486 research outputs found
‘Didi, are you Hindu?’ Politics of Secularism in Women's Activism in India:Case-study of a Grassroots Women's Organization in Rural Uttar Pradesh
Promoting transformative and impactful research on gender and social equity in the context of climate change : implemented in Argentina, Bangladesh, Benin, Democratic Republic of the Congo, Nepal, and Nigeria
The project was designed to build the capacity of IDRC staff and country research teams to develop and implement socially transformative research that contributes to effective and long-term climate action. The report summarizes the results of the project measured against four goals agreed upon for the project (described in Section 3) and concludes that the project goals were met. A set of five project activities implemented by the Gender at Work’s Gender Action Learning (GAL) methodology are described in Section 5, along with reflections on implementation challenges
Stochastic Heterostructures in B/N-Doped Carbon Nanotubes
Carbon nanotubes are one-dimensional and very narrow. These obvious facts
imply that under doping with boron and nitrogen, microscopic doping
inhomogeneity is much more important than for bulk semiconductors. We consider
the possibility of exploiting such fluctuations to create interesting devices.
Using self-consistent tight-binding (SCTB), we study heavily doped highly
compensated nanotubes, revealing the spontaneous formation of structures
resembling chains of random quantum dots, or nano-scale diode-like elements in
series. We also consider truly isolated impurities, revealing simple scaling
properties of bound state sizes and energies.Comment: 4 pages RevTeX, 4 PostScript figure
Sodium glucose co-transporter 2 inhibition increases epidermal growth factor expression and improves outcomes in patients with type 2 diabetes
Underlying molecular mechanisms of the kidney protective effects of sodium glucose co-transporter 2 (SGLT2) inhibitors are not fully elucidated. Therefore, we studied the association between urinary epidermal growth factor (uEGF), a mitogenic factor involved in kidney repair, and kidney outcomes in patients with type 2 diabetes (T2D). The underlying molecular mechanisms of the SGLT2 inhibitor canagliflozin on EGF using single-cell RNA sequencing from kidney tissue were examined. Urinary EGF-to-creatinine ratio (uEGF/Cr) was measured in 3521 CANagliflozin cardioVascular Assessment Study (CANVAS) participants at baseline and week 52. Associations of uEGF/Cr with kidney outcome were assessed using multivariable-adjusted Cox regression models. Single-cell RNA sequencing was performed using protocol kidney biopsy tissue from ten young patients with T2D on SGLT2i, six patients with T2D on standard care only, and six healthy controls (HCs). In CANVAS, each doubling in baseline uEGF/Cr was associated with a 12% (95% confidence interval 1-22) decreased risk of kidney outcome. uEGF/Cr decreased after 52 weeks with placebo and remained stable with canagliflozin (between-group difference +7.3% (2.0-12.8). In young persons with T2D, EGF mRNA was primarily expressed in the thick ascending loop of Henle. Expression in biopsies from T2D without SGLT2i was significantly lower compared to HCs, whereas treatment with SGLT2i increased EGF levels closer to the healthy state. In young persons with T2D without SGLT2i, endothelin-1 emerged as a key regulator of the EGF co-expression network. SGLT2i treatment was associated with a shift towards normal EGF expression. Thus, decreased uEGF represents increased risk of kidney disease progression in patients with T2D. Canagliflozin increased kidney tissue expression of EGF and was associated with a downstream signaling cascade linked to tubular repair and reversal of tubular injury.</p
Elimination of Identity?based Discrimination in Food and Nutrition Programmes in India
India's growth story in recent years is being criticised for its inability to reduce the ever?increasing income inequality and higher incidence of malnutrition among its children, particularly those belonging to marginalised groups such as Scheduled Castes (SCs). This article examines the prevalence of identity?based discrimination in health and nutritional programmes and finds it to be one of the important reasons for the higher incidence of malnutrition among SC children. While examining the guidelines of two major nutritional support programmes – the Integrated Child Development Services (ICDS) and the Mid Day Meal (MDM) Scheme – the article argues for making these more caste? and gender?sensitive in order to eliminate discrimination. It offers policy recommendations to address and monitor the discrimination in nutrition programmes. These include greater participation by marginalised groups like SCs in service planning and delivery, ensuring quality and promoting accountability; training and sensitisation of service providers; and the revision of administrative guidelines
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Living with arsenic in the environment: An examination of current awareness of farmers in the Bengal basin using hybrid feature selection and machine learning
High levels of arsenic in drinking water and food materials continue to pose a global health challenge. Over 127 million people alone in Bangladesh (BD) and West Bengal (WB) state of India are exposed to elevated levels of arsenic in drinking water. Despite decades of research and outreach, arsenic awareness in communities continue to be low. Specifically, very few studies reported arsenic awareness among low-income farming communities. A comprehensive approach to assess arsenic awareness is a key step in identifying research and development priorities so that appropriate stakeholder engagement may be designed to tackle arsenic menace. In this study, we developed a comprehensive arsenic awareness index (CAAI) and identified key awareness drivers (KADs) of arsenic to help evaluate farmers’ preferences in dealing with arsenic in the environment. The CAAI and KADs were developed using a questionnaire survey in conjunction with ten machine learning (ML) models coupled with a hybrid feature selection approach. Two questionnaire surveys comprising of 73 questions covering health, water and community, and food were conducted in arsenic affected areas of WB and BD. Comparison of CAAIs showed that the BD farmers were generally more arsenic-aware (CAAI = 7.7) than WB farmers (CAAI = 6.8). Interestingly, the reverse was true for the awareness linked to arsenic in the food chain. Application of hybrid feature selection identified 15 KADs, which included factors related to stakeholder interventions and cropping practices instead of commonly perceived factors such as age, gender and income. Among ML algorithms, classification and regression trees and single C5.0 tree could estimate CAAIs with an average accuracy of 84%. Both communities agreed on policy changes on water testing and clean water supply. The CAAI and KADs combination revealed a contrasting arsenic awareness between the two farming communities, albeit their cultural similarities. Specifically, our study shows the need for increasing awareness of risks through the food chain in BD, whereas awareness campaigns should be strengthened to raise overall awareness in WB possibly through media channels as deemed effective in BD
Effects of columnar disorder on flux-lattice melting in high-temperature superconductors
The effect of columnar pins on the flux-lines melting transition in
high-temperature superconductors is studied using Path Integral Monte Carlo
simulations. We highlight the similarities and differences in the effects of
columnar disorder on the melting transition in YBaCuO
(YBCO) and the highly anisotropic BiSrCaCuO (BSCCO) at
magnetic fields such that the mean separation between flux-lines is smaller
than the penetration length. For pure systems, a first order transition from a
flux-line solid to a liquid phase is seen as the temperature is increased. When
adding columnar defects to the system, the transition temperature is not
affected in both materials as long as the strength of an individual columnar
defect (expressed as a flux-line defect interaction) is less than a certain
threshold for a given density of randomly distributed columnar pins. This
threshold strength is lower for YBCO than for BSCCO. For higher strengths the
transition line is shifted for both materials towards higher temperatures, and
the sharp jump in energy, characteristic of a first order transition, gives way
to a smoother and gradual rise of the energy, characteristic of a second order
transition. Also, when columnar defects are present, the vortex solid phase is
replaced by a pinned Bose glass phase and this is manifested by a marked
decrease in translational order and orientational order as measured by the
appropriate structure factors. For BSCCO, we report an unusual rise of the
translational order and the hexatic order just before the melting transition.
No such rise is observed in YBCO.Comment: 32 pages, 13 figures, revte
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