JOHN LOCKE E O LIBERALISMO POLÍTICO: UMA ANÁLISE DO DIREITO DE PROPRIEDADE E DA SEPARAÇÃO DE PODERES EM "DOIS TRATADOS DO GOVERNO CIVIL".

As ideias de propriedade e de separação de poderes surgem com os ideais liberais que remontam o final do século XVII. Tais questões são normalmente atrelados a obra de John Locke, cuja importância é inegável para o desenvolvimento do pensamento político ocidental. O objeto que se pretende tratar no presente artigo, a função da propriedade e a separação das funções estatais, a partir dos debates realizados pelo referido autor, refletem bem esta condição. Serão estes traços que se pretenderá apontar, buscando-se, na historicidade, o reconhecimento fundamental da própria experiência do direito e do Estado.

A IRMANDADE DO ROSÁRIO EM CURITIBA – A OBLITERAÇÃO DOS NEGROS NA HISTÓRIA DA CIDADE

Nota de Pesquisa referente à Pesquisa Coletiva dos integrantes do PET História referente à Irmandade do Rosário de Curitiba, tratando sobre sua função na sociedade, a obliteração dos negros na história do municipio e do estado, além de fzer um estudo sobre a arquitetura da Igreja dos Pretos de Curitib

Solução salina hipertônica aumenta a pressão de perfusão cerebral no transplante do fígado para hepatite fulminante: resultados preliminares

During orthotopic liver transplantation for fulminant hepatic failure, some patients may develop sudden deterioration of cerebral perfusion and oxygenation, mainly due to increased intracranial pressure and hypotension, which are likely responsible for postoperative neurological morbidity and mortality. In the present study, we hypothesized that the favorable effects of hypertonic saline solution (NaCl 7.5%, 4 mL/kg) infusion on both systemic and cerebral hemodynamics, demonstrated in laboratory and clinical settings of intracranial hypertension and hemorrhagic shock resuscitation, may attenuate the decrease in cerebral perfusion pressure that often occurs during orthotopic liver transplantation for fulminant hepatic failure. METHODS: 10 patients with fulminant hepatic failure in grade IV encephalopathy undergoing orthotopic liver transplantation with intracranial pressure monitoring were included in this study. The effect on cerebral and systemic hemodynamics in 3 patients who received hypertonic saline solution during anhepatic phase (HSS group) was examined, comparing their data with historical controls obtained from surgical procedure recordings in 7 patients (Control group). The maximal intracranial pressure and the corresponding mean arterial pressure values were collected in 4 time periods: (T1) the last 10 min of the dissection phase, (T2) the first 10 minutes at the beginning of anhepatic phase, (T3) at the end of the anhepatic phase, and (T4) the first 5 minutes after graft reperfusion. RESULTS: Immediately after hypertonic saline solution infusion, intracranial pressure decreased 50.4%. During the first 5 min of reperfusion, the intracranial pressure remained stable in the HSS group, and all these patients presented an intracranial pressure lower than 20 mm Hg, while in the Control group, the intracranial pressure increased 46.5% (P < 0.001). The HSS group was the most hemodynamically stable; the mean arterial pressure during the first 5 min of reperfusion increased 21.1% in the HSS group and decreased 11.1% in the Control group (P < 0.001). During the first 5 min of reperfusion, cerebral perfusion pressure increased 28.3% in the HSS group while in the Control group the cerebral perfusion pressure decreased 28.5% (P < 0.001). Serum sodium at the end of the anhepatic phase and 3 hours after reperfusion was significantly higher in the HSS group (153.00 &plusmn; 2.66 and 149.00 &plusmn; 1.73 mEq/L) than in the Control group (143.71 &plusmn; 3.30 and 142.43 &plusmn; 1.72 mEq/L), P = 0.003 and P < 0.001 respectively. CONCLUSION: Hypertonic saline solution can be successfully used as an adjunct in the neuroprotective strategy during orthotopic liver transplantation for fulminant hepatic failure, reducing intracranial pressure while restoring arterial blood pressure, promoting sustained increase in the cerebral perfusion pressure.Neste estudo testamos a hipótese de que os efeitos benéficos decorrentes da administração da solução salina hipertônica (NaCl 7,5%, 4 mL/kg) sobre a hemodinâmica sistêmica e cerebral na hipertensão intracraniana e no choque hemorrágico, possam atenuar a diminuição da pressão de perfusão cerebral que freqüentemente acompanha o transplante do fígado para hepatite fulminante. MÉTODO: Foram estudados 10 pacientes com hepatite fulminante em encefalopatia grau IV e monitorização de pressão intracraniana submetidos ao transplante do fígado. A hemodinâmica sistêmica e cerebral de 3 pacientes que receberam solução salina hipertônica durante a fase anepática (Grupo SSH) foi analisada comparando com os dados obtidos de 7 pacientes transplantados anteriormente nas mesmas condições (Grupo Controle). Os valores de pressão intracraniana máxima e a correspondente pressão arterial média foram coletados em quatro tempos: (T1) nos últimos 10 min da fase de disseccão, (T2) nos primeiros 10 minutos da fase anepática, (T3) no final da fase anepática e (T4) nos primeiros 5 min da reperfusão RESULTADO: Imediatamente após a infusão da solução salina hipertônica a pressão intracraniana diminuiu 50,4%. Nos primeiros 5 min da reperfusão a pressão intracraniana no Grupo SSH se manteve estável e todos os pacientes apresentavam pressão intracraniana menor que 20 mmHg enquanto no Grupo Controle a pressão intracraniana aumentou 46,5% (

Identificação biológica e molecular de vírus detectados em espécies de cucurbitáceas provenientes do Estado do Tocantins

Cucurbit crops may be affected by several virus diseases, which might cause up to 100% of yield losses. Due to its environmental conditions, favorable to the emergence of viruses, the state of Tocantins has shown a high incidence of virus diseases in the field. The main objective of this study was to identify and characterize, serological. Biological and molecularly, 25 virus isolates from pumpkin and watermelon collected in some regions of this state showing characteristic symptoms of viruses. Fourteen (56%) of the 25 isolates studied, were identified as Squash mosaic virus (SqMV). Seven of them were detected in Caserta squash and another seven in watermelon. The remaining isolates were identified as Zucchini yellow mosaic virus (ZYMV). SqMV showed higher incidence when compared to the other Brazilian States, where it normally either have not been detected or detected in very low incidence. It shows the importance of SqMV for Tocantins region.As cucurbitáceas podem ser afetadas por várias doenças, dentre elas as viróticas, as quais podem provocar perdas de até 100% da produção. Devido às condições climáticas, serem favoráveis a ocorrência de viroses, o estado do Tocantins tem apresentado grande incidência dessas doenças no campo. Este trabalho foi realizado com a finalidade de identificar sorológica e molecularmente 25 isolados de abóbora e melancia coletados em diversos municípios do estado que apresentavam sintomas característicos de viroses. Catorze dos 25 isolados estudados, ou seja, 56%, foram identificados como Squash mosaic virus (SqMV), tendo sete deles sido provenientes de abóbora ‘Caserta’ e sete de melancia. Os demais isolados foram identificadoscomo Zucchini yellow mosaic virus (ZYMV). Ao contrário do que ocorre em outras regiões brasileiras, o SqMV foi o vírus com maior incidência nas amostras coletadas em Tocantins, indicando a sua importância para a região

Portuguese recommendations for the use of biological therapies in patients with axial spondyloarthritis - 2016 update

Objective: To update the recommendations for the treatment of axial spondyloarthritis (axSpA) with biological therapies, endorsed by the Portuguese Society of Rheumatology. Methods: These treatment recommendations were formulated by Portuguese rheumatologists based on lite - rature evidence and consensus opinion. At a national meeting, the recommendations included in this document were discussed and updated. A draft of the full text of the recommendations was then circulated and suggestions were incorporated. A final version was again circulated before publication and the level of agreement among Portuguese Rheumatologists was anonymously assessed using an online survey. Results: A consensus was achieved regarding the initiation, assessment of response and switching of biological therapies in patients with axSpA. In total, seven recommendations were produced. The first recommendation is a general statement indicating that biological therapy is not a first-line drug treatment option and should only be used after conventional treatment has failed. The second recommendation is also a ge - neral statement about the broad concept of axSpA adopted by these recommendations that includes both non-radiographic and radiographic axSpA. Recommendations 3 to 7 deal with the definition of active di - sease (including the recommended threshold of 2.1 for the Ankylosing Spondylitis Disease Activity Score [ASDAS] or the threshold of 4 [0-10 scale] for the Bath Ankylosing Spondylitis Disease Activity Index [BASDAI]), conventional treatment failure (nonsteroidal anti-inflammatory drugs being the first-line drug treatment), assessment of response to treatment (based on an ASDAS improvement of at least 1.1 units or a BASDAI improvement of at least 2 units [0-10 scale] or at least 50%), and strategy in the presence of an ina - dequate response (where switching is recommended) or in the presence of long-term remission (where a process of biological therapy optimization can be consi - dered, either a gradual increase in the interval between doses or a decrease of each dose of the biological the - rapy). Conclusion: These recommendations may be used for guidance in deciding which patients with axSpA should be treated with biological therapies. They co - ver a rapidly evolving area of therapeutic intervention. As more evidence becomes available and more biological therapies are licensed, these recommendations will have to be updated

Rediscovery of Chiococca insularis (Ridley) C.M.Taylor & M.R.V. Barbosa (Rubiaceae), a species presumed extinct, on the island of Fernando de Noronha, Pernambuco, Brazil

Chiococca insularis (Ridley) C.M.Taylor & M.R.V.Barbosa (Rubiaceae) was described by Henry Nicholas Ridley in 1890, based on a collection he made on the island of Fernando de Noronha (Pernambuco, Brazil) in 1887. Since then, this species had not been collected again and has been treated as probably extinct. After 130 years, we discovered two new populations in the southwestern portion of the island, and the conservation status of the species is reassessed. A full description of the species, with previously unseen or unmeasured characters, habitat information and photographs of the plant and environment are provided

Distribuição de abundância de espécies da comunidade arbórea do topo de um morro na floresta estacional subtropical

Modelos ecológicos de distribuição de espécies (DAEs) em uma comunidade arbórea foram investigados para constatar: (i) se as variáveis ambientais são divididas de maneira estocástica e de modo similar entre as espécies; (ii) se cada espécie exaure mais da metade do nicho ecológico existente; (iii) se a comunidade arbórea possui muitas espécies com níveis intermediários de abundância e poucas espécies raras e comuns; (iv) e se, na sucessão secundária, as espécies colonizadoras tardias têm as maiores necessidades de um nicho especializado, de tal modo que são mais raras que as espécies colonizadoras iniciais. Obteve-se os dados em oito unidades amostrais de dimensões de 20m x 50m, distribuídas sistematicamente, perfazendo 0,8ha de amostra; ajustaram-se cinco modelos de DAEs (broken-stick, niche-preemption, log-normal, Zipf e Zipf-Mandelbrot) para a amostra e para as unidades amostrais; os critérios de acurácia dos modelos foram: Akaike, Bayesiano e Deviance. O modelo ecológico de DAEs que descreveu o ranking/abundância das espécies para a comunidade arbórea foi o Zipf-Mandelbrot. Os modelos ecológicos de DAEs que caracterizaram as unidades amostrais foram: niche-preemption, Zipf e Zipf-Mandelbrot. O modelo Zipf-Mandelbrot postula a colonização das espécies sob as exigências de condições ambientais prévias para o estabelecimento, assim, detecta-se uma comunidade arbórea em estágio de maturidade. Os modelos ecológicos de DAEs obtidos para as unidades amostrais, separadamente, evidenciam a disparidade da distribuição de abundância de espécies no interior da comunidade arbórea, que se interpretou como o efeito da heterogeneidade das condições e dos recursos ambientais, além de perturbações naturais, que originam um mosaico vegetacional

Air contaminants and litter fall decomposition in urban forest areas: The case of São Paulo - SP, Brazil

Background Urban forests are usually affected by several types of atmospheric contaminants and by abnormal variations in weather conditions, thus facilitating the biotic homogenization and modification of ecosystem processes, such as nutrient cycling. Peri-urban forests and even natural forests that surround metropolitan areas are also subject to anthropogenic effects generated by cities, which may compromise the dynamics of these ecosystems. Hence, this study advances the hypothesis that the forests located at the margins of the Metropolitan Region of São Paulo (MRSP), Brazil, have high concentrations of atmospheric contaminants leading to adverse effects on litter fall stock. Methods The production, stock and decomposition of litter fall in two forests were quantified. The first, known as Guarapiranga forest, lies closer to the urban area and is located within the MRSP, approximately 20 km from the city center. The second, Curucutu forest, is located 70 km from the urban center. This forest is situated exactly on the border of the largest continuum of vegetation of the Atlantic Forest. To verify the reach of atmospheric pollutants from the urban area, levels of heavy metals (Cd, Pb, Ni, Cu) adsorbed on the litter fall deposited on the soil surface of the forests were also quantified. Results The stock of litter fall and the levels of heavy metals were generally higher in the Guarapiranga forest in the samples collected during the lower rainfall season (dry season). Non-metric multidimensional scaling multivariate analysis showed a clear distinction of the sample units related to the concentrations of heavy metals in each forest. A subtle difference between the units related to the dry and rainy seasons in the Curucutu forest was also noted. Multivariate Analysis of Variance revealed that both site and season of the year (dry or rainy) were important to differentiate the quantity of heavy metals in litter fall stock, although the analysis did not show the interaction between these two factors. Precipitation appeared to be an important factor to disperse air pollutants; one method to better regulate this process is the development and integration of green infrastructure at city level, which might contribute to nature-based solutions. Conclusions Results suggest that although the Curucutu forest is not very far from the MRSP, which could result in heavy metal levels similar to those observed in the Guarapiranga forest, the weather conditions, geographic location and rainfall rates might act as efficient physical barriers against the dispersion of pollutants in the urban area. However, it is important to highlight that in the period studied (2012–2013), MRSP presented unusual features during the winter period marked by the highest levels of precipitation which was due to several numbers of frontal systems and also due to their permanence for a couple days in the region. Thus, it is recommended to continue this study in order to obtain a database for characterizing the seasonal variation of air pollution levels in the litter fall and their adverse effects on ecosystem processes in these remnants of the Atlantic Forest