Is speech the new blood? Recent progress in AI-based disease detection from audio in a nutshell

In recent years, advancements in the field of artificial intelligence (AI) have impacted several areas of research and application. Besides more prominent examples like self-driving cars or media consumption algorithms, AI-based systems have further started to gain more and more popularity in the health care sector, however whilst being restrained by high requirements for accuracy, robustness, and explainability. Health-oriented AI research as a sub-field of digital health investigates a plethora of human-centered modalities. In this article, we address recent advances in the so far understudied but highly promising audio domain with a particular focus on speech data and present corresponding state-of-the-art technologies. Moreover, we give an excerpt of recent studies on the automatic audio-based detection of diseases ranging from acute and chronic respiratory diseases via psychiatric disorders to developmental disorders and neurodegenerative disorders. Our selection of presented literature shows that the recent success of deep learning methods in other fields of AI also more and more translates to the field of digital health, albeit expert-designed feature extractors and classical ML methodologies are still prominently used. Limiting factors, especially for speech-based disease detection systems, are related to the amount and diversity of available data, e. g., the number of patients and healthy controls as well as the underlying distribution of age, languages, and cultures. Finally, we contextualize and outline application scenarios of speech-based disease detection systems as supportive tools for health-care professionals under ethical consideration of privacy protection and faulty prediction

Bringing the Discussion of Minima Sharpness to the Audio Domain: a Filter-Normalised Evaluation for Acoustic Scene Classification

The correlation between the sharpness of loss minima and generalisation in the context of deep neural networks has been subject to discussion for a long time. Whilst mostly investigated in the context of selected benchmark data sets in the area of computer vision, we explore this aspect for the audio scene classification task of the DCASE2020 challenge data. Our analysis is based on twodimensional filter-normalised visualisations and a derived sharpness measure. Our exploratory analysis shows that sharper minima tend to show better generalisation than flat minima -even more so for out-of-domain data, recorded from previously unseen devices-, thus adding to the dispute about better generalisation capabilities of flat minima. We further find that, in particular, the choice of optimisers is a main driver of the sharpness of minima and we discuss resulting limitations with respect to comparability. Our code, trained model states and loss landscape visualisations are publicly available.Comment: This work has been submitted to the IEEE for possible publicatio

Evaluating the impact of voice activity detection on speech emotion recognition for autistic children

Individuals with autism are known to face challenges with emotion regulation, and express their affective states in a variety of ways. With this in mind, an increasing amount of research on automatic affect recognition from speech and other modalities has recently been presented to assist and provide support, as well as to improve understanding of autistic individuals' behaviours. As well as the emotion expressed from the voice, for autistic children the dynamics of verbal speech can be inconsistent and vary greatly amongst individuals. The current contribution outlines a voice activity detection (VAD) system specifically adapted to autistic children's vocalisations. The presented VAD system is a recurrent neural network (RNN) with long short-term memory (LSTM) cells. It is trained on 130 acoustic Low-Level Descriptors (LLDs) extracted from more than 17 h of audio recordings, which were richly annotated by experts in terms of perceived emotion as well as occurrence and type of vocalisations. The data consist of 25 English-speaking autistic children undertaking a structured, partly robot-assisted emotion-training activity and was collected as part of the DE-ENIGMA project. The VAD system is further utilised as a preprocessing step for a continuous speech emotion recognition (SER) task aiming to minimise the effects of potential confounding information, such as noise, silence, or non-child vocalisation. Its impact on the SER performance is compared to the impact of other VAD systems, including a general VAD system trained from the same data set, an out-of-the-box Web Real-Time Communication (WebRTC) VAD system, as well as the expert annotations. Our experiments show that the child VAD system achieves a lower performance than our general VAD system, trained under identical conditions, as we obtain receiver operating characteristic area under the curve (ROC-AUC) metrics of 0.662 and 0.850, respectively. The SER results show varying performances across valence and arousal depending on the utilised VAD system with a maximum concordance correlation coefficient (CCC) of 0.263 and a minimum root mean square error (RMSE) of 0.107. Although the performance of the SER models is generally low, the child VAD system can lead to slightly improved results compared to other VAD systems and in particular the VAD-less baseline, supporting the hypothesised importance of child VAD systems in the discussed context

Personalised depression forecasting using mobile sensor data and ecological momentary assessment

Introduction Digital health interventions are an effective way to treat depression, but it is still largely unclear how patients’ individual symptoms evolve dynamically during such treatments. Data-driven forecasts of depressive symptoms would allow to greatly improve the personalisation of treatments. In current forecasting approaches, models are often trained on an entire population, resulting in a general model that works overall, but does not translate well to each individual in clinically heterogeneous, real-world populations. Model fairness across patient subgroups is also frequently overlooked. Personalised models tailored to the individual patient may therefore be promising. Methods We investigate different personalisation strategies using transfer learning, subgroup models, as well as subject-dependent standardisation on a newly-collected, longitudinal dataset of depression patients undergoing treatment with a digital intervention (N=65 patients recruited). Both passive mobile sensor data as well as ecological momentary assessments were available for modelling. We evaluated the models’ ability to predict symptoms of depression (Patient Health Questionnaire-2; PHQ-2) at the end of each day, and to forecast symptoms of the next day. Results In our experiments, we achieve a best mean-absolute-error (MAE) of 0.801 (25% improvement) for predicting PHQ-2 values at the end of the day with subject-dependent standardisation compared to a non-personalised baseline (MAE=1.062). For one day ahead-forecasting, we can improve the baseline of 1.539 by 12% to a MAE of 1.349 using a transfer learning approach with shared common layers. In addition, personalisation leads to fairer models at group-level. Discussion Our results suggest that personalisation using subject-dependent standardisation and transfer learning can improve predictions and forecasts, respectively, of depressive symptoms in participants of a digital depression intervention. We discuss technical and clinical limitations of this approach, avenues for future investigations, and how personalised machine learning architectures may be implemented to improve existing digital interventions for depression

Synchronization in interpersonal speech

Abstract: During both positive and negative dyadic exchanges, individuals will often unconsciously imitate their partner. A substantial amount of research has been made on this phenomenon, and such studies have shown that synchronization between communication partners can improve interpersonal relationships. Automatic computational approaches for recognizing synchrony are still in their infancy. In this study, we extend on previous work in which we applied a novel method utilizing hand-crafted low-level acoustic descriptors and autoencoders (AEs) to analyse synchrony in the speech domain. For this purpose, a database consisting of 394 in-the-wild speakers from six different cultures, is used. For each speaker in the dyadic exchange, two AEs are implemented. Post the training phase, the acoustic features for one of the speakers is tested using the AE trained on their dyadic partner. In this same way, we also explore the benefits that deep representations from audio may have, implementing the state-of-the-art Deep Spectrum toolkit. For all speakers at varied time-points during their interaction, the calculation of reconstruction error from the AE trained on their respective dyadic partner is made. The results obtained from this acoustic analysis are then compared with the linguistic experiments based on word counts and word embeddings generated by our word2vec approach. The results demonstrate that there is a degree of synchrony during all interactions. We also find that, this degree varies across the 6 cultures found in the investigated database. These findings are further substantiated through the use of 4,096 dimensional Deep Spectrum features.Received funding from : Bavarian State Ministry of Education, Science and the Arts in the framework of the Centre Digitisation.Bavaria (ZD.B