WZ Sagittae as a DQ Herculis star

We argue that quiescent WZ Sge is a rapidly spinning magnetic rotator in which most of the matter transfered from the secondary is ejected from the system. Assuming that the observed 27.87 s oscillation period is due to the spinning white dwarf we propose that the other observed principal period of 28.96 s is a beat due to reprocessing of the rotating white dwarf beam on plasma blobs in Keplerian rotation at the outer disc rim. The weaker, transient, 29.69 s period is identified as a beat with the Keplerian period of the magnetosphere. WZ Sge evolves through a cycle of spin-up and spin-down phases. During the spin-down phase it is a DQ Her star, during the spin-up phase it should be a ER UMa star.Comment: 8 pages, 5 figures; accepted for publication in MNRA

The minimum period problem in cataclysmic variables

We investigate if consequential angular momentum losses (CAML) or an intrinsic deformation of the donor star in CVs could increase the CV bounce period from the canonical theoretical value ~65 min to the observed value $P_{min} \approx77$ min, and if a variation of these effects in a CV population could wash out the theoretically predicted accumulation of systems near the minimum period (the period spike). We are able to construct suitably mixed CV model populations that a statisticial test cannot rule out as the parent population of the observed CV sample. However, the goodness of fit is never convincing, and always slightly worse than for a simple, flat period distribution. Generally, the goodness of fit is much improved if all CVs are assumed to form at long orbital periods. The weighting suggested by King, Schenker & Hameury (2002) does not constitute an improvment if a realistically shaped input period distribution is used. Put your abstract here.Comment: 10 pages, Latex, 13 postscript figures, Accepted for publication in MNRA

Revisiting an Old Riddle: What Determines Genetic Diversity Levels within Species?

Understanding why some species have more genetic diversity than others is central to the study of ecology and evolution, and carries potentially important implications for conservation biology. Yet not only does this question remain unresolved, it has largely fallen into disregard. With the rapid decrease in sequencing costs, we argue that it is time to revive it.</p

Excellent overall and chronic graft-versus-host-disease-free event-free survival in Fanconi anaemia patients undergoing matched related- and unrelated-donor bone marrow transplantation using alemtuzumab–Flu–Cy: the UK experience

Haematopoietic stem cell transplantation (HSCT) remains the only curative option in Fanconi anaemia (FA). We analysed the outcome of children transplanted for FA between 1999 and 2018 in the UK. A total of 94 transplants were performed in 82 patients. Among the donors, 51·2% were matched related donors (MRD) while the remainder were alternative donors. Most patients received a fludarabine–cyclophosphamide (Flu–Cy)‐based conditioning regimen (86·6%) and in vivo T‐cell depletion with alemtuzumab (69·5%). Five‐year overall survival (OS) was 85·4% [70·4–93.2] with MRD, 95·7% [72·9–99.4] with matched unrelated donors (MUD), 44·4% [6·6–78.5] with mismatched unrelated donors (MMUD) and 44·4% [13·6–71.9] with mismatched related donors (MMRD) (P < 0·001). Other factors significantly impacting OS were pre‐transplant bone marrow status, source of stem cells, cytomegalovirus (CMV) serostatus, preparation with Flu–Cy, use of total body irradiation (TBI) and alemtuzumab as serotherapy. In multivariate analysis, absence of myelodysplastic syndrome (MDS) or leukaemia, bone marrow as source of stem cells, cytomegalovirus (CMV) other than +/− (Recipient/Donor) and Flu–Cy were protective factors for five‐year OS. Five‐year chronic graft‐versus‐host‐disease (cGVHD)‐free event‐free survival was 75·4% with the same risk factors except for CMV serostatus. Five‐year non‐relapse mortality was 13·8% [7·3–22.3]. Only five patients (6·1%) developed grade II–IV acute GVHD and two patients chronic GVHD. These data confirm the excellent outcome of matched related or unrelated HSCT in children with FA

Outbursts of EX Hydrae Revisited

We present optical spectroscopy of EX Hya during its 1991 outburst. This outburst is characterised by strong irradiation of the front face of the secondary star by the white dwarf, an overflowing stream which is seen strongly in HeII and by a dip in the light curves, which extends from 0.1-0.6 in the binary and spin phases. Strong irradiation of the accretion curtain and that of the inner regions of the disc led to strong emission of HeII and to the suppression of the Hg and Hb emission. Disc overflow was observed in quiescence in earlier studies, where the overflow stream material was modulated at high velocities close to 1000 km/s. In outburst, the overflowing material is modulated at even higher velocities (~1500 km/s). These are streaming velocities down the field lines close to the white dwarf. Evidence for material collecting near the outer edge of the disc and corotating with the accretion curtain was observed. In decline, this material and the accretion curtain obscured almost all the emission near binary phase 0.4, causing a dip. The dip minimum nearly corresponds with spin pulse minimum. This has provided additional evidence for an extended accretion curtain, and for the corotation of material with the accretion curtain at the outer edge of the disc. From these observations we suggest that a mechanism similar to that of Spruit & Taam, where outbursts result due to the storage and release of matter outside the magnetosphere, triggers the outbursts of EX Hya. This is followed by the irradiation of the secondary star due to accretion induced radiation.Comment: 12 pages, 14 figures, 1 table. Figures 6, 7, 8 and 11 at low resolution. Paper accepted by the Monthly Notices of the Royal Astronomical Societ

Secular changes in the quiescence of WZ Sge: the development of a cavity in the inner disk

We find a dimming during optical quiescence of the cataclysmic variable WZ Sge by about half a magnitude between superoutbursts. We connect the dimming with the development of a cavity in the inner part of the accretion disk. We suggest that, when the cavity is big enough, accretion of material is governed by the magnetic field of the white dwarf and pulsations from the weakly magnetic white dwarf appear. The time scale of forming the cavity is about a decade, and it persists throughout the whole quiescent phase. Such a cavity can be accommodated well by the proposed magnetic propeller model for WZ Sge, where during quiescence mass is being expelled by the magnetic white dwarf from the inner regions of the accretion disk to larger radii.Comment: 10 pages, 4 figures, accepted for publication in Astronomy and Astrophysics; following referee report, many textual changes, figures improved, more historic data added, conclusions unchange

Evaluating the Evidence for Transmission Distortion in Human Pedigrees

Children of a heterozygous parent are expected to carry either allele with equal probability. Exceptions can occur, however, due to meiotic drive, competition among gametes, or viability selection, which we collectively term “transmission distortion” (TD). Although there are several well-characterized examples of these phenomena, their existence in humans remains unknown. We therefore performed a genome-wide scan for TD by applying the transmission disequilibrium test (TDT) genome-wide to three large sets of human pedigrees of European descent: the Framingham Heart Study (FHS), a founder population of European origin (HUTT), and a subset of the Autism Genetic Resource Exchange (AGRE). Genotyping error is an important confounder in this type of analysis. In FHS and HUTT, despite extensive quality control, we did not find sufficient evidence to exclude genotyping error in the strongest signals. In AGRE, however, many signals extended across multiple SNPs, a pattern highly unlikely to arise from genotyping error. We identified several candidate regions in this data set, notably a locus in 10q26.13 displaying a genome-wide significant TDT in combined female and male transmissions and a signature of recent positive selection, as well as a paternal TD signal in 6p21.1, the same region in which a significant TD signal was previously observed in 30 European males. Neither region replicated in FHS, however, and the paternal signal was not visible in sperm competition assays or as allelic imbalance in sperm. In maternal transmissions, we detected no strong signals near centromeres or telomeres, the regions predicted to be most susceptible to female-specific meiotic drive, but we found a significant enrichment of top signals among genes involved in cell junctions. These results illustrate both the potential benefits and the challenges of using the TDT to study transmission distortion and provide candidates for investigation in future studies

A Search for Rapid Photometric Variability in Symbiotic Binaries

We report on our survey for rapid (time scale of minutes) photometric variability in symbiotic binaries. These binaries are becoming an increasingly important place to study accretion onto white dwarfs since they are candidate Type Ia supernovae progenitors. Unlike in most cataclysmic variables, the white dwarfs in symbiotics typically accrete from a wind, at rates greater than or equal to 10^{-9} solar masses per year. In order to elucidate the differences between symbiotics and other white dwarf accretors, as well as search for magnetism in symbiotic white dwarfs, we have studied 35 primarily northern symbiotic binaries via differential optical photometry. Our study is the most comprehensive to date of rapid variability in symbiotic binaries. We have found one magnetic accretor, Z And, previously reported by Sokoloski & Bildsten (1999). In four systems (EG And, BX Mon, CM Aql, and BF Cyg), some evidence for flickering at a low level (roughly 10 mmag) is seen for the first time. These detections are, however, marginal. For 25 systems, we place tight upper limits (order of mmag) on both aperiodic and periodic variability, highlighting a major difference between symbiotics and cataclysmic variables. The remaining five of the objects included in our sample (the 2 recurrent novae RS Oph and T CrB, plus CH Cyg, o Ceti, and MWC 560) had previous detections of large-amplitude optical flickering, and we present our extensive observations of these systems in a separate paper. We discuss the impact of our results on the ``standard'' picture of wind-fed accretion, and speculate on the possibility that in most symbiotics, light from quasi-steady nuclear burning on the surface of the white dwarf hides the fluctuating emission from accretion.Comment: 24 pages, 17 figures. Submitted to MNRAS (12/21/00), and revised in response to referee comments (3/30/01

Brown Dwarfs and the Cataclysmic Variable Period Minimum

Using improved, up-to-date stellar input physics tested against observations of low-mass stars and brown dwarfs we calculate the secular evolution of low-mass donor cataclysmic variables (CVs), including those which form with a brown dwarf donor. Our models confirm the mismatch between the calculated minimum period (Pmin ~ 70 min) and the observed short-period cut-off (~ 80 min) in the CV period histogram. We find that tidal and rotational corrections applied to the one-dimensional stellar structure equations have no significant effect on the period minimum. Theoretical period distributions synthesized from our model sequences always show an accumulation of systems at the minimum period, a feature absent from the observed distribution. We suggest that non-magnetic CVs become unobservable as they are effectively trapped in permanent quiescence before they reach Pmin, and that small-number statistics may hide the period spike for magnetic CVs.Comment: 10 pages; accepted for publication in MNRA