Exploring the future of tourism and quality of life

Few studies to date have examined the impact of tourism on quality of life (QoL) as conventional research has tended to focus, instead, on resident attitudes towards tourism and tourism ’s impacts in particular (Smith, 1977; 1989). Even less research has addressed whether tourism can drive or facilitate sustainable development (Miller and Twining-Ward, 2005) or whether tourism can contribute to the subjective wellbeing of those involved in travel and tourism. Impact studies generally ask residents to agree or disagree with statements regarding perceived impacts from tourism on their community. By contrast, QoL research aims to understand how these impacts are internalised and influence an individual’s overall life satisfaction (Andereck et al, 2007). With terms used interchangeably QoL, happiness and well-being refer to one’s satisfaction with life, and feelings of contentment or fulfilment with one’s experiences in the world (ibid.). Whether tourism as phenomena and practice may support the growing body of evidence that demonstrates a positive relationship between existential factors such as life purpose / meaning, personal growth and wellbeing (Vella-Brodrick, 2007) was the topic of intense debate during the 2008 Business Enterprises for Sustainable Travel Education Network (BEST EN) Think Tank VIII

Total plasma magnesium, zinc, copper and selenium concentrations in obese patients before and after bariatric surgery

Funding: This work was supported by the British Heart Foundation (grant code: FS/20/3/34956).Obesity enhances the risk of type-2 diabetes, cardiovascular disease and inflammatory conditions and often leads to metal dyshomeostasis, which contributes to the negative health aspects associated with the disease. In severe cases, bariatric surgery can be recommended to achieve sustained weight loss and improvement in health. Here, magnesium, zinc, copper and selenium concentrations were examined in 24 obese patients (7 males; 17 females) before and 9 months after undergoing Roux-en-Y gastric bypass surgery. All patients lost weight over this period, with the mean BMI reducing from 51.2±7.1 kg/m2 to 37.2±5.5 kg/m2. Moreover, whole-blood glycated haemoglobin (HbA1c), as a marker of average glycaemia, was also measured and a correlative analysis of this parameter with metal concentrations performed. Significant alterations in the plasma concentrations of magnesium, zinc (both increased by 13.2% and 25.2% respectively) and copper (decreased by 7.9%) were observed over this period (plasma selenium concentration was unchanged), with BMI values correlating with plasma magnesium (p=0.004) and zinc (p=0.022) concentrations. At 9 months post-surgery, an increase in mean zinc/copper ratio was observed (0.86±0.29 compared to 0.63±0.14 pre-surgery). Comparison of whole-blood HbA1c concentrations pre- and post-surgery revealed a reduction from 6.50±1.28% pre-surgery to 5.51±0.49% post-surgery. Differences in plasma HbA1c and magnesium at either pre- and post-surgery correlated significantly, as did HbA1c and magnesium levels when pre- and post-surgery values were analysed together. Collectively, this work reveals that bariatric surgery, in conjunction with lifestyle/dietary changes, lead to improvements in the nutritional status of magnesium, zinc and copper. Furthermore, the observed improvements in magnesium and zinc were associated with weight loss and in the case of magnesium, to better glycaemic control.Publisher PDFPeer reviewe

A Millimeter-Wave Galactic Plane Survey With The BICEP Polarimeter

In addition to its potential to probe the Inflationary cosmological paradigm, millimeter-wave polarimetry is a powerful tool for studying the Milky Way galaxy's composition and magnetic field structure. Towards this end, presented here are Stokes I, Q, and U maps of the Galactic plane from the millimeter-wave polarimeter BICEP covering the Galactic longitude range 260 - 340 degrees in three atmospheric transmission windows centered on 100, 150, and 220 GHz. The maps sample an optical depth 1 < AV < 30, and are consistent with previous characterizations of the Galactic millimeter-wave frequency spectrum and the large-scale magnetic field structure permeating the interstellar medium. Polarized emission is detected over the entire region within two degrees of the Galactic plane and indicates that the large-scale magnetic field is oriented parallel to the plane of the Galaxy. An observed trend of decreasing polarization fraction with increasing total intensity rules out the simplest model of a constant Galactic magnetic field throughout the Galaxy. Including WMAP data in the analysis, the degree-scale frequency spectrum of Galactic polarization fraction is plotted between 23 and 220 GHz for the first time. A generally increasing trend of polarization fraction with electromagnetic frequency is found, which varies from 0.5%-1.5%at frequencies below 50 GHz to 2.5%-3.5%above 90 GHz. The BICEP and WMAP data are fit to a two-component (synchrotron and dust) model showing that the higher frequency BICEP data are necessary to tightly constrain the amplitude and spectral index of Galactic dust. Furthermore, the dust amplitude predicted by this two-component fit is consistent with model predictions of dust emission in the BICEP bands

Stellar Half-Mass Radii of 0.5<z<2.30.5<z<2.3 Galaxies: Comparison with JWST/NIRCam Half-Light Radii

We use CEERS JWST/NIRCam imaging to measure rest-frame near-IR light profiles of $>$500 $M_\star>10^{10}~M_\odot$ galaxies in the redshift range $0.5<z<2.3$. We compare the resulting rest-frame 1.5-2$\mu$m half-light radii ($R_{\rm{NIR}}$) with stellar half-mass radii (\rmass) derived with multi-color light profiles from CANDELS HST imaging. In general agreement with previous work, we find that $R_{\rm{NIR}}$ and \rmass~are up to 40\%~smaller than the rest-frame optical half-light radius $R_{\rm{opt}}$. The agreement between $R_{\rm{NIR}}$ and \rmass~is excellent, with negligible systematic offset ($<$0.03 dex) up to $z=2$ for quiescent galaxies and up to $z=1.5$ for star-forming galaxies. We also deproject the profiles to estimate \rmassd, the radius of a sphere containing 50\% of the stellar mass. We present the $R-M_\star$ distribution of galaxies at $0.5<z<1.5$, comparing $R_{\rm{opt}}$, \rmass~and \rmassd. The slope is significantly flatter for \rmass~and \rmassd~ compared to $R_{\rm{opt}}$, mostly due to downward shifts in size for massive star-forming galaxies, while \rmass~and \rmassd~do not show markedly different trends. Finally, we show rapid size evolution ($R\propto (1+z)^{-1.7\pm0.1}$) for massive ($M_\star>10^{11}~M_\odot$) quiescent galaxies between $z=0.5$ and $z=2.3$, again comparing $R_{\rm{opt}}$, \rmass~and \rmassd. We conclude that the main tenets of the size evolution narrative established over the past 20 years, based on rest-frame optical light profile analysis, still hold in the era of JWST/NIRCam observations in the rest-frame near-IR.Comment: Submitted to ApJ. Comments welcom

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML

Leukemia stem cells (LSCs) have the capacity to self-renew and propagate disease upon serial transplantation in animal models, and elimination of this cell population is required for curative therapies. Here, we describe a series of pooled, in vivo RNAi screens to identify essential transcription factors (TFs) in a murine model of acute myeloid leukemia (AML) with genetically and phenotypically defined LSCs. These screens reveal the heterodimeric, circadian rhythm TFs Clock and Bmal1 as genes required for the growth of AML cells in vitro and in vivo. Disruption of canonical circadian pathway components produces anti-leukemic effects, including impaired proliferation, enhanced myeloid differentiation, and depletion of LSCs. We find that both normal and malignant hematopoietic cells harbor an intact clock with robust circadian oscillations, and genetic knockout models reveal a leukemia-specific dependence on the pathway. Our findings establish a role for the core circadian clock genes in AML.National Institutes of Health (U.S.) (Grant P01 CA066996)National Institutes of Health (U.S.) (Grant R01 HL082945)National Cancer Institute (U.S.) (Grant P30-CA14051

Convective and Wave Signatures in Ozone Profiles Over the Equatorial Americas: Views from TC4 (2007) and SHADOZ

During the months of July-August 2007 NASA conducted a research campaign called the Tropical Composition, Clouds and Climate Coupling (TC4) experiment. Vertical profiles of ozone were measured daily using an instrument known as an ozonesonde, which is attached to a weather balloon and launch to altitudes in excess of 30 km. These ozone profiles were measured over coastal Las Tablas, Panama (7.8N, 80W) and several times per week at Alajuela, Costa Rica (ION, 84W). Meteorological systems in the form of waves, detected most prominently in 100- 300 in thick ozone layer in the tropical tropopause layer, occurred in 50% (Las Tablas) and 40% (Alajuela) of the soundings. These layers, associated with vertical displacements and classified as gravity waves ("GW," possibly Kelvin waves), occur with similar stricture and frequency over the Paramaribo (5.8N, 55W) and San Cristobal (0.925, 90W) sites of the Southern Hemisphere Additional Ozonesondes (SHADOZ) network. The gravity wave labeled layers in individual soundings correspond to cloud outflow as indicated by the tracers measured from the NASA DC-8 and other aircraft data, confirming convective initiation of equatorial waves. Layers representing quasi-horizontal displacements, referred to as Rossby waves, are robust features in soundings from 23 July to 5 August. The features associated with Rossby waves correspond to extra-tropical influence, possibly stratospheric, and sometimes to pollution transport. Comparison of Las Tablas and Alajuela ozone budgets with 1999-2007 Paramaribo and San Cristobal soundings shows that TC4 is typical of climatology for the equatorial Americas. Overall during TC4, convection and associated meteorological waves appear to dominate ozone transport in the tropical tropopause layer

Azimuthal Angle Correlations for Rapidity Separated Hadron Pairs in d+Au Collisions at sqrt(s_NN) = 200 GeV

We report on two-particle azimuthal angle correlations between charged hadrons at forward/backward (deuteron/gold going direction) rapidity and charged hadrons at mid-rapidity in deuteron-gold (d+Au) and proton-proton (p+p) collisions at sqrt(s_NN) = 200 GeV. Jet structures are observed in the correlations which we quantify in terms of the conditional yield and angular width of away side partners. The kinematic region studied here samples partons in the gold nucleus carrying nucleon momentum fraction x~0.1 to x~0.01. Within this range, we find no x dependence of the jet structure in d+Au collisions.Comment: 330 authors, 6 pages text, 4 figures, no tables. Submitted to Phys. Rev. Lett. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm

Centrality dependence of charged hadron production in deuteron+gold and nucleon+gold collisions at sqrt(s_NN)=200 GeV

We present transverse momentum (p_T) spectra of charged hadrons measured in deuteron-gold and nucleon-gold collisions at \sqrts = 200 GeV for four centrality classes. Nucleon-gold collisions were selected by tagging events in which a spectator nucleon was observed in one of two forward rapidity detectors. The spectra and yields were investigated as a function of the number of binary nucleon-nucleon collisions, \nu, suffered by deuteron nucleons. A comparison of charged particle yields to those in p+p collisions show that the yield per nucleon-nucleon collision saturates with \nu for high momentum particles. We also present the charged hadron to neutral pion ratios as a function of p_T.Comment: 330 authors, 15 pages text, 16 figures, 3 tables. Submitted to Phys. Rev. Lett. v2 has minor changes to reflect revisions during review process. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm

Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia

Despite extensive insights into the underlying genetics and biology of acute myeloid leukemia (AML), overall survival remains poor and new therapies are needed. We found that casein kinase 1 α (Csnk1a1), a serine-threonine kinase, is essential for AML cell survival in vivo. Normal hematopoietic stem and progenitor cells (HSPCs) were relatively less affected by shRNA-mediated knockdown of Csnk1a1. To identify downstream mediators of Csnk1a1 critical for leukemia cells, we performed an in vivo pooled shRNA screen and gene expression profiling. We found that Csnk1a1 knockdown results in decreased Rps6 phosphorylation, increased p53 activity, and myeloid differentiation. Consistent with these observations, p53-null leukemias were insensitive to Csnk1a1 knockdown. We further evaluated whether D4476, a casein kinase 1 inhibitor, would exhibit selective antileukemic effects. Treatment of leukemia stem cells (LSCs) with D4476 showed highly selective killing of LSCs over normal HSPCs. In summary, these findings demonstrate that Csnk1a1 inhibition causes reduced Rps6 phosphorylation and activation of p53, resulting in selective elimination of leukemia cells, revealing Csnk1a1 as a potential therapeutic target for the treatment of AML

Deuteron and antideuteron production in Au+Au collisions at sqrt(s_NN)=200 GeV

The production of deuterons and antideuterons in the transverse momentum range 1.1 < p_T < 4.3 GeV/c at mid-rapidity in Au + Au collisions at sqrt(s_NN)=200 GeV has been studied by the PHENIX experiment at RHIC. A coalescence analysis comparing the deuteron and antideuteron spectra with those of protons and antiprotons, has been performed. The coalescence probability is equal for both deuterons and antideuterons and increases as a function of p_T, which is consistent with an expanding collision zone. Comparing (anti)proton yields p_bar/p = 0.73 +/- 0.01, with (anti)deuteron yields: d_bar/d = 0.47 +/- 0.03, we estimate that n_bar/n = 0.64 +/- 0.04.Comment: 326 authors, 6 pages text, 5 figures, 1 Table. Submitted to PRL. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm