A survey of HC_3N in extragalactic sources: Is HC_3N a tracer of activity in ULIRGs?

Context. HC_3N is a molecule that is mainly associated with Galactic star-forming regions, but it has also been detected in extragalactic environments. Aims. To present the first extragalactic survey of HC_3N, when combining earlier data from the literature with six new single-dish detections, and to compare HC_3N with other molecular tracers (HCN, HNC), as well as other properties (silicate absorption strength, IR flux density ratios, C_(II) flux, and megamaser activity). Methods. We present mm IRAM 30 m, OSO 20 m, and SEST observations of HC_3N rotational lines (mainly the J = 10–9 transition) and of the J = 1–0 transitions of HCN and HNC. Our combined HC_3N data account for 13 galaxies (excluding the upper limits reported for the non-detections), while we have HCN and HNC data for more than 20 galaxies. Results. A preliminary definition “HC_3N-luminous galaxy” is made based upon the HC_3N/HCN ratio. Most (~80%) HC_3N-luminous galaxies seem to be deeply obscured galaxies and (U)LIRGs. A majority (~60% or more) of the HC3N-luminous galaxies in the sample present OH mega- or strong kilomaser activity. A possible explanation is that both HC_3N and OH megamasers need warm dust for their excitation. Alternatively, the dust that excites the OH megamaser offers protection against UV destruction of HC_3N. A high silicate absorption strength is also found in several of the HC_3N-luminous objects, which may help the HC3N to survive. Finally, we find that a high HC_3N/HCN ratio is related to a high dust temperature and a low C_(II) flux

MICROFINANCE MARKET NICHES AND CLIENT PROFILES IN BOLIVIA

This paper presents and interprets descriptive statistics generated from data obtained in a survey of clients of five microfinance organizations believed to be among the best in Bolivia. These lenders represent different combinations of organizational design, lending technology, and market area of operations. Two are regulated financial intermediaries and three are NGOs. Two operate in rural areas (PRODEM and Sartawi) and three operate in urban areas (BancoSol, FIE, and Caja Los Andes). Two offer individual loans and three grant loans through joint liability groups. The paper discusses household-enterprise profiles of a sample of 622 clients and identifies terms and conditions of loan contracts with these organizations to evaluate the depth and quality of their outreach. The interpretation seeks to establish connections between key characteristics of the clients and features of the lending technologies that lead to the matching of classes of borrowers with particular organizations and that influence the choice of market niches. Data on loan sizes suggest the existence of different but broadly overlapping market niches associated with three tiers of clients. The sharpest distinction is between urban and rural clients. The matching between clients and organizations also reflects a weak but positive correlation between levels of poverty and loan sizes. According to an index of basic needs fulfillment of their clients, these organizations can be ranked as: FIE and Caja Los Andes (first tier), BancoSol (second tier), and PRODEM and Sartawi (third tier). The same ranking is obtained when clients are ordered according to loan size, the ratio of loan size to the value of sales, and the value of monthly sales. The three tiers of clients are associated with different socio-economic features of their household-enterprises: sex, education, household size, access to electricity, water supplies, and sewage facilities, employment-generating capacity of the enterprise, informality and separation of household and enterprise, occupations and the like. The development of lending technologies that do not rely on standard financial statements and collateralizable assets is a formidable innovation that explains the outreach and sustainability of these organizations. Differences in the guarantees required for loans dominate distinctions in lending technology. Trade-offs between loan size, interest rates, and guarantee requirements attract different subsets of the clientele. Joint liability seems to be appropriate for very poor people, but group borrowers eventually outgrow this relationship. Caja Los Andes and FIE have shown that it is possible to supply individual loans to poor people and be profitable. Most clients are satisfied with the services received. The lowest satisfaction concerns loan sizes and loan-size rationing may be widespread. At least in urban areas, increasing competition will force these organizations to improve their services and adjust loan sizes. All of these organizations are expanding the frontier of microfinance by developing lending technologies for a much poorer clientele than is reached by collateral-based lenders. This is a formidable achievement.Financial Economics,

La biblioteca universitària com a centre de recursos per a l’aprenentatge i la recerca

L’Espai Europeu d’Ensenyament Superior suposarà una de les transformacions més importants per a les universitats. D’un sistema d’ensenyament tradicional basat en la docència es passarà a un nou sistema educatiu basat en l’aprenentatge. Aquesta situació de canvi i transformació que viu la universitat afectarà també les seves biblioteques, institucions que sempre han estat lligades als objectius de la universitat. Per tal d’assumir aquests reptes nous cal un nou model de biblioteca que sigui part activa del procés d’aprenentatge. En el nou paradigma, la biblioteca restarà configurada com a centre de recursos per a l’aprenentatge i la recerca (CRAI). A l’article es revisa el concepte de CRAI i els serveis que presta, i s’analitzen algunes qüestions sobre el procés engegat per les biblioteques universitàries espanyoles per tal d’ajustarse al nou model.Publicad

Hydrogen Fluoride in High-Mass Star-forming Regions

Hydrogen fluoride has been established to be an excellent tracer of molecular hydrogen in diffuse clouds. In denser environments, however, the HF abundance has been shown to be approximately two orders of magnitude lower. We present Herschel/HIFI observations of HF J=1-0 toward two high-mass star formation sites, NGC6334 I and AFGL 2591. In NGC6334 I the HF line is seen in absorption in foreground clouds and the source itself, while in AFGL 2591 HF is partially in emission. We find an HF abundance with respect to H2 of 1.5e-8 in the diffuse foreground clouds, whereas in the denser parts of NGC6334 I, we derive a lower limit on the HF abundance of 5e-10. Lower HF abundances in dense clouds are most likely caused by freeze out of HF molecules onto dust grains in high-density gas. In AFGL 2591, the view of the hot core is obstructed by absorption in the massive outflow, in which HF is also very abundant 3.6e-8) due to the desorption by sputtering. These observations provide further evidence that the chemistry of interstellar fluorine is controlled by freeze out onto gas grains.Comment: accepted in Ap

C-C bond-forming and bond-breaking processes from the reaction of diesters with Me3SnLi. Synthesis of complex bridged polycycles and di-alkyl aromatic compounds

This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in The Journal of Organic Chemistry (JOC), copyright © American Chemical Society after peer review. To access the final edited and published work see https://doi.org/10.1021/acs.joc.8b02891.1,2-Aromatic diesters can be transformed into strained bridged polycyclic structures by a two-step procedure consisting of an initial reductive alkylation promoted by alkaline metals, followed by a reaction of the resulting unsaturated diesters with Me3SnLi. We propose that a stanna-Brook rearrangement plays a fundamental role in the formation of the polycyclic organotin acetals obtained. These unusual compounds could be further functionalized by tin–lithium exchange followed by alkylation of the newly formed tertiary carbanion. Alternatively, dialkylated aromatic hydrocarbons have been prepared via a decarbonilation reaction promoted by Me3SnLi. 1,4-Aromatic diesters were reductively dialkylated and then transformed into norbornadienone derivatives by reaction with Me3SnLi. Several stable dibenzonorbornadienones 41 have been prepared in just two steps starting from anthracene 38. The corresponding naphthalene analogues gave 1,4-dialkylnaphthalenes. The synthetic protocols described provide access to structures that are not easily obtained through existing synthetic methodologies.Financial support from Ministerio de Economía y Competitividad of Spain (CTQ2017-84354-P), Xunta de Galicia (GRC 2014/029 and Centro singular de investigación de Galicia accreditation 2016-2019, ED431G/09), and the European Union (European Regional Development Fund-ERDF) is gratefully acknowledged.S

Microfinance Market Niches and Client Profiles in Bolivia

This paper presents and interprets descriptive statistics generated from data obtained in a survey of clients of five microfinance organizations believed to be among the best in Bolivia. These lenders represent different combinations of organizational design, lending technology, and market area of operations. Two are regulated financial intermediaries and three are NGOs. Two operate in rural areas (PRODEM and Sartawi) and three operate in urban areas (BancoSol, FIE, and Caja Los Andes). Two offer individual loans and three grant loans through joint liability groups. The paper discusses household-enterprise profiles of a sample of 622 clients and identifies terms and conditions of loan contracts with these organizations to evaluate the depth and quality of their outreach. The interpretation seeks to establish connections between key characteristics of the clients and features of the lending technologies that lead to the matching of classes of borrowers with particular organizations and that influence the choice of market niches. Data on loan sizes suggest the existence of different but broadly overlapping market niches associated with three tiers of clients. The sharpest distinction is between urban and rural clients. The matching between clients and organizations also reflects a weak but positive correlation between levels of poverty and loan sizes. According to an index of basic needs fulfillment of their clients, these organizations can be ranked as: FIE and Caja Los Andes (first tier), BancoSol (second tier), and PRODEM and Sartawi (third tier). The same ranking is obtained when clients are ordered according to loan size, the ratio of loan size to the value of sales, and the value of monthly sales. The three tiers of clients are associated with different socio-economic features of their household-enterprises: sex, education, household size, access to electricity, water supplies, and sewage facilities, employment-generating capacity of the enterprise, informality and separation of household and enterprise, occupations and the like. The development of lending technologies that do not rely on standard financial statements and collateralizable assets is a formidable innovation that explains the outreach and sustainability of these organizations. Differences in the guarantees required for loans dominate distinctions in lending technology. Trade-offs between loan size, interest rates, and guarantee requirements attract different subsets of the clientele. Joint liability seems to be appropriate for very poor people, but group borrowers eventually outgrow this relationship. Caja Los Andes and FIE have shown that it is possible to supply individual loans to poor people and be profitable. Most clients are satisfied with the services received. The lowest satisfaction concerns loan sizes and loan-size rationing may be widespread. At least in urban areas, increasing competition will force these organizations to improve their services and adjust loan sizes. All of these organizations are expanding the frontier of microfinance by developing lending technologies for a much poorer clientele than is reached by collateral-based lenders. This is a formidable achievement

Disrupted Ultradian activity rhythms and Differential expression of several clock genes in interleukin-6-Deficient Mice

The characteristics of the cycles of activity and rest stand out among the most intensively investigated aspects of circadian rhythmicity in humans and experimental animals. Alterations in the circadian patterns of activity and rest are strongly linked to cognitive and emotional dysfunctions in severe mental illnesses such as Alzheimer's disease (AD) and major depression (MDD). The proinflammatory cytokine interleukin 6 (IL-6) has been prominently associated with the pathogenesis of AD and MDD. However, the potential involvement of IL-6 in the modulation of the diurnal rhythms of activity and rest has not been investigated. Here, we set out to study the role of IL-6 in circadian rhythmicity through the characterization of patterns of behavioral locomotor activity in IL-6 knockout (IL-6 KO) mice and wild-type littermate controls. Deletion of IL-6 did not alter the length of the circadian period or the amount of locomotor activity under either light-entrained or free-running conditions. IL-6 KO mice also presented a normal phase shift in response to light exposure at night. However, the temporal architecture of the behavioral rhythmicity throughout the day, as characterized by the quantity of ultradian activity bouts, was significantly impaired under light-entrained and free-running conditions in IL-6 KO. Moreover, the assessment of clock gene expression in the hippocampus, a brain region involved in AD and depression, revealed altered levels of cry1, dec2, and rev-erb-beta in IL-6 KO mice. These data propose that IL-6 participates in the regulation of ultradian activity/rest rhythmicity and clock gene expression in the mammalian brain. Furthermore, we propose IL-6-dependent circadian misalignment as a common pathogenetic principle in some neurodegenerative and neuropsychiatric disorders

Optimization of a laccase-mediator stage for TCF bleaching of flax pulp

7 p.-3 fig.-3 tab.Flax pulp obtained by anthraquinone-soda pulping, resulting in a kappa number of 11.1, a viscosity of 950 ml/g and 36.7% ISO brightness, was bleached in a totally chlorine-free sequence using the enzyme laccase from the fungus Pycnoporus cinnabarinus and 1-hydroxybenzotriazole (HBT) as redox mediator (stage L), followed by a hydrogen peroxide stage (P). The laccase treatment was optimized using a three-variable sequential statistical plan over the following ranges: 1–20 U/g o.d.p. (oven-dried pulp) laccase dose, 0.5–7.5% o.d.p. HBT dose and 1–24 h reaction time. The influence of these variables on several pulp properties after the P stage of the LP sequence was examined.The models defined from the results obtained predicted variations in ISO brightness, viscosity and kappa number of 57.6–74.8%, 590–955 ml/g and 0–6.2, respectively. The variables most strongly influencing these pulp properties were found to be the reaction time and the enzyme dose. A compromise was adopted as regards the operating conditions in order to ensure optimum results. The study was completed by conducting a biobleaching assay in a pressurized reactor (590 kPa) to assess the effect of oxygen pressure. The high pressure level resulted in improved pulp properties by the laccase-mediator system.This work was supported by Spanish CICyT (Project PPQ2000–1068-C02-02, and FEDER Project 2FD97-0896-C02) and Comunidad Autónoma de Madrid, the EU Commission (QLK3-99-590) and the Spanish grant 2002FI 00556.Peer reviewe