Adaptable energy systems integration by modular, standardized and scalable system architectures

Energy conversion and distribution of heat and electricity is characterized by long planning horizons, investment periods and depreciation times, and it is thus difficult to plan and tell the technology that optimally fits for decades. Uncertainties include future energy prices, applicable subsidies, regulation, and even the evolution of market designs. To achieve higher adaptability to arbitrary transition paths, a technical concept based on integrated energy systems is envisioned and described. The problem of intermediate steps of evolution is tackled by introducing a novel paradigm in urban infrastructure design. It builds on standardization, modularization and economies of scale for underlying conversion units. Building on conceptual arguments for such a platform, it is then argued how actors like (among others) municipalities and district heating system operators can use this as a practical starting point for a manageable and smooth transition towards more environmental friendly supply technologies, and to commit to their own pace of transition (bearable investment/risk). Merits are not only supported by technical arguments but also by strategical and societal prospects like technology neutrality and availability of real options

Propuesta de Supply Chain Management y logística para la empresa Madecentro Colombia S.A.S.

El grupo colaborativo 207115_31 de este Diplomado de profundización en Supply Chain Management y logística como opción de grado del periodo 1602 de 2023, decidió de manera equitativa trabajar en la propuesta de su implementación en la empresa Madecentro Colombia S.A.S. Antiguamente la forma de direccionar los procesos que requería una empresa no tenían como tal un nombre o un dominio, hoy en día ya existe otra forma de ver y orientar a una compañía, aunque muchas veces existe una confusión de conceptos en cuanto a logística y SCM, la logística es aquella que se encarga de coordinar los procesos relacionados con la distribución de la mercancía y es parte de Supply Chain Management, claramente la logística es un pilar fundamental dentro de SCM, porque sin ella no existiría el control necesario en cada uno de los componentes de una cadena de suministro. Supply Chain Management es un proyecto dentro de una empresa que reúne los aspectos más relevantes de está buscando la mejor forma de planificar y desarrollar procesos que conlleven al éxito de la misma, por ello es que Supply Chain es mucho más que logística de una organización sino que esta aporta una cadena de valor a los procesos orientados, la gestión de una cadena de suministro debe estar presente en cada uno de los departamentos de una empresa, comenzando por la gerencia, continuando con administración, contabilidad, compras, marketing, producción, almacén, distribución y servicios de postventa entre otros, su aplicación puede ser muy favorable a la hora de la respectiva toma de decisiones. La elección de la empresa Madecentro fue unánime, todos los participantes del grupo estuvimos de acuerdo en trabajar en esta compañía, ya que esta es un empresa Colombiana, del sector de la manufactura y cuya actividad económica se basa en la fabricación y distribución de artículos de madera, la cual tiene varias sedes y puntos de venta en diferentes ciudades del país, lo cual era propicio para una posible visita presencial, se espera la consolidación de la mayor información posible que se pueda reunir y con ayuda de contenidos bibliográficos poder plasmar las ideas y compactar mejor la propuesta de logística y Supply Chain en Madecentro. El propósito de este proyecto tiene como finalidad el desglose de cada uno de los aspectos que componen a Madecentro Colombia S.A.S, para que de manera detallada se analice la situación actual y de manera argumentativa proponer algunos cambios o soluciones que serían de gran impacto para la mejora de los procesos logísticos, encontramos que Madecentro es una compañía que está muy bien direccionada ya que su crecimiento ha sido bastante, tiene gran cantidad de clientes fieles lo cual permite que esta se posicione en un alto nivel en el mercado, algo que destaca en la compañía es la fabricación de productos bajo pedido y por diseño del cliente lo cual hace que los artículos sean totalmente personalizados. Esta propuesta de Supply Chain Management y Logística en la empresa Madecentro Colombia S.A.S está compuesto por 12 capítulos en donde el grupo colaborativo propone nuevas estrategias e ideas que complementan cada uno de los aspectos que componen una cadena de suministro, estos temas están relacionados básicamente a las mejores prácticas tales son: estructura de la red, aprovisionamiento, almacenamiento, distribución, gestión de inventarios, posición logística de Colombia en el mercado, mega tendencias de SCM y Logística. La realización de este proyecto fue muy satisfactorio para todos los participantes ya que en este trabajo están plasmados todos los conocimientos que adquirimos durante la carrera, especialmente la gestión de cadenas de suministro y logística.The collaborative group 207115_31 of this Deepening Diploma in Supply Chain Management and Logistics as a degree option for period 1602 of 2023, decided equally to work on the proposal for its implementation in the company Madecentro Colombia S.A.S. In the past, the way of directing the processes that a company required did not have a name or a domain as such, today there is another way of seeing and guiding a company, although many times there is a confusion of concepts in terms of logistics and SCM , logistics is the one that is in charge of coordinating the processes related to the distribution of merchandise and is part of Supply Chain Management, clearly logistics is a fundamental pillar within SCM, because without it the necessary control would not exist in each of the components of a supply chain. Supply Chain Management is a project within a company that brings together the most relevant aspects of looking for the best way to plan and develop processes that lead to its success, which is why Supply Chain is much more than logistics of an organization but rather Since it provides a value chain to the oriented processes, the management of a supply chain must be present in each of the departments of a company, beginning with management, continuing with administration, accounting, purchasing, marketing, production, warehouse , distribution and after-sales services among others, its application can be very favorable at the time of the respective decision-making. The choice of the Madecentro company was unanimous, all the group participants agreed to work in this company, since this is a Colombian company, in the manufacturing sector and whose economic activity is based on the manufacture and distribution of articles of madera, which has several offices and points of sale in different cities of the country, which was propitious for a possible face-to-face visit, the consolidation of the greatest possible information that can be gathered is expected and with the help of bibliographic contents

The Helicobacter pylori Genome Project : insights into H. pylori population structure from analysis of a worldwide collection of complete genomes

Helicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host and with differential gastric disease risk. Here, we provide insights into H. pylori population structure as a part of the Helicobacter pylori Genome Project (HpGP), a multi-disciplinary initiative aimed at elucidating H. pylori pathogenesis and identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from 50 countries and generated high-quality genome sequences. We analysed core genome diversity and population structure of the HpGP dataset and 255 worldwide reference genomes to outline the ancestral contribution to Eurasian, African, and American populations. We found evidence of substantial contribution of population hpNorthAsia and subpopulation hspUral in Northern European H. pylori. The genomes of H. pylori isolated from northern and southern Indigenous Americans differed in that bacteria isolated in northern Indigenous communities were more similar to North Asian H. pylori while the southern had higher relatedness to hpEastAsia. Notably, we also found a highly clonal yet geographically dispersed North American subpopulation, which is negative for the cag pathogenicity island, and present in 7% of sequenced US genomes. We expect the HpGP dataset and the corresponding strains to become a major asset for H. pylori genomics

Difusión colectiva y térmica para un sistema de n partículas atmosféricas asimétricas e interactuantes

En este trabajo se propone un modelo mecánico estadístico en e cual se connsidera a la attmósfera como un gas de N partícula asímetricas e interactuantes, bajo esta consideracion se utiliza termodinámica mesoscóppica fuera de equilibrio para determinar un conjunto de ecuaciones tipo Fokker-Planc como funckciones de la posición, tiempo, veloccidad angula y la orientación molecular de cada partícula asimétrica. Usando el balance del momento lineal en el régimen difusivo se determina expresione para 1, 2 y N partículas que permiten calcular la presión que ejercen las moléculas atmosféricas asimétricas sobre otras partículas, así como la difusión térmica colectiva correspondient tes. Se obtuvo una explicación teórica de las ecuaciones de continuidad en fu unción de la velocidad angular y la orientación molecular de cada i-ésima partícula as a simétrica, de manera e balance de masa y la ley de conservació del momento lineal

Benefit of primary percutaneous coronary interventions in the elderly with ST segment elevation myocardial infarction

Objective: Primary percutaneous coronary intervention (P-PCI) has demonstrated its efficacy in patients with ST segment elevation myocardial infarction (STEMI). However, patients with STEMI ≥75 years receive less P-PCI than younger patients despite their higher in-hospital morbimortality. The objective of this analysis was to determine the effectiveness of P-PCI in patients with STEMI ≥75 years. Methods: We included 979 patients with STEMI ≥75 years, from the ATención HOspitalaria del Síndrome coronario study, a registry of 8142 consecutive patients with acute coronary syndrome admitted at 31 Spanish hospitals in 2014-2016. We calculated a propensity score (PS) for the indication of P-PCI. Patients that received or not P-PCI were matched by PS. Using logistic regression, we compared the effectiveness of performing P-PCI versus non-performance for the composite primary event, which included death, reinfarction, acute pulmonary oedema or cardiogenic shock during hospitalisation. Results: Of the included patients, 81.5 % received P-PCI. The matching provided two groups of 169 patients with and without P-PCI. Compared with its non-performance, P-PCI presented a composite event OR adjusted by PS of 0.55 (95% CI 0.34 to 0.89). Conclusions: Receiving a P-PCI was significantly associated with a reduced risk of major intrahospital complications in patients with STEMI aged 75 years or older

Benefit of primary percutaneous coronary interventions in the elderly with ST segment elevation myocardial infarction

Altres ajuts: Supported by: MARATO TV3 (081630); Red RedIAPP RD06/0018; CP12/03287; CIBER Epidemiología y Salud Pública; CIBERCV de enfermedades Cardiovasculares, Fondo Europeo de Desarrollo Regional (FEDER) (European Regional Development Funds -ERDF-); FIS CP12/03287, FIS 14/00449, FIS PI081327, FIS INTRASALUD PI1101801.Primary percutaneous coronary intervention (P-PCI) has demonstrated its efficacy in patients with ST segment elevation myocardial infarction (STEMI). However, patients with STEMI ≥75 years receive less P-PCI than younger patients despite their higher in-hospital morbimortality. The objective of this analysis was to determine the effectiveness of P-PCI in patients with STEMI ≥75 years. We included 979 patients with STEMI ≥75 years, from the ATención HOspitalaria del Síndrome coronario study, a registry of 8142 consecutive patients with acute coronary syndrome admitted at 31 Spanish hospitals in 2014-2016. We calculated a propensity score (PS) for the indication of P-PCI. Patients that received or not P-PCI were matched by PS. Using logistic regression, we compared the effectiveness of performing P-PCI versus non-performance for the composite primary event, which included death, reinfarction, acute pulmonary oedema or cardiogenic shock during hospitalisation. Of the included patients, 81.5 % received P-PCI. The matching provided two groups of 169 patients with and without P-PCI. Compared with its non-performance, P-PCI presented a composite event OR adjusted by PS of 0.55 (95% CI 0.34 to 0.89). Receiving a P-PCI was significantly associated with a reduced risk of major intrahospital complications in patients with STEMI aged 75 years or older