Buprenorphine added on brief cognitive behavioral therapy for treatment of methamphetamine use disorder

Background: Methamphetamine (MA) use remains a major public health concern around the world. Recent findings suggest that buprenorphine may be helpful for cocaine use reduction. Moreover, animal studies described reduced dopamine peak effect following MA use, due to the administration of low dose buprenorphine. Objectives: This study examined the effectiveness of buprenorphine with brief cognitive behavioral therapy on MA use disorder. Methods: The study was conducted in an outpatient substance abuse treatment center in Qazvin, Iran. Nineteen MA users received buprenorphine for 24 weeks combined with brief cognitive behavioral therapy in an outpatient substance abuse treatment program, three times per week, as a before and after non - randomization study. Clinical outcomes included treatment retention, MA use, degree of MA dependency and craving, quality of life, cognitive abilities questionnaire, addiction severity and also adverse events. Data was analyzed by performing repeated measures analysis and the Friedman test for nonparametric variables. Results: Fifteen participants completed the study during six months and frequency of MA use was significantly decreased at 24 weeks (P < 0.001). There were also significant reductions in craving (P < 0.001), degree of MA dependence (P < 0.001), and improvements in quality of life, cognitive ability, and some subscales of addiction severity. Conclusions: The results of this preliminary clinical study demonstrated that buprenorphine could potentially attenuate MA craving and alternate rewarding effects of MA and had promising effects on cognitive impairment. Furthermore, buprenorphine can be considered as a harm reduction intervention in some communities, in which the people, as a result of cultural beliefs, do not accept a therapy, which only consists of counseling and no medications

The transcriptome of the novel dinoflagellate Oxyrrhis marina (Alveolata: Dinophyceae): response to salinity examined by 454 sequencing

This is the final version of the article. Available from [BioMed Central via the DOI in this record.BACKGROUND: The heterotrophic dinoflagellate Oxyrrhis marina is increasingly studied in experimental, ecological and evolutionary contexts. Its basal phylogenetic position within the dinoflagellates make O. marina useful for understanding the origin of numerous unusual features of the dinoflagellate lineage; its broad distribution has lent O. marina to the study of protist biogeography; and nutritive flexibility and eurytopy have made it a common lab rat for the investigation of physiological responses of marine heterotrophic flagellates. Nevertheless, genome-scale resources for O. marina are scarce. Here we present a 454-based transcriptome survey for this organism. In addition, we assess sequence read abundance, as a proxy for gene expression, in response to salinity, an environmental factor potentially important in determining O. marina spatial distributions. RESULTS: Sequencing generated ~57 Mbp of data which assembled into 7, 398 contigs. Approximately 24% of contigs were nominally identified by BLAST. A further clustering of contigs (at ≥ 90% identity) revealed 164 transcript variant clusters, the largest of which (Phosphoribosylaminoimidazole-succinocarboxamide synthase) was composed of 28 variants displaying predominately synonymous variation. In a genomic context, a sample of 5 different genes were demonstrated to occur as tandem repeats, separated by short (~200-340 bp) inter-genic regions. For HSP90 several intergenic variants were detected suggesting a potentially complex genomic arrangement. In response to salinity, analysis of 454 read abundance highlighted 9 and 20 genes over or under expressed at 50 PSU, respectively. However, 454 read abundance and subsequent qPCR validation did not correlate well - suggesting that measures of gene expression via ad hoc analysis of sequence read abundance require careful interpretation. CONCLUSION: Here we indicate that tandem gene arrangements and the occurrence of multiple transcribed gene variants are common and indicate potentially complex genomic arrangements in O. marina. Comparison of the reported data set with existing O. marina and other dinoflagellates ESTs indicates little sequence overlap likely as a result of the relatively limited extent of genome scale sequence data currently available for the dinoflagellates. This is one of the first 454-based transcriptome surveys of an ancestral dinoflagellate taxon and will undoubtedly prove useful for future comparative studies aimed at reconstructing the origin of novel features of the dinoflagellates.This work was supported by a NERC grant (NE/F005237/1) awarded to PCW, DJSM, and CDL. We would like to thank Dr Margret Hughes of the Liverpool CGR for conducting 454 sequencing, and Dr Kevin Ashelford for invaluable scripting and bioinformatics support

A Survey on Semi-Supervised Learning for Delayed Partially Labelled Data Streams

Unlabelled data appear in many domains and are particularly relevant to streaming applications, where even though data is abundant, labelled data is rare. To address the learning problems associated with such data, one can ignore the unlabelled data and focus only on the labelled data (supervised learning); use the labelled data and attempt to leverage the unlabelled data (semi-supervised learning); or assume some labels will be available on request (active learning). The first approach is the simplest, yet the amount of labelled data available will limit the predictive performance. The second relies on finding and exploiting the underlying characteristics of the data distribution. The third depends on an external agent to provide the required labels in a timely fashion. This survey pays special attention to methods that leverage unlabelled data in a semi-supervised setting. We also discuss the delayed labelling issue, which impacts both fully supervised and semi-supervised methods. We propose a unified problem setting, discuss the learning guarantees and existing methods, explain the differences between related problem settings. Finally, we review the current benchmarking practices and propose adaptations to enhance them

Quasars probing intermediate redshift star-forming galaxies

We present a sample of 46 [OIII]-emitting galaxies at z<0.8 detected in the fibre spectra of quasars from the SDSS-DR7 through an automatic search procedure. We also detect [OII] and Hb emission lines from most of these galaxies in the SDSS spectra. We study both the emission and absorption properties of a sub-sample of 17 galaxies in the redshift range z=0.4-0.7, where MgII lines are covered by the SDSS spectra. The measured lower-limits on the star-formation rates of these galaxies are in the range 0.2-20 M_sun/yr. The emission line luminosities and (O/H) metallicities from R23 measured in this sample are similar to what is found in normal galaxies at these redshifts. Thus, this constitutes a unique sample of intermediate redshift star-forming galaxies where we can study the QSO absorber - galaxy connection. Strong MgII (W>1A) as well as MgI absorption lines are detected in the QSO spectra at the redshift of most of these galaxies. Strong FeII (W>1A) absorption lines are also generally detected whenever the appropriate wavelength ranges are covered. This suggests that most of these systems could be bona-fide Damped Lyman-alpha systems. We investigate various possible relations between the MgII rest equivalent widths and the emission line properties. We find a possible (2 sigma) correlation between the emission-line metallicity of the galaxies and the MgII rest equivalent width of the absorbers [truncated].Comment: 15 pages, 11 figures, 5 tables. accepted for publication in MNRA

Isolated galaxies: residual of primordial building blocks?

CONTEXT.The mass assembly is believed to be the dominant process of early galaxy formation. This mechanism of galaxy building can proceed either by repeated major mergers with other systems, or by means of accretion of matter from the surrounding regions. AIMS.In this paper we compare the properties of local disk galaxies that appear isolated, i.e. not tidally affected by other galaxies during the last few Gyr within the volume given by cz<= 5000 km/s, with those galaxies at z values from 0.25 to 5. METHODS.Effective radii for 203 isolated galaxies and 1645 galaxies from the RC3 have been collected and the two samples have been analyzed statistically. A similar comparison has been made with half light radii studied at high z from the literature. RESULTS.We found that isolated galaxies are in general smaller than other present epoch galaxies from the RC3. We notice the lack of systems larger than 7 kpc among them. Their size distribution appears to be similar to that of galaxies at 1.4 <= z <= 2. The models of the merging history also indicate that the isolated galaxies did stop their merging process at about that redshift, evolving passively since then. The galaxy density seems to have remained unchanged since that epoch. CONCLUSIONS.Isolated galaxies appears to be the end products of the merging process as proposed in the hierarchical accretion scenario at around z=1.4. For this class of galaxies this was the last significant merging event in their lives and have evolved passively since then. This is confirmed by the analytical estimate of the merging fraction with z and by the comparison with sizes of distant galaxies.Comment: 6 pages, 3 figures. Accepted for publication in A&A. A&A style file added to the sourc

Star formation history of KDG 61 and KDG 64 from spectroscopy and colour-magnitude diagrams

A study of two dE/dSph members of the nearby M 81 group of galaxies, KDG 61 and UGC 5442 = KDG 64, has been made. Direct Hubble Space Telescope (HST) Advanced Camera for Surveys (ACS) images and integrated-light spectra of 6 m telescope of Special Astrophysical Observatory of Russian Academy of Sciences have been used for quantitative star formation history analysis. The spectroscopic and colour-magnitude diagrams analysis gives consistent results. These galaxies appear to be dominated by an old population (12-14 Gyr) of low metallicity ([Fe/H]~-1.5). Stars of ages about 1 to 4 Gyr have been detected in both galaxies. The later population shows marginal metal enrichment. We do not detect any significant radial gradients in age or metallicity in these galaxies. Our radial velocity measurement suggests that the HII knot on the line-of-sight of KDG 61 is not gravitationally attached to the galaxy.Comment: 16 pages, 13 figures, accepted by MNRA

Search for CP Violation in Charged D Meson Decays

We report results of a search for CP violation in the singly Cabibbo-suppressed decays D+ -> K- K+ pi+, phi pi+, K*(892)0 K+, and pi- pi+ pi+ based on data from the charm hadroproduction experiment E791 at Fermilab. We search for a difference in the D+ and D- decay rates for each of the final states. No evidence for a difference is seen. The decay rate asymmetry parameters A(CP), defined as the difference in the D+ and D- decay rates divided by the sum of the decay rates, are measured to be: A(CP)(K K pi) = -0.014 +/- 0.029, A(CP)(phi pi) = -0.028 +/- 0.036, A(CP)(K*(892) K) = -0.010 +/- 0.050, and A(CP)(pi pi pi) = -0.017 +/- 0.042.Comment: 13 pages, 5 figures, 1 table; Elsevier LaTe

Does Pilocarpine-Induced Epilepsy in Adult Rats Require Status epilepticus?

Pilocarpine-induced seizures in rats provide a widely animal model of temporal lobe epilepsy. Some evidences reported in the literature suggest that at least 1 h of status epilepticus (SE) is required to produce subsequent chronic phase, due to the SE-related acute neuronal damage. However, recent data seems to indicate that neuro-inflammation plays a crucial role in epileptogenesis, modulating secondarily a neuronal insult. For this reason, we decided to test the following hypotheses: a) whether pilocarpine-injected rats that did not develop SE can exhibit long-term chronic spontaneous recurrent seizures (SRS) and b) whether acute neurodegeneration is mandatory to obtain chronic epilepsy. Therefore, we compared animals injected with the same dose of pilocarpine that developed or did not SE, and saline treated rats. We used telemetric acquisition of EEG as long-term monitoring system to evaluate the occurrence of seizures in non-SE pilocarpineinjected animals. Furthermore, histology and MRI analysis were applied in order to detect neuronal injury and neuropathological signs. Our observations indicate that non-SE rats exhibit SRS almost 8 (+/22) months after pilocarpine-injection, independently to the absence of initial acute neuronal injury. This is the first time reported that pilocarpine injected rats without developing SE, can experience SRS after a long latency period resembling human pathology. Thus, we strongly emphasize the important meaning of including these animals to model human epileptogenesis in pilocarpine induced epilepsy