Photodegradation of nimodipine and felodipine in microheterogeneous systems

Indexación: Web of Science; ScieloThe photochemical behavior of nimodipine (NIMO) and felodipine (FELO), photolabile drugs widely used as antihypertensive calcium channel blockers, is studied in constrained media. Specifically, we are interested in the kinetic analysis of 4-aryl-1,4-dihydropyridine photodegradation processes when they are incorporated in biological-mimicking systems like micelles or liposomes. In order to establish if the nature of the head of surfactant (ionic or nonionic) could be important modulating the photo-reactivity of these drugs, we studied the photodegradation of NIMO and FELO incorporated in micelles formed with sodium dodecyl sulfate (SDS, anionic), dodecyl-pyridinium chloride (DPC, cationic) and mono lauryl sucrose ester (MLS, nonionic) as surfactants. Additionally, the results of the photodegradation of these compounds in liposomes were also included. The results clearly indicate that both dihydropyridines studied, NIMO and FELO, are located near to the interface, but the surface charge of micelles does not affect neither, the photodegradation rate constant nor the photodegradation products profile. The absence of singlet oxygen generation in micellar media is consistent with the proposition of these 4-aryl-1,4-dihidropyridines located near to the interface of the micelle, where a polar environment is sensed. In addition, the ethanol preferential location on membranes and dihydropyridine enhanced photodegradation by alcohol presence are interesting results to consider in future research.http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000300025&nrm=is

Análisis al esquema de ordenamiento territorial en sus componentes urbano, rural y genera del municipio de trujillo valle del cauca del año 2015

La presente propuesta de ajuste integral del Esquema de Ordenamiento Territorial (EOT) del municipio de Trujillo Valle del año 2015, corresponde a una herramienta que planifica constantemente orienta, controla y promueve los tres niveles del E.O.T., las diferentes acciones de los diferentes sectores privado como público y comunitario promoviendo las mejores condiciones de la comunidad del Municipio y a optimizar de la mejor manera sus recursos. En este sentido se hace necesario realizar el primer ajuste integral con el propósito de analizar el contexto de los sistemas de innovación, ocupando y utilizando el espacio de acuerdo a las practicas que se edifiquen para el mejoramiento de la sociedad, en lo económico, cultura en conformidad del medio ambiente. y sus tres componentes. El artículo 28 deberá definir la vigencia de sus diferentes contenidos y las condiciones que ameritan su revisión, en concordancia con: El contenido estructural tendrán una vigencia de tres periodos constitucionales. Los contenidos de los componentes urbano y rural de mediano plazo tendrán una vigencia de dos periodos constitucionales. Las zonas urbanas y rurales de corto plazo se regirán durante un periodo constitucional completo (Ley 388, 1997).Abstract This provision of the Comprehensive Order of the Territorial Order (EOT) of the Municipality of Trujillo Valle del Año 2015, corresponds to a permanent planning instrument, destination, milestone and regular promotion, medium and long beach, the activities of the public, private and communal sectors, in order to explore the quality of life of the inhabitants of the municipality, to be used in optimal conditions. In this sense, it is necessary to enable the implementation of a comprehensive example with the opportunity to analyze the context of the transformation, occupation and use of space saving systems to the strategies that are built for social, economic, cultural and urban development. in harmony the environment and its three components. Article 28 defines the duration of the different contexts and the conditions that the US has reviewed, in accordance with: The structural content tends to a convention of three constitutional periods. The contexts of the urban and rural components of the median square tend to have a validity of the constitutional periods. Urban and rural parcels are governed by a complete constitutional period (Law 388, 1997)

A sociological injection to the technology acceptaction acceptance model: reply to our critics

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Computational Intelligence Techniques for Predicting Earthquakes

Nowadays, much effort is being devoted to develop techniques that forecast natural disasters in order to take precautionary measures. In this paper, the extraction of quantitative association rules and regression techniques are used to discover patterns which model the behavior of seismic temporal data to help in earthquakes prediction. Thus, a simple method based on the k–smallest and k–greatest values is introduced for mining rules that attempt at explaining the conditions under which an earthquake may happen. On the other hand patterns are discovered by using a tree-based piecewise linear model. Results from seismic temporal data provided by the Spanish’s Geographical Institute are presented and discussed, showing a remarkable performance and the significance of the obtained results.Ministerio de Ciencia y tecnología TIN2007-68084-C-02Junta de Andalucía P07-TIC-0261

Review of SGLT2i for the Treatment of Renal Complications: Experience in Patients with and Without T2D

The management of type 2 diabetes (T2D) involves decreasing plasma glucose levels and reducing cardiovascular and microvascular complications. Diabetic kidney disease (DKD), defined as presence of albuminuria, impaired glomerular filtration, or both, is an insidious microvascular complication of diabetes that generates a substantial personal and clinical burden. The progressive reduction in renal function and increased albuminuria results in an increase of cardiovascular events. Thus, patients with DKD require exhaustive control of the associated cardiovascular risk factors. People with diabetes and renal impairment have fewer options of antidiabetic drugs because of contraindications, adverse effects, or altered pharmacokinetics. Sodium-glucose cotransporter type 2 inhibitors (SGLT2i) reduce blood glucose concentrations by blocking the uptake of sodium and glucose in the proximal tubule and promoting glycosuria, and these agents now have an important role in the management of T2D. The results of several cardiovascular outcomes trials suggested that SGLT2i are associated with improvements in renal endpoints in addition to their reduction in cardiovascular events and mortality, which represents a major advance in the care of this population. The dedicated kidney outcomes trials have confirmed the renoprotective action of SGLT2i across different glomerular filtration and albuminuria values, even in patients with non-diabetic chronic kidney disease. Notably, this improvement in kidney function may indirectly benefit cardiac function through multifaceted interorgan cross talk, which can break the cardiorenal vicious circle linked to T2D. In this article, we briefly review the different mechanisms of action that may explain the renal beneficial effects of SGLT2i and disclose the results of the key renal outcome trials and the subsequent update of related clinical guidelines

E-learning uses in Andalusian universities: situation and good practices analysis

El artículo que presentamos está basado en un estudio realizado con el objetivo de analizar el uso del eLearning en las diferentes universidades andaluzas a través de: medidas políticas para su incorporación, conocer los usos del profesorado y alumnado de las diferentes universidades, problemas técnicos y didácticos, grado de satisfacción o las percepciones que los responsables de dichas instituciones. Las técnicas de recogida de datos fueron tanto cuantitativas como cualitativas. Algunas de las conclusiones del estudio son: formación deficitaria en lo que se refiere a capacitación del profesorado para la incorporación de las TICs, incorporación en las nuevas modalidades de aprendizaje por parte del profesorado relativamente reciente y actitud positiva del alumnado a la formación online. Palabras clave:Formación online, satisfacción del alumnado, educación superior, experiencias universitarias, buenas prácticas.This paper displays some of the results from research carried out in Andalusia (Spain) to evaluate the impact of the educational innovation policy developed by the regional government through widely introducing Information and Communication Technologies (ICT) in primary and secondary schools (ICT Centres). Specifically, the effect of the measures used to integrate ICTs on the educational administra-tion and education centres is analysed. This integration is analysed not only at an institutional level, concerning the organization of the centres, but also in that referring to the permanent teacher's trai-ning actions and the implications and repercutions in the teaching-learning processes and the classro-om and thus its repercussions in teaching-learning processes

Synergistic effects of ethanolic plant extract mixtures against food-borne pathogen bacteria

Plant extracts are an important part in agroecology, as they benefit environment in combating pathogenic organisms, without resorting to synthetic chemicals. The objective of this study was to evaluate the antibacterial activity of mixtures of ethanol extracts from semi-desert plants [creosote bush (Larrea tridentata), tarbush (Flourensia cernua) and paddle cactus (Opuntia ficus-indica)] against Enterobacter aerogenes, Escherichia coli, Salmonella typhi and Staphylococcus aureus. The maximum antimicrobial activity was achieved with the creosote  bush–tarbush-paddle cactus mix (1:1:1) v/v, followed by paddle cactus-tarbush (1:1) v/v. E. coli was the bacterial strain that showed the highest growth inhibition as consequence of the concentration of plant extracts (4000 and 5000 ppm of tarbush). While with the creosote bush plant extracts, the highest inhibition halos were observed. Synergistic effects were observed when mixtures of ethanolic plant extract against food-borne pathogen bacteria were used, so this may be a better way to design alternative pathogen control methodologies for food-borne pathogen bacteria.Keywords: Larrea tridentate, Flourensia cernua, Opuntia ficus-indica, ethanolic plant extract mixtures, foodborne pathogenAfrican Journal of Biotechnology, Vol. 13(5), pp. 699-704, 29 January, 201

Rational Coformer Selection in the Development of 6-Propyl-2-thiouracil Pharmaceutical Cocrystals

The following supporting information can be downloaded at: https://www. mdpi.com/article/10.3390/ph16030370/s1This research was funded by Project B-FQM-478-UGR20 (FEDER-Universidad de Granada, Spain). A.F. thanks MICIU/AEI of Spain (project PID2020-115637GB-I00, FEDER) for financial support.Pharmaceutical multicomponent solids have proved to efficiently modulate the physico- chemical properties of active pharmaceutical ingredients. In this context, polyphenols are interesting coformers for designing pharmaceutical cocrystals due to their wide safety profile and interesting antioxidant properties. The novel 6-propyl-2-thiouracil multicomponent solids have been obtained by mechanochemical synthesis and fully characterized by powder and single-crystal X-ray diffraction methods. The analysis of supramolecular synthons has been further performed with computational methods, with both results revealing a robust supramolecular organization influenced by the different positions of the hydroxyl groups within the polyphenolic coformers. All novel 6-propyl-2-thiouracil cocrystals show an enhanced solubility profile, but unfortunately, their thermodynamic stability in aqueous media is limited to 24 h.FEDER-Universidad de Granada, Spain B-FQM-478-UGR20Spanish Government PID2020-115637GB-I0

Construcción de cursos hipermedia adaptativos basados en Web utilizando AHA

In this paper we are going to introduce a system to build adaptive hypermedia web-based courses. Using it, any teacher can quickly creates a web-based course that lets the adaptation both the presentation and the navigation depend on the level of each particular student’s knowledge. In order to develop it we have used the AHA generic adaptive systems (de Bra, 98). We have performed it several modification on it to specialize and power it in the educational area. We are going to show a linux course as example of using our system. Currently this course is being used by students of the University of Cordoba. The linux course Cristóbal Romero Morales, Sebastián Ventura Soto, Carlos de Castro together with our system can be downloaded from Internet free. We are also developing an author tool so that the teacher can build easily the course without having to know the AHA internal structure.En el este artículo vamos a presentar una sistema para la construcción de curso hipermedia adaptativos basados en web. Cualquier profesor utilizando nuestro sistema puede crear rápidamente un curso basado en web que además permite la adaptación tanto de la presentación como de la navegación dependiendo del nivel de conocimiento de cada alumno en particular. Para desarrollarlo hemos utilizado de base el sistema adaptativo genérico AHA (de Bra, 98), al que le hemos realizado varias modificaciones importantes para especializarlo y potenciarlo en el área de educación. Como ejemplo de utilización vamos a mostrar un curso de linux que hemos construido utilizando nuestro sistema y que actualmente está siendo utilizado por estudiantes de la Universidad de Córdoba. También estamos desarrollando una herramienta autor para que el profesor pueda construir el curso fácilmente sin la necesidad de conocer la estructura interna de AHA

Por don Cristoual Ortiz Rojano de Morales, familiar del Santo Oficio de la Inquisicion, vezino de la villa de Vaena en el pleito que contra el trata doña Maria de Ordaz vezina de dicha villa

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