Encouraging Bipartisanship: Polarization and Civility as Rhetorical Tools for Ameliorating the U.S. Senate’s Partisan Environment

On October 1, 2013, the Senate buckled under the pressure of intense partisanship. Dramatically demonstrating their lack of mutual agreement, senators refrained from conducting the nation’s business for 16 days. Considerable media attention covered this shut down, especially the ensuing rhetorical activities of the Senate’s female policymakers who urged bipartisanship. The flurry of activity surrounding the legislative impasse sparked this dissertation’s conceptual orientation. Accordingly, this investigation reveals how Washington lawmakers can, in good faith, set aside partisan views in order to accommodate policy objectives. This project reveals rhetorical strategies that, when utilized, are capable of facilitating Senate bipartisanship. Each chapter analyzes a variety of women senators’ discourse, including 98 floor speeches and 75 media texts, to critically assess how their rhetorical strategies elevated the Senate’s partisan environment. Specifically, Chapter II examines how constitutive rhetoric and the rhetoric of polarization helped these policymakers create a bipartisan reality. Chapter III discusses media framing and narrative theory to understand how journalists constructed the government shutdown narrative. Chapter IV employs Campbell’s (1989) model of feminine style to assess how female senators encourage civility. Finally, Chapter V argues that by using rhetoric that urges civility, relationship building, and rhetoric of polarization, the senators strengthened legislative deliberation In conclusion, the dissertation contributes to the scholarly conversation about civility, incivility, and bipartisanship. The project’s findings expose rhetorically complex scenarios facing the government’s legislative bodies, the rhetorical maintenance of deliberation, and how cooperative lawmakers rhetorically construct civility. Close attention to the discourse of female senators reveals, I argue, a comprehension of how motivated policymakers can rhetorically construct a bipartisan legislative body

Encouraging College Student Democratic Engagement Through a Collaborative Voter

Drawing on challenges I experienced when teaching a political communication course, I designed an upper-level undergraduate course with the objective of developing students’ civic competence and democratic engagement. The major class assignment, which is the focal point of this best practices essay, was a four-step collaborative voter mobilization project designed and executed by undergraduate students. I use research, classroom conversations, and student observations to discuss four best practices for encouraging students to participate in electoral politics: (a) fostering political efficacy, (b) peer-to-peer learning, (c) experiential learning, and (d) learning through reflection. This essay breaks a four-step collaborative voting mobilization project down into easily implementable steps for those seeking to inculcate attitudes and behaviors that foster democratic engagement whether that be in schools, universities, or within the broader community

The measurement of skinfold thickness in newborn infants

This thesis concerns the Caliper Measurement of Skinfold Thickness in newborn infants. The technique has been used in adults for about eighty years and provides values which have been shown to be closely related to body fat as calculated from volumetric analysis, densitometry and roentgenogram measurements. Nomograms and regression equations allowing the direct calculation of total body fat from skinfold thiclmess measurements have subsequently been developed. Durnin in the University of Glasgow has extended the use of the technique to adolescents and Tanner has pioneered its use in children aged 1 month to 4 years. Its application however has been extremely limited in newborn infants. The reasons for this are probably two-fold; the first is the suspected unreliability of the technique, many potential sources of error existing, the second is lack of knowledge as to the exact clinical significance of the values. The work presented here seeks to improve this position and is described in three sections. Section I consists of an examination of the technique as applied to neonates. Section II examines the values in normal, premature and light-for-dates infants and Section III describes the gross chemistry of skinfold tissue in autopsied infants. CONCLUSIONS It is thus concluded from the evidence collected here] A. That measurement of skinfold thickness in the newborn by the technique described is reliable and that the "error" in fact reflects a change in tissue behaviour and probably its water content. B. That skinfold thickness values are closely related to the infant's birth weight and crown heel length, that they increase with gestation, and that female values are significantly greater than male values at term. C. That the percentage of water in skinfold tissue declines with increasing maturity whether denoted by birth weight, crown. heel length or gestational age; That female water values at term are significantly lower than male ones; and that no such trend or difference exists in percentage fat nor in lipid patterns as visualized in thin layer chromatographs. Of particular interest in these findings is the recurring link between skinfold thickness and tissue water - in explaining the error; in the opposite but matching trends with gestation; and in the opposite but matching sex differences at term. The possibility must be raised that skinfold thickness values reflect tissue water in an inverse way . In any case, this simple technique can be reliably used in newborn infants, is closely linked to other growth indices and may provide readily accessible information on the infants state of hydration. (Abstract shortened by ProQuest.)

Birth incidence, deaths and hospitalisations of children and young people with Down syndrome, 1990–2015: birth cohort study

Objective: To investigate current Down syndrome live birth and death rates, and childhood hospitalisations, compared with peers.Setting: General community.Participants: All live births with Down syndrome, 1990–2015, identified via Scottish regional cytogenetic laboratories, each age–sex–neighbourhood deprivation matched with five non-Down syndrome controls. Record linkage to Scotland’s hospital admissions and death data.Primary outcome: HRs comparing risk of first hospitalisation (any and emergency), readmission for children with Down syndrome and matched controls were calculated using stratified Cox proportional hazards (PH) model, and length of hospital stay was calculated using a conditional log-linear regression model.Results: 689/1479 (46.6%) female and 769/1479 (51.9%) male children/young people with Down syndrome were identified (1.0/1000 births, with no reduction over time); 1235 were matched. 92/1235 (7.4%) died during the period, 18.5 times more than controls. More of the Down syndrome group had at least one admission (incidence rate ratio(IRR) 72.89 (68.72–77.32) vs 40.51 (39.15–41.92); adjusted HR=1.84 (1.68, 2.01)) and readmissions (IRR 54.85 (51.46–58.46) vs 15.06 (14.36–15.80); adjusted HR=2.56 (2.08, 3.14)). More of their admissions were emergencies (IRR 56.78 (53.13–60.72) vs 28.88 (27.73–30.07); first emergency admission adjusted HR=2.87 (2.61, 3.15)). Children with Down syndrome had 28% longer first admission after birth. Admission rate increased from 1990–2003 to 2004–2014 for the Down syndrome group (from 90.7% to 92.2%) and decreased for controls (from 63.3% to 44.8%).Conclusions: We provide contemporaneous statistics on the live birth rate of babies with Down syndrome, and their childhood death rate. They require more hospital admissions, readmissions emergency admissions and longer lengths of stays than their peers, which has received scant research attention in the past. This demonstrates the importance of statutory planning as well as informal support to families to avoid added problems in child development and family bonding over and above that brought by the intellectual disabilities associated with Down syndrome

Investigating the effectiveness and acceptability of oral health and related health behaviour interventions in adults with severe and multiple disadvantage:Protocol for a mixed-methods systematic review

Increasing numbers of people in England experience homelessness, substance use, and repeated offending (known as ‘severe and multiple disadvantage’; SMD). Populations experiencing SMD often have extremely poor oral health, which is closely inter-linked with high levels of substance use, smoking, and poor diet. This study aims to undertake an evidence synthesis to identify the effectiveness, resource requirements, and factors influencing the implementation and acceptability of oral health and related health behaviour interventions in adults experiencing SMD. Two systematic reviews will be conducted using mixed-methods. Review 1 will investigate the effectiveness and resource implications of oral health and related health behaviours (substance use, smoking, diet) interventions; Review 2 will investigate factors influencing the implementation of such interventions. The population includes adults (≥18 years) experiencing SMD. Standard review methods in terms of searches, screening, data extraction, and quality appraisal will be conducted. Narrative syntheses will be conducted. If feasible, a meta-analysis will be conducted for Review 1 and a thematic synthesis for Review 2. Evidence from the two reviews will then be synthesised together. Input from people with experience of SMD will be sought throughout to inform the reviews. An initial logic model will be iteratively refined during the review.</jats:p

Models for Access to Maternal Smoking cessation Support (MAMSS): a study protocol of a quasi-experiment to increase the engagement of pregnant women who smoke in NHS Stop Smoking Services

Background: Maternal smoking is a key cause of poor outcomes for mothers, babies and children and Wales has higher rates of smoking in pregnancy than any other UK country. Despite various improvements within the NHS Stop Smoking Service to strengthen the intervention for pregnant women, referrals and successful quit attempts for this group have continued to remain extremely low. A key element of UK national guidance for smoking cessation during pregnancy is to provide a flexible and tailored service to help increase levels of engagement. This study aims to test the effectiveness of three different models of service delivery to address the gap in the evidence base about how to deliver a flexible, tailored smoking cessation service to pregnant women. Methods: This study will adopt a quasi-experimental design over a 12 month period. The setting is four of Wales’ seven Health Boards using an integrated approach between maternity services, local public health teams and the NHS Stop Smoking Service. Core recommendations from UK public health guidance are being implemented across intervention and usual care sites. Stop smoking support for pregnant women in intervention sites is being delivered more flexibly than in usual care sites. Both qualitative and quantitative approaches will be adopted to capture important contextual information and consider multiple perspectives. A health economic analysis will be undertaken using a cost-consequences analysis approach. The primary outcome measure is engagement with stop smoking services (defined as having at least one face-to-face therapeutic contact with a clinician). Discussion: Supporting pregnant women to stop smoking is a challenging area of public health. The proposed study will address several areas where there are key evidence gaps relating to smoking cessation interventions for pregnant women. Specifically, how best to encourage pregnant women to attend a specialist stop smoking support service, how to deliver the service and who should provide it

Broad Epigenetic Signature of Maternal Care in the Brain of Adult Rats

BACKGROUND: Maternal care is associated with long-term effects on behavior and epigenetic programming of the NR3C1 (GLUCOCORTICOID RECEPTOR) gene in the hippocampus of both rats and humans. In the rat, these effects are reversed by cross-fostering, demonstrating that they are defined by epigenetic rather than genetic processes. However, epigenetic changes at a single gene promoter are unlikely to account for the range of outcomes and the persistent change in expression of hundreds of additional genes in adult rats in response to differences in maternal care. METHODOLOGY/PRINCIPAL FINDINGS: We examine here using high-density oligonucleotide array the state of DNA methylation, histone acetylation and gene expression in a 7 million base pair region of chromosome 18 containing the NR3C1 gene in the hippocampus of adult rats. Natural variations in maternal care are associated with coordinate epigenetic changes spanning over a hundred kilobase pairs. The adult offspring of high compared to low maternal care mothers show epigenetic changes in promoters, exons, and gene ends associated with higher transcriptional activity across many genes within the locus examined. Other genes in this region remain unchanged, indicating a clustered yet specific and patterned response. Interestingly, the chromosomal region containing the protocadherin-α, -β, and -γ (Pcdh) gene families implicated in synaptogenesis show the highest differential response to maternal care. CONCLUSIONS/SIGNIFICANCE: The results suggest for the first time that the epigenetic response to maternal care is coordinated in clusters across broad genomic areas. The data indicate that the epigenetic response to maternal care involves not only single candidate gene promoters but includes transcriptional and intragenic sequences, as well as those residing distantly from transcription start sites. These epigenetic and transcriptional profiles constitute the first tiling microarray data set exploring the relationship between epigenetic modifications and RNA expression in both protein coding and non-coding regions across a chromosomal locus in the mammalian brain

The effect of sex and irritable bowel syndrome on HPA axis response and peripheral glucocorticoid receptor expression

Background & Aims: Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been reported in irritable bowel syndrome (IBS). Enhanced HPA axis responses have been associated with reduced glucocorticoid receptor (GR) mediated negative feedback inhibition. We aimed to study the effects of IBS status, sex, or presence of early adverse life events (EAL) on the cortisol response to corticotropin-releasing factor (CRF) and adrenocorticotropic hormone (ACTH), and on GR mRNA expression in peripheral blood mononuclear cells (PBMCs). Methods: Rome III+ IBS patients and healthy controls underwent CRF (1μg/kg ovine) and ACTH (250μg) stimulation tests with serial plasma ACTH and cortisol levels measured (n=116). GR mRNA levels were measured using quantitative PCR (n=143). Area under the curve (AUC) and linear mixed effects models were used to compare ACTH and cortisol response measured across time between groups. Results: There were divergent effects of IBS on the cortisol response to ACTH by sex. In men, IBS was associated with an increased AUC (p= 0.009), but in women AUC was blunted in IBS(p=0.006). Men also had reduced GR mRNA expression (p=0.007). Cumulative exposure to EALs was associated with an increased HPA response. Lower GR mRNA was associated with increased pituitary HPA response and increased severity of overall symptoms and abdominal pain in IBS. Conclusion: This study highlights the importance of considering sex in studies of IBS and the stress response in general. Our findings also provide support for PBMC GR mRNA expression as a peripheral marker of central HPA response

Prevention of SIV Rectal Transmission and Priming of T Cell Responses in Macaques after Local Pre-exposure Application of Tenofovir Gel

Martin Cranage and colleagues find that topical tenofovir gel can protect against rectal challenge with SIV in a macaque model, and can permit the induction of SIV-specific T cell responses