The Political Economy of Natural Resource Use: Lessons for Fisheries Reform

This report discusses key lessons drawn from reform experience in the wider natural resource sector that might inform successful reform in fisheries. This report is a compilation of 12 papers prepared by acknowledged international experts in the fields of fisheries and wider natural resource reform which were reviewed at a workshop convened by the Property and Environment Research Center (PERC) in May 2009.The report forms an important initial input into an ongoing enquiry into the political economy of fisheries reform initiated by the World Bank in partnership with the Partnership for African Fisheries (a United Kingdom Department for International Development funded program of the New Partnership for African Development (NEPAD))

A phase I clinical and pharmacokinetic study of capecitabine (Xeloda®) and irinotecan combination therapy (XELIRI) in patients with metastatic gastrointestinal tumours

Capecitabine is a highly active oral fluoropyrimidine that is an attractive alternative to 5-fluorouracil in colorectal cancer treatment. The current study, undertaken in 27 patients with gastrointestinal tumours, aimed to assess the toxicity and potential for significant pharmacokinetic interactions of a combination regimen incorporating capecitabine with 3-weekly irinotecan (XELIRI). Irinotecan (200 and 250 mg m−2) was administered as a 90-min infusion on day 1 in combination with escalating capecitabine doses (700–1250 mg m−2 twice daily) administered on days 2–15 of a 3-week treatment cycle. Pharmacokinetics were characterised on days 1 and 2 of the first two cycles. A total of 103 treatment cycles were administered. The principal dose-limiting toxicities were diarrhoea and neutropenia. Capecitabine 1150 mg m−2 twice daily with irinotecan 250 mg m−2 was identified as the maximum-tolerated dose and capecitabine 1000 mg m−2 with irinotecan 250 mg m−2 was identified as the recommended dose for further study. Analyses confirmed that there were no significant pharmacokinetic interactions between the two agents. The combination was clinically active, with complete and partial responses achieved in heavily pretreated patients. This study indicates that XELIRI is a potentially feasible and clinically active regimen in patients with advanced gastrointestinal cancer

Predicting bee community responses to land-use changes: Effects of geographic and taxonomic biases

Land-use change and intensification threaten bee populations worldwide, imperilling pollination services. Global models are needed to better characterise, project, and mitigate bees' responses to these human impacts. The available data are, however, geographically and taxonomically unrepresentative; most data are from North America and Western Europe, overrepresenting bumblebees and raising concerns that model results may not be generalizable to other regions and taxa. To assess whether the geographic and taxonomic biases of data could undermine effectiveness of models for conservation policy, we have collated from the published literature a global dataset of bee diversity at sites facing land-use change and intensification, and assess whether bee responses to these pressures vary across 11 regions (Western, Northern, Eastern and Southern Europe; North, Central and South America; Australia and New Zealand; South East Asia; Middle and Southern Africa) and between bumblebees and other bees. Our analyses highlight strong regionally-based responses of total abundance, species richness and Simpson's diversity to land use, caused by variation in the sensitivity of species and potentially in the nature of threats. These results suggest that global extrapolation of models based on geographically and taxonomically restricted data may underestimate the true uncertainty, increasing the risk of ecological surprises

Errors in RNA-Seq quantification affect genes of relevance to human disease

BACKGROUND: RNA-Seq has emerged as the standard for measuring gene expression and is an important technique often used in studies of human disease. Gene expression quantification involves comparison of the sequenced reads to a known genomic or transcriptomic reference. The accuracy of that quantification relies on there being enough unique information in the reads to enable bioinformatics tools to accurately assign the reads to the correct gene. RESULTS: We apply 12 common methods to estimate gene expression from RNA-Seq data and show that there are hundreds of genes whose expression is underestimated by one or more of those methods. Many of these genes have been implicated in human disease, and we describe their roles. We go on to propose a two-stage analysis of RNA-Seq data in which multi-mapped or ambiguous reads can instead be uniquely assigned to groups of genes. We apply this method to a recently published mouse cancer study, and demonstrate that we can extract relevant biological signal from data that would otherwise have been discarded. CONCLUSIONS: For hundreds of genes in the human genome, RNA-Seq is unable to measure expression accurately. These genes are enriched for gene families, and many of them have been implicated in human disease. We show that it is possible to use data that may otherwise have been discarded to measure group-level expression, and that such data contains biologically relevant information. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13059-015-0734-x) contains supplementary material, which is available to authorized users

Plankton community structure and variability in the Scotia Sea: austral summer 2003

Plankton community structure in the Scotia Sea was investigated during January/early February 2003 based on phytoplankton cell counts from 20 m depth and mesozooplankton counts from 0 to 400 m net hauls. Cluster analysis and multi-dimensional scaling revealed 4 major groups of stations within each ordination that broadly corresponded geographically. A grouping of stations to the east of the Antarctic Peninsula was characterised by low phytoplankton cell counts. The corresponding grouping of stations in the mesozooplankton data were characterised by low abundance, overwintered state of many species, low egg production rates, and low carbon mass of copepod instars. In contrast, groupings of stations in the northern part of the Scotia Sea were characterised as chlorophyll and mesozooplankton rich, and the summer generation was well advanced. Latitude was most strongly correlated with mesozooplankton community pattern (rank correlation ρ = 0.608), whereas surface chlorophyll a was a weaker correlate (ρ = 0.344) but along with measures of sizefractioned chlorophyll contributed towards explaining variation in species stages carbon mass and egg production rates. Additional hauls to 1000 m with an LHPR indicated copepod populations were broadly in an overwintered state in the south of the region, whereas to the north of South Georgia recruitment had been completed and some species were undergoing a seasonal descent. A comparison with January/February 2000 revealed higher abundances of krill larvae throughout the Scotia Sea in 2000 as well as a more advanced generation of the copepod Calanoides acutus. Ice cover during the 2 years differed considerably; in 2000 the position of the summer ice edge broadly accorded with the 25 yr average, whereas in 2003 the ice edge lay much further north than usual. We suggest that the timing of ice retreat influenced the timing of reproduction with the late retreat in 2003 causing delayed reproduction and reduced population sizes

International and US medical graduates in US cities

This study examines the comparative distributions of postresident international medical graduates (IMGs) and US medical graduates (USMGs) in high and low poverty areas of US cities. Existing research has established that IMGs are more likely than USMGs to practice in urban areas, yet there is the question whether IMGs locate more frequently than USMGs in urban poverty areas.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45782/1/11524_2006_Article_BF02351505.pd