4,605 research outputs found
The Persistence of Cool Galactic Winds in High Stellar Mass Galaxies Between z~1.4 and ~1
We present an analysis of the MgII 2796, 2803 and FeII 2586, 2600 absorption
line profiles in coadded spectra of 468 galaxies at 0.7 < z < 1.5. The galaxy
sample, drawn from the Team Keck Treasury Redshift Survey of the GOODS-N field,
has a range in stellar mass (M_*) comparable to that of the sample at z~1.4
analyzed in a similar manner by Weiner et al. (2009; W09), but extends to lower
redshifts and has specific star formation rates which are lower by ~0.6 dex. We
identify outflows of cool gas from the Doppler shift of the MgII absorption
lines and find that the equivalent width (EW) of absorption due to outflowing
gas increases on average with M_* and star formation rate (SFR). We attribute
the large EWs measured in spectra of the more massive, higher-SFR galaxies to
optically thick absorbing clouds having large velocity widths. The outflows
have hydrogen column densities N(H) > 10^19.3 cm^-2, and extend to velocities
of ~500 km/s. While galaxies with SFR > 10 Msun/yr host strong outflows in both
this and the W09 sample, we do not detect outflows in lower-SFR (i.e., log
M_*/Msun < 10.5) galaxies at lower redshifts. Using a simple galaxy evolution
model which assumes exponentially declining SFRs, we infer that strong outflows
persist in galaxies with log M_*/Msun > 10.5 as they age between z=1.4 and z~1,
presumably because of their high absolute SFRs. Finally, using high resolution
HST/ACS imaging in tandem with our spectral analysis, we find evidence for a
weak trend (at 1 sigma significance) of increasing outflow absorption strength
with increasing galaxy SFR surface density.Comment: Submitted to ApJ. 25 pages, 19 figures, Figure 2 reduced in
resolution. Uses emulateapj forma
DNA methylation signature is prognostic of choroid plexus tumor aggressiveness
Abstract: Background: Histological grading of choroid plexus tumors (CPTs) remains the best prognostic tool to distinguish between aggressive choroid plexus carcinoma (CPC) and the more benign choroid plexus papilloma (CPP) or atypical choroid plexus papilloma (aCPP); however, these distinctions can be challenging. Standard treatment of CPC is very aggressive and often leads to severe damage to the young child’s brain. Therefore, it is crucial to distinguish between CPC and less aggressive entities (CPP or aCPP) to avoid unnecessary exposure of the young patient to neurotoxic therapy. To better stratify CPTs, we utilized DNA methylation (DNAm) to identify prognostic epigenetic biomarkers for CPCs. Methods: We obtained DNA methylation profiles of 34 CPTs using the HumanMethylation450 BeadChip from Illumina, and the data was analyzed using the Illumina Genome Studio analysis software. Validation of differentially methylated CpG sites chosen as biomarkers was performed using pyrosequencing analysis on additional 22 CPTs. Sensitivity testing of the CPC DNAm signature was performed on a replication cohort of 61 CPT tumors obtained from Neuropathology, University Hospital Münster, Germany. Results: Generated genome-wide DNAm profiles of CPTs showed significant differences in DNAm between CPCs and the CPPs or aCPPs. The prediction of clinical outcome could be improved by combining the DNAm profile with the mutational status of TP53. CPCs with homozygous TP53 mutations clustered as a group separate from those carrying a heterozygous TP53 mutation or CPCs with wild type TP53 (TP53-wt) and showed the worst survival outcome. Specific DNAm signatures for CPCs revealed AK1, PER2, and PLSCR4 as potential biomarkers for CPC that can be used to improve molecular stratification for diagnosis and treatment. Conclusions: We demonstrate that combining specific DNAm signature for CPCs with histological approaches better differentiate aggressive tumors from those that are not life threatening. These findings have important implications for future prognostic risk prediction in clinical disease management
Switching the stereochemical outcome of 6-endo-trig cyclizations; Synthesis of 2,6-Cis-6-substituted 4-oxopipecolic acids
A base-mediated 6-endo-trig cyclization of
readily accessible enone-derived α-amino acids has been
developed for the direct synthesis of novel 2,6-cis-6-
substituted-4-oxo-L-pipecolic acids. A range of aliphatic and
aryl side chains were tolerated by this mild procedure to give
the target compounds in good overall yields. Molecular
modeling of the 6-endo-trig cyclization allowed some insight as
to how these compounds were formed, with the enolate
intermediate generated via an equilibrium process, followed by irreversible tautomerization/neutralization providing the driving force for product formation. Stereoselective reduction and deprotection of the resulting 2,6-cis-6-substituted 4-oxo-L-pipecolic acids to the corresponding 4-hydroxy-L-pipecolic acids was also performed
Incidence and drug treatment of emotional distress after cancer diagnosis : a matched primary care case-control study
Notes This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License.Peer reviewedPublisher PD
Wavelength calibration for OSIRIS/GTC* tunable filters
OSIRIS (Optical System for Imaging and low Resolution Integrated
Spectroscopy) is the first light instrument of the Gran Telescopio Canarias
(GTC). It provides a flexible and competitive tunable filter (TF). Since it is
based on a Fabry-Perot interferometer working in collimated beam, the TF
transmission wavelength depends on the position of the target with respect to
the optical axis. This effect is non-negligible and must be accounted for in
the data reduction. Our paper establishes a wavelength calibration for OSIRIS
TF with the accuracy required for spectrophotometric measurements using the
full field of view (FOV) of the instrument. The variation of the transmission
wavelength across the FOV is well described by
, where is the central
wavelength, represents the physical distance from the optical axis, and
mm is the effective focal length of the camera lens. This
new empirical calibration yields an accuracy better than 1\,\AA\ across the
entire OSIRIS FOV (8\arcmin8\arcmin), provided that the position
of the optical axis is known within 45 m ( 1.5 binned pixels). We
suggest a calibration protocol to grant such precision over long periods, upon
re-alignment of OSIRIS optics, and in different wavelength ranges. This
calibration differs from the calibration in OSIRIS manual which, nonetheless,
provides an accuracy \AA\, for R\lesssim 2\arcmin.Comment: 22 pages, 7 figures, accepted for publication in PAS
Ubiquitous outflows in DEEP2 spectra of star-forming galaxies at z=1.4
Galactic winds are a prime suspect for the metal enrichment of the
intergalactic medium and may have a strong influence on the chemical evolution
of galaxies and the nature of QSO absorption line systems. We use a sample of
1406 galaxy spectra at z~1.4 from the DEEP2 redshift survey to show that
blueshifted Mg II 2796, 2803 A absorption is ubiquitous in starforming galaxies
at this epoch. This is the first detection of frequent outflowing galactic
winds at z~1. The presence and depth of absorption are independent of AGN
spectral signatures or galaxy morphology; major mergers are not a prerequisite
for driving a galactic wind from massive galaxies. Outflows are found in
coadded spectra of galaxies spanning a range of 30x in stellar mass and 10x in
star formation rate (SFR), calibrated from K-band and from MIPS IR fluxes. The
outflows have column densities of order N_H ~ 10^20 cm^-2 and characteristic
velocities of ~ 300-500 km/sec, with absorption seen out to 1000 km/sec in the
most massive, highest SFR galaxies. The velocities suggest that the outflowing
gas can escape into the IGM and that massive galaxies can produce
cosmologically and chemically significant outflows. Both the Mg II equivalent
width and the outflow velocity are larger for galaxies of higher stellar mass
and SFR, with V_wind ~ SFR^0.3, similar to the scaling in low redshift
IR-luminous galaxies. The high frequency of outflows in the star-forming galaxy
population at z~1 indicates that galactic winds occur in the progenitors of
massive spirals as well as those of ellipticals. The increase of outflow
velocity with mass and SFR constrains theoretical models of galaxy evolution
that include feedback from galactic winds, and may favor momentum-driven models
for the wind physics.Comment: Accepted by ApJ. 25 pages, 17 figures. Revised to add discussions of
intervening absorbers and AGN-driven outflows; conclusions unchange
An Electrochemical Study of Frustrated Lewis Pairs: A Metal-free Route to Hydrogen Oxidation
[Image: see text] Frustrated Lewis pairs have found many applications in the heterolytic activation of H(2) and subsequent hydrogenation of small molecules through delivery of the resulting proton and hydride equivalents. Herein, we describe how H(2) can be preactivated using classical frustrated Lewis pair chemistry and combined with in situ nonaqueous electrochemical oxidation of the resulting borohydride. Our approach allows hydrogen to be cleanly converted into two protons and two electrons in situ, and reduces the potential (the required energetic driving force) for nonaqueous H(2) oxidation by 610 mV (117.7 kJ mol(–1)). This significant energy reduction opens routes to the development of nonaqueous hydrogen energy technology
Saturation of electrical resistivity
Resistivity saturation is observed in many metallic systems with a large
resistivity, i.e., when the resistivity has reached a critical value, its
further increase with temperature is substantially reduced. This typically
happens when the apparent mean free path is comparable to the interatomic
separations - the Ioffe-Regel condition. Recently, several exceptions to this
rule have been found. Here, we review experimental results and early theories
of resistivity saturation. We then describe more recent theoretical work,
addressing cases both where the Ioffe-Regel condition is satisfied and where it
is violated. In particular we show how the (semiclassical) Ioffe-Regel
condition can be derived quantum-mechanically under certain assumptions about
the system and why these assumptions are violated for high-Tc cuprates and
alkali-doped fullerides.Comment: 16 pages, RevTeX, 15 eps figures, additional material available at
http://www.mpi-stuttgart.mpg.de/andersen/saturation
Modeling dose-response relationships of the effects of fesoterodine in patients with overactive bladder
<p>Abstract</p> <p>Background</p> <p>Fesoterodine is an antimuscarinic for the treatment of overactive bladder, a syndrome of urgency, with or without urgency urinary incontinence (UUI), usually with increased daytime frequency and nocturia. Our objective was to develop predictive models to describe the dose response of fesoterodine.</p> <p>Methods</p> <p>Data from subjects enrolled in double-blind, placebo-controlled phase II and III trials were used for developing longitudinal dose-response models.</p> <p>Results</p> <p>The models predicted that clinically significant and near-maximum treatment effects would be seen within 3 to 4 weeks after treatment initiation. For a typical patient with 11 micturitions per 24 hours at baseline, predicted change was -1.2, -1.7, and -2.2 micturitions for placebo and fesoterodine 4 mg and 8 mg, respectively. For a typical patient with 2 UUI episodes per 24 hours at baseline, predicted change was -1.05, -1.26, and -1.43 UUI episodes for placebo and fesoterodine 4 mg and 8 mg, respectively. Increase in mean voided volume was estimated at 9.7 mL for placebo, with an additional 14.2 mL and 28.4 mL for fesoterodine 4 mg and 8 mg, respectively.</p> <p>Conclusions</p> <p>A consistent dose response for fesoterodine was demonstrated for bladder diary endpoints in subjects with overactive bladder, a result that supports the greater efficacy seen with fesoterodine 8 mg in post hoc analyses of clinical trial data. The dose-response models can be used to predict outcomes for doses not studied or for patient subgroups underrepresented in clinical trials.</p> <p>Trial Registration</p> <p>The phase III trials used in this analysis have been registered at ClinicalTrials.gov (NCT00220363 and NCT00138723).</p
Cytokine treatment optimises the immunotherapeutic effects of umbilical cord-derived MSC for treatment of inflammatory liver disease
Background: Mesenchymal stromal cells (MSC) possess immunomodulatory properties and low immunogenicity, both crucial properties for their development into an effective cellular immunotherapy. They have shown benefit in clinical trials targeting liver diseases; however the efficacy of MSC therapy will benefit from improvement of the immunomodulatory and immunogenic properties of MSC. Methods: MSC derived from human umbilical cords (ucMSC) were treated for 3 days in vitro with various inflammatory factors, interleukins, vitamins and serum deprivation. Their immunogenicity and immunomodulatory capacity were examined by gene-expression analysis, surface-marker expressions, IDO activity, PGE2 secretion and inhibition of T cell proliferation and IFNγ production. Furthermore, their activation of NK cell cytotoxicity was investigated via CD107a expre
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