Exploring sustainable experiences in tourism.

This study explores the vaguely defined concept of sustainableexperiences. Specifically, it questions how perceived experiencevalue at tourism destinations can be enhanced through sustainableexperience dimensions. Although experiences and sustainabletourism are intrinsically interlinked, knowledge of sustainableexperiences and how they can be included in experience design toenhance perceived value is limited. Within a lake context, localstakeholders, researchers and students were invited to activelyidentify and co-design sustainable experience dimensions using,among others, interviews with residents and tourists. Ourfindingssuggest four sustainable experience dimensions: interaction withthe natural environment; interaction with the cultural environment;insights and views; and lake-based activities. The study advocatesfor future research and management to better incorporatesustainable experience dimensions to holistically enhance tourists’perceived experience value and destination sustainability.publishedVersio

Penggunaan Ekstrak Selulosa Alang-Alang (Imperata cylindrica L.) sebagai Bahan Pengisi dan Penghancur Tablet Paracetamol

Lebih dari 90% produksi obat di Indonesia bergantung pada impor bahan baku, termasuk selulosa. Alang-alang (Imperata cylindrica L.) memiliki kandungan selulosa tinggi dan potensial sebagai bahan pengisi dan penghancur tablet. Penelitian ini bertujuan untuk mengeksplorasi penggunaan optimal selulosa dari alang-alang dan mengamati kualitas granul dan tablet yang dihasilkan. Metode yang digunakan untuk ekstraksi selulosa dari alang-alang adalah delignifikasi. Selanjutnya dikarakterisasi dengan spektroskopi FTIR. Dilanjutkan dengan pembuatan tablet granulasi basah dengan tiga formulasi berbeda yaitu selulosa dan Avicel, pengujian karakteristik kualitas granul dan tablet serta disolusi. Data dianalisis menggunakan metode Simplex Lattice Design dengan Software Design Expert. Kombinasi selulosa alang-alang dan Avicel PH 101 dalam karakteristik granul mempengaruhi karakteristik distribusi ukuran partikel, % fines, dan laju alir yang tidak memenuhi persyaratan, sedangkan kadar air, sudut diam, dan kompresibilitas memenuhi persyaratan. Sifat kualitas tablet parasetamol kombinasi selulosa dan Avicel PH 101 tidak memenuhi persyaratan kekerasan tablet dan waktu hancur. Uji disolusi ketiga formula memenuhi syarat. Selulosa dari alang-alang dapat digunakan sebagai pengganti sebagian Avicel PH 101 dengan perbandingan masing-masing 8,54% dan 6,46% untuk Avicel PH 101 dan selulosa untuk menghasilkan karakteristik kualitas tablet yang dapat diterima

EVALUASI PENGGUNAAN ANTIBIOTIK DENGAN METODE ATC/DDD DAN PDD DENGAN DU 90% PADA PENDERITA ISPA NON PNEUMONIA DI PUSKESMAS KABUPATEN SAMPANG

Irrational use of antibiotics can cause an increase in morbidity and mortality, while also causing resistance to antibiotics. Evaluate the use of antibiotics aimed at reducing the use of antibiotics in ARI Non-Pneumonia as well as supporting government programs that the use of antibiotics for ARI non-pneumonia is no more than 20%. This research is descriptive in nature with a cross-sectional design and retrospective data collection in the January-September 2019 period. The data used are the use of antibiotics in Non-pneumonia ARI in the Sampang Regency. Evaluation of the use of this antibiotic using the ATC / DDD, PDD, PDD and DDD Comparison Ratio as well as 90% DU. There are 7 types of antibiotics used for Non-Pneumonia ISPA and 2 types of antibiotics included in DU90% are amoxicillin 500 mg by 44.63% and ciprofloxacin 500 mg by 44.58%. Quantitative data analysis using ATC / DDD shows that the most widely used antibiotic is amoxicillin 500 mg of 742.58 DDD / 1000 patient-days. Inappropriate use of antibiotics can increase the incidence of resistance. A policy is needed to control the use of antibiotics in Puskesmas to reduce antibiotic resistance and its side effects

Advanced Nanobiomaterials: Vaccines, Diagnosis and Treatment of Infectious Diseases

The use of nanoparticles has contributed to many advances due to their important properties such as, size, shape or biocompatibility. The use of nanotechnology in medicine has great potential, especially in medical microbiology. Promising data show the possibility of shaping immune responses and fighting severe infections using synthetic materials. Different studies have suggested that the addition of synthetic nanoparticles in vaccines and immunotherapy will have a great impact on public health. On the other hand, antibiotic resistance is one of the major concerns worldwide; a recent report of the World Health Organization (WHO) states that antibiotic resistance could cause 300 million deaths by 2050. Nanomedicine offers an innovative tool for combating the high rates of resistance that we are fighting nowadays, by the development of both alternative therapeutic and prophylaxis approaches and also novel diagnosis methods. Early detection of infectious diseases is the key to a successful treatment and the new developed applications based on nanotechnology offer an increased sensibility and efficiency of the diagnosis. The aim of this review is to reveal and discuss the main advances made on the science of nanomaterials for the prevention, diagnosis and treatment of infectious diseases. Highlighting innovative approaches utilized to: (i) increasing the efficiency of vaccines; (ii) obtaining shuttle systems that require lower antibiotic concentrations; (iii) developing coating devices that inhibit microbial colonization and biofilm formationThis work has benefited by the financial support of a grant of the Romanian National Authority for Scientific Research and Innovation, CNCS–UEFISCDI, project number PN-II-RU-TE-2014-4-2269S

Pembuatan Tablet Bukal Metronidazol Mukoadhesif Menggunakan Carbopol 940 30% Secara Granulasi Kering

Penelitian ini dilakukan untuk mengetahui pemenuhan karakteristik granul dan tablet yang dihasilkan sesuai dengan yang dipersyaratkan pustaka dan pengaruh penggunaan Carbopol® 940 30% sebagai polimer mukoadhesi pada pembuatan tablet bukal mukoadhesi metronidazol. Pembuatan tablet dilakukan dengan metode granulasi kering. Formula tablet bukal mukoadhesi metronidazol baik tanpa Carbopol® 940 maupun dengan 30% Carbopol® 940 menghasilkan granul yang tidak memenuhi parameter kandungan lembab dan persen fines namun masih memenuhi parameter karakteristik granul yang lain yaitu daya alir, kompresibilitas dan homogenitas serta karakteristik tablet meliputi keseragaman bobot, ukuran, kekerasan, friabilitas, kandungan bahan aktif sesuai dengan yang dipersyaratkan pustaka dengan perbedaan tidak bermakna (α=0,05). Pada uji pengembangan tablet, penggunaan 30% Carbopol® 940 menunjukkan peningkatan indeks sebanyak 9,74 kali dibandingkan tanpa penggunaan Carbopol®. Dilakukan uji mukoadhesi menggunakan usus kelinci dengan metode “tensile strength”, daya mukoadhesi dengan penggunaan 30% Carbopol® 940 meningkat 5,43 kali yang ditunjukkan oleh berat beban 31,67 gram. Carbopol® 940 juga mampu menghambat pelepasan obat dari matriks tablet hingga menit ke-600 yang dibuktikan dengan uji disolusi

CORRELATION ANALYSIS BETWEEN THE SERVICE QUALITY, CUSTOMER SATISFACTION, AND CUSTOMER LOYALTY OF VIVA GENERIK PHARMACY IN SEMARANG

Today, pharmacy service has become more developed along with the enhancement of society awareness of the importance of health. Therefore, as one of the health service facilities, pharmacy is required not only to give priority on product prices and varieties but also to provide qualified service for the patients. Viva Generik pharmacy as a new comer should have the ability to understand the situation and should have the competitive advantage. This study used a survey method. Data were collected with a purposive sampling method using the instrument of closed questionnaires. The questionnaires were tested for the validity and the reliability to 40 respondents who were the consumers of Viva Generik pharmacy. Questionnaires were given to 150 respondents, then were analyzed using qualitative descriptive statistics to identify the respondents characteristic. Quantitative analysis was used to identify the quality of the service and to see the correlation between service quality, satisfaction, and customer loyalty of Viva Generik pharmacy. As a result, Viva Generik pharmacys consumers tended to agree that the quality of service given by Viva Generik pharmacy was good. Simultaneously, service quality variables gave a positive impact to the customer satisfaction and the customer loyalty. It was just the tangible dimension that gave the significant impact on the customer satisfaction and customer loyalty. It was also disclosed that the customer satisfaction brought a significant impact on the customer loyalty to Viva Generik pharmacy

CULTURAL CONFLICT EXPERIENCED BY THE CENTRAL CHARACTER IN THE NOVEL CRAZY RICH ASIAN BY KEVIN KWAN

Cultural conflict can occur because the diversity of cultures, religions, and races. When we refuse to learn about other cultures, stereotype, misinterpretation and tendency to change attitudes toward other ethnicity might happen. The purposes of this thesis is to explore the cultural conflict and the settlement in Kevin Kwans novel Crazy Rich Asian. This novel presents Rachel Chu and Nicholas Young as the central character. The research is conducted by means of descriptive analysis method. The results shows that the cultural conflicts experienced by Rachel and Nick were caused by stereotypes, misunderstandings, ethnocentrism and materialism, a high sense of selfishness that made the conflict continue without any resolution.Keywords: Crazy Rich Asian; Cultural Conflict; Culture