Forecasting Irish Inflation: A Composite Leading Indicator

This paper presents the results of research into the construction of a composite leading indicator of the Irish rate of inflation, as measured by the annual percentage change in the Consumer Price Index (CPI). It follows the work of Fagan and Fell (1994) who applied the business cycle leading indicator methodology, initially established by Mitchell and Burns (1938,1946), to construct a composite leading indicator of the Irish business cycle.

HLA-DQA1*05 carriage associated with development of anti-drug antibodies to infliximab and adalimumab in patients with Crohn's Disease

Anti-tumor necrosis factor (anti-TNF) therapies are the most widely used biologic drugs for treating immune-mediated diseases, but repeated administration can induce the formation of anti-drug antibodies. The ability to identify patients at increased risk for development of anti-drug antibodies would facilitate selection of therapy and use of preventative strategies.This article is freely available via Open Access. Click on Publisher URL to access the full-text

Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.

BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700

Processes of elite power and low-carbon pathways: experimentation, financialisation, and dispossession

What is a low-carbon pathway? To many, it is a way of mitigating climate change. To others, it is about addressing market failure or capturing the co-benefits attached to low-carbon systems, such as jobs or improved health. To still others, it represents building adaptive capacity and resilience in the face of climate change. However, these interpretations can fail to acknowledge how pathways of low-carbon transitions can also become intertwined with processes and structures of inequality, exclusion and injustice. Using a critical lens that draws from a variety of disciplines, this article explores three ways through which responses to climate change can entrench, exacerbate or reconfigure the power of elites. As society attempts to create a low-carbon society, including for example via coastal protection efforts, disaster recovery, or climate change mitigation and renewable energy, these efforts intersect with at least three processes of elite power: experimentation, financialisation, and dispossession. Experimentation is when elites use the world as a laboratory to test or pilot low-carbon technologies or policy models, transferring risks yet not always sharing benefits. Financialisation refers to the expansion and proliferation of finance, capital, and financial markets in the global economy and many national economies, processes of which have recently extended to renewable energy. Dispossession is when elites use decarbonisation as a process through which to appropriate land, wealth, or other assets (and in the process make society more majoritarian and/or unequal). We explore these three themes using a variety of evidence across illustrative case studies, including hard and soft coastal protection measures (Bangladesh, Netherlands), climate risk insurance (Malawi), and renewable energy auctions and associated processes of finance and investment (South Africa and Mexico)