to mediate the relationship between LTP and long-term memory. The second aim of the current study was to explore the relationship between LTP and memory in groups differing with respect to brain-derived neurotrophic factor (BDNF) Val66Met; a single-nucleotide polymorphism (SNP) implicated in memory function.Methods: Participants were split into three genotype groups (Val/Val, Val/Met, Met/Met) and were presented with both an EEG paradigm for inducing LTP-like enhancements of the visually-evoked response, and a test of visual memory.Results: The magnitude of LTP 40 min after induction was predictive of long-term memory performance. Additionally, the BDNF Met allele was associated with both reduced LTP and reduced memory performance.Conclusions: The current study not only presents the first evidence for a relationship between sensory LTP and human memory performance, but also demonstrates how targeting this relationship can provide insight into factors implicated in variation in human memory performance. It is anticipated that this will be of utility to future clinical studies of disrupted memory function

The future of Arctic sea-ice biogeochemistry and ice-associated ecosystems

The Arctic sea-ice-scape is rapidly transforming. Increasing light penetration will initiate earlier seasonal primary production. This earlier growing season may be accompanied by an increase in ice algae and phytoplankton biomass, augmenting the emission of dimethylsulfide and capture of carbon dioxide. Secondary production may also increase on the shelves, although the loss of sea ice exacerbates the demise of sea-ice fauna, endemic fish and megafauna. Sea-ice loss may also deliver more methane to the atmosphere, but warmer ice may release fewer halogens, resulting in fewer ozone depletion events. The net changes in carbon drawdown are still highly uncertain. Despite large uncertainties in these assessments, we expect disruptive changes that warrant intensified long-term observations and modelling efforts

Behavioural specification of grid services with the KAoS Policy Language

Complex services in Service-Oriented Architectures such as the Grid typically require to be configured in multiple ways that cannot be anticipated by service designers; we illustrate this requirement by studying the myGrid registry, a Grid Registry capable of supporting annotations of service descriptions by third-party users. Instead, services have to be conceived so that they can be configured at deployment and run time. We argue that KAOS is a powerful and flexible language that can help define such configurations. Using our registry case study, we examine the requirements that the definition of such complex configurations brings on policy languages and explain how they can be satisfied. Specifically, we use role-value maps to express constraints between property values; we introduce a notion of PolicySet with associated parameters that support constraints within a well defined scope; finally, we define a notion of Context that allows us to refer to property values that were extant in past execution environments. Essentially, these concepts allow us to add constraints to values in policy definitions, to organise policies in coherent and structure blocks, and to refer to the execution history. The paper discusses these concepts and how they are implemented in a binding of the KAOS policy language to the myGrid Registry

Near-infrared measurements of brain oxygenation in stroke

We investigated the feasibility of using frequency-domain near-infrared spectroscopy (fdNIRS) to study brain oxygenation in the first few hours of stroke onset. The OxiplexTS® fdNIRS system was used in this study. Using a standard probing protocol based on surface landmarks, we measured brain tHb and StO2 in healthy volunteers, cadavers, and acute stroke patients within 9 h of stroke onset and 3 days later. We obtained measurements from 11 controls, 5 cadavers, and 5 acute stroke patients. StO2 values were significantly lower in cadavers compared to the controls and stroke patients. Each stroke patient had at least one area with reduced StO2 on the stroke side compared to the contralateral side. The evolution of tHb and StO2 at 3 days differed depending on whether a large infarct occurred. This study shows the proof of principle that quantified measurements of brain oxygenation using NIRS could be used in the hectic environment of acute stroke management. It also highlights the current technical limitations and future challenges in the development of this unique bedside monitoring tool for stroke.National Sciences and Engineering Research Council; Alberta Innovates Health SolutionsYe