Adenomatoid tumor of the uterus; report of a rare incidentaloma

Adenomatoid tumor of the uterus is extremely rare and usually an incidental finding in the uteri removed surgically for some other cause as in the present case. The histogenesis of this tumor has been controversial ever since its discovery, although the most favored and proposed is a mesothelial origin. Grossly it is usually mistaken for a leiomyoma. The tumor may have a variety of histomorphologic patterns with rare bizarre appearances, at times leading to an erroneous diagnosis of metastatic adenocarcinoma

Uterine leiomyosarcoma metastasizing to multiple sites: a rare presentation

Uterine leiomyosarcoma is a rare malignant neoplasm which has a dismal outcome especially when associated with widespread metastasis. It shows early metastasis primarily to the lungs, peritoneal cavity, bones, pelvic and para-aortic lymph nodes. We report simultaneous metastasis to the scalp, breast and soft tissue from leiomyosarcoma arising in the uterine broad ligament. Leiomyosarcoma poses a diagnostic difficulty at the metastatic site, especially when the primary site is unknown. Correct tumor typing and separating a primary from a metastatic one is important because of the different treatment modalities for both. Fine Needle Aspiration Cytology (FNAC) has emerged as an indispensable preliminary modality in investigating the metastatic disease and therefore cytomorphological recognition of the tumor presumes a great significance

Multiple cysticerci as an unusual cause of mesenteric lymph node enlargement: a case report

<p>Abstract</p> <p>Introduction</p> <p>Cysticercosis is a disease caused by infestation with the larval stage of the intestinal cestode <it>Taenia solium</it>. The parasite usually localizes to subcutaneous tissues and muscles causing palpable or visible nodules, to the brain leading to epileptic attacks, and to the eyes with visible nodules leading to blindness and atrophy.</p> <p>Case presentation</p> <p>Here we present the case of a 15-year-old girl who was incidentally detected as having mesenteric lymph node enlargement caused by multiple cysticerci. This is the second case report of lymph node enlargement due to cysticercus infestation.</p> <p>Conclusion</p> <p>This rare mode of presentation of cysticercus infestation highlights the importance of parasites as a cause of treatable lymph node enlargement.</p

Death and organization: Heidegger’s thought on death and life in organizations

Mortality has not been given the attention it deserves within organization studies. Even when it has been considered, it is not usually in terms of its implications for own lives and ethical choices. In particular, Heidegger’s writing on death has been almost entirely ignored both in writing on death and writing on organizational ethics, despite his insights into how our mortality and the ethics of existence are linked. In this paper, we seek to address this omission by arguing that a consideration of death may yield important insights about the ethics of organizational life. Most important of these is that a Heideggerian approach to death brings us up against fundamental ethical questions such as what our lives are for, how they should be lived and how we relate to others. Heideggerarian thought also reconnects ethics and politics, as it is closely concerned with how we can collectively make institutions that support our life projects rather than thwart or diminish them

Morpho-biochemical characterization of a RIL population for seed parameters and identification of candidate genes regulating seed size trait in lentil (Lens culinaris Medik.)

The seed size and shape in lentil (Lens culinaris Medik.) are important quality traits as these influences the milled grain yield, cooking time, and market class of the grains. Linkage analysis was done for seed size in a RIL (F5:6) population derived by crossing L830 (20.9 g/1000 seeds) with L4602 (42.13 g/1000 seeds) which consisted of 188 lines (15.0 to 40.5 g/1000 seeds). Parental polymorphism survey using 394 SSRs identified 31 polymorphic primers, which were used for the bulked segregant analysis (BSA). Marker PBALC449 differentiated the parents and small seed size bulk only, whereas large seeded bulk or the individual plants constituting the large-seeded bulk could not be differentiated. Single plant analysis identified only six recombinant and 13 heterozygotes, of 93 small-seeded RILs (<24.0 g/1000 seed). This clearly showed that the small seed size trait is very strongly regulated by the locus near PBLAC449; whereas, large seed size trait seems governed by more than one locus. The PCR amplified products from the PBLAC449 marker (149bp from L4602 and 131bp from L830) were cloned, sequenced and BLAST searched using the lentil reference genome and was found amplified from chromosome 03. Afterward, the nearby region on chromosome 3 was searched, and a few candidate genes like ubiquitin carboxyl-terminal hydrolase, E3 ubiquitin ligase, TIFY-like protein, and hexosyltransferase having a role in seed size determination were identified. Validation study in another RIL mapping population which is differing for seed size, showed a number of SNPs and InDels among these genes when studied using whole genome resequencing (WGRS) approach. Biochemical parameters like cellulose, lignin, and xylose content showed no significant differences between parents and the extreme RILs, at maturity. Various seed morphological traits like area, length, width, compactness, volume, perimeter, etc., when measured using VideometerLab 4.0 showed significant differences for the parents and RILs. The results have ultimately helped in better understanding the region regulating the seed size trait in genomically less explored crops like lentils

Aspiration cytology of rheumatoid nodulosis: Diagnostic method of choice

Rheumatoid nodules occur as an extraarticular manifestation of rheumatoid disease. Generally they are diagnosed by histology and seldom by fine needle aspiration (FNA). To our knowledge only two papers have described the cytologic characteristics of rheumatoid nodule.1,2 Below we describe our experience with FNA in a case of rheumatoid nodulosis. A 35-year-old man presented with multiple subcutaneous nodules on a heel, a knee and the hands, present for three years. They had gradually increased in size and number. They measured 1.0-2.5 cm in diameter, were nontender and firm, and had smooth surfaces. Investigations performed included hemogram, erythrocyte sedimentation rate, routine urinalysis, creatinine, uric acid, cholesterol, triglyceride and chest radiograph; all were noncontributory except for rheumatoid factor, which was positive. Roentgenograms of relevant joints were normal. The possibility of rheumatoid nodules was considered. FNA was advised to confirm the nature of the nodules. Since the patient had no history of arthritis, FNA was performed on nodules on a hand and heel with a 23-gauge needle. Smears prepared from the aspirate were air dried and stained with May-Gr\ufcnwald-Giemsa stain. The smears revealed the typical picture of a rheumatoid nodule: necrotic background material, lymphocytes, plasma cells, histiocytes (some giant and multinucleated) and elongated, large mesenchymal cells, probably elongated histiocytes

Gastrointestinal lipomas presenting as obstruction

Lipomas are benign tumours common at other sites but rare in the gastrointestinal tract. The colon is the commonest location for lipomas in the gastrointestinal tract, but gastric and duodenal lipomas are rare. Most of the lipomas are clinically silent but rarely they can present with bleeding or obstruction. Large lipomas causing obstruction can mimic malignant tumours clinically as well as on endoscopy. To rule out malignant lesion and avoid extensive surgical procedures biopsy or intraoperative frozen section is a must

Cytomorphologic spectrum in aspirates of extra-adrenal paraganglioma

Background: Paraganglioma is a rare tumor arising from clusters of neuroendocrine cells in association with sympathetic and parasympathetic nervous system. It poses a diagnostic challenge because of its widespread anatomic distribution, subtle clinical manifestations, and a variety of morphologic patterns. Aim: The aim of this study is to have an insight into the diverse morphologic spectrum of extra-adrenal paraganglioma (EAP). Materials and Methods: A retrospective analysis of seven cytologically diagnosed cases of EAP over a period of 10 years was performed. There were five superficial swellings and two deep seated retroperitoneal masses. The superficial swellings were aspirated directly, and the retroperitoneal masses were aspirated under ultrasound guidance using 22-gauge lumbar puncture needle fitted to a 10 mL syringe. Smears were reviewed for cellularity, pattern, cell shape, cytoplasm, nuclear features, and background. Results: The age of patients ranged from 25 to 75 years; four patients were males and three were females. Sites involved were carotid body region (four cases), para-pharyngeal space (one case) and para-aortic region (two cases). All the cases yielded hemorrhagic material on fine-needle aspiration. Smears showed scattered and clusters of cells and loosely cohesive acini of tumor cells. Cells were round to polygonal with pleomorphic nuclei, granular chromatin, inconspicuous nucleoli, and moderate to abundant cytoplasm containing fine pink granules and vacuolations. The cases were confirmed on radiology and histopathology. Conclusion: The cytologic features in EAP along with pertinent clinicoradiologic findings help in making an accurate preoperative diagnosis of an otherwise rare tumor