Development and Maintenance of Self-Disclosure on Facebook: The Role of Personality Traits

This study explored the relationships between Facebook self-disclosure and personality traits in a sample of Italian users. The aim was to analyze the predictive role of Big Five personality traits on different parameters of breadth and depth of selfdisclosed behaviors online. Facebook users, aged between 18 and 64 years of age (Mage = 25.3 years, SD = 6.8; N = 958), of which 51% were female, voluntarily completed an online survey assessing personality traits and Facebook self-disclosure. Results at a series of hierarchical regression analyses significantly corroborated the hypotheses that high extroverted and openness people tend to disclose on Facebook a significant amount of personal information, whereas high consciousness and agreeableness users are less inclined to do it. Furthermore, more extroverts and agreeableness people develop less intimacy on Facebook, differently from those with high levels of openness. Results also corroborated the hypothesis of a full mediation of time usage in the relationship between personality factors such as extroversion and conscientiousness with breadth of Facebook self-disclosure. Overall, according to the findings of the current study, personality traits and Facebook self-disclosure become central both as predictive variables for depicting the different profiles of potential addicted and as variables to help educators, teachers, and clinicians to develop training or therapeutic programs aimed at preventing the risk of Internet addiction. Limitations of the study are discussed, and directions for future research are suggested

Finestre ed epifanie nella poesia di Raymond Carver: Happiness, Rain, The Window

What equates Raymond Carver’s poems Happiness, Rain and The Window is the fact that they are not “narrative” poems, but fragments of moments lived in front of a window. The poet records what he sees outside the house: the nature or common people interacting, and somehow they are images that give back to his inner eye truths or reflections of the sense of life itself, his and human kind’s. The visions that the window shows to Raymond Carver are epiphanies.The three poems are equated not only by the presence of the window, but most of all by the same structure. The aim of the poet is to fix on paper the revelation he received from the image before the epiphany fades.This paper will examine the three fundamental moments of these poems: the determination of the time and space, the epiphany, and the subsequent reflection on it. There will also be an analysis of Raymond Carver’s style and how it contributes to describe daily events, to convey to the reader a pure and distilled image of his visions

“My yesterdays are disappearing, and my tomorrows are uncertain”: Alzheimer’s Disease and the Impossible Survivor Narrative in Lisa Genova’s Still Alice

The protagonist of Lisa Genova’s novel Still Alice, Alice Howland, is a Harvard Professor of Cognitive Psychology who is diagnosed with early-onset Alzheimer’sdisease at the age of 50. In order to save traces of her past as it progressively wears away, and to maintain control of her life despite the illness, Alice comes up with several coping strategies. She also creates a support group composed of others suffering from the disease, while submitting to an experimental therapy.The diagnosis of Alzheimer’s disease still leaves no hope for a positive outcome— that is why, according to Martina Zimmermann, a novel about it does not match the survivor narrative type. In any case, as this contribution hopes to convey, a novel such as Still Alice, the author of which is a neuroscientist, can help patients and their families understand what they are dealing with and what to expect, in a narrative that is not intended as a “cure” or a success story, but mostly as an aid to manage the inevitable disappearance of memory, orientation and family relations.The protagonist of Lisa Genova’s novel Still Alice, Alice Howland, is a Harvard Professor of Cognitive Psychology who is diagnosed with early-onset Alzheimer’sdisease at the age of 50. In order to save traces of her past as it progressively wears away, and to maintain control of her life despite the illness, Alice comes up with several coping strategies. She also creates a support group composed of others suffering from the disease, while submitting to an experimental therapy.The diagnosis of Alzheimer’s disease still leaves no hope for a positive outcome— that is why, according to Martina Zimmermann, a novel about it does not match the survivor narrative type. In any case, as this contribution hopes to convey, a novel such as Still Alice, the author of which is a neuroscientist, can help patients and their families understand what they are dealing with and what to expect, in a narrative that is not intended as a “cure” or a success story, but mostly as an aid to manage the inevitable disappearance of memory, orientation and family relations

Villain or Victim? Il caso Yates in “Dear Husband” di Joyce Carol Oates

In 2009, Joyce Carol Oates published the collection of short stories Dear Husband, which contained the eponymous story inspired by the case of Andrea Yates, a Texan housewife who had killed her five children in the house bathtub in 2001. The woman, who was sectioned in 2007, declared that hers had been “a mother’s final act of mercy”, as she had meant to save her children from the devil. She had been suffering from post-partum psychosis, a condition that made it hard to judge whether she was aware of what she was doing while drowning her kids.The essay analyzes the depiction that Oates made of Yates in her short story, and considers the treatment that the author reserved to her character: is she portrayed as a villain or a victim? With the help of Paul Ricoeur’s concepts of “guilt” and “impurity”, and a comparison between the actuality of the Yeats case and its fictional counterpart, it will be possible to understand the point of view of the author on the culpability of Andrea Yates

A Silvia (o Un'amante alla finestra)

I Creativ

Real-world Use of Mold-Active Triazole Prophylaxis in the Prevention of Invasive Fungal Diseases: Results From a Subgroup Analysis of a Multicenter National Registry

BACKGROUND: Antifungal prophylaxis can prevent invasive fungal diseases (IFDs) in high-risk, immunocompromised patients. This study assessed the real-world use of mold-active triazoles (MATs) for the prevention of IFDs. METHODS: This subgroup analysis of a multicenter, observational, prospective registry in the United States from March 2017 to April 2020 included patients who received MATs for prophylaxis (isavuconazole, posaconazole, and voriconazole) at study index/enrollment. The primary objective was to describe patient characteristics and patterns of MAT use. Exploratory assessments included the frequency of breakthrough IFDs and MAT-related adverse drug reactions (ADRs). RESULTS: A total of 1177 patients (256 isavuconazole, 397 posaconazole, 272 voriconazole, and 252 multiple/sequenced MATs at/after index/enrollment) were included in the prophylaxis subgroup analysis. Patient characteristics were similar across MAT groups, but risk factors varied. Hematological malignancy predominated (76.5%) across all groups. Breakthrough IFDs occurred in 7.1% (73/1030) of patients with an investigator\u27s assessment (5.0% [11/221] isavuconazole; 5.3% [20/374] posaconazole; 4.0% [9/226] voriconazole; and 15.8% [33/209] multiple/sequenced MATs). CONCLUSIONS: Breakthrough IFDs were uncommon in patients who received MATs for prophylaxis

Final results of the second prospective AIEOP protocol for pediatric intracranial ependymoma

BACKGROUND: This prospective study stratified patients by surgical resection (complete = NED vs incomplete = ED) and centrally reviewed histology (World Health Organization [WHO] grade II vs III). METHODS: WHO grade II/NED patients received focal radiotherapy (RT) up to 59.4 Gy with 1.8 Gy/day. Grade III/NED received 4 courses of VEC (vincristine, etoposide, cyclophosphamide) after RT. ED patients received 1-4 VEC courses, second-look surgery, and 59.4 Gy followed by an 8-Gy boost in 2 fractions on still measurable residue. NED children aged 1-3 years with grade II tumors could receive 6 VEC courses alone. RESULTS: From January 2002 to December 2014, one hundred sixty consecutive children entered the protocol (median age, 4.9 y; males, 100). Follow-up was a median of 67 months. An infratentorial origin was identified in 110 cases. After surgery, 110 patients were NED, and 84 had grade III disease. Multiple resections were performed in 46/160 children (28.8%). A boost was given to 24/40 ED patients achieving progression-free survival (PFS) and overall survival (OS) rates of 58.1% and 68.7%, respectively, in this poor prognosis subgroup. For the whole series, 5-year PFS and OS rates were 65.4% and 81.1%, with no toxic deaths. On multivariable analysis, NED status and grade II were favorable for OS, and for PFS grade II remained favorable. CONCLUSIONS: In a multicenter collaboration, this trial accrued the highest number of patients published so far, and results are comparable to the best single-institution series. The RT boost, when feasible, seemed effective in improving prognosis. Even after multiple procedures, complete resection confirmed its prognostic strength, along with tumor grade. Biological parameters emerging in this series will be the object of future correlatives and reports

NATIVE CHARACTERIZATION AND QC PROFILING OF HUMAN AMNIOTIC MESENCHYMAL STROMAL CELL VESICULAR FRACTIONS FOR SECRETOME-BASED THERAPY

Human amniotic mesenchymal stromal cells (hAMSCs) have unique immunomodulatory properties making them attractive candidates for regenerative applications in inflammatory diseases. Most of their beneficial properties are mediated through their secretome. The bioactive factors concurring to its therapeutic activity are still unknown. Evidence suggests synergy between the two main components of the secretome, soluble factors and vesicular fractions, pivotal in shifting inflammation and promoting self-healing. Biological variability and the absence of quality control (QC) protocols hinder secretome-based therapy translation to clinical applications. Moreover, vesicular secretome contains a multitude of particles with varying size, cargos and functions whose complexity hinders full characterization and comprehension. This study achieved a significant advancement in secretome characterization by utilizing native, FFF-based separation and characterizing extracellular vesicles derived from hAMSCs. This was accomplished by obtaining dimensionally homogeneous fractions then characterized based on their protein content, potentially enabling the identification of subpopulations with diverse functionalities. This method proved to be successful as an independent technique for secretome profiling, with the potential to contribute to the standardization of a qualitative method. Additionally, it served as a preparative separation tool, streamlining populations before ELISA and LC-MS characterization. This approach facilitated the categorization of distinctive and recurring proteins, along with the identification of clusters associated with vesicle activity and functions. However, the presence of proteins unique to each fraction obtained through the FFF separation tool presents a challenge for further analysis of the protein content within these cargoes

Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis

Anti-tumor necrosis factor alpha (anti-TNF) biologic therapy is a widely used treatment for rheumatoid arthritis (RA). It is unknown why some RA patients fail to respond adequately to anti-TNF therapy, which limits the development of clinical biomarkers to predict response or new drugs to target refractory cases. To understand the biological basis of response to anti-TNF therapy, we conducted a genome-wide association study (GWAS) meta-analysis of more than 2 million common variants in 2,706 RA patients from 13 different collections. Patients were treated with one of three anti-TNF medications: etanercept (n = 733), infliximab (n = 894), or adalimumab (n = 1,071). We identified a SNP (rs6427528) at the 1q23 locus that was associated with change in disease activity score (ΔDAS) in the etanercept subset of patients (P = 8×10-8), but not in the infliximab or adalimumab subsets (P>0.05). The SNP is predicted to disrupt transcription factor binding site motifs in the 3′ UTR of an immune-related gene, CD84, and the allele associated with better response to etanercept was associated with higher CD84 gene expression in peripheral blood mononuclear cells (P = 1×10-11 in 228 non-RA patients and P = 0.004 in 132 RA patients). Consistent with the genetic findings, higher CD84 gene expression correlated with lower cross-sectional DAS (P = 0.02, n = 210) and showed a non-significant trend for better ΔDAS in a subset of RA patients with gene expression data (n = 31, etanercept-treated). A small, multi-ethnic replication showed a non-significant trend towards an association among etanercept-treated RA patients of Portuguese ancestry (n = 139, P = 0.4), but no association among patients of Japanese ancestry (n = 151, P = 0.8). Our study demonstrates that an allele associated with response to etanercept therapy is also associated with CD84 gene expression, and further that CD84 expression correlates with disease activity. These findings support a model in which CD84 genotypes and/or expression may serve as a useful biomarker for response to etanercept treatment in RA patients of European ancestry. © 2013 Cui et al

Involvement of GTA protein NC2β in Neuroblastoma pathogenesis suggests that it physiologically participates in the regulation of cell proliferation

<p>Abstract</p> <p>Background</p> <p>The General Transcription Apparatus (GTA) comprises more than one hundred proteins, including RNA Polymerases, GTFs, TAFs, Mediator, and cofactors such as heterodimeric NC2. This complexity contrasts with the simple mechanical role that these proteins are believed to perform and suggests a still uncharacterized participation to important biological functions, such as the control of cell proliferation.</p> <p>Results</p> <p>To verify our hypothesis, we analyzed the involvement in Neuroblastoma (NB) pathogenesis of GTA genes localized at 1p, one of NB critical regions: through RT-PCR of fifty eight NB biopsies, we demonstrated the statistically significant reduction of the mRNA for NC2β (localized at 1p22.1) in 74% of samples (p = 0.0039). Transcripts from TAF13 and TAF12 (mapping at 1p13.3 and 1p35.3, respectively) were also reduced, whereas we didn't detect any quantitative alteration of the mRNAs from GTF2B and NC2α (localized at 1p22-p21 and 11q13.3, respectively). We confirmed these data by comparing tumour and constitutional DNA: most NB samples with diminished levels of NC2β mRNA had also genomic deletions at the corresponding locus.</p> <p>Conclusion</p> <p>Our data show that NC2β is specifically involved in NB pathogenesis and may be considered a new NB biomarker: accordingly, we suggest that NC2β, and possibly other GTA members, are physiologically involved in the control of cell proliferation. Finally, our studies unearth complex selective mechanisms within NB cells.</p