Trust in everyday life

Although trust plays a pivotal role in many aspects of life, very little is known about the manifestation of trust and distrust in everyday life. In this work, we integrated several prior approaches to trust and investigated the prevalence and key determinants of trust (vs. distrust) in people’s natural environments, using preregistered experience-sampling methodology. Across more than 4,500 social interactions from a heterogeneous sample of 427 participants, results showed high average levels of trust, but also considerable variability in trust across contexts. This variability was attributable to aspects of trustee perception, social distance, as well as three key dimensions of situational interdependence: conflict of interests, information (un)certainty, and power imbalance. At the dispositional level, average everyday trust was shaped by general trust, moral identity, and zero-sum beliefs. The social scope of most trust-related traits, however, was moderated by social distance: Whereas moral identity buffered against distrusting distant targets, high general distrust and low social value orientation amplified trust differences between close vs. distant others. Furthermore, a laboratory-based trust game predicted everyday trust only with regard to more distant but not close interaction partners. Finally, everyday trust was linked to self-disclosure and to cooperation, particularly in situations of high conflict between interaction partners’ interests. We conclude that trust can be conceptualized as a relational hub that interconnects the social perception of the trustee, the relational closeness between trustor and trustee, key structural features of situational interdependence, and behavioral response options such as self-disclosure

Sarcopenia Predicts Early Dose-Limiting Toxicities and Pharmacokinetics of Sorafenib in Patients with Hepatocellular Carcinoma

BACKGROUND: Sorafenib induces frequent dose limiting toxicities (DLT) in patients with advanced hepatocellular carcinoma (HCC). Sarcopenia has been associated with poor performance status and shortened survival in cancer patients. PATIENTS AND METHODS: The characteristics of Child Pugh A cirrhotic patients with HCC receiving sorafenib in our institution were retrospectively analyzed. Sorafenib plasma concentrations were determined at each visit. Toxicities were recorded during the first month of treatment, and sarcopenia was determined from baseline CT-scans. RESULTS: Forty patients (30 males) were included. Eleven (27.5%) were sarcopenic. Eighteen patients (45%) experienced a DLT during the first month of treatment. Sarcopenic patients experienced significantly more DLTs than non-sarcopenic patients did (82% versus 31%, p = 0.005). Grade 3 diarrhea was significantly more frequent in sarcopenic patients than in non-sarcopenic patients (45.5% versus 6.9%, p = 0.01), but not grade 3 hand foot syndrome reaction (9% versus 17.2%, p = 1). On day 28, median sorafenib AUC (n = 17) was significantly higher in sarcopenic patients (102.4 mg/l.h versus 53.7 mg/l.h, p = 0.013). CONCLUSIONS: Among cirrhotic Child Pugh A patients with advanced HCC, sarcopenia predicts sorafenib exposure and the occurrence of DLT within the first month of treatment

Evolution and Functional Diversification of Fructose Bisphosphate Aldolase Genes in Photosynthetic Marine Diatoms

Diatoms and other chlorophyll-c containing, or chromalveolate, algae are among the most productive and diverse phytoplankton in the ocean. Evolutionarily, chlorophyll-c algae are linked through common, although not necessarily monophyletic, acquisition of plastid endosymbionts of red as well as most likely green algal origin. There is also strong evidence for a relatively high level of lineage-specific bacterial gene acquisition within chromalveolates. Therefore, analyses of gene content and derivation in chromalveolate taxa have indicated particularly diverse origins of their overall gene repertoire. As a single group of functionally related enzymes spanning two distinct gene families, fructose 1,6-bisphosphate aldolases (FBAs) illustrate the influence on core biochemical pathways of specific evolutionary associations among diatoms and other chromalveolates with various plastid-bearing and bacterial endosymbionts. Protein localization and activity, gene expression, and phylogenetic analyses indicate that the pennate diatom Phaeodactylum tricornutum contains five FBA genes with very little overall functional overlap. Three P. tricornutum FBAs, one class I and two class II, are plastid localized, and each appears to have a distinct evolutionary origin as well as function. Class I plastid FBA appears to have been acquired by chromalveolates from a red algal endosymbiont, whereas one copy of class II plastid FBA is likely to have originated from an ancient green algal endosymbiont. The other copy appears to be the result of a chromalveolate-specific gene duplication. Plastid FBA I and chromalveolate-specific class II plastid FBA are localized in the pyrenoid region of the chloroplast where they are associated with β-carbonic anhydrase, which is known to play a significant role in regulation of the diatom carbon concentrating mechanism. The two pyrenoid-associated FBAs are distinguished by contrasting gene expression profiles under nutrient limiting compared with optimal CO2 fixation conditions, suggestive of a distinct specialized function for each. Cytosolically localized FBAs in P. tricornutum likely play a role in glycolysis and cytoskeleton function and seem to have originated from the stramenopile host cell and from diatom-specific bacterial gene transfer, respectively

Pompejiföreställningen : Undersökningar av det historiska odlingslandskapets destruktiva inverkan på järnålderbosättningen vid Änge, Buttle socken. Rapport från arkeologisk undersökning vid Buttle Änge 2017. Del II

In the preface to his and Gerda Boëthius' book on Gotland's Iron Age settlement sites, John Nihlén described the stone wall house sites and 'adjoining field walls' as Sweden's Pompeii. The description vividly illustrate how Nihlén perceived the preservation status of the stone wall houses. Nihlén seems to have thought that the stone wall houses had been covered by a 'protecting layer of volcanic dust' and laid untouched since the day they had been abandoned. Even though most of Nihlén's theories on the Iron Age settlement sites of Gotland has since been dismissed, the 'Pompeii idea' has seemingly been passed on to later generations of researchers (as for instance in the work of Carlsson 1979 and Cassel 1998). This conception is however far from accurate. Field inventories on Central and Eastern Gotland, as well as cartographical studies and the result of the excavations at Änge, Buttle parish has clearly demonstrated how the stone wall house sites has been damaged and affected by cultivation and other activities during Early Modern and Modern times. To further investigate and document the impact and extent of destructive elements on stone wall house sites, special attention was given to the topic during the 2017 excavation campaign at Änge. The survey was divided into three different sections; 1. Excavation and analysis of the construction and chronology for so called 'field walls' or ancient enclosures [sw. stensträngar]; 2.To evaluate the hypothesis that 'impediments' (marked objects in fields) on historical maps represent ancient remains, particularly stone wall houses; and finally 3. to define the spacial extent of the Iron Age settlement site, to be able to conclude which of the historical features that can be labelled as 'destructive elements'. The fieldwork section of the project was carried out within the borders of the research projects Climate Change and Social Competition: re-approaching the Archaeology of Gotland AD 300-900 and Houses and Hierarchies: From Roman to Viking influences on Gotland Island in the Baltic sea, and conducted in July and August of 2017 in conjunction with Uppsala university campus Gotland's summer-semester fieldwork-course for archaeology students. The excavation documentation and the preliminary results of the survey is presented in this report.OBS: Andreeff är författare för 2017, del 1; Melander är författare för 2017, del 2.</p

The significance of microstructure heterogeneities on the fatigue thresholds of aluminum castings

Industrial in-series aluminum castings contain a wide range of microstructural heterogeneities like differences in secondary dendrite arm spacing (SDAS), eutectic silicon and intermetallic precipitates of varying morphologies and diverse-shaped and-sized porosity. Regarding to technical and economic limitations, the complete elimination of them is hard to achieve, which requires conservative design, i.e., increased wall thicknesses to accommodate the failure tolerance. To improve the performance of cast aluminum products concerning safety and fatigue properties, the present work deals with the significance of such structures with respect to the threshold for crack propagation ΔKI,th under pure bending and the fatigue behaviour in the high-and very-high-cycle-fatigue regime (HCF and VHCF). Therefore, two automotive cast alloys taken from engine blocks (AlSi8Cu3) and cylinder heads (AlSi7Cu0.5Mg) and a gravity die cast set (AlSi7Mg0.3), either T6 conditioned or additionally hot isostatic pressed (HIP), were used. For in-series castings, two positions of maximal difference in cooling rate and respective microstructure were extracted. With this set of specimens, the significance of SDAS in interaction with (i) eutectic silicon regions, (ii) intermetallic precipitates in varying occurrence, (iii) the crystallographic orientation, and (iv) the porosity in correlation with the fatigue threshold is shown and compared with first results of fatigue damaging mechanisms in quasi pore-free material