Cosmic cookery : making a stereoscopic 3D animated movie.

This paper describes our experience making a short stereoscopic movie visualizing the development of structure in the universe during the 13.7 billion years from the Big Bang to the present day. Aimed at a general audience for the Royal Society's 2005 Summer Science Exhibition, the movie illustrates how the latest cosmological theories based on dark matter and dark energy are capable of producing structures as complex as spiral galaxies and allows the viewer to directly compare observations from the real universe with theoretical results. 3D is an inherent feature of the cosmology data sets and stereoscopic visualization provides a natural way to present the images to the viewer, in addition to allowing researchers to visualize these vast, complex data sets. The presentation of the movie used passive, linearly polarized projection onto a 2m wide screen but it was also required to playback on a Sharp RD3D display and in anaglyph projection at venues without dedicated stereoscopic display equipment. Additionally lenticular prints were made from key images in the movie. We discuss the following technical challenges during the stereoscopic production process; 1) Controlling the depth presentation, 2) Editing the stereoscopic sequences, 3) Generating compressed movies in display speci¯c formats. We conclude that the generation of high quality stereoscopic movie content using desktop tools and equipment is feasible. This does require careful quality control and manual intervention but we believe these overheads are worthwhile when presenting inherently 3D data as the result is signi¯cantly increased impact and better understanding of complex 3D scenes

The ACS Fornax Cluster Survey. II. The Central Brightness Profiles of Early-Type Galaxies: A Characteristic Radius on Nuclear Scales and the Transition from Central Luminosity Deficit to Excess

We analyse HST surface brightness profiles for 143 early-type galaxies in the Virgo and Fornax Clusters. Sersic models provide accurate descriptions of the global profiles with a notable exception: the observed profiles deviate systematically inside a characteristic "break" radius of R_b ~ 0.02R_e where R_e is the effective radius of the galaxy. The sense of the deviation is such that bright galaxies (M_B < -20) typically show central light deficits with respect to the inward extrapolation of the Sersic model, while the great majority of low- and intermediate-luminosity galaxies (-19.5 < M_B < -15) show central light excesses; galaxies occupying a narrow range of intermediate luminosities (-20 < M_B < -19.5) are usually well fitted by Sersic models over all radii. The slopes of the central surface brightness profiles, when measured at fixed fractions of R_e, vary smoothly as a function of galaxy luminosity in a manner that depends sensitively on the choice of measurement radius. We show that a recent claim of strong bimodality in slope is likely an artifact of the galaxy selection function used in that study. To provide a more robust characterization of the inner regions of galaxies, we introduce a parameter that describes the central luminosity deficit or excess relative to the inward extrapolation of the outer Sersic model. We find that this parameter varies smoothly over the range of ~ 720 in blue luminosity spanned by the Virgo and Fornax sample galaxies, with no evidence for a dichotomy. We argue that the central light excesses (nuclei) in M_B > -19 galaxies may be the analogs of the dense central cores that are predicted by some numerical simulations to form via gas inflows. (ABRIDGED)Comment: To appear in the Astrophysical Journal, December 2007. Full resolution paper available at http://www.cfa.harvard.edu/~ajordan/ACSFCS/Home.htm

Silk from Crickets: A New Twist on Spinning

Raspy crickets (Orthoptera: Gryllacrididae) are unique among the orthopterans in producing silk, which is used to build shelters. This work studied the material composition and the fabrication of cricket silk for the first time. We examined silk-webs produced in captivity, which comprised cylindrical fibers and flat films. Spectra obtained from micro-Raman experiments indicated that the silk is composed of protein, primarily in a beta-sheet conformation, and that fibers and films are almost identical in terms of amino acid composition and secondary structure. The primary sequences of four silk proteins were identified through a mass spectrometry/cDNA library approach. The most abundant silk protein was large in size (300 and 220 kDa variants), rich in alanine, glycine and serine, and contained repetitive sequence motifs; these are features which are shared with several known beta-sheet forming silk proteins. Convergent evolution at the molecular level contrasts with development by crickets of a novel mechanism for silk fabrication. After secretion of cricket silk proteins by the labial glands they are fabricated into mature silk by the labium-hypopharynx, which is modified to allow the controlled formation of either fibers or films. Protein folding into beta-sheet structure during silk fabrication is not driven by shear forces, as is reported for other silks

Interpolation of landslide movements to improve the accuracy of 4D geoelectrical monitoring

Measurement sensors permanently installed on landslides will inevitably change their position over time due to mass movements. To interpret and correct the recorded data, these movements have to be determined. This is especially important in the case of geoelectrical monitoring, where incorrect sensor positions produce strong artefacts in the resulting resistivity models. They may obscure real changes, which could indicate triggering mechanisms for landslide failure or reactivation. In this paper we introduce a methodology to interpolate movements from a small set of sparsely distributed reference points to a larger set of electrode locations. Within this methodology we compare three interpolation techniques, i.e., a piecewise planar, bi-linear spline, and a kriging based interpolation scheme. The performance of these techniques is tested on a synthetic and a real-data example, showing a recovery rate of true movements to about 1% and 10% of the electrode spacing, respectively. The significance for applying the proposed methodology is demonstrated by inverse modelling of 4D electrical resistivity tomography data, where it is shown that by correcting for sensor movements corresponding artefacts can virtually be removed and true resistivity changes be imaged

A combined geomorphological and geophysical approach to characterising relict landslide hazard on the Jurassic Escarpments of Great Britain

The Jurassic Escarpment in the North York Moors in Northern Britain has a high density of deep-seated relict landslides but their regional hazard is poorly understood due to a lack of detailed case studies. Investigation of a typical relict landslide at Great Fryup Dale suggests that the crop of the Whitby Mudstone Formation is highly susceptible to landslide hazards. The mudstone lithologies along the Escarpment form large multiple rotational failures which break down at an accelerated rate during wetter climates and degrade into extensive frontal mudflows. Geomorphological mapping, high resolution LiDAR imagery, boreholes, and geophysical ERT surveys are deployed in a combined approach to delimit internal architecture of the landslide. Cross-sections developed from these data indicate that the main movement displaced a bedrock volume of c. 1 × 107 m3 with a maximum depth of rupture of c. 50 m. The mode of failure is strongly controlled by lithology, bedding, joint pattern, and rate of lateral unloading. Dating of buried peats using the AMS method suggests that the 10 m thick frontal mudflow complex was last active in the Late Holocene, after c. 2270 ± 30 calendar years BP. Geomorphic mapping and dating work indicates that the landslide is dormant, but slope stability modelling suggests that the slope is less stable than previously assumed; implying that this and other similar landslides in Britain may become more susceptible to reactivation or extension during future wetter climatic phases. This study shows the value of a multi-technique approach for landslide hazard assessment and to enhance national landslide inventories

An Eccentric Circumbinary Accretion Disk and the Detection of Binary Massive Black Holes

We present a two-dimensional grid-based hydrodynamic simulation of a thin, viscous, locally-isothermal corotating disk orbiting an equal-mass Newtonian binary point mass on a fixed circular orbit. We study the structure of the disk after multiple viscous times. The binary maintains a central hole in the viscously-relaxed disk with radius equal to about twice the binary semimajor axis. Disk surface density within the hole is reduced by orders of magnitude relative to the density in the disk bulk. The inner truncation of the disk resembles the clearing of a gap in a protoplanetary disk. An initially circular disk becomes elliptical and then eccentric. Disturbances in the disk contain a component that is stationary in the rotating frame in which the binary is at rest; this component is a two-armed spiral density wave. We measure the distribution of the binary torque in the disk and find that the strongest positive torque is exerted inside the central low-density hole. We make connection with the linear theory of disk forcing at outer Lindblad resonances (OLRs) and find that the measured torque density distribution is consistent with forcing at the 3:2 (m=2) OLR, well within the central hole. We also measure the time dependence of the rate at which gas accretes across the hole and find quasi-periodic structure. We discuss implications for variability and detection of active galactic nuclei containing a binary massive black hole.Comment: 10 pages; replaced to match ApJ version; includes new physical interpretation of torque density (Sec. 4.1); large mpeg animation is available at http://www.tapir.caltech.edu/~milos/circBinaryEccDisk.mp

Population-Attributable Risk Estimates for Risk Factors Associated with Campylobacter Infection

In 2001-2002, a multicenter, prospective case-control study involving 1,714 participants ≥5 years of age was conducted in Australia to identify risk factors for Campylobacter infection. Adjusted population-attributable risks (PARs) were derived for eac

Solution-Phase Combinatorial Chemistry in Lead Discovery

Solution-phase approaches in combinatorial chemistry complement solid-phase approaches and each can be used to advantage in particular circumstances. Solution-phase synthesis of pools of compounds, whilst allowing successful identification of a selection of good lead structures for medicinal chemistry programmes, also reinforced a number of the disadvantages of such an approach. Solution-phase parallel synthesis of discrete compounds has, however, proved to be a very useful and popular approach both for lead generation and in lead optimisation work. The range of chemistry suitable for use in such approaches is expanding rapidly and some of these chemistries are discussed. The current focus is on enhancing the quality of compounds prepared in array formats, and we describe a number of useful approaches which are being developed to that end

Expression of Cholera Toxin B–Proinsulin Fusion Protein in Lettuce and Tobacco Chloroplasts – Oral Administration Protects Against Development of Insulitis in Non-Obese Diabetic Mice

Lettuce and tobacco chloroplast transgenic lines expressing the cholera toxin B subunit–human proinsulin (CTB-Pins) fusion protein were generated. CTB-Pins accumulated up to ~16% of total soluble protein (TSP) in tobacco and up to ~2.5% of TSP in lettuce. Eight milligrams of powdered tobacco leaf material expressing CTB-Pins or, as negative controls, CTB–green fluorescent protein (CTB-GFP) or interferon–GFP (IFN-GFP), or untransformed leaf, were administered orally, each week for 7 weeks, to 5-week-old female non-obese diabetic (NOD) mice. The pancreas of CTB-Pins-treated mice showed decreased infiltration of cells characteristic of lymphocytes (insulitis); insulin-producing β-cells in the pancreatic islets of CTB-Pins-treated mice were significantly preserved, with lower blood or urine glucose levels, by contrast with the few β-cells remaining in the pancreatic islets of the negative controls. Increased expression of immunosuppressive cytokines, such as interleukin-4 and interleukin-10 (IL-4 and IL-10), was observed in the pancreas of CTB-Pins-treated NOD mice. Serum levels of immunoglobulin G1 (IgG1), but not IgG2a, were elevated in CTB-Pins-treated mice. Taken together, T-helper 2 (Th2) lymphocyte-mediated oral tolerance is a likely mechanism for the prevention of pancreatic insulitis and the preservation of insulin-producing β-cells. This is the first report of expression of a therapeutic protein in transgenic chloroplasts of an edible crop. Transplastomic lettuce plants expressing CTB-Pins grew normally and transgenes were maternally inherited in T1 progeny. This opens up the possibility for the low-cost production and delivery of human therapeutic proteins, and a strategy for the treatment of various other autoimmune diseases

Simulating the influences of groundwater on regional geomorphology using a distributed, dynamic, landscape evolution modelling platform

A dynamic landscape evolution modelling platform (CLiDE) is presented that allows a variety of Earth system interactions to be explored under differing environmental forcing factors. Representation of distributed surface and subsurface hydrology within CLiDE is suited to simulation at sub-annual to centennial time-scales. In this study the hydrological components of CLiDE are evaluated against analytical solutions and recorded datasets. The impact of differing groundwater regimes on sediment discharge is examined for a simple, idealised catchment, Sediment discharge is found to be a function of the evolving catchment morphology. Application of CLiDE to the upper Eden Valley catchment, UK, suggests the addition of baseflow-return from groundwater into the fluvial system modifies the total catchment sediment discharge and the spatio-temporal distribution of sediment fluxes during storm events. The occurrence of a storm following a period of appreciable antecedent rainfall is found to increase simulated sediment fluxes