6,089 research outputs found
An experimental apparatus for measuring the Casimir effect at large distances
An experimental set-up for the measurement of the Casimir effect at
separations larger than a few microns is presented. The apparatus is based on a
mechanical resonator and uses a homodyne detection technique to sense the
Casimir force in the plane-parallel configuration. First measurements in the
3-10 micrometer range show an unexpected large force probably due to patch
effects.Comment: Proceedings of the workshop On the 60 Years on Casimir Effec
Hunter-gatherer mobility and territories in the dunefields of center Argentina
The distribution of certain rocks in the landscape allows us to reconstruct diverse aspects of past hunter-gatherer behavior. In this work, we evaluate the mobility patterns employed by these groups and the presence or absence of boundaries in the Aeolian system of the center of Argentina. To accomplish this objective, we consider two types of evidence: 1) raw material frequencies and distributions in three areas of this Aeolian System and 2) presence and frequency of knapping stones from Tandilia sources. We construct a fall-off curve that is based on the relationship between the frequency of an item and the distance to the source of supply. The characteristics of each area yielded the human groups that inhabited delineate different modes of exploitation of the rocks. The fall-off curve documents a steep drop-off between 300 and 350 km from the Tandilia source and the spatial analysis indicates that within this distance the source probably represents the threshold of direct access to the quarries. Tandilia stone-tools seem to systematically supply a relatively wide area of the Central Pampean Dunefields of the Pampa grasslands, through varied processes, but they arrive at very low frequencies over great distances. The presence of Tandilia rocks in the Western Pampean Dunefields and Western Pampas Sand Mantles and Dunefields indicates social interaction between human groups that shared some common technological knowledge. The presence of stones in the Central Pampean Dunefields coming from the xerophytic woodland of the Dry Pampas can be related with contacts and exchanges among the hunter-gatherer group that occupied different territories
Open and / or laparoscopic surgical treatment of liver hydatic cysts
Hydatid disease is a severe parasitic disease with a widely ranging distribution. In the human being the liver is the most frequent organ affected. 1 The treatment should be individualized to the morphology, size, number and location of the cysts, that is why a variety of surgical operations have been advocated from complete resection like total pericystectomy or partial hepatectomy to laparoscopy to a minimally invasive procedures like percutaneous aspiration of cysts to conservative drug therapy. 3-4 This study compares laparoscopic versus open management of the hydatid cyst of liver the surgical approach to liver echinococcosis is still a controversial issue and shows our results of surgical treatment of liver hydatid cysts during a 3-years period
Abastecimiento y Explotación de Materias Primas en el Arroyo Tapaque (Buenos Aires, Argentina)
Este trabalho apresenta as análises efetuadas sobre os materiais líticos provenientes dos sítios Núcleo Central 1 e Cerro Três Lomas 1, situados no setor norte-ocidental do sistema de montanha de Tandilla (Argentina). Examinam-se as estratégias de exploração realizadas nos setores de abastecimento, descrevem-se as formas de transferência e como foram empregadas as matérias-primas nos sítios situados na microrregião de estudo
casimir effect a novel experimental approach at large separation
A novel experimental set-up for the measurement of the Casimir effect at separations larger than a few microns is presented. The apparatus is based on a mechanical resonator and will use a homodyne detection technique to sense the Casimir force in the plane–parallel configuration
Search for CP Violation in the Decay Z -> b (b bar) g
About three million hadronic decays of the Z collected by ALEPH in the years
1991-1994 are used to search for anomalous CP violation beyond the Standard
Model in the decay Z -> b \bar{b} g. The study is performed by analyzing
angular correlations between the two quarks and the gluon in three-jet events
and by measuring the differential two-jet rate. No signal of CP violation is
found. For the combinations of anomalous CP violating couplings, and , limits of \hat{h}_b < 0.59h^{\ast}_{b} < 3.02$ are given at 95\% CL.Comment: 8 pages, 1 postscript figure, uses here.sty, epsfig.st
Search for the glueball candidates f0(1500) and fJ(1710) in gamma gamma collisions
Data taken with the ALEPH detector at LEP1 have been used to search for gamma
gamma production of the glueball candidates f0(1500) and fJ(1710) via their
decay to pi+pi-. No signal is observed and upper limits to the product of gamma
gamma width and pi+pi- branching ratio of the f0(1500) and the fJ(1710) have
been measured to be Gamma_(gamma gamma -> f0(1500)). BR(f0(1500)->pi+pi-) <
0.31 keV and Gamma_(gamma gamma -> fJ(1710)). BR(fJ(1710)->pi+pi-) < 0.55 keV
at 95% confidence level.Comment: 10 pages, 3 figure
Search for GeV Gamma-ray Counterparts of Gravitational Wave Events by CALET
We present results on searches for gamma-ray counterparts of the LIGO/Virgo
gravitational-wave events using CALorimetric Electron Telescope ({\sl CALET})
observations. The main instrument of {\sl CALET}, CALorimeter (CAL), observes
gamma-rays from GeV up to 10 TeV with a field of view of nearly 2 sr.
In addition, the {\sl CALET} gamma-ray burst monitor (CGBM) views 3 sr
and sr of the sky in the 7 keV -- 1 MeV and the 40 keV -- 20 MeV
bands, respectively, by using two different crystal scintillators. The {\sl
CALET} observations on the International Space Station started in October 2015,
and here we report analyses of events associated with the following
gravitational wave events: GW151226, GW170104, GW170608, GW170814 and GW170817.
Although only upper limits on gamma-ray emission are obtained, they correspond
to a luminosity of erg s in the GeV energy band
depending on the distance and the assumed time duration of each event, which is
approximately the order of luminosity of typical short gamma-ray bursts. This
implies there will be a favorable opportunity to detect high-energy gamma-ray
emission in further observations if additional gravitational wave events with
favorable geometry will occur within our field-of-view. We also show the
sensitivity of {\sl CALET} for gamma-ray transient events which is the order of
~erg\,cm\,s for an observation of 100~s duration.Comment: 12 pages, 8 figures, 1 table. Accepted for publication in
Astrophysical Journa
On-orbit Operations and Offline Data Processing of CALET onboard the ISS
The CALorimetric Electron Telescope (CALET), launched for installation on the
International Space Station (ISS) in August, 2015, has been accumulating
scientific data since October, 2015. CALET is intended to perform long-duration
observations of high-energy cosmic rays onboard the ISS. CALET directly
measures the cosmic-ray electron spectrum in the energy range of 1 GeV to 20
TeV with a 2% energy resolution above 30 GeV. In addition, the instrument can
measure the spectrum of gamma rays well into the TeV range, and the spectra of
protons and nuclei up to a PeV.
In order to operate the CALET onboard ISS, JAXA Ground Support Equipment
(JAXA-GSE) and the Waseda CALET Operations Center (WCOC) have been established.
Scientific operations using CALET are planned at WCOC, taking into account
orbital variations of geomagnetic rigidity cutoff. Scheduled command sequences
are used to control the CALET observation modes on orbit. Calibration data
acquisition by, for example, recording pedestal and penetrating particle
events, a low-energy electron trigger mode operating at high geomagnetic
latitude, a low-energy gamma-ray trigger mode operating at low geomagnetic
latitude, and an ultra heavy trigger mode, are scheduled around the ISS orbit
while maintaining maximum exposure to high-energy electrons and other
high-energy shower events by always having the high-energy trigger mode active.
The WCOC also prepares and distributes CALET flight data to collaborators in
Italy and the United States.
As of August 31, 2017, the total observation time is 689 days with a live
time fraction of the total time of approximately 84%. Nearly 450 million events
are collected with a high-energy (E>10 GeV) trigger. By combining all operation
modes with the excellent-quality on-orbit data collected thus far, it is
expected that a five-year observation period will provide a wealth of new and
interesting results.Comment: 11 pages, 7 figures, published online 27 February 201
Indole and 2,4-Thiazolidinedione conjugates as potential anticancer modulators
Background. Thiazolidinediones (TZDs), also called glitazones, are five-membered carbon ring molecules commonly used for the management of insulin resistance and type 2 diabetes. Recently, many prospective studies have also documented the impact of these compounds as anti-proliferative agents, though several negative side effects such as hepatotoxicity, water retention and cardiac issues have been reported. In this work, we synthesized twenty-six new TZD analogues where the thiazolidinone moiety is directly connected to an N-heterocyclic ring in order to lower their toxic effects. Methods. By adopting a widely applicable synthetic method, twenty-sixTZDderivatives were synthesized and tested for their antiproliferative activity in MTT and Wound healing assays with PC3 (prostate cancer) and MCF-7 (breast cancer) cells. Results. Three compounds, out of twenty-six, significantly decreased cellular viability and migration, and these effects were even more pronounced when compared with rosiglitazone, a well-known member of the TZD class of antidiabetic agents. As revealed by Western blot analysis, part of this antiproliferative effect was supported by apoptosis studies evaluating BCL-xL and C-PARP protein expression. Conclusion. Our data highlight the promising potential of these TZD derivatives as anti-proliferative agents for the treatment of prostate and breast cancer
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