Does a short symptom checklist accurately diagnose ADHD?

Several abbreviated checklists perform well in distinguishing children with attention deficit/ hyperactivity disorder (ADHD) from those without ADHD under ideal conditions and in research settings. While many guidelines and experts recommend using these checklists as an efficient method to collect data from multiple sources (strength of recommendation: B, based on extrapolation from cohort studies to define test characteristics and consensus opinion), experts point out the subjective nature of responses on behavior rating scales, and the limitations in using checklists as the sole source of information

Why Users (Don’t) Use Password Managers at a Large Educational Institution

We quantitatively investigated the current state of Password Manager (PM) usage and general password habits at a large, private university in the United States. Building on prior qualitative findings from SOUPS 2019, we survey n=277 faculty, staff, and students, finding that 77% of our participants already use PMs, but users of third-party PMs, as opposed to browser-based PMs, were significantly less likely to reuse their passwords across accounts. The largest factor encouraging PM adoption is perceived ease-of-use, indicating that communication and institutional campaigns should focus more on usability factors. Additionally, our work indicates the need for design improvements for browser-based PMs to encourage less password reuse as they are more widely adopted

Sterile inflammation as a factor in human male infertility: Involvement of Toll like receptor 2, biglycan and peritubular cells

Changes in the wall of seminiferous tubules in men with impaired spermatogenesis imply sterile inflammation of the testis. We tested the hypothesis that the cells forming the wall of seminiferous tubules, human testicular peritubular cells (HTPCs), orchestrate inflammatory events and that Toll like receptors (TLRs) and danger signals from the extracellular matrix (ECM) of this wall are involved. In cultured HTPCs we detected TLRs, including TLR2. A TLR-2 ligand (PAM) augmented interleukin 6 (IL-6), monocyte chemo-attractant protein-1 (MCP-1) and pentraxin 3 (PTX3) in HTPCs. The ECM-derived proteoglycan biglycan (BGN) is secreted by HTPCs and may be a TLR2-ligand at HTPCs. In support, recombinant human BGN increased PTX3, MCP-1 and IL-6 in HTPCs. Variable endogenous BGN levels in HTPCs derived from different men and differences in BGN levels in the tubular wall in infertile men were observed. In testes of a systemic mouse model for male infertility, testicular sterile inflammation and elevated estradiol (E2) levels, BGN was also elevated. Hence we studied the role of E2 in HTPCs and observed that E2 elevated the levels of BGN. The anti-estrogen ICI 182,780 blocked this action. We conclude that TLR2 and BGN contribute to sterile inflammation and infertility in man

Sterile inflammation as a factor in human male infertility: Involvement of Toll like receptor 2, biglycan and peritubular cells

Changes in the wall of seminiferous tubules in men with impaired spermatogenesis imply sterile inflammation of the testis. We tested the hypothesis that the cells forming the wall of seminiferous tubules, human testicular peritubular cells (HTPCs), orchestrate inflammatory events and that Toll like receptors (TLRs) and danger signals from the extracellular matrix (ECM) of this wall are involved. In cultured HTPCs we detected TLRs, including TLR2. A TLR-2 ligand (PAM) augmented interleukin 6 (IL-6), monocyte chemo-attractant protein-1 (MCP-1) and pentraxin 3 (PTX3) in HTPCs. The ECM-derived proteoglycan biglycan (BGN) is secreted by HTPCs and may be a TLR2-ligand at HTPCs. In support, recombinant human BGN increased PTX3, MCP-1 and IL-6 in HTPCs. Variable endogenous BGN levels in HTPCs derived from different men and differences in BGN levels in the tubular wall in infertile men were observed. In testes of a systemic mouse model for male infertility, testicular sterile inflammation and elevated estradiol (E2) levels, BGN was also elevated. Hence we studied the role of E2 in HTPCs and observed that E2 elevated the levels of BGN. The anti-estrogen ICI 182,780 blocked this action. We conclude that TLR2 and BGN contribute to sterile inflammation and infertility in man

A-B Transition in Superfluid ³He and Cosmological Phase Transitions

First-order phase transitions in the very early universe are a prediction of many extensions of the Standard Model of particle physics and could provide the departure from equilibrium needed for a dynamical explanation of the baryon asymmetry of the Universe. They could also produce gravitational waves of a frequency observable by future space-based detectors such as the Laser Interferometer Space Antenna. All calculations of the gravitational wave power spectrum rely on a relativistic version of the classical nucleation theory of Cahn-Hilliard and Langer, due to Coleman and Linde. The high purity and precise control of pressure and temperature achievable in the laboratory made the first-order A to B transition of superfluid 3He ideal for test of classical nucleation theory. As Leggett and others have noted, the theory fails dramatically. The lifetime of the metastable A phase is measurable, typically of order minutes to hours, far faster than classical nucleation theory predicts. If the nucleation of B phase from the supercooled A phase is due to a new, rapid intrinsic mechanism that would have implications for first-order cosmological phase transitions as well as predictions for gravitational wave production in the early universe. Here we discuss studies of the A-B phase transition dynamics in 3He, both experimental and theoretical, and show how the computational technology for cosmological phase transition can be used to simulate the dynamics of the A-B transition, support the experimental investigations of the A-B transition in the QUEST-DMC collaboration with the goal of identifying and quantifying the mechanism(s) responsible for nucleation of stable phases in ultra-pure metastable quantum phases

New results on the pd --> 3He eta production near threshold

Measurements on the eta meson production in proton-deuteron collisions have been performed using the COSY-11 facility at COSY Juelich. Here we present preliminary results on total and differential cross sections for the pd --> 3He eta reaction at five excess energies between Q = 5.1 and Q = 40.6 MeV. The obtained angular distributions for the emitted eta mesons in the center of mass system expose a transition from an almost isotropic emission to a highly anisotropic distribution. The extracted total cross sections support a strong eta-3He final state interaction and will be compared with model predictions.Comment: Presented at MESON 2004: 8th International Workshop on Meson Production, Properties and Interactions, Cracow, Poland, 4-8 Jun 2004, 3 pages, Submitted to Int. J. Mod. Phys.

Characterizing temporary hydrological regimes at a European scale

Monthly duration curves have been constructed from climate data across Europe to help address the relative frequency of ecologically critical low flow stages in temporary rivers, when flow persists only in disconnected pools in the river bed. The hydrological model is 5 based on a partitioning of precipitation to estimate water available for evapotranspiration and plant growth and for residual runoff. The duration curve for monthly flows has then been analysed to give an estimate of bankfull flow based on recurrence interval. The corresponding frequency for pools is then based on the ratio of bank full discharge to pool flow, arguing from observed ratios of cross-sectional areas at flood 10 and low flows to estimate pool flow as 0.1% of bankfull flow, and so estimate the frequency of the pool conditions that constrain survival of river-dwelling arthropods and fish. The methodology has been applied across Europe at 15 km resolution, and can equally be applied under future climatic scenarios