Plataforma de transformación y empoderamiento para mujeres víctimas en Bogotá.

Resumen El presente trabajo es el resultado de un proceso de sistematización de la experiencia Grupo Distrital de Seguimiento e Incidencia al Auto 092 “Mujer y Desplazamiento”, la cual se analizó desde la línea de investigación de memoria y paz, que hace referencia a las consecuencias que han sufrido las mujeres víctimas dentro del marco del conflicto armado en Colombia, el tema es abordado desde la perspectiva de las mujeres lideresas. A partir de la investigación cualitativa se organiza y reconstruye los procesos desarrollados por la experiencia GDSA 092, a través de un trabajo de campo y un análisis conceptual, los cuales se complementan entre sí, para revelar la importancia de la Innovación social en los procesos transformadores a través del paradigma holístico, que permite la atención integral al ser humano como una totalidad. Esta experiencia ha logrado que cada mujer que hace parte de los procesos tenga una perspectiva de lo que significa la incidencia política de las mujeres lideresas víctimas en la ciudad de Bogotá, asimismo visibiliza los procesos estratégicos y de cooperación con las entidades gubernamentales en los métodos de transformación por medio de modelos de educación popular, ofreciendo nuevos conocimientos, fortaleciendo sus saberes raizales, llevando a cabo procesos resilientes, garantizando bienestar socioeconómico, y promoviendo la participación política de las mujeres. A la fecha la experiencia ha logrado intervenir a más de 400 mujeres por medio de talleres de formación, dando luz a nuevas generaciones de liderazgos femeninos y abriendo la posibilidad de nuevos espacios de participación e incidencia con garantías.This work is the result of a process of systematizing the experience of the District Monitoring and Advocacy Group to Auto 092 "Women and Displacement", which was analyzed from the line of research of memory and peace, which refers to the consequences that women victims have suffered within the framework of the armed conflict in Colombia, the issue is approached from the perspective of women leaders. Based on qualitative research, the processes developed by the GDSA 092 experience are organized and reconstructed, through field work and conceptual analysis, which complement each other, to reveal the importance of social innovation in transformative processes through the holistic paradigm, which allows comprehensive care for the human being as a whole. This experience has achieved that each woman who is part of the processes has a perspective of what the political incidence of female leaders victims in the city of Bogotá means, it also makes visible the strategic processes and cooperation with government entities in the methods of transformation through popular education models, offering new knowledge, strengthening their root knowledge, carrying out resilience, guaranteeing socioeconomic well- being, and promoting the political participation of women. Until the date, the experience has managed to intervene more than 400 women through training workshops, giving birth to new generations of female leaders and opening the possibility of new spaces for participation and advocacy with guarantees

Biodegradable poly(D,L-lactide-co-glycolide)/poly(L-γ-glutamic acid) nanoparticles conjugated to folic acid for targeted delivery of doxorubicin

A novel targeted drug delivery nanoparticle system based on poly(D,L-lactide-co-glycolide) acid (PLGA) for delivery of doxorubicin (DOX) was developed. DOX-PLGA NPs were obtained by the emulsification-solvent evaporation technique. Then, their surface was modified with poly(L-γ-glutamic acid) (γ-PGA) and finally conjugated to modified folic acid (FA) as a targeting ligand. The surface modification and FA conjugation were followed by UV–Vis and FT-IR spectroscopies. Morphology was observed by TEM/SEM. Particle size, PDI and zeta potential were measured using DLS studies. Encapsulation and loading efficiencies, and DOX release kinetics were determined. Specific uptake and cell viability of DOX-PLGA/γ-PGA-FA NPs were tested in HeLa cells. Quasi-spherical nanoparticleswith a particle size lower than 600nm(DLS)were obtained. Spectroscopic techniques demonstrated the successful surface modification with γ-PGA and FA conjugation. Release profile of DOX-PLGA/γ-PGA-FA NPs showed a release of 55.4 ± 0.6% after seven days, in an acidic environment. HeLa cells exhibited a decrease in viability when treated with DOX-PLGA/γ-PGA-AF NPs, and cellular uptake was attributed to FA receptor-mediated endocytosis. These results suggest that DOX-PLGA/γ-PGA-FA NPs are a potential targeted drug carrier for further applications in cancer therapy.This study was supported by the International Atomic Energy Agency (CRP-F22064, Contract No. 18358) and the Universidad Autónoma del Estado de México, through the project No. 3543/2013CHT

Manganese Inhalation Induces Dopaminergic Cell Loss: Relevance to Parkinson’s Disease

Parkinson’s disease (PD) experimental models are crucial in the assessment of possible therapies. Nevertheless, even though PD was one of the first neurodegenerative conditions to be modeled, there are limitations such as spontaneous recovery; lack of bilateral damage, which is a PD characteristic; animal intensive care after neurotoxin administration; and ultrastructural and biochemical nonspecific alterations but mostly the neurodegenerative time course observed in humans. In this chapter, we investigated the effects of divalent and trivalent manganese inhalation on rats and mice to obtain a novel PD animal model inducing bilateral and progressive dopaminergic cell death. We found that after 5 or 6 months of inhalation, there was more than 70% decrease in the number of TH-immunopositive neurons, and these alterations are correlated with an evident motor performance deficits manifested as akinesia, postural instability, and action tremor. More interesting is the fact that these alterations were reverted with l-DOPA treatment, implying that the motor alterations are associated with nigrostriatal dopaminergic innervation, postulating new light for the understanding of manganese neurotoxicity as an appropriate PD experimental model. Our results are contributing to the development of a suitable PD animal model, reproducible, sensitive, time-efficient, and readily applicable behavioral tests

Differences Between Intact and Ovariectomized Hemiparkinsonian Rats in Response to L-DOPA, Melatonin, and L-DOPA/Melatonin Coadministration on Motor Behavior and Cytological Alterations

Parkinson?s disease (PD) higher incidence has been observed in postmenopausal women compared to premenopausal women, suggesting estrogen neuroprotective effect. L-DOPA (LD) chronic treatment causes dyskinesia; evidences indicate that LD increases the preexisting oxidative stress condition. This study determines melatonin ability, alone or in combination with LD (LD/Mel) to protect dopaminergic loss induced by 6-OHDA in a rat PD model in ovariectomized (OVX) and intact (with ovaries (W/OV)) rats on motor behavior and cytological alterations, comparing with LD-only treated rats. LD/Mel-treated rats showed dyskinesia decrease (score 5–7.5) and had the best performance in the staircase test (five pellets) throughout all studies. The beam walking time was 20–35 s, showing good coordination (as control group (20–38 s)), dopaminergic cells increase of 22.8% (W/OV rats) and 27.2% (OVX rats) in the contralateral side as well as 100% conservation in the contralateral dendritic spines. Our results suggest that LD/Mel co-administration and estrogen presence result in an efficient treatment to reduce dyskinesia through the conservation of some dopaminergic cells, which imply a well-preserved neuropil of a less denervated striatum. We assume that these results are because of a synergistic effect between LD, melatonin and estrogens

University Educator and Staff Well-being and Common Mental Health Symptoms during the COVID-19 Pandemic in the Philippines

Educators and staff adapted to work-from-home setup amidst the covid-19 pandemic.  The transition to full-online classes and services leads to poor mental health. The current study explored the association of educator and staff personal characteristics, well-being, and mental health.  326 university employees completed the demographic profile, mental health, and well-being scales. Various hierarchical regression was conducted to determine if personal characteristics and well-being predict common mental health symptoms (depression, anxiety, and stress). Series of multivariate analyses of variance (MANOVA) was conducted to determine the difference between the levels of mental health symptoms according to mental health category, and personal characteristics. The results support the hypothesis with psychological and emotional well-being inversely predicting depression, anxiety, and stress. However, social well-being failed to serve as a significant determinant of common mental health symptoms. MANOVA obtained a significant difference with common mental health symptoms and mental health category and personal characteristics

Servicios ecosistémicos de la cuenca alta del río Fucha

112 páginasEl presente estudio, desarrollado por un grupo de estudiantes del Colegio Técnico José Félix Restrepo IED, busca reinterpretar los servicios ecosistémicos de las coberturas vegetales de la cuenca alta del río Fucha, entre las carreras sexta y sexta Este. Este fue el tema principal de la investigación. Contiene información de los recursos naturales que nos ofrecen y que nos benefician no solo a los seres humanos, sino a toda a la biodiversidad que se encuentra sobre la cuenca del río. Entre los servicios se encuentran, por ejemplo, el agua potable limpia y los procesos de descomposición de desechos. Estos se pueden dividir en cuatro categorías amplias como aprovisionamientos (es decir la producción de agua y de alimentos), regulación (el control del clima y de las enfermedades), polinización de cultivos de aves e insectos y, finalmente, la cultural, de la que nos beneficiamos los estudiantes, vecinos y demás personas que hacemos uso de los servicios ecosistémicos que nos ofrece la cuenca. Con esta investigación se busca, por otra parte, conocer un poco más de los grandes beneficios que podemos recibir de la naturaleza y que hacen que la vida humana sea posible

Turismo Chino a México el Turismo del Futuro

Tesina (Licenciatura en Turismo), Instituto Politécnico Nacional, Escuela Superior de Turismo, 2016, 1 archivo PDF, (684 páginas).tesis.ipn.m

DETERMINACIÓN DE LOS FACTORES QUE INCIDEN EN LA ELECCIÓN DE UNA UNIVERSIDAD, APLICANDO EL ANÁLISIS FACTORIAL EXPLORATORIO, CASO DE ESTUDIO: PERSPECTIVA DEL INSTITUTO TECNOLÓGICO DE MILPA ALTA

En la presente investigación se busca determinar los factores que inciden en la elección de una universidad. Para ello se implementó una encuesta por Mamani [1]. El cual menciona factores relevantes en la elección de una institución de nivel superior; por consiguiente, los factores más relevantes en estudiantes de media superior son: plan de estudios, familia, ubicación,económico, examen y apoyo de becas; si bien el conocer sus necesidades de los posibles prospe3.ctos permitirá ofrecer un servicioeducativo de calidad donde los futuros prospectos se sientan tomados en cuenta, y así poder cubrir sus necesidades. &nbsp

DETERMINACIÓN DE LOS FACTORES QUE INCIDEN EN LA ELECCIÓN DE UNA INSTITUCIÓN DE MEDIA SUPERIOR, APLICANDO EL ANÁLISIS FACTORIAL EXPLORATORIO

En la presente investigación titulada "Determinación de los factores que inciden en la elección de una institución de media superior,aplicando el análisis factorial exploratorio. " Tiene como objetivo saber cuáles son los factores que inciden en la elección de la media superior como bien lo menciona Mamani Gracias a la implementación de la encuesta por Mamani [1]. Por consiguiente, se obtuvieron los siguientes resultados según la jerarquización de porcentajes; Donde el plan de estudio funge con un 74% el cual es fundamental para los estudiantes que van estudiar la media superior, así como el costo 57%, familia 46%, el examen con 49% y apoyo de becascon 46%, lo cual indica que dichos factores son prioridad para los candidatos que desean ingresar a la media superior

In vitro nutritional quality and antioxidant activity of three weed species as feed additives for sheep in the Central Highlands of Mexico.

9 páginas, 5 tablas, 1 figuraSheep production is traditional for rural communities in Mexico, based on natural grasslands and semi-stabled feeding. Quality forages are necessary to improve productivity in these systems. Weeds are an alternative to feed ruminants and to manage crops. Also, many plants have secondary metabolites beneficial for livestock. The objective was to assess the nutritive value in vitro and the antioxidant activity of three weeds (Tithonia tubiformis, Cosmos bipinnatus, and Tagetes lucida) and four treatments (T0 = control diet, T1 = diet + 5% T. tubiformis, T2 = diet + 5% C. bipinnatus, and T3 = diet + 5% T. lucida). Nutritive value was determined from chemical composition by standard methods and mineral contents by inductively coupled plasma analyses. Secondary compounds, total phenols (TP), total tannins (TT), condensed tannins (CT), and phenolic compounds, were determined by high-performance liquid chromatography, and total antioxidant activity was determined by measuring the oxygen radical absorbance capacity. Rumen fermentation kinetics and in vitro digestibility of dry matter (IVDMD), organic matter (IVOMD), and neutral detergent fibre (IVNDFD) were determined per species and treatment by in vitro gas production. T. tubiformis had the highest CP and TP contents (P  0.05) were found in rumen kinetics parameters, IVDMD, IVOMD, IVNDFD, or metabolizable energy, indicating that the tested weeds can be used as additives to increase antioxidant activity in sheep diets without negative effects.Authors are thankful for financial support from the Autonomous University of the State of Mexico (Universidad Autónoma del Estado de México [UAEM]) through grants UAEM 3101/2011U and 4334/2017/CI. Additional financial support was provided by the Ministry of the Economy and Competitiveness (Ministerio de Economía y Competitividad) of Spain through the National Program I + D + I (Programa Nacional I + D + I) through grant AGL2016-76035-C2-1-R. Our gratitude also to the National Council for Science and Technology (Consejo Nacional de Ciencia y Tecnología [CONACYT]) of Mexico for the postgraduate studies grant for Lucero Karen Díaz-Medina. The authors also thank the Institute of Natural Resources and Agrobiology of Salamanca (Instituto de Recursos Naturales y Agrobiología de Salamanca [IRNASA]) in Spain for the support and chemical analyses for minerals, antioxidant activity and phenolic compounds.Peer reviewe