1,091 research outputs found
The origin of the LMC stellar bar: clues from the SFH of the bar and inner disk
We discuss the origin of the LMC stellar bar by comparing the star formation
histories (SFH) obtained from deep color-magnitude diagrams (CMDs) in the bar
and in a number of fields in different directions within the inner disk. The
CMDs, reaching the oldest main sequence turnoffs in these very crowded fields,
have been obtained with VIMOS on the VLT in service mode, under very good
seeing conditions. We show that the SFHs of all fields share the same patterns,
with consistent variations of the star formation rate as a function of time in
all of them. We therefore conclude that no specific event of star formation can
be identified with the formation of the LMC bar, which instead likely formed
from a redistribution of disk material that occurred when the LMC disk became
bar unstable, and shared a common SFH with the inner disk thereafter. The
strong similarity between the SFH of the center and edge of the bar rules out
significant spatial variations of the SFH across the bar, which are predicted
by scenarios of classic bar formation through buckling mechanisms.Comment: MNRAS Letters, accepte
Impact of Scale Dependent Bias and Nonlinear Structure Growth on the ISW Effect: Angular Power Spectra
We investigate the impact of nonlinear evolution of the gravitational
potentials in the LCDM model on the Integrated Sachs-Wolfe (ISW) contribution
to the CMB temperature power spectrum, and on the cross-power spectrum of the
CMB and a set of biased tracers of the mass. We use an ensemble of N-body
simulations to directly follow the potentials and compare results to
perturbation theory (PT). The predictions from PT match the results to high
precision for k<0.2 h/Mpc. We compute the nonlinear corrections to the angular
power spectrum and find them to be <10% of linear theory for l<100. These
corrections are swamped by cosmic variance. On scales l>100 the departures are
more significant, however the CMB signal is more than a factor 10^3 larger at
this scale. Nonlinear ISW effects therefore play no role in shaping the CMB
power spectrum for l<1500. We analyze the CMB--density tracer cross-spectrum
using simulations and renormalized bias PT, and find good agreement. The usual
assumption is that nonlinear evolution enhances the growth of structure and
counteracts linear ISW on small scales, leading to a change in sign of the
CMB-LSS cross-spectrum at small scales. However, PT analysis suggests that this
trend reverses at late times when the logarithmic growth rate
f(a)=dlnD/dlna<0.5 or om_m(a)<0.3. Numerical results confirm these expectations
and we find no sign change in ISW-LSS cross-power for low redshifts.
Corrections due to nonlinearity and scale dependence of the bias are found to
be <10% for l<100, therefore below the S/N of the current and future
measurements. Finally, we estimate the CMB--halo cross-correlation coefficient
and show that it can be made to match that for CMB--dark matter to within 5%
for thin redshift shells, mitigating the need to model bias evolution.Comment: 27 pages, 19 figure. Hi-res. version:
http://www.itp.uzh.ch/~res/NonlinearISW.HiRes.pd
Impact of Systematic Errors in Sunyaev-Zel'dovich Surveys of Galaxy Clusters
Future high-resolution microwave background measurements hold the promise of
detecting galaxy clusters throughout our Hubble volume through their
Sunyaev-Zel'dovich (SZ) signature, down to a given limiting flux. The number
density of galaxy clusters is highly sensitive to cluster mass through
fluctuations in the matter power spectrum, as well as redshift through the
comoving volume and the growth factor. This sensitivity in principle allows
tight constraints on such quantities as the equation of state of dark energy
and the neutrino mass. We evaluate the ability of future cluster surveys to
measure these quantities simultaneously when combined with PLANCK-like CMB
data. Using a simple effective model for uncertainties in the cluster mass-SZ
flux relation, we evaluate systematic shifts in cosmological constraints from
cluster SZ surveys. We find that a systematic bias of 10% in cluster mass
measurements can give rise to shifts in cosmological parameter estimates at
levels larger than the statistical errors. Systematic errors are
unlikely to be detected from the mass and redshift dependence of cluster number
counts alone; increasing survey size has only a marginal effect. Implications
for upcoming experiments are discussed.Comment: 12 pages, 6 figures; accepted to JCAP; revised to match submitted
versio
The ALHAMBRA survey : Estimation of the clustering signal encoded in the cosmic variance
The relative cosmic variance () is a fundamental source of
uncertainty in pencil-beam surveys and, as a particular case of count-in-cell
statistics, can be used to estimate the bias between galaxies and their
underlying dark-matter distribution. Our goal is to test the significance of
the clustering information encoded in the measured in the ALHAMBRA
survey. We measure the cosmic variance of several galaxy populations selected
with band luminosity at as the intrinsic dispersion in
the number density distribution derived from the 48 ALHAMBRA subfields. We
compare the observational with the cosmic variance of the dark
matter expected from the theory, . This provides an
estimation of the galaxy bias . The galaxy bias from the cosmic variance is
in excellent agreement with the bias estimated by two-point correlation
function analysis in ALHAMBRA. This holds for different redshift bins, for red
and blue subsamples, and for several band luminosity selections. We find
that increases with the band luminosity and the redshift, as expected
from previous work. Moreover, red galaxies have a larger bias than blue
galaxies, with a relative bias of . Our results
demonstrate that the cosmic variance measured in ALHAMBRA is due to the
clustering of galaxies and can be used to characterise the affecting
pencil-beam surveys. In addition, it can also be used to estimate the galaxy
bias from a method independent of correlation functions.Comment: Astronomy and Astrophysics, in press. 9 pages, 4 figures, 3 table
The role of ZFP57 and additional KRAB-zinc finger proteins in the maintenance of human imprinted methylation and multi-locus imprinting disturbances.
Genomic imprinting is an epigenetic process regulated by germline-derived DNA methylation that is resistant to embryonic reprogramming, resulting in parental origin-specific monoallelic gene expression. A subset of individuals affected by imprinting disorders (IDs) displays multi-locus imprinting disturbances (MLID), which may result from aberrant establishment of imprinted differentially methylated regions (DMRs) in gametes or their maintenance in early embryogenesis. Here we investigated the extent of MLID in a family harbouring a ZFP57 truncating variant and characterize the interactions between human ZFP57 and the KAP1 co-repressor complex. By ectopically targeting ZFP57 to reprogrammed loci in mouse embryos using a dCas9 approach, we confirm that ZFP57 recruitment is sufficient to protect oocyte-derived methylation from reprogramming. Expression profiling in human pre-implantation embryos and oocytes reveals that unlike in mice, ZFP57 is only expressed following embryonic-genome activation, implying that other KRAB-zinc finger proteins (KZNFs) recruit KAP1 prior to blastocyst formation. Furthermore, we uncover ZNF202 and ZNF445 as additional KZNFs likely to recruit KAP1 to imprinted loci during reprogramming in the absence of ZFP57. Together, these data confirm the perplexing link between KZFPs and imprint maintenance and highlight the differences between mouse and humans in this respect
Pattern and process in Amazon tree turnover, 1976-2001
Previous work has shown that tree turnover, tree biomass and large liana densities have increased in mature tropical forest plots in the late twentieth century. These results point to a concerted shift in forest ecological processes that may already be having significant impacts on terrestrial carbon stocks, fluxes and biodiversity. However, the findings have proved controversial, partly because a rather limited number of permanent plots have been monitored for rather short periods. The aim of this paper is to characterize regional-scale patterns of 'tree turnover' (the rate with which trees die and recruit into a population) by using improved datasets now available for Amazonia that span the past 25 years. Specifically, we assess whether concerted changes in turnover are occurring, and if so whether they are general throughout the Amazon or restricted to one region or environmental zone. In addition, we ask whether they are driven by changes in recruitment, mortality or both. We find that: (i) trees 10 cm or more in diameter recruit and die twice as fast on the richer soils of southern and western Amazonia than on the poorer soils of eastern and central Amazonia; (ii) turnover rates have increased throughout Amazonia over the past two decades; (iii) mortality and recruitment rates have both increased significantly in every region and environmental zone, with the exception of mortality in eastern Amazonia; (iv) recruitment rates have consistently exceeded mortality rates; (v) absolute increases in recruitment and mortality rates are greatest in western Amazonian sites; and (vi) mortality appears to be lagging recruitment at regional scales. These spatial patterns and temporal trends are not caused by obvious artefacts in the data or the analyses. The trends cannot be directly driven by a mortality driver (such as increased drought or fragmentation-related death) because the biomass in these forests has simultaneously increased. Our findings therefore indicate that long-acting and widespread environmental changes are stimulating the growth and productivity of Amazon forests
The Atacama Cosmology Telescope: A Measurement of the 600< ell <8000 Cosmic Microwave Background Power Spectrum at 148 GHz
We present a measurement of the angular power spectrum of the cosmic
microwave background (CMB) radiation observed at 148 GHz. The measurement uses
maps with 1.4' angular resolution made with data from the Atacama Cosmology
Telescope (ACT). The observations cover 228 square degrees of the southern sky,
in a 4.2-degree-wide strip centered on declination 53 degrees South. The CMB at
arcminute angular scales is particularly sensitive to the Silk damping scale,
to the Sunyaev-Zel'dovich (SZ) effect from galaxy clusters, and to emission by
radio sources and dusty galaxies. After masking the 108 brightest point sources
in our maps, we estimate the power spectrum between 600 < \ell < 8000 using the
adaptive multi-taper method to minimize spectral leakage and maximize use of
the full data set. Our absolute calibration is based on observations of Uranus.
To verify the calibration and test the fidelity of our map at large angular
scales, we cross-correlate the ACT map to the WMAP map and recover the WMAP
power spectrum from 250 < ell < 1150. The power beyond the Silk damping tail of
the CMB is consistent with models of the emission from point sources. We
quantify the contribution of SZ clusters to the power spectrum by fitting to a
model normalized at sigma8 = 0.8. We constrain the model's amplitude ASZ < 1.63
(95% CL). If interpreted as a measurement of sigma8, this implies sigma8^SZ <
0.86 (95% CL) given our SZ model. A fit of ACT and WMAP five-year data jointly
to a 6-parameter LCDM model plus terms for point sources and the SZ effect is
consistent with these results.Comment: 15 pages, 8 figures. Accepted for publication in Ap
Spectral Distortions of the CMB as a Probe of Inflation, Recombination, Structure Formation and Particle Physics
Following the pioneering observations with COBE in the early 1990s, studies
of the cosmic microwave background (CMB) have focused on temperature and
polarization anisotropies. CMB spectral distortions - tiny departures of the
CMB energy spectrum from that of a perfect blackbody - provide a second,
independent probe of fundamental physics, with a reach deep into the primordial
Universe. The theoretical foundation of spectral distortions has seen major
advances in recent years, which highlight the immense potential of this
emerging field. Spectral distortions probe a fundamental property of the
Universe - its thermal history - thereby providing additional insight into
processes within the cosmological standard model (CSM) as well as new physics
beyond. Spectral distortions are an important tool for understanding inflation
and the nature of dark matter. They shed new light on the physics of
recombination and reionization, both prominent stages in the evolution of our
Universe, and furnish critical information on baryonic feedback processes, in
addition to probing primordial correlation functions at scales inaccessible to
other tracers. In principle the range of signals is vast: many orders of
magnitude of discovery space could be explored by detailed observations of the
CMB energy spectrum. Several CSM signals are predicted and provide clear
experimental targets, some of which are already observable with present-day
technology. Confirmation of these signals would extend the reach of the CSM by
orders of magnitude in physical scale as the Universe evolves from the initial
stages to its present form. The absence of these signals would pose a huge
theoretical challenge, immediately pointing to new physics.Comment: Astro2020 Science White Paper, 5 pages text, 13 pages in total, 3
Figures, minor update to reference
Improved Selective Class i HDAC and Novel Selective HDAC3 Inhibitors: Beyond Hydroxamic Acids and Benzamides
The application of class I HDAC inhibitors as cancer therapies is well established, but more recently their development for nononcological indications has increased. We report here on the generation of improved class I selective human HDAC inhibitors based on an ethylketone zinc binding group (ZBG) in place of the hydroxamic acid that features the majority of HDAC inhibitors. We also describe a novel set of HDAC3 isoform selective inhibitors that show stronger potency and selectivity than the most commonly used HDAC3 selective tool compound RGFP966. These compounds are again based on an alternative ZBG with respect to the ortho-anilide that is featured in HDAC3 selective compounds reported to date
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