Innovation policy in the Norwegian aquaculture industry: Reshaping aquaculture production innovation networks

While aquaculture production in a number of countries has been highly successful in terms of production growth, there is also a number of instances where the rapid growth has been curtailed due to sustainability challenges. In response, fostering sustainable aquaculture production has become a key policy and research agenda. The point of departure for this paper is the radical technological innovations based sustainable restructuring dynamics of the Norwegian salmon farming industry, which despite becoming one of the most profitable aquaculture industries in the world, has in recent years seen its growth curtailed due to sustainability challenges. To address these challenges and to enable the use of new areas currently inaccessible by the incumbent aquaculture technology, the Norwegian authorities launched in 2015 a new type of innovation policy instrument, known as development licences. Based on a mapping of the aquaculture production technology development projects as well as in-depth interviews, this paper elucidates how the targeted innovation policy instrument has instigated the sustainable restructuring process of the Norwegian aquaculture industry. Our findings indicate that in the short term, the innovation policy appears to have succeeded in the reconfiguration, and more precisely, the ’renewal’ process of the aquaculture production technology innovation networks (ecosystems) thanks to the entry of the new capable actors into the segment. However, we emphasise that the overall success of the innovation policy instrument will ultimately hinge upon sufficiently addressing certain aspects of the institutional failures in the sector.Innovation policy in the Norwegian aquaculture industry: Reshaping aquaculture production innovation networkspublishedVersio

Sjømatnæringen og Covid-19 - Tiltak, strategier, muligheter og utfordringer

I mars 2020 erklærte Verdens helseorganisasjon (WHO) at Covid-19 var en pandemi og den norske regjeringen innførte en nasjonal nedstenging av samfunnet. Denne rapporten presenterer en studie av konsekvenser av korona for den norske sjømatnæringen, tiltak og strategier, muligheter og utfordringer. Intervju med aktører i næringen synligjør at det var viktig at næringen ble definert som samfunnskritisk og at forum dialog mellom myndigheter og næring ble etablert tidlig. Samtidig traff tiltak knyttet til stengte grenser havbruk og hvitfisksektoren ulikt. Rapporten gir kunnskap som kan være verdifull for fremtidig krisehåndtering i næringen.publishedVersio

Phosphatase of regenerating liver-3 regulates cancer cell metabolism in multiple myeloma

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Functional studies on transfected cell microarray analysed by linear regression modelling

Transfected cell microarray is a promising method for accelerating the functional exploration of the genome, giving information about protein function in the living cell. The microarrays consist of clusters of cells (spots) overexpressing or silencing a particular gene product. The subsequent analysis of the phenotypic consequences of such perturbations can then be detected using cell-based assays. The focus in the present study was to establish an experimental design and a robust analysis approach for fluorescence intensity data, and to address the use of replicates for studying regulation of gene expression with varying complexity and effect size. Our analysis pipeline includes measurement of fluorescence intensities, normalization strategies using negative control spots and internal control plasmids, and linear regression (ANOVA) modelling for estimating biological effects and calculating P-values for comparisons of interests. Our results show the potential of transfected cell microarrays in studying complex regulation of gene expression by enabling measurement of biological responses in cells with overexpression and downregulation of specific gene products, combined with the possibility of assaying the effects of external stimuli. Simulation experiments show that transfected cell microarrays can be used to reliably detect even quantitatively minor biological effects by including several technical and experimental replicates

Product forms and price transmission in major European salmon markets

Product development is often an important component in increasing demand for successful aquaculture species. However, this topic has not received much attention due to limited data availability. In this paper, we investigate how the composition of salmon sales differ by product form by comparing the four largest European countries in terms of salmon consumption: France, Germany, Spain and the United Kingdom. The composition of salmon products varies significantly across countries, with unprocessed products dominating in Spain and highly processed products being the most important in the United Kingdom. We also find a high degree of price transmission for the less processed consumer products in all markets, while the price transmission is zero for most highly processed products. This is important since it implies that the more processed consumer products are largely are insulated from the high price volatility of salmon at the producer level

Cytotoxic Effect on Human Myeloma Cells and Leukemic Cells by the Agaricus blazei Murill Based Mushroom Extract, Andosan™

Agaricus blazei Murill is an edible mushroom of the Basidiomycetes family, which has been found to contain a number of compounds with antitumor properties, such as proteoglycans and ergosterol. In the present investigation, we show that the commercial mushroom product Andosan, which contains 82.4% Agaricus blazei Murill, together with medicinal mushrooms Hericium erinaceus (14.7%) and Grifola frondosa (2.9%), has a cytotoxic effect on primary myeloma cells, other myeloma cell lines, and leukemia cell lines in vitro. Although the exact content and hence the mechanisms of action of the Andosan extract are unknown, we have found in this investigation indications of cell cycle arrest when myeloma cell lines are cultivated with Andosan. This may be one of the possible explanations for the cytotoxic effects of Andosan

The natural compound forskolin synergizes with dexamethasone to induce cell death in myeloma cells via BIM

We have previously demonstrated that activation of the cyclic adenosine monophosphate (cAMP) pathway kills multiple myeloma (MM) cells both in vitro and in vivo. In the present study we have investigated the potential of enhancing the killing of MM cell lines and primary MM cells by combining the cAMP-elevating compound forskolin with the commonly used MM therapeutic drugs melphalan, cyclophosphamide, doxorubicin, bortezomib and dexamethasone. We observed that forskolin potentiated the killing induced by all the tested agents as compared to treatment with the single agents alone. In particular, forskolin had a synergistic effect on the dexamethasone-responsive cell lines H929 and OM-2. By knocking down the proapoptotic BCL-2 family member BIM, we proved this protein to be involved in the synergistic induction of apoptosis by dexamethasone and forskolin. The ability of forskolin to maintain the killing of MM cells even at lower concentrations of the conventional agents suggests that forskolin may be used to diminish treatment-associated side effects. Our findings support a potential role of forskolin in combination with current conventional agents in the treatment of MM

The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells

<p>Accumulation and aggregation of misfolded proteins is a hallmark of several diseases collectively known as proteinopathies. Autophagy has a cytoprotective role in diseases associated with protein aggregates. Age-related macular degeneration (AMD) is the most common neurodegenerative eye disease that evokes blindness in elderly. AMD is characterized by degeneration of retinal pigment epithelial (RPE) cells and leads to loss of photoreceptor cells and central vision. The initial phase associates with accumulation of intracellular lipofuscin and extracellular deposits called drusen. Epidemiological studies have suggested an inverse correlation between dietary intake of marine n-3 polyunsaturated fatty acids (PUFAs) and the risk of developing neurodegenerative diseases, including AMD. However, the disease-preventive mechanism(s) mobilized by n-3 PUFAs is not completely understood. In human retinal pigment epithelial cells we find that physiologically relevant doses of the n-3 PUFA docosahexaenoic acid (DHA) induce a transient increase in cellular reactive oxygen species (ROS) levels that activates the oxidative stress response regulator NFE2L2/NRF2 (nuclear factor, erythroid derived 2, like 2). Simultaneously, there is a transient increase in intracellular protein aggregates containing SQSTM1/p62 (sequestosome 1) and an increase in autophagy. Pretreatment with DHA rescues the cells from cell cycle arrest induced by misfolded proteins or oxidative stress. Cells with a downregulated oxidative stress response, or autophagy, respond with reduced cell growth and survival after DHA supplementation. These results suggest that DHA both induces endogenous antioxidants and mobilizes selective autophagy of misfolded proteins. Both mechanisms could be relevant to reduce the risk of developing aggregate-associate diseases such as AMD.</p

MYC amplifications in myeloma cell lines; correlation with MYC-inhibitor efficacy

In multiple myeloma, elevated MYC expression is related to disease initiation and progression. We found that in myeloma cell lines, MYC gene amplifications were common and correlated with MYC mRNA and protein. In primary cell samples MYC mRNA levels were also relatively high; however gene copy number alterations were uncommon. Elevated levels of MYC in primary myeloma cells have been reported to arise from complex genetic aberrations and are more common than previously thought. Thus, elevated MYC expression is achieved differently in myeloma cell lines and primary cells. Sensitivity of myeloma cell lines to the MYC inhibitor 10058-F4 correlated with MYC expression, supporting that the activity of 10058-F4 was through specific inhibition of MYC.Copyright @ 2008-2015 Impact Journals, LLC. All rights reserved. Impact Journals is a trademark of Impact Journals, LLC . All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License