Análise de fator neurotrófico derivado do cérebro (BDNF) em pacientes portadores de distrofias musculares progressivas

Trabalho de Conclusão de Curso, para a obtenção do grau de Bacharel no curso de Fisioterapia da Universidade do Extremo Sul Catarinense, UNESC.As Distrofias Musculares Progressivas (DMP) são caracterizadas por degeneração progressiva e irreversível da musculatura esquelética, levando a uma fraqueza muscular e perda da capacidade motora. O Fator Neurotrófico do Cérebro (BDNF) é uma neurotrofina, a qual desempenha um importante papel nos processos de crescimento, diferenciação, sobrevivência e plasticidade neuronal. O presente estudo comparou os níveis de BDNF em 24 portadores de DMP com o grupo controle, através da coleta de 15 mL de sangue periférico. Os níveis de BDNF foram analisados pelo Kit Elisa e constatou-se que apenas a Distrofia Miotônica Tipo 1 apresentou alterações significativas (p<0,05) quando comparados com os controles, demonstrando atividade que corroboram para uma plasticidade neuronal neste tipo de DMP

Predicció de complicacions maternes i fetals en pacients amb Pre-eclàmpsia

PE is classified as the third cause of global maternal deaths and it is also associated with increased perinatal morbidity and mortality, For all these conditions, an accurate identification of those patients at highest risk of complications remains a goal for modern obstetrics in developed countries. This would lead to a more appropriate management of these high-risk patients with a more intensive strategy and the possibility of home monitoring for those patients with a low-risk of complications. Third-trimester abnormal uterine artery Doppler has been related to worse perinatal outcomes among patients both with and without pregnancy complications. Furthermore, in PE clinical severity has been directly related to the extension of placental ischemia: the larger the ischemia, the more severe the clinical manifestations and the poorer the perinatal outcome. However, the role of uterine artery Doppler evaluation in the identification of pregnancy at risk of maternal or foetal morbidity with early-onset PE has not been investigated. In that context, our first article evaluated the performance of Uterine Doppler in the prognostic assessment of adverse outcomes. Our second article further explored the performance of Uterine Doppler in early-PE. Moreover, the excess in anti-angiogenic factors produced by the placenta may cause damage to the vasculature and distal orga. Karumanchi et al. showed that excess sFlt-1 would mediate the multiple symptoms of PE. Parallel, circulating PlGF levels are much lower in those patients who would develop PE than in normal pregnancies. The concentration of circulating PlGF begins to decrease 9 to 11 weeks before the onset of pre-eclampsia, with substantial reductions during the 5 weeks before the onset of hypertension or proteinuria. In that context, placental growth factor (PlGF) has emerged as a potential tool to be included in diagnostic and prognostic algorithms. This pro-angiogenic marker seems to be a more sensitive and precise predictor of PE than any other single biomarker, as it reflects placental function. Low concentrations of PlGF may reflect poor placentation and thus a response to oxidative stress in the placenta, which are mainly present in early PE. However, this excellent profile of PlGF as a marker of early PE may limit its clinical applicability for prognostic assessment if a high number of women already have very low levels at the onset of PE. The median of PlGF was of 12 pg/mL in women with either early onset or preterm PE. According to our results: 1- Uterine Doppler was the best predictive parameter for perinatal outcomes in pregnancies with PE and it was even more effective than classical clinical parameters 2- Uterine Doppler should be incorporated in the management strategy of PE at the clinical onset of the disease 3- Early-onset preeclamptic patients with impaired uterine Doppler are at higher risk of maternal and neonatal complications. 4- Uterine Doppler may help in the prognostic evaluation of early-PE and should be incorporated in the management strategy at its clinical onset 5- Very low PlGF is a highly prevalent finding in early onset PE leading to its low specificity and low positive predictive value 6- The predictive role of a low PlGF level in predicting maternal complications in very early PE is limite

Biography of Things – A Ball

The presented text is a study of interest in ball as an element of formation and perception of childhood. The research project was embedded in the paradigm of qualitative, interpretative research, where the focus was on the language of the preschooler, which becomes a reflection of the world of physical culture present in the mind of the child – the narrator. The problem of research is focused on the question: To what extent is the ball and its meanings an element of material culture located in the area of physical culture, and in what circumstances is it a determinant of child-specific pre-school folklore? The resulting space of the presented analyzes is an element of the phenomenographic method, where the use of a partially structured interview with preschool children (N = 80) provided the basis for the analysis of the perception and use of a ball in the cognitive theory of a child’s language space. The main conclusions from the research are: 1) for younger children, the ball is more often an attribute of spontaneous play than conventional actions (governed by rules and patterns), 2) for 5- and 6-year-olds, the ball is an artifact of attractive motor activity, training complex motor skills and competition. In middle childhood, the ball is a domain of spontaneous emotionality and an attribute of children’s play, which becomes a material for perceiving, interpreting and situating oneself in a specific culture of movement. The research was conducted in ten municipal kindergartens in the city of Slupsk, Poland in 2016–2019

BetaSAC: A New Conditional Sampling For RANSAC

International audienceWe present a new strategy for RANSAC sampling named BetaSAC, in reference to the beta distribution. Our proposed sampler builds a hypothesis set incrementally, select- ing data points conditional on the previous data selected for the set. Such a sampling is shown to provide more suitable samples in terms of inlier ratio but also of consistency and potential to lead to an accurate parameters estimation. The algorithm is presented as a general framework, easily implemented and able to exploit any kind of prior infor- mation on the potential of a sample. As with PROSAC, BetaSAC converges towards RANSAC in the worst case. The benefits of the method are demonstrated on the homog- raphy estimation problem

WINE CONSUMER TRAITS

It is essential to attain solidity inside the triangle: experience – satisfaction – and loyalty of wine consumers. However, for this to be achieved, it is necessary to understand wine consumer traits, which is the central objective of this paper. This paper thus lays out the demographic, socio-economic, and psychological traits of wine consumers, followed by the possible categorisations of wine consumers, and finally, types of wine consumer loyalty

Between Contestation and Conformism: Cluster Analysis of the Poles’ Attitudes During the Second Wave of the COVID-19 Pandemic

The aim of the article is to identify the factors that contribute to the differentiation of attitudes towards the coronavirus pandemic in three areas: 1) course of the pandemic; 2) evaluation of the actions of various actors in the fight against the pandemic; and 3) assessment of the restrictions introduced during the pandemic. The analysis is based on a survey conducted among the Polish population. A hierarchical cluster analysis procedure was conducted on the 15 variables using Ward’s method. We distinguished five groups: 1) dissenters, 2) government’s critics, 3) conformists, 4) critical conformists and 5) bystanders. Based on the cluster analysis we argue that: various models of social compliance with restrictions and of crisis management can be identified during pandemic, pandemic followed different trajectories for different groups and was differently experienced, the credibility of the statistics is an important element in shaping attitudes towards the pandemic

MYC's Fine Line Between B Cell Development and Malignancy

The transcription factor MYC is transiently expressed during B lymphocyte development, and its correct modulation is essential in defined developmental transitions. Although temporary downregulation of MYC is essential at specific points, basal levels of expression are maintained, and its protein levels are not completely silenced until the B cell becomes fully differentiated into a plasma cell or a memory B cell. MYC has been described as a proto-oncogene that is closely involved in many cancers, including leukemia and lymphoma. Aberrant expression of MYC protein in these hematological malignancies results in an uncontrolled rate of proliferation and, thereby, a blockade of the differentiation process. MYC is not activated by mutations in the coding sequence, and, as reviewed here, its overexpression in leukemia and lymphoma is mainly caused by gene amplification, chromosomal translocations, and aberrant regulation of its transcription. This review provides a thorough overview of the role of MYC in the developmental steps of B cells, and of how it performs its essential function in an oncogenic context, highlighting the importance of appropriate MYC regulation circuitry

Wykorzystywanie zwłok więźniów do badań w instytutach anatomicznych w III Rzeszy

The article describes the process of using prisoners’ bodies for research by scientist of Third Reich. Anatomical institutes which before the Second World War trained medical students on the basis of few human preparation, between 1939–1945 gained unlimited access to resources of human bodies. The primary source of preparations were prisoners’ decapitated bodies. For the purposes of the national economy Third Reich all corps were deprived of a legal protection. At the same time the Ministry of Justice of Third Reich adopted a regulation which standardized the equipment of dissectingrooms. This situation had given a chance to German scientist to pursue practically all research projects. Some of these project like receiving soap from human fat was the subject of a future investigation conducted by United Nations War Crimes Commission.W artykule opisano sposób korzystania z ciał więźniów do badań przez naukowców z Trzeciej Rzeszy. Instytuty anatomiczne w latach 1939–1945 uzyskały nieograniczony dostęp do ciał ludzkich zasobów. Podstawowym źródłem preparatowi byli więźniowie. Dla celów gospodarki narodowej III.Rzeszy wszystkie korpusy zostały pozbawione ochrony prawnej. Jednocześnie Ministerstwo Sprawiedliwości III Rzeszy przyjęło rozporządzenie standaryzacji wyposażenia sal sekcyjnych. Ta sytuacja dała szansę niemieckim naukowcom do realizacji praktycznie wszystkich projektów badawczych. Niektóre z tych projektów, takich jak mydło z ludzkiego tłuszczu, były przedmiotem dalszych badań przeprowadzonych przez Komisję Zbrodni Wojennych ONZ