NODDI-SH: a computational efficient NODDI extension for fODF estimation in diffusion MRI

Diffusion Magnetic Resonance Imaging (DMRI) is the only non-invasive imaging technique which is able to detect the principal directions of water diffusion as well as neurites density in the human brain. Exploiting the ability of Spherical Harmonics (SH) to model spherical functions, we propose a new reconstruction model for DMRI data which is able to estimate both the fiber Orientation Distribution Function (fODF) and the relative volume fractions of the neurites in each voxel, which is robust to multiple fiber crossings. We consider a Neurite Orientation Dispersion and Density Imaging (NODDI) inspired single fiber diffusion signal to be derived from three compartments: intracellular, extracellular, and cerebrospinal fluid. The model, called NODDI-SH, is derived by convolving the single fiber response with the fODF in each voxel. NODDI-SH embeds the calculation of the fODF and the neurite density in a unified mathematical model providing efficient, robust and accurate results. Results were validated on simulated data and tested on \textit{in-vivo} data of human brain, and compared to and Constrained Spherical Deconvolution (CSD) for benchmarking. Results revealed competitive performance in all respects and inherent adaptivity to local microstructure, while sensibly reducing the computational cost. We also investigated NODDI-SH performance when only a limited number of samples are available for the fitting, demonstrating that 60 samples are enough to obtain reliable results. The fast computational time and the low number of signal samples required, make NODDI-SH feasible for clinical application

Infinite Feature Selection on Shore-Based Biomarkers Reveals Connectivity Modulation after Stroke

Connectomics is gaining increasing interest in the scientific and clinical communities. It consists in deriving models of structural or functional brain connections based on some local measures. Here we focus on structural connectivity as detected by diffusion MRI. Connectivity matrices are derived from microstructural indices obtained by the 3D-SHORE. Typically, graphs are derived from connectivity matrices and used for inferring node properties that allow identifying those nodes that play a prominent role in the network. This information can then be used to detect network modulations induced by diseases. In this paper we take a complementary approach and focus on link as opposed to node properties. We hypothesize that network modulation can be better described by measuring the connectivity alteration directly in the form of modulation of the properties of white matter fiber bundles constituting the network communication backbone. The goal of this paper is to detect the paths that are most altered by the pathology by exploiting a feature selection paradigm. Temporal changes on connection weights are treated as features and those playing a leading role in a patient versus healthy controls classification task are detected by the Infinite Feature Selection (Inf-FS) method. Results show that connection paths with high discriminative power can be identified that are shared by the considered microstructural descriptors allowing a classification accuracy ranging between 83% and 89%

Switching multiple model filter for boost-phase missile tracking

This paper introduces a filter for tracking a ballistic missile during its boost phase. This filter includes a new switching algorithm and a modified interacting multiple model unscented filter (IMMUF), where the Markov transition matrix is time variable. Position, velocity, and all unknown parameters of a medium-range ballistic missile model are reconstructed. Simulations demonstrate that the new filter is able to consistently estimate a missile's trajectory and all unknown parameters and to outperform the previous forms of the IMMUF

Cell aging preserves cellular immortality in the presence of lethal levels of damage.

Cellular aging, a progressive functional decline driven by damage accumulation, often culminates in the mortality of a cell lineage. Certain lineages, however, are able to sustain long-lasting immortality, as prominently exemplified by stem cells. Here, we show that Escherichia coli cell lineages exhibit comparable patterns of mortality and immortality. Through single-cell microscopy and microfluidic techniques, we find that these patterns are explained by the dynamics of damage accumulation and asymmetric partitioning between daughter cells. At low damage accumulation rates, both aging and rejuvenating lineages retain immortality by reaching their respective states of physiological equilibrium. We show that both asymmetry and equilibrium are present in repair mutants lacking certain repair chaperones, suggesting that intact repair capacity is not essential for immortal proliferation. We show that this growth equilibrium, however, is displaced by extrinsic damage in a dosage-dependent response. Moreover, we demonstrate that aging lineages become mortal when damage accumulation rates surpass a threshold, whereas rejuvenating lineages within the same population remain immortal. Thus, the processes of damage accumulation and partitioning through asymmetric cell division are essential in the determination of proliferative mortality and immortality in bacterial populations. This study provides further evidence for the characterization of cellular aging as a general process, affecting prokaryotes and eukaryotes alike and according to similar evolutionary constraints

La construcción de un currículo intercultural a partir del diálogo de saberes: descripción y análisis de una experiencia de formación docente continua

En este trabajo pretendemos dar a conocer los fundamentos y algunos resultados de la sistematización y análisis de un módulo curricular focalizado en la enseñanza de las ciencias fácticas y formales, que formó parte del posgrado en Interculturalidad y Bilingüismo, desarrollado en un centro de formación docente de la provincia de Jujuy (Argentina). Nuestra intención ha sido revisar la experiencia didáctica, para construir nuevos aprendizajes y socializarlos con quienes transitan caminos similares. Hemos identificado algunos aspectos que posibilitarían y fortalecerían el diseño e implementación de propuestas didácticas interculturales para la enseñanza de las ciencias naturales, así como aquéllos que funcionarían como obstaculizadores. Este proceso de formación docente continua posee la singularidad de haber sido el primero en nuestro país en un posgrado de actualización docente y, en este sentido, constituye un aporte como innovación didáctica.In this work we intend to make public the bases and results of the curriculum module focused on formal and factual science´s systematization and analysis, which was part of the post degree in Intercultural and Bilingualism, developed of teacher education center of the province de Jujuy (Argentina). Our intention has been to review the teaching experience, to build new learning and socializing with those who travel similar paths. We have identified some aspects that would enable and strengthen the design and implementation of intercultural educational proposals for the teaching of natural sciences as well as those which would operate as obstacles.Fil: Dumrauf, Ana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; ArgentinaFil: Menegaz, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentin

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Ecomorphological implications of primate dietary variability: an experimental model

The evolution and function of the mammalian skull and feeding apparatus is intimately related to the mechanical demands imposed by food items. The diets of wild species are often seasonal and thus individuals may experience multiple masticatory loading regimes across their ontogeny. However, despite the temporal complexity of many mammalian diets, it remains poorly understood how such long-term dietary variability affects the growth and form of the craniomandibular complex. This experimental research evaluated the effects of longitudinal variation in dietary mechanical properties on craniomandibular morphology and on the biological processes that underlie functional adaptation in this region. Results suggest that the skeletal morphology of adults, particularly those characters associated with the mandibular joint and muscle insertion sites, best reflect an individual's diet. Furthermore, variations in bone physiology and growth rates were observed to be influenced more by an individual's masticatory loading history than by absolute levels of loading. This study emphasizes the character- and age-specific nature of phenotypic plasticity related to variation in dietary properties. Furthermore, this work also highlights the importance of long-term, ontogenetic studies for assessing the impact of diet on craniomandibular form. This enhanced understanding is critical for evaluating ecomorphological reconstructions of feeding behavior in living and fossil mammals

Ontogenetic and functional modularity in the rodent mandible

The material properties of diets consumed by juvenile individuals are known to affect adult morphological outcomes. However, much of the current experimental knowledge regarding dietary effects on masticatory form is derived from studies in which individuals are fed a non-variable diet for the duration of their postweaning growth period. Thus, it remains unclear how intra-individual variation in diet, due to ontogenetic variation in feeding behaviors or seasonal resource fluctuations, affects the resulting adult morphology. Furthermore, the mandible is composed of multiple developmental and functional subunits, and the extent to which growth and plasticity among these modules is correlated may be misestimated by studies that examine non-variable masticatory function in adults only. To address these gaps in our current knowledge, this study raised Sprague Dawley rats (n = 42) in four dietary cohorts from weaning to skeletal maturity. Two cohorts were fed a stable (“annual”) diet of either solid or powdered pellets. The other two cohorts were fed a variable (“seasonal”) diet consisting of solid/powdered pellets for the first half of the study, followed by a shift to the opposite diet. Results of longitudinal morphometric analyses indicate that variation in the mandibular corpus is more prominent at immature ontogenetic stages, likely due to processes of dental eruption and the growth of tooth roots. Furthermore, adult morphology is influenced by both masticatory function and the ontogenetic timing of this function, e.g., the consumption of a mechanically resistant diet. The morphology of the coronoid process was found to separate cohorts on the basis of their early weanling diet, suggesting that the coronoid process/temporalis muscle module may have an early plasticity window related to high growth rates during this life stage. Conversely, the morphology of the angular process was found to be influenced by the consumption of a mechanically resistant diet at any point during the growth period, but with a tendency to reflect the most recent diet. The prolonged plasticity window of the angular process/pterygomasseteric muscle module may be related to delayed ossification and muscular maturation within this module. The research presented here highlights the importance of more naturalistic models of mammalian feeding, and underscores the need for a better understanding of the processes of both morphological and behavioral maturation that follow weaning