1,721 research outputs found
Understanding the effects of time perspective: A meta-analysis testing a self-regulatory framework
Despite extensive evidence that time perspective is associated with a range of important outcomes across a variety of life domains (e.g., health, education, wealth), the question of why time perspective has such wide-reaching effects remains unknown. The present review proposes that self-regulatory processes can offer insight into why time perspective is linked to outcomes. To test this idea we classified measures of time perspective according to the dimension of time perspective that they reflected (e.g., past, present-hedonistic, future) and measures of self-regulation according to the self-regulatory process (i.e., goal setting, goal monitoring, and goal operating), ability, or outcome that they reflected. A systematic search identified 378 studies, reporting 2,000 tests of the associations between measures of time perspective and self-regulation. Random-effects meta-analyses with robust variance estimation found that a future time perspective had small-to-medium-sized positive associations with goal setting (r+ = 0.25), goal monitoring (r+ = 0.19), goal operating (r+ = 0.24), self-regulatory ability (r+ = 0.35), and outcomes (r+ = 0.18). Present time perspective, including being present-hedonistic and present-fatalistic, was negatively associated with self-regulatory processes, ability, and outcomes (r+ ranged from −0.00 to −0.27). Meta-analytic mediation models found that the relationship between future time perspective and outcomes was mediated by goal monitoring, goal operating, and self-regulatory ability, but not goal setting. As the first test of why time perspective is associated with key outcomes, the findings highlight the central role of self-regulation processes and abilities for understanding why people with certain time perspectives experience better outcomes
A Formulation of Noether's Theorem for Fractional Problems of the Calculus of Variations
Fractional (or non-integer) differentiation is an important concept both from
theoretical and applicational points of view. The study of problems of the
calculus of variations with fractional derivatives is a rather recent subject,
the main result being the fractional necessary optimality condition of
Euler-Lagrange obtained in 2002. Here we use the notion of Euler-Lagrange
fractional extremal to prove a Noether-type theorem. For that we propose a
generalization of the classical concept of conservation law, introducing an
appropriate fractional operator.Comment: Accepted for publication in the Journal of Mathematical Analysis and
Application
The Self Model and the Conception of Biological Identity in Immunology
The self/non-self model, first proposed by F.M. Burnet, has dominated immunology for sixty years now. According to this model, any foreign element will trigger an immune reaction in an organism, whereas endogenous elements will not, in normal circumstances, induce an immune reaction. In this paper we show that the self/non-self model is no longer an appropriate explanation of experimental data in immunology, and that this inadequacy may be rooted in an excessively strong metaphysical conception of biological identity. We suggest that another hypothesis, one based on the notion of continuity, gives a better account of immune phenomena. Finally, we underscore the mapping between this metaphysical deflation from self to continuity in immunology and the philosophical debate between substantialism and empiricism about identity
Lymph node topology dictates T cell migration behavior
Adaptive immunity is initiated by T cell recognition of foreign peptides presented on dendritic cells (DCs) by major histocompatibility molecules. These interactions take place in secondary lymphoid tissues, such as lymph nodes (LNs) and spleen, and hence the anatomical structure of these tissues plays a crucial role in the development of immune responses. Two-photon microscopy (2PM) imaging in LNs suggests that T cells walk in a consistent direction for several minutes, pause briefly with a regular period, and then take off in a new, random direction. Here, we construct a spatially explicit model of T cell and DC migration in LNs and show that all dynamical properties of T cells could be a consequence of the densely packed LN environment. By means of 2PM experiments, we confirm that the large velocity fluctuations of T cells are indeed environmentally determined rather than resulting from an intrinsic motility program. Our simulations further predict that T cells self-organize into microscopically small, highly dynamic streams. We present experimental evidence for the presence of such turbulent streams in LNs. Finally, the model allows us to estimate the scanning rates of DCs (2,000 different T cells per hour) and T cells (100 different DCs per hour)
Necessary and sufficient conditions for the fractional calculus of variations with Caputo derivatives
We prove optimality conditions for different variational functionals
containing left and right Caputo fractional derivatives. A sufficient condition
of minimization under an appropriate convexity assumption is given. An
Euler-Lagrange equation for functionals where the lower and upper bounds of the
integral are distinct of the bounds of the Caputo derivative is also proved.
Then, the fractional isoperimetric problem is formulated with an integral
constraint also containing Caputo derivatives. Normal and abnormal extremals
are considered.Comment: Submitted 6/March/2010 to Communications in Nonlinear Science and
Numerical Simulation; revised 12/July/2010; accepted for publication
16/July/201
Towards the Thermodynamics of Localization Processes
We study the entropy time evolution of a quantum mechanical model, which is
frequently used as a prototype for Anderson's localization. Recently Latora and
Baranger [V. Latora, M. Baranger, Phys. Rev.Lett. 82, 520(1999)] found that
there exist three entropy regimes, a transient regime of passage from dynamics
to thermodynamics, a linear in time regime of entropy increase, namely a
thermodynamic regime of Kolmogorov kind, and a saturation regime. We use the
non-extensive entropic indicator recently advocated by Tsallis [ C. Tsallis, J.
Stat. Phys. 52, 479 (1988)] with a mobile entropic index q, and we find that
with the adoption of the ``magic'' value q = Q = 1/2 the Kolmogorov regime
becomes more extended and more distinct than with the traditional entropic
index q = 1. We adopt a two-site model to explain these properties by means of
an analytical treatment and we argue that Q =1/2 might be a typical signature
of the occurrence of Anderson's localization.Comment: 13 pages, 8 figures submitted to Phys. Rev.
Isoperimetric problems of the calculus of variations with fractional derivatives
In this paper we study isoperimetric problems of the calculus of variations
with left and right Riemann-Liouville fractional derivatives. Both situations
when the lower bound of the variational integrals coincide and do not coincide
with the lower bound of the fractional derivatives are considered.Comment: Submitted 02-Oct-2009; revised 30-Jun-2010; accepted 10-May-2011; for
publication in the journal Acta Mathematica Scienti
Triple oxygen isotopic composition of the high-<sup>3</sup>He/<sup>4</sup>He mantle
Measurements of Xe isotope ratios in ocean island basalts (OIB) suggest that Earth’s mantle accreted heterogeneously, and that compositional remnants of accretion are sampled by modern, high-3He/4He OIB associated with the Icelandic and Samoan plumes. If so, the high-3He/4He source may also have a distinct oxygen isotopic composition from the rest of the mantle. Here, we test if the major elements of the high-3He/4He source preserve any evidence of heterogeneous accretion using measurements of three oxygen isotopes on olivine from a variety of high-3He/4He OIB locations. To high precision, the Δ17O value of high-3He/4He olivines from Hawaii, Pitcairn, Baffin Island and Samoa, are indistinguishable from bulk mantle olivine (Δ17OBulk Mantle − Δ17OHigh 3He/4He olivine = −0.002 ± 0.004 (2 × SEM)‰). Thus, there is no resolvable oxygen isotope evidence for heterogeneous accretion in the high-3He/4He source. Modelling of mixing processes indicates that if an early-forming, oxygen-isotope distinct mantle did exist, either the anomaly was extremely small, or the anomaly was homogenised away by later mantle convection.
The δ18O values of olivine with the highest 3He/4He ratios from a variety of OIB locations have a relatively uniform composition (∼5‰). This composition is intermediate to values associated with the depleted MORB mantle and the average mantle. Similarly, δ18O values of olivine from high-3He/4He OIB correlate with radiogenic isotope ratios of He, Sr, and Nd. Combined, this suggests that magmatic oxygen is sourced from the same mantle as other, more incompatible elements and that the intermediate δ18O value is a feature of the high-3He/4He mantle source. The processes responsible for the δ18O signature of high-3He/4He mantle are not certain, but δ18O–87Sr/86Sr correlations indicate that it may be connected to a predominance of a HIMU-like (high U/Pb) component or other moderate δ18O components recycled into the high-3He/4He source
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