Contribuciones a la flora del Sistema Ibérico, 9

Se dan notícias corológicas sobre 22 táxones vasculares raras o poco conocidas en la zona, localizadas en el Sistema Ibérico a su paso por las provincias de Cuenca, Guadalajara, Teruel y [email protected]

Clinical characteristics and risk of relapse for patients with stage I-II diffuse large B cell lymphoma treated in first line with immunochemotherapy

Diffuse large b-cell lymphoma (DLBCL) is an aggressive and potentially curable lymphoma that presents itself as stage I-II in 30% of all cases. It is known that in these localized stages, 15-20% of patients treated without rituximab eventually relapse, but less data exist regarding rituximab era. We have analyzed clinico-pathological features and risk of relapse in 98 patients with I-II stage DLBCL in complete response (CR) or unconfirmed CR (CRu) after first-line treatment consisting of immunochemotherapy. Twelve patients (12.2%) eventually relapsed. Late relapse, more than two years after diagnosis, occurred in three patients, and early relapse, less than two years after diagnosis, was documented in nine patients. Median time from diagnosis to relapse was 0.61 years for patients with early relapse and 3.66 years for patients with late relapse. The second CR rate obtained was similar in the late and in early relapsing patients, being 33% versus 44% (p = 0.072), respectively. Three-year overall survival (OS) was 22% for early relapsing patients and 33% for late relapsing patients (p = 0.65). In conclusion, patients who are diagnosed with stage I-II DLBCL and achieve a CR/CRu with first line immunochemotherapy have a good prognosis. However, a proportion of patients relapse, and this is less frequent in patients treated with first line with immunochemotherapy. These patients have a poor prognosis

Low-Dose PET/CT and Full-Dose Contrast-Enhanced CT at the Initial Staging of Localized Diffuse Large B-Cell Lymphomas

Computed tomography (CT) has been used as the reference imaging technique for the initial staging of diffuse large B-cell lymphoma until recent days, when the introduction of positron emission tomography (PET)/CT imaging as a hybrid technique has become of routine use. However, the performance of both examinations is still common. The aim of this work was to compare the findings between low-dose 2-deoxy-2-(F-18) fluoro-D-glucose (F-18-FDG) PET/CT and full-dose contrast-enhanced CT (ceCT) in 28 patients with localized diffuse large B-cell lymphoma according to PET/CT findings, in order to avoid the performance of ceCT. For each technique, a comparison in the number of nodal and extranodal involved regions was performed. PET/CT showed more lesions than ceCT in both nodal (41 vs. 36) and extranodal localizations (16 vs. 15). Disease staging according to both techniques was concordant in 22 patients (79%) and discordant in 6 patients (21%), changing treatment management in 3 patients (11%). PET/CT determined a better staging and therapeutic approach, making the performance of an additional ceCT unnecessary

Why Music Therapists Choose to Work with a Clinical Population: An International Pilot Survey

(1) Background: Throughout their career, music therapists make decisions regarding the clinical population they choose to work with. Though such decisions can have broad implications on the professional development of the music therapist, not much is known about the reasons for making these decisions and whether they are affected by demographic or professional factors. (2) Methods: In this pilot study, we surveyed 439 music therapists from six countries (i.e., Austria, the Czech Republic, Germany, Israel, Spain, and Switzerland) using an online questionnaire. We asked the respondents to explain why they chose to work with their main clienteles, and we examined whether their reasons were connected to demographic factors such as country of origin, gender, and seniority, and professional factors such as experience as a music therapist and population one works with. (3) Results: The category analysis of these responses pointed at nine distinct reasons that could be grouped into "practical reasons", "reasons of connection", and "innovation". There were differences in reasoning between music therapists from different countries, and with different degrees of seniority, but not between male and female music therapists. (4) Discussion: The implications on training programs and on policy makers are discussed as well as the importance of this subject to the development of music therapists' professional identity

Outpatients' opinion and experience regarding telepharmacy during the COVID-19 pandemic: the Enopex Project

[Abstract] Background: Telepharmacy, as a remote pharmaceutical care procedure, is being used worldwide during the COVID-19 pandemic, with the aim of preserving the health of patients and professionals. Its future development should incorporate the assessment of patient perception, but no research study has investigated it. Objective: The objective was to poll the opinions and experiences of outpatients with telepharmacy through a purpose-developed questionnaire and to assess it's quality through an internal validity and reliability analysis. Methods: Cross-sectional observational study of adult patients who used telepharmacy services during the COVID-19 lockdown period in Spain. The subjects answered a 24-item questionnaire, after giving their informed consent. Place of delivery, informed pharmacotherapeutic follow-up, opinion about telepharmacy, future development, ethics/satisfaction, and coordination constituted the six questionnaire categories. After assessing the adequate sample size with the Kaiser-Meyer-Olkin test, the Bartlett sphericity test analyzed the validity of the questionnaire. The intraclass correlation coefficient and Cronbach's α coefficient calculations verified the reliability and internal consistency. Results: A total of 9442 interviews were administered to patients from 81 hospitals, of which 8079 were valid (52.8% female). A 54.1% were aged between 41-65 years; 42.7% had been in treatment for more than 5 years; 42.8% lived between 6-31 miles from the hospital. As many as 96.7% of patients were "satisfied" or "very satisfied" with telepharmacy, 97.5% considering it complementary to their usual follow-up; 55.9% expressed a preference for being followed up face to face when visiting the hospital. 75.6% said they had rather receive their medication at home. The sample size obtained was deemed appropriate [the Kaiser-Meyer-Olkin test (0.789) and Bartlett's sphericity test (p<0.005)]. The reliability analysis resulted in a Cronbach α = 0.7. Conclusion: Patients have shown high satisfaction with telepharmacy and the ENOPEX questionnaire is a tool with sufficient validity and reliability to be used in the evaluation of the care that patients receive through telepharmacy

El soporte conservativo en piezas textiles: valoración de la idoneidad del Fosshape

[ES] El presente trabajo va encaminado a valorar la importancia del soporte conservativo en el ámbito de la preservación textil. Para ello se han recopilado y estudiado los materiales y técnicas de construcción más comúnmente utilizadas para la fabricación de este tipo de soportes expositivos, en base a los resultados obtenidos de la encuesta realizada a aquellas instituciones de mayor relevancia en la elaboración de este tipo de soportes. Esta revisión ha puesto de manifiesto la utilización de un nuevo material denominado FOSSHAPE®, cuyas características específicas amplía la gama de posibilidades en la construcción de maniquíes y soportes conservativos, específicamente para aquellos de menor tamaño, que no necesitan estructuras internas rígidas para su construcción. Con el objetivo de determinar las características específicas de este material se ha realizado un estudio comparando dos espesores, FOSSHAPE® 300 y FOSSHAPE® 600, por medio de microscopía óptica, medición de pH, análisis colorimétrico y FTIR-ATR, antes y después de su envejecimiento artificial acelerado por radiación UV para evaluar su respuesta ante este factor de degradación. Esta investigación plantea un estudio preliminar de este nuevo material (FOSSHAPE®) con el objetivo de evaluar, por un lado, su interacción a nivel físico-químico con los estratos conservativos superiores y, en definitiva, determinar su idoneidad como soporte para la conservación (almacenaje y exhibición) de piezas textiles. Los resultados obtenidos evidencian un mejor comportamiento del FOSSHAPE® 300 que del FOSSHAPE® 600 frente a la radiación UV.[EN] The aim of this research is to assess the importance of textile storage and exhibition supportsused for textile conservation. For this purpose, most commonly materials and construction techniques worldwide used for this purpose have been compiled and review based on the results obtained of the survey propose to those Museums and Institutions well-known for the use and construction of this kind of conservative supports. This review has revealed the use of a new material called Fosshape®, whose specific characteristics extend the range of possibilities in the construction of mannequins and conservative supports, more specifically for those of smaller size, which don’t need rigid internal structures for their construction. In order to determine the specific characteristics of this material an extensive study was carried out comparing both thicknesses, Fosshape® 300 and Fosshape® 600, by means of optical microscopy, pH measurements, colorimetric analysis and FTIR-ATR, before and after UV accelerated artificial aging to evaluate the degradation induced by light. This research proposes a preliminary study of this new material (FOSSHAPE®) in order to assess its physico-chemical influence regarding upper conservative layers and more specifically, to determine its suitability as a storage and exhibition support for textile conservation, to conclude, the results obtained show a better behaviour of FOSSHAPE® 300 than FOSSHAPE® 600 after UV radiation.Agradecer al Instituto Inter-Universitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Departamento de Química, UPV-UV (Universitat Politécnica de València - Universitat de València). Y a todas las instituciones que han contestado a nuestra encuesta y mensajes: Smithsonian Insitution, Centre de Documentació i Museu Tèxtil, Cristobal Balenciaga Museo, Musée des Tissus, San Jose Museum of Quilt and Textiles y Museu del Disseny de Barcelona. Y a Brian Jeffrey, creador del FosshapeCavaller Mercadal, M.; Vicente Palomino, S.; Yusa Marco, DJ.; Montesinos Ferrandis, EM. (2020). El soporte conservativo en piezas textiles: valoración de la idoneidad del Fosshape. Arché. (13 - 14 - 15):51-60. http://hdl.handle.net/10251/156586516013 - 14 - 1

Feasibility of the internet attachment-based compassion therapy in the general population: protocol for an open-label uncontrolled pilot trial

Background: Compassion-based interventions delivered over the internet are showing promising results for the promotion of psychological health and well-being. Several studies have highlighted their feasibility, acceptance, and preliminary efficacy. However, this is an incipient field of research, and to the best of our knowledge, there are no data available from Spanish-speaking countries. Objective: The aim of this study is to investigate the feasibility, acceptance, and preliminary efficacy of the Internet Attachment-Based Compassion Therapy (iABCT), a web-based version of the Attachment-Based Compassion Therapy, in Spanish speakers from the general population. Methods: This feasibility study features a single-arm, uncontrolled, within-group design with an embedded qualitative and quantitative process evaluation at baseline, immediately after the intervention and at the 3-month follow-up. A minimum of 35 participants from the general population will be allocated to iABCT. Feasibility measures will include attrition rate, patterns of use of the web-based system, and participants' acceptability, usability, and opinion. The primary outcome was measured using the Pemberton Happiness Index. Secondary outcomes were measured using the Compassion Scale, Self-Compassion Scale, Forms of Self-Criticizing/Attacking and Self-Reassuring Scale-Short form, Five Facets of Mindfulness Questionnaire, Relationships Questionnaire, General Health Questionnaire, Non-Attachment Scale, International Positive and Negative Affect Schedule Short Form, Purpose-In-Life Test, and difficulties regarding the practice of compassion (Compassion Practice Quality Questionnaire). Mixed models will be used to evaluate primary and secondary outcome measures. A qualitative content analysis of the participants' qualitative responses will also be performed. Results: Enrollment started in February 2020 and will be finished in April 2020. Data analysis will start in October 2020. Conclusions: To our knowledge, this study will, for the first time, show data on the feasibility, acceptability, and preliminary efficacy of web-based compassion (and self-compassion) training-that is, the adapted iABCT-in Spanish speakers from the general population. Further aspects of their implementation (ie, facilitators, barriers, and unwanted effects) and mechanisms of change will be investigated. This study will allow the revision and fine-tuning of the developed intervention, study design, and planning procedures, as well as the initiation of a future randomized controlled trial

The direct and indirect effects of COVID‐19 pandemic in a real‐life hematological setting

Background: Clinical outcomes of novel coronavirus 2019 disease (COVID-19) in onco-hematological patients are unknown. When compared to non-immunocompromised patients, onco-hematological patients seem to have higher mortality rates. Aims: We describe the characteristics and outcomes of a consecutive cohort of 24 onco-hematological patients with COVID-19 during the first month of the pandemic. We also describe variations in healthcare resource utilization within our hematology department. Methods and results: Data from patients between the first month of the pandemic were retrospectively collected. Clinical and logistic data were also collected and compared with the average values from the prior 3 months of activity. Prevalence of COVID-19 in our hematological population was 0.4%. Baseline characteristics were as follows: male sex: 83%, lymphoid diseases: 46%, median age: 69 (22-82) years. Median follow-up in survivors was 14 (9-28) days and inpatient mortality rate was 46%. Average time to moderate/severe respiratory insufficiency and death were 3 (1-10) and 10 (3-18) days, respectively. Only 1 out of every 12 patients who developed moderate to severe respiratory insufficiency recovered. Upon univariate analysis, the following factors were associated with higher mortality: age ≥ 70 years (P = .01) and D-dimer ≥900 mcg/L (P = .04). With respect to indirect effects during the COVID-19 pandemic, and when compared with the prior 3 months of activity, inpatient mortality (excluding patients with COVID-19 included in the study) increased by 56%. This was associated with a more frequent use of vasoactive drugs (+300%) and advanced respiratory support (+133%) in the hematology ward. In the outpatient setting, there was a reduction in initial visits (-55%) and chemotherapy sessions (-19%). A significant increase in phone visits was reported (+581%). Conclusion: COVID-19 pandemic is associated with elevated mortality in hematological patients. Negative indirect effects are also evident within this setting

Fragilidad en pacientes con Enfermedad renal crónica avanzada en tratamiento renal conservador

Antecedentes: La prevalencia de Enfermedad Renal Crónica es superior al 20% en mayores 64 an~os y se asocia con importante morbimortalidad. En ellos el Tratamiento Renal Conservador es una opción legítima de tratamiento. En los últimos an~os la fragilidad se ha convertido en un campo de investigación en mayores y debe ser tenida en cuenta en pacientes ancianos con Enfermedad Renal. Objetivos: Determinar número de pacientes frágiles en Tratamiento Renal Conservador según Escala FRAIL. Determinar si la fragilidad se relaciona con la comorbilidad y la situación funcional. Material y Método: Seleccionamos en consulta de Enfermedad Renal Crónica Avanzada a pacientes mayores de 75 an~os orientados a Tratamiento Renal Conservador. Recogemos Criterios de Fragilidad de Fraid, índice de Comorbilidad de Charlson, Escala de Lawton y Brody, Evaluación para la capacidad de la marcha de FAC e índice de Barthel. Resultados: Se incluyen 80 pacientes 51,2% varones con edad media 84,7 ± 4 an~os y eFG 16,5 ml/min/1,73m2. El 51,2% cumplen criterios de fragilidad. No encontramos diferencias significativas en la escala Charlson entre los pacientes frágiles (8,61 ± 1,28) y no frágiles (8,39 ± 1,36) p= 0,55. La escala de Lawton y Brody y la escala FAC de la marcha se relacionaron con fragilidad (p = 0.001, p = 0.018 respectivamente). Conclusiones: El 51,2% de los pacientes Tratamiento Renal Conservador cumplen criterios de fragilidad por lo que consideramos esta escala válida como herramienta en la toma de decisiones. La fragilidad no se correlaciona con el índice de Charlson: la patología valorada por este test puede no ser sensible a la hora de estudiar esta situación clínica. Encontramos buena correlación con los test que valoran la situación funcional, tanto en la escala de actividades instrumentales de Lawton Brody (útil para detectar primeros grados de deterioro) y para la escala FAC de la marcha

Feasibility and outcomes after dose reduction of immunochemotherapy in young adults with Burkitt lymphoma and leukemia: results of the BURKIMAB14 trial

High dose -intensive or infusional intermediate -dose immunochemotherapy is highly effective treatment for Burkitt lymphoma irrespective of human immunodeficiency virus (HIV) infection. However, toxicities of these regimens are relevant, especially in older adults and elderly patients. The prospective multicenter BURKIMAB14 trial included four to six blocks of immunochemotherapy according to stage (localized: 1 and 2 non -bulky; advanced: 2 bulky, 3, 4) and age, with dose reduction in patients >55 years old. Dose -intensity of chemotherapy was reduced in patients 55 years old had a significantly higher treatment -related mortality despite dose reduction of chemotherapy. With a median follow-up of 3.61 years the 4 -year OS probability was 73% (range, 63-81%). Age (55 years) and stage (localized vs. advanced) had prognostic significance. No significant differences in OS were observed in HIV -positive versus HIV -negative patients. The results of BURKIMAB14 are similar to those of other dose -intensive immunochemotherapy trials. Age >55 years and advanced stage, but not HIV infection, were associated with poor survival. Dose reduction of chemotherapy in young adults in CMR is safe and does not impact outcomes (clinicaltrials gov. Identifier: NCT05049473)