Pancreatic hamartoma in a premature Trisomy 18 female

Pancreatic hamartomas are extremely rare tumors in adults and even more so in children. They are lesions characterized by acinar, islet and ductal components found in varying proportions and in a disorganized pattern. We report a case of a premature female with trisomy 18 diagnosed by amniocentesis. The newborn was delivered by cesarean section at thirty-three weeks of gestation and expired within one hour of birth. Postmortem examination exhibited numerous features associated with Trisomy 18 including lanugo on the torso and arms, micrognathia, microstomia, left low-set ear with small flat pinna, closed ear canal, clenched fists with overlapping fingers, rocker-bottom feet, narrow pelvis, large right diaphragmatic hernia and left pulmonary hypoplasia. Microscopic examination of the pancreas revealed an area, 1.2 cm in greatest dimension, with branching ducts and cysts lined by cuboidal epithelium intermingled within primitive mesenchymal proliferation and exocrine glands. The cysts measured up to 0.2 cm and were surrounded by a collarette of proliferating spindle cells as highlighted by Masson’s trichrome stain. A diagnosis of pancreatic hamartoma was rendered. A total of thirty-four cases of pancreatic hamartomas have been reported in the literature including twenty-seven in adults, five in children and two in newborns. Our case may be the third pancreatic hamartoma reported in association with Trisomy 18. We recommend that careful examination of the pancreas be performed in individuals with Trisomy 18 to further characterize this lesion as one of the possible abnormal findings associated with this syndrome

Drawing the Architectural Heritage on the Coast of the Mediterranean (1936-39)

During the civil war (1936-39) was built a network of defensive settlements on the coast in anticipation of attacks enemies, forming the so-called 'wall Mediterranean', because of its similarity with the Wall Atlantic of the World War II. These enclaves were composed of groups of batteries, bunkers and buildings. This communication comes to inventory and draw the remains of more than 50 architectures that are located in the Valencian South Coast (from Denia to Torrevieja), documenting the first ruins of hormigion armed with our history. It's a set of military settlements anti-aircraft, mostly scattered coastal rural, which are a great heritage and landscape value, and from which planes haven't been preserved. It is to lift current state record of them all, proceeding to its typological classification, in order to contribute to its assessment and protection on the grounds that they constitute a legacy of architectural heritage that increases our cultural memory.history

Pancreatic hamartoma in a premature Trisomy 18 female

Pancreatic hamartomas are extremely rare tumors in adults and even more so in children. They are lesions characterized by acinar, islet and ductal components found in varying proportions and in a disorganized pattern. We report a case of a premature female with trisomy 18 diagnosed by amniocentesis. The newborn was delivered by cesarean section at thirty-three weeks of gestation and expired within one hour of birth. Postmortem examination exhibited numerous features associated with Trisomy 18 including lanugo on the torso and arms, micrognathia, microstomia, left low-set ear with small flat pinna, closed ear canal, clenched fists with overlapping fingers, rocker-bottom feet, narrow pelvis, large right diaphragmatic hernia and left pulmonary hypoplasia. Microscopic examination of the pancreas revealed an area, 1.2 cm in greatest dimension, with branching ducts and cysts lined by cuboidal epithelium intermingled within primitive mesenchymal proliferation and exocrine glands. The cysts measured up to 0.2 cm and were surrounded by a collarette of proliferating spindle cells as highlighted by Masson’s trichrome stain. A diagnosis of pancreatic hamartoma was rendered. A total of thirty-four cases of pancreatic hamartomas have been reported in the literature including twenty-seven in adults, five in children and two in newborns. Our case may be the third pancreatic hamartoma reported in association with Trisomy 18. We recommend that careful examination of the pancreas be performed in individuals with Trisomy 18 to further characterize this lesion as one of the possible abnormal findings associated with this syndrome

Study of the thermal behavior of the aluminium dust stabilized with gypsum

[ES]El polvo de aluminio (pAl) es un residuo peligroso procedente de la metalurgia secundaría del aluminio. Con objeto de reducir la reactividad del mismo, en el CENIM se ha desarrollado un proceso de estabilización/solidificación mediante su fraguado con yeso. En este trabajo se presenta el estudio del comportamiento térmico del pAl estabilizado con el yeso, con el fin de establecer la influencia del residuo en las reacciones de hidratación/deshidratación del yeso durante el proceso del fraguado, a saber: deshidratación parcial del sulfato calcico dihidrato, deshidratación del hemihidrato, deshidratación del hidróxido de aluminio y transformación de anhidrita soluble en anhidrita insoluble. Asimismo se ha estudiado la cinética asociada a cada una de las reacciones anteriormente mencionadas mediante Calorimetría Diferencial de Barrido.[EN]The aluminium dust is a hazardous waste from the secondary aluminium remelting industry. A stabilization/solidification process was developed at CENIM with the aim of decreasing its reactivity. Gypsum was used as a binder material. Tliis work summarizes the study of the thermal behavior of the aluminium dust stabilized with gypsum, in order to establish the influence of the residue in the reactions of hydration/dehydration of the gypsum during the hardening process, namely: partial dehydration of calcium sulphate dihydrate, dehydration of calcium sulphate hemi'hydrate, dehydration of aluminium hydroxide and anhydrite soluble/anhydrite insoluble transformation. The activation energy associated to all those reactions was determined by Differential Scanning Calorimetry.Los autores agradecen a la Consejería de Educación de la Comunidad de Madrid la financiación del proyecto (07M/0136/2000) y a la empresa Recuperación y Reciclaje Román por el apoyo a esta investigación.Peer reviewe

A BRIEF REVIEW ON THE ADVANTAGES, HINDRANCES AND ECONOMIC FEASIBILITY OF STIRLING ENGINES AS A DISTRIBUTED GENERATION SOURCE AND COGENERATION TECHNOLOGY

The present paper aims to provide a brief review of the potentiality and economic feasibility of the Stirling engine as a distributed generation source and cogeneration technology. Another objective was the determination of hindrances which may be preventing the feasibility of the Stirling technology. With these intentions, a research based on a combination of preselected keywords was performed at the Metasearch of CAPES (Brazil's Higher Education Coordination of Personnel Perfecting). No filters in relation to the research period or to particular geographical regions were employed, thus publications until 2017’s middle were included and the research was conducted on a global level. Next, the selection of papers which contained some of the keywords was made, consisting initially of the read of the publications’ abstracts. The remaining ones were then further explored and had their relevant information incorporated, according to the scope of this work. It is worth mentioning that other accredited sources which dealt with important aspects of the topic were also included. Furthermore, a table containing some examples of products concerning the application of the Stirling engine as a distributed generation and cogeneration technology is presented. Ultimately, it is concluded that the Stirling technology, despite its advantages and suitability regarding the proposed applications, is not yet commercially feasible, having currently only a minor presence in the market. This scenario can be attributed to the need for further research and technical development as well as cost reduction

Miositis viral con rabdomiólisis secundaria: un caso confirmado y revisión de la literatura

Rhabdomyolysis is a severe syndrome that can produce acute renal failure and even death. Causative mechanisms of rhabdomyolysis include various viruses, among which are the Coxsackie viruses. We report the case of a 36-year-old woman who had rhabdomyolysis due to Coxsackie A9 virus, with severe muscle involvement, though with no important kidney damage. She recovered with intravenous hydration and alkalinization of the urine.La rabdomiólisis es un síndrome grave que puede producir insuficiencia renal aguda e incluso la muerte. Los mecanismos causantes de rabdomiólisis incluyen varios virus, entre los que se encuentran los virus Coxsackie. Presentamos el caso de una mujer de 36 años de edad que tenía rabdomiólisis debido a Coxsackie A9, con afectación muscular grave, aunque sin daño renal importante. Se recuperó con la hidratación intravenosa y la alcalinización de la orina

"Dos hombres y medio": la "sitcom" y el paraíso de la masculinidad

Las relaciones familiares han sido el telón de fondo de las series de televisión desde su origen. Series legendarias como La casa de la pradera (NBC, 1974-1983), El show de Bill Cosby (NBC, 1984-1992) o Los Simpson (FOX, 1989-) han dado grandes audiencias a televisiones de todo el mundo. Conforme los tiempos van cambiando, las historias van adaptándose a nuevos estilos de vida y, a veces, esos relatos desdibujan o reinterpretan la naturaleza originaria de lo que representan. Tal es el caso de Frasier (NBC, 1993¬2004) o de Modern Family (ABC, 2009-). Se dice que la televisión es reflejo de la sociedad, pero también hay que admitir que la televisión conforma los estilos de vida de quienes la ven. El término ‘familia’ no se limita al hecho de vivir en un domicilio común. Se refiere, sobre todo, a los vínculos que se establecen entre las personas que comparten su vida y que dan garantía de unidad, afecto y seguridad a los individuos que habitan bajo un mismo techo. Existen pues convivencias o comunidades de tipo familiar que participan de los rasgos de la familia al poner todo en común. Pero no necesariamente se organizan como estructuras jerárquicas donde se infunde la paternidad y la maternidad. De este tipo de comunidades basadas en la amistad trata, por ejemplo, la serie de televisión Friends (NBC, 1994-2004). El adjetivo ‘familiar’ implica una serie de valores universales y permanentes, comunes a todos los países, como la protección, la construcción de la propia identidad basada en las relaciones, en la alteridad y en la aceptación mutua. En cambio, lo que distingue radicalmente a la familia de otras convivencias de carácter familiar son el ejercicio de la autoridad y la aceptación de la subordinación durante la educación y el aprendizaje. Es el primer escenario del crecimiento madurativo de las personas. La convivencia familiar está basada en una cierta estabilidad que da lugar a conflictos propios. Esos conflictos son la base dramática de las series de televisión y el motivo de conexión y disfrute con cualquier audiencia. La representación de las relaciones familiares explica el éxito comercial de estos contenidos convirtiéndolos en puntos de referencia con los que el público se identifica con independencia de su situación actual1. Al estudiar los rasgos familiares presentes en las obras de ficción se descubren desviaciones patéticas que permiten interpretar el sentido de la serie. Con el estudio de lo patético en los contenidos de los medios se puede dar razón de las incoherencias 1 M. MEDINA, “Explotación económica de las series familiares de televisión”, Comunicación y Sociedad, XX (1), 2007, pp. 51-85. internas de estos productos que, a veces, no les han impedido alcanzar éxitos comerciales y que apuntan a visiones muy agudas de los cambios culturales2. En el presente capítulo queremos reflexionar sobre las relaciones que se establecen en la serie Dos hombres y medio [Two men and a half -CBS, 2003-2005] y, sobre todo, el concepto de masculinidad que presenta. Es una comedia estadounidense que se ha emitido en más de cincuenta países y ha contado con más de doce temporadas. Por un lado, se observa que la fuente de comicidad es el patetismo de los dos personajes principales que han perdido su rol paterno para desarrollar el filial, frente a la ironía del hijo adolescente, que asume la paternidad a pesar de su corta edad. Por otra parte, el patetismo se apoya en la crítica a lo que denominamos el “paraíso de la masculinidad en la postmodernidad”. Ese paraíso, resultado de años de un feminismo beligerante, se basa en una vida sin especiales ataduras y una búsqueda constante de relaciones seudo-amorosas que son fruto de una ansiedad interminable y generan una inestabilidad permanente3. Estos rasgos son comunes en la sociedad actual y desdibujan la estabilidad que aportan relaciones basadas en un compromiso sólido y constructivo. Los productos audiovisuales se crean gracias a unos estándares que funcionan y una idea preconcebida de las relaciones humanas. Por tanto, son elaborados por un equipo de profesionales y se producen para que la audiencia los vea y goce con su consumo. El presente análisis narrativo irá acompañado de un breve apunte sobre los rasgos de producción que permiten entender la obra audiovisual en su contexto y un análisis de los datos de audiencia de la serie emitida en España de 2010 a 2014. Antes del análisis, se ofrece una revisión de estudios académicos, que permite conocer otros enfoques de análisis narrativo de los programas de televisión y de esta serie en particular

Prospects for a Dark Matter annihilation signal towards the Sagittarius dwarf galaxy with ground based Cherenkov telescopes

Dwarf galaxies are widely believed to be among the best targets for indirect dark matter searches using high-energy gamma rays; and indeed gamma-ray emission from these objects has long been a subject of detailed study for ground-based atmospheric Cherenkov telescopes. Here, we update current exclusion limits obtained on the closest dwarf, the Sagittarius dwarf galaxy, in light of recent realistic dark matter halo models. The constraints on the velocity-weighted annihilation cross section of the dark matter particle are of a few 10$^{-23}$ cm$^{3}$s$^{-1}$ in the TeV energy range for a 50 h exposure. The limits are extrapolated to the sensitivities of future Cherenkov Telescope Arrays. For 200 h of observation time, the sensitivity at 95% C.L. reaches 10$^{-25}$ cm$^{3}$s$^{-1}$. Possible astrophysical backgrounds from gamma-ray sources dissembled in Sagittarius dwarf are studied. It is shown that with long-enough observation times, gamma-ray background from millisecond pulsars in a globular cluster contained within Sagittarius dwarf may limit the sensitivity to dark matter annihilations.Comment: 12 pages, 5 figures, 2 tables, accepted for publication in Ap

Phenomenology of the nMSSM from colliders to cosmology

Low energy supersymmetric models provide a solution to the hierarchy problem and also have the necessary ingredients to solve two of the most outstanding issues in cosmology: the origin of dark matter and baryonic matter. One of the most attractive features of this framework is that the relevant physical processes are related to interactions at the weak scale and therefore may be tested in collider experiments in the near future. This is true for the Minimal Supersymmetric Standard Model (MSSM) as well as for its extension with the addition of one singlet chiral superfield, the so-called nMSSM. It has been recently shown that within the nMSSM an elegant solution to both the problem of baryogenesis and dark matter may be found, that relies mostly on the mixing of the singlet sector with the Higgs sector of the theory. In this work we review the nMSSM model constraints from cosmology and present the associated collider phenomenology at the LHC and the ILC. We show that the ILC will efficiently probe the neutralino, chargino and Higgs sectors, allowing to confront cosmological observations with computations based on collider measurements. We also investigate the prospects for a direct detection of dark matter and the constraints imposed by the current bounds of the electron electric dipole moment in this model.Comment: 44 pp, 10 figures; Fig.9 replaced; discussion on CP violation extended and references added; few minor additions in text about details of the cut

Coverage-based quality metric of mutation operators for test suite improvement

The choice of mutation operators is a fundamental aspect in mutation testing to guide the tester to an effective test suite. Designing a set of mutation operators is subject to a trade-off between effectiveness and computational cost: a larger mutation population might uncover more faults, but will take longer to analyse. With the aim of resolving this trade-off, several authors have defined an assortment of metrics to determine the most valuable operators. In this work, we extend an existing quality metric by incorporating an additional source of data and coverage information and therefore investigate the extent to which mutants that are often covered but rarely killed can improve the evaluation of mutation operators for the refinement of the test suite. As a case study, we analyse C++ class-level operators based on the new coverage-based quality metric to assess whether the original metric is enhanced. The results when selecting the best-valued operators show that this metric has great potential to help the tester in finding effective mutation operators. In comparison with the metric from which it is derived, the use of coverage data allows to reduce the number of mutants but often loses fewer test cases and, in addition, retains those that seem hard to design