Utility of Vascular Endothelial Growth Factor Inhibitors in the Treatment of Ovarian Cancer: From Concept to Application

Despite recent advances in the management of ovarian cancer, it remains the most lethal gynecologic malignancy. Vascular endothelial growth factor (VEGF) has been shown to play a pivotal role in the progression of ovarian cancer leading to the eventual development of malignant ascites. On this basis, agents rendering VEGF ineffective by neutralizing VEGF (bevacizumab), blocking its receptors (aflibercept), or interfering with the postreceptor signaling pathways (sunitinib) provide us with the rational treatment options. These agents are generally used in combination with the standard chemotherapeutic drugs. Here, we discuss the basis of and the logic behind the use of these agents in the treatment of epithelial ovarian cancer, as well as their evaluation in different preclinical and clinical studies

Validity and Cross-Cultural Adaptation of the Persian Version of the Oxford Elbow Score

Oxford Elbow Score (OES) is a patient-reported questionnaire used to assess outcomes after elbow surgery. The aim of this study was to validate and adapt the OES into Persian language. After forward-backward translation of the OES into Persian, a total number of 92 patients after elbow surgeries completed the Persian OES along with the Persian DASH and SF-36. To assess test-retest reliability, 31 randomly selected patients (34%) completed the Persian OES again after three days while abstaining from all forms of therapeutic regimens. Reliability of the Persian OES was assessed by measuring intraclass correlation coefficient (ICC) for test-retest reliability and Cronbach's alpha for internal consistency. Spearman's correlation coefficient was used to test the construct validity. Cronbach's alpha coefficient was 0.92 showing excellent reliability. Cronbach's alpha for function, pain, and social-psychological subscales was 0.95, 0.86, and 0.85, respectively. Intraclass correlation coefficient (ICC) was 0.85 for the overall questionnaire and 0.90, 0.76, and 0.75 for function, pain, and social-psychological subscales, respectively. Construct validity was confirmed as the Spearman correlation between OES and DASH was 0.80. Persian OES is a valid and reliable patient-reported outcome measure to assess postsurgical elbow status in Persian speaking population

6G Positioning and Sensing Through the Lens of Sustainability, Inclusiveness, and Trustworthiness

6G promises a paradigm shift in which positioning and sensing are inherently integrated, enhancing not only the communication performance but also enabling location- and context-aware services. Historically, positioning and sensing have been viewed through the lens of cost and performance trade-offs, implying an escalated demand for resources, such as radio, physical, and computational resources, for improved performance. However, 6G goes beyond this traditional perspective to encompass a set of broader values, namely sustainability, inclusiveness, and trustworthiness. This paper aims to: (i) shed light on these important value indicators and their relationship with the conventional key performance indicators, and (ii) unveil the dual nature of 6G in relation to these key value indicators (i.e., ensuring operation according to the values and enabling services that affect the values)

Loop diagrams in space with SU(2) fuzziness

The structure of loop corrections is examined in a scalar field theory on a three dimensional space whose spatial coordinates are noncommutative and satisfy SU(2) Lie algebra. In particular, the 2- and 4-point functions in $\phi^4$ scalar theory are calculated at the 1-loop order. The theory is UV-finite as the momentum space is compact. It is shown that the non-planar corrections are proportional to a one dimensional $\delta$-function, rather than a three dimensional one, so that in transition rates only the planar corrections contribute.Comment: v1: 12 pages, LaTeX, submitted PLB, v2: missing 2\pi is restored in 4-point function; last paragraph improve

Prevalence of helminth parasites in digestive tract of Persian sturgeon (Acipenser persicus) broodstocks southeast of the Caspian Sea

We collected 100 specimens of Persian sturgeon brood stocks propagated in Shahid Marjani Fish Culture Center to study internal parasites during March, April and May 2005. The center is located in the southeast of the Caspian Sea. Three different parasite species were recovered from digestive tract (stomach and intestine) of the fish. Cucullanus sphaerocephalus, Skrjabinopsolus semiarmatus showed the highest incidence and highest mean intensity (with prevalence of 80% and 55% respectively) but Leptorhynchoides plagicephalus had the lower prevalene 2 %. The prevalence of S. semiarmatus and C. sphaerocephalus were higher in males than in females whereas the intensity of these parasites was higher in females than in males. Statistical analysis of data showed a significant relationship between the occurrence of S. semiarmatus and the sex of the fish. There was a significant relationship between the occurrence of C. sphaerocephalus and the length of the fish (P 6 0.05). Forty nine percent of the fish had less than 10 worms. It was also found that the internal parasites of A. persicus in the southeast of the Caspian Sea are the same as those found in the southwest but the diversity of parasites were fewer in the former

Quantum mechanics on space with SU(2) fuzziness

Quantum mechanics of models is considered which are constructed in spaces with Lie algebra type commutation relations between spatial coordinates. The case is specialized to that of the group SU(2), for which the formulation of the problem via the Euler parameterization is also presented. SU(2)-invariant systems are discussed, and the corresponding eigenvalue problem for the Hamiltonian is reduced to an ordinary differential equation, as it is the case with such models on commutative spaces.Comment: 12 pages, no figs, LaTe

Dual-Polarized Highly Folded Bowtie Antenna with Slotted Self-Grounded Structure for Sub-6 GHz 5G Applications

In this paper, a novel dual-polarized highly-folded self-grounded Bowtie antenna that is excited through I-shaped slots is proposed for applications in sub-6GHz 5G multiple-input-multiple-output (MIMO) antenna systems. The antenna consists of two pairs of folded radiation petals whose base is embedded in a double layer of FR-4 substrate with a common ground-plane which is sandwiched between the two substrate layers. The ground-plane is defected with two I-shaped slots located under the radiation elements. Each pair of radiation elements are excited through a microstrip line on the top layer with RF signal that is 180° out of phase with respect to each other. The RF signal is coupled to the pair of feedlines on the top layer through the I-shaped slots from the two microstrip feedlines on the underside of the second substrate. The proposed feed mechanism gets rid of the otherwise bulky balun. The Bowtie antenna is a compact solution with dimensions of 32×32×33.8 mm3. Measured results have verified that the antenna operates over a frequency range of 3.1–5 GHz and exhibits an average gain and antenna efficiency in the vertical and horizontal polarizations of 7.5 dBi and 82.6%, respectively

Mortality and disability-adjusted life years in North Africa and Middle East attributed to kidney dysfunction : a systematic analysis for the Global Burden of Disease Study 2019

The authors would like to thank the hard work of the staff of the Institute for Health Metrics and Evaluation (IHME) for providing the best possible epidemiologic estimation of diseases in almost all regions and countries of the world, trying to reduce and eliminate poverty of knowledge and information about the diseases globally. Also, the core team authors sincerely thank all the collaborators of the GBD 2019 study who contributed to this study by providing data or a precise review of the manuscript. Publisher Copyright: © The Author(s) 2023. Published by Oxford University Press on behalf of the ERA. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.Peer reviewe

Quasi-free limit in the deuteron-deuteron three-body break-up process

Detailed measurements of vector and tensor analyzing powers of the 2H(~d, dp)n breakup process are presented. The data were obtained using a polarized deuteron-beam with an energy of 65 MeV/nucleon impinging on a liquid-deuterium target. The experiment was conducted at the AGOR facility at KVI using the BINA 4 -detection system. The focus of this contribution is to analyze data of the dd scattering process in the regime at which the neutron acts as a spectator, which we refer to as the quasi-free (QF) limit. To achieve this, events for which the final-state deuteron and proton are coplanar have been analyzed and the data have been sorted for various reconstructed momenta of the missing neutron. In the limit of vanishing neutron momentum and at small deuteron-proton momentum transfer, the data match very well with measured and predicted spin observables of the elastic deuteron-proton scattering process. The agreement deteriorates rapidly with increasing neutron momentum and deuteron-proton momentum transfer. The results of coplanar configurations in four-body phase space are compared with the results of recent available theoretical calculations based on the Single-Scattering Approximation