Merkel Cell Polyomavirus DNA in Persons without Merkel Cell Carcinoma

Merkel cell polyomavirus (MCPyV) DNA was detected in 88% of Merkel cell carcinomas in contrast to 16% of other skin tumors. MCPyV was also found in anogenital and oral samples (31%) and eyebrow hairs (50%) of HIV-positive men and in forehead swabs (62%) of healthy controls. MCPyV thus appears to be widespread

Evolution of faint radio sources in the VIDEO-XMM3 field

© 2013 The Authors Published by Oxford University Press on behalf of the Royal Astronomical SocietyIt has been speculated that low-luminosity radio-loud active galactic nuclei (AGN) have the potential to serve as an important source of AGN feedback, and may be responsible for suppressing star formation activity in massive elliptical galaxies at late times. As such the cosmic evolution of these sources is vitally important to understand the significance of such AGN feedback processes and their influence on the global star formation history of the Universe. In this paper, we present a new investigation of the evolution of faint radio sources out to z ~ 2.5. We combine a 1 square degree Very Large Array radio survey, complete to a depth of 100 μJy, with accurate 10 band photometric redshifts from the following surveys: Visible and Infrared Survey Telescope for Astronomy Deep Extragalactic Observations and Canada-France-Hawaii Telescope Legacy Survey. The results indicate that the radio population experiences mild positive evolution out to z ~ 1.2 increasing their space density by a factor of ~3, consistent with results of several previous studies. Beyond z = 1.2, there is evidence of a slowing down of this evolution. Star-forming galaxies drive the more rapid evolution at low redshifts, z 1.2. The evolution is best fitted by pure luminosity evolution with star-forming galaxies evolving as (1 + z)2.47 ± 0.12 and AGN as (1 + z)1.18 ± 0.21M.Peer reviewe

Herschel-ATLAS: Far-infrared properties of radio-loud and radio-quiet quasars

This is pre-copyedited, author-produced pdf of an article accepted for publication in Monthly Notices of the Royal Astronomical Society following peer review. The version of record, E. Kalfountzou, et al., ‘Herschel-ATLAS: Far-infrared properties of radio-loud and radio-quiet quasars’, MNRAS, Vol 42(2): 1181-1196, first published online June 11, 2014, is available online via doi: 10.1093/mnras/stu782 Published by Oxford University Press on behalf of the Royal Astronomical Society.We have constructed a sample of radio-loud and radio-quiet quasars from the Faint Images Radio Sky at Twenty-one centimetres and the Sloan Digital Sky Survey Data Release 7, over the Herschel-ATLAS Phase 1 area (9h, 12h and 14 h . 5 ). Using a stacking analysis, we find a significant correlation between the far-infrared (FIR) luminosity and 1.4-GHz luminosity for radio-loud quasars. Partial correlation analysis confirms the intrinsic correlation after removing the redshift contribution, while for radio-quiet quasars, no partial correlation is found. Using a single-temperature grey-body model, we find a general trend of lower dust temperatures in case of radio-loud quasars compared to radio-quiet quasars. Also, radio-loud quasars are found to have almost constant mean values of dust mass along redshift and optical luminosity bins. In addition, we find that radio-loud quasars at lower optical luminosities tend to have on average higher FIR and 250-μm luminosity with respect to radio-quiet quasars with the same optical luminosites. Even if we use a two-temperature grey-body model to describe the FIR data, the FIR luminosity excess remains at lower optical luminosities. These results suggest that powerful radio jets are associated with star formation especially at lower accretion ratesPeer reviewe

Herschel-ATLAS/GAMA: What determines the far-infrared properties of radio galaxies?

We perform a stacking analysis of Herschel Astrophysical Terahertz Large Area Survey (H-ATLAS) data in order to obtain isothermal dust temperatures and rest-frame luminosities at 250 μm (L_250), for a well-defined sample of 1599 radio sources over the H-ATLAS Phase 1/Galaxy and Mass Assembly (GAMA) area. The radio sample is generated using a combination of NRAO VLA Sky Survey data and K-band United Kingdom Infrared Telescope Deep Sky Survey–Large Area Survey data, over the redshift range 0.01 < z < 0.8. The far-infrared (FIR) properties of the sample are investigated as a function of 1.4-GHz luminosity, redshift, projected radio-source size and radio spectral index. In order to search for stellar-mass-dependent relations, we split the parent sample into those sources which are below and above 1.5 L∗_(K). After correcting for stellar mass and redshift, we find no relation between the 250-μm luminosity and the 1.4-GHz radio luminosity of radio active galactic nuclei. This implies that a galaxy's nominal radio luminosity has little or no bearing on the star formation rate (SFR) and/or dust mass content of the host system, although this does not mean that other variables (e.g. radio source size) related to the jets do not have an effect. The L_250 of both the radio detected and non-radio-detected galaxies (defined as those sources not detected at 1.4 GHz but detected in the Sloan Digital Sky Survey with r′ 30 kpc) counterparts. The higher dust temperature suggests that this may be attributed to enhanced SFRs in compact radio galaxies, but whether this is directly or indirectly due to radio activity (e.g. jet-induced or merger-driven star formation) is as yet unknown. For matched samples in L_K and g′–r′, sub-1.5 L∗_K and super-1.5 L∗_K radio-detected galaxies have 0.89±0.18 and 0.49±0.12 times the 250 μm luminosity of their non-radio-detected counterparts. Thus, while no difference in L_250 is observed in sub-1.5 L∗_K radio-detected galaxies, a strong deficit is observed in super-1.5 L∗_K radio-detected galaxies. We explain these results in terms of the hotter, denser and richer halo environments massive radio galaxies maintain and are embedded in. These environments are expected to quench the cold gas and dust supply needed for further star formation and therefore dust production. Our results indicate that all massive radio galaxies (>1.5 L∗_K) may have systematically lower FIR luminosities (∼25 per cent) than their colour-matched non-radio-detected counterparts. Finally, no relation between radio spectral index and L_250 is found for the subset of 1.4-GHz radio sources with detections at 330 MHz

The Intra-Cochlear Impedance-Matrix (IIM) test for the Nucleus® cochlear implant

The IIM test was found to be straightforward to perform clinically and demonstrated reproducible data with narrow ranges in normally-functioning devices. Because this test uses a very low stimulation level the IIM test is well suited for children or multiply handicapped CI users who cannot reliably report on their auditory percepts. The new algorithms show potential to improve implant integrity testing capabilities if implemented in future clinical software

Human papillomavirus type 8 E6 oncoprotein inhibits transcription of the PDZ protein syntenin-2

The E6 proteins from high-risk alpha human papillomavirus (HPV) types (e.g., HPV16) are characterized by the presence of a PDZ-binding motif through which they interact with a number of cellular PDZ domain-containing substrates and cooperate in their degradation. The ability of these E6 proteins to bind to PDZ domain proteins correlates with the oncogenic potential of the virus. The E6 proteins of oncogenic HPV from the genus Betapapillomavirus (betaPV, e.g., HPV8) do not encode a PDZ-binding motif. We found that the PDZ domain protein syntenin-2 is transcriptionally downregulated in primary human epidermal keratinocytes (PHEK) by HPV8 E6. The mRNA levels of the known HPV16 E6 PDZ protein targets Dlg, Scribble, Magi-1, Magi-3, PSD95, and Mupp1 were not changed by HPV8 E6. Decreased protein levels of syntenin-2 were observed in cell extracts from PHEK expressing HPV5, -8, -16, -20, and -38 E6 but not in HPV1 and -4 E6-positive keratinocytes. Surprisingly, HPV16 E6 also repressed transcription of syntenin-2 but with a much lower efficiency than HPV8 E6. In healthy human skin, syntenin-2 expression is localized in suprabasal epidermal layers. In organotypic skin cultures, the differentiation-dependent expression of syntenin-2 was absent in HPV8 E6- and E6E7-expressing cells. In basal cell carcinomas of the skin, syntenin-2 was not detectable, whereas in squamous cell carcinomas, expression was located in differentiated areas. Short hairpin RNA-mediated knockdown of syntenin-2 led to an inhibition of differentiation and an increase in the proliferation capacity in PHEK. These results identified syntenin-2 as the first PDZ domain protein controlled by HPV8 and HPV16 at the mRNA level

Use of remote control in the intraoperative telemetry of cochlear implant: multicentric study

A avaliação convencional da telemetria neural e de impedâncias implica o uso do computador acoplado a uma interface, o software fornece o estímulo e a visualização das respostas. Recentemente, foi lançado um controle remoto (CR220®), que possibilita testes intraoperatórios com instrumental mínimo.Avaliar a concordância dos valores das impedâncias e dos limiares da telemetria neural e o tempo de execução no procedimento convencional e pelo controle remoto. Estudo prospectivo transversal multicêntrico. Foram incluídas as avaliações intraoperatórias de implante coclear compatível com o uso do CR220®. Os testes foram realizados nos 22 eletrodos para comparar os tempos de execução nas duas situações. Foi analisada a concordância dos valores do limiar da telemetria neural obtidos em cinco eletrodos e a concordância das impedâncias foi avaliada pelo número de eletrodos com valores alterados em cada procedimento. Não houve diferença significante entre as impedâncias. Obteve-se moderada a forte correlação entre os limiares do potencial de ação composto eletricamente evocado. O tempo médio para os procedimentos com o CR220 foi significativamente menor do que com o procedimento convencional. O uso do CR220 proporcionou registros bem-sucedidos para a telemetria de impedância e a telemetria automática de respostas neurais85450250The conventional evaluation of neural telemetry and impedance requires the use of the computer coupled to an interface, with software that provides visualization of the stimulus and response. Recently, a remote control (CR220®) was launched in the market, that allows the performance of intraoperative tests with minimal instrumentation. To evaluate the agreement of the impedance values and neural telemetry thresholds, and the time of performance in the conventional procedure and by the remote control. Multicentric prospective cross-sectional study. Intraoperative evaluations of cochlear implants compatible with the use of CR220® were included. The tests were carried out in the 22 electrodes to compare the time of performance in the two situations. The agreement of the neural telemetry threshold values obtained from five electrodes was analyzed, and the agreement of impedance was evaluated by the number of electrodes with altered values in each procedure. There were no significant difference between the impedance values. There was a moderate to strong correlation between the electrically-evoked compound action potential thresholds. The mean time to perform the procedures using the CR220 was significantly lower than that with the conventional procedure. The use of the CR220 provided successful records for impedance telemetry and automatic neural response telemetr